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The map label for this gene is ilvY [H]

Identifier: 197119130

GI number: 197119130

Start: 3186379

End: 3187359

Strand: Reverse

Name: ilvY [H]

Synonym: Gbem_2757

Alternate gene names: 197119130

Gene position: 3187359-3186379 (Counterclockwise)

Preceding gene: 197119132

Following gene: 197119129

Centisome position: 69.06

GC content: 60.86

Gene sequence:

>981_bases
ATGGTCTTGATGGACGCGATGGACAACCTTGAACTGATGATCACTAGAGGACAAAACATGGACCTGCGGGAACTGGAAGT
ATTTCTCACCGTCGCCGAGACACTCCACTTCGGTCGCGCCAGCCAGGCCTGCAACCTGAGCCCGTCGGCTTTGACCCGGA
CTATTCAGCGCATGGAGGAGCAACTGGAACAGCCGCTTTTCCTGCGCGACAACAGGACGGTAACGCTTTCGCCGGCGGGG
GAGCGCCTCAAAAGCTACGCCCGCCTCTGCCTGCAGGAGTGGCAGAGCTTCCGCGCCGCCATAAAGGACGAGCAGTCGGT
GGCGGGAACGTTATCTATATACGCTTCCATCACCGCGGTCTACAGCCTGCTTCCCGAACTGCTGGAGTCGTACCGGGAAA
AGTACCCGGAGGTCCAACTTGAATTGAGGACGGGGGCCGCGGAGCAGGCGGTGACGCAGGTGCAAAACGGGGAGATAGAC
CTTGCCGTGGCGGCACTCCCCGACCGGCATAGCTCGAACTTGGAATTTCTCCCCATCGCCACCATACCGCTCATCTTCAT
CGCGCCGCGCCACGCGATTGCTGCGGATGTTCCGCAGGAGGGTGGCGAACTCGACCTCTCCCGGGCACCGCTGGTGTTGC
CGCAGACAGGGCTTTCCCGAAGGAGGCTCGATCAGTGGCTCAAGGAGCACCGCATTTCGCCAAACATCACCTCCGAGGTC
TCGGGCAATGAGGCCATTATCGCCATGGTGCGGCTTGGCTGCGGGGTCGGCATCGTGCCGCAACTGGTTCTGGAGCGAAG
CCCCTTCAGGGACGAGGTGGCGGTGCTGGAGAAGGCGCCTTCATTGAAACCGTACGAGGTGGGGCTTTGCTGCGGCAGGC
GCAACCTGCAGCGCCCCAGCGTGAAGGCATTCTGGCAACTGGCGGAGAAGCAGTCTATAAACCAAAAGAAGGTCACGCAA
AGACGCAAAGGCGCCAAGTAA

Upstream 100 bases:

>100_bases
ATTGCGTAAATTGAATTATTGTGCATATTGTATTGCGCCTGGCGCAACGTGGACTTCCCTCACCCCGGCCCTCTCCCGGA
GGGCGAGGGGGAATGGACTC

Downstream 100 bases:

>100_bases
AATCTATATTTCCTCTTCATCGATTGTCATTGATCCTGCCGCGACTGTCACCAAGAGGGAGTTCACGCTCTGTTGTCTTT
GCGTCTTTGCGGCTTTGCGT

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MVLMDAMDNLELMITRGQNMDLRELEVFLTVAETLHFGRASQACNLSPSALTRTIQRMEEQLEQPLFLRDNRTVTLSPAG
ERLKSYARLCLQEWQSFRAAIKDEQSVAGTLSIYASITAVYSLLPELLESYREKYPEVQLELRTGAAEQAVTQVQNGEID
LAVAALPDRHSSNLEFLPIATIPLIFIAPRHAIAADVPQEGGELDLSRAPLVLPQTGLSRRRLDQWLKEHRISPNITSEV
SGNEAIIAMVRLGCGVGIVPQLVLERSPFRDEVAVLEKAPSLKPYEVGLCCGRRNLQRPSVKAFWQLAEKQSINQKKVTQ
RRKGAK

Sequences:

>Translated_326_residues
MVLMDAMDNLELMITRGQNMDLRELEVFLTVAETLHFGRASQACNLSPSALTRTIQRMEEQLEQPLFLRDNRTVTLSPAG
ERLKSYARLCLQEWQSFRAAIKDEQSVAGTLSIYASITAVYSLLPELLESYREKYPEVQLELRTGAAEQAVTQVQNGEID
LAVAALPDRHSSNLEFLPIATIPLIFIAPRHAIAADVPQEGGELDLSRAPLVLPQTGLSRRRLDQWLKEHRISPNITSEV
SGNEAIIAMVRLGCGVGIVPQLVLERSPFRDEVAVLEKAPSLKPYEVGLCCGRRNLQRPSVKAFWQLAEKQSINQKKVTQ
RRKGAK
>Mature_326_residues
MVLMDAMDNLELMITRGQNMDLRELEVFLTVAETLHFGRASQACNLSPSALTRTIQRMEEQLEQPLFLRDNRTVTLSPAG
ERLKSYARLCLQEWQSFRAAIKDEQSVAGTLSIYASITAVYSLLPELLESYREKYPEVQLELRTGAAEQAVTQVQNGEID
LAVAALPDRHSSNLEFLPIATIPLIFIAPRHAIAADVPQEGGELDLSRAPLVLPQTGLSRRRLDQWLKEHRISPNITSEV
SGNEAIIAMVRLGCGVGIVPQLVLERSPFRDEVAVLEKAPSLKPYEVGLCCGRRNLQRPSVKAFWQLAEKQSINQKKVTQ
RRKGAK

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=299, Percent_Identity=41.4715719063545, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI157672245, Length=288, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=31.8725099601594, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787806, Length=291, Percent_Identity=26.8041237113402, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI145693105, Length=257, Percent_Identity=26.0700389105058, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=259, Percent_Identity=28.1853281853282, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788887, Length=246, Percent_Identity=26.0162601626016, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790399, Length=273, Percent_Identity=26.7399267399267, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787601, Length=182, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=24.3027888446215, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=23.2283464566929, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788481, Length=250, Percent_Identity=28, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI48994962, Length=178, Percent_Identity=30.3370786516854, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=24.4979919678715, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788296, Length=264, Percent_Identity=25.3787878787879, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786401, Length=143, Percent_Identity=29.3706293706294, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788706, Length=305, Percent_Identity=25.9016393442623, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787128, Length=139, Percent_Identity=31.6546762589928, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790262, Length=253, Percent_Identity=25.296442687747, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87081904, Length=180, Percent_Identity=25.5555555555556, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87082132, Length=247, Percent_Identity=24.6963562753036, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36452; Mature: 36452

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLMDAMDNLELMITRGQNMDLRELEVFLTVAETLHFGRASQACNLSPSALTRTIQRMEE
CEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QLEQPLFLRDNRTVTLSPAGERLKSYARLCLQEWQSFRAAIKDEQSVAGTLSIYASITAV
HHHCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YSLLPELLESYREKYPEVQLELRTGAAEQAVTQVQNGEIDLAVAALPDRHSSNLEFLPIA
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEHH
TIPLIFIAPRHAIAADVPQEGGELDLSRAPLVLPQTGLSRRRLDQWLKEHRISPNITSEV
HHCEEEECCCHHHHCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
SGNEAIIAMVRLGCGVGIVPQLVLERSPFRDEVAVLEKAPSLKPYEVGLCCGRRNLQRPS
CCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCH
VKAFWQLAEKQSINQKKVTQRRKGAK
HHHHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MVLMDAMDNLELMITRGQNMDLRELEVFLTVAETLHFGRASQACNLSPSALTRTIQRMEE
CEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QLEQPLFLRDNRTVTLSPAGERLKSYARLCLQEWQSFRAAIKDEQSVAGTLSIYASITAV
HHHCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YSLLPELLESYREKYPEVQLELRTGAAEQAVTQVQNGEIDLAVAALPDRHSSNLEFLPIA
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEHH
TIPLIFIAPRHAIAADVPQEGGELDLSRAPLVLPQTGLSRRRLDQWLKEHRISPNITSEV
HHCEEEECCCHHHHCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
SGNEAIIAMVRLGCGVGIVPQLVLERSPFRDEVAVLEKAPSLKPYEVGLCCGRRNLQRPS
CCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCH
VKAFWQLAEKQSINQKKVTQRRKGAK
HHHHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]