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The map label for this gene is uppS [H]

Identifier: 197119125

GI number: 197119125

Start: 3182301

End: 3183050

Strand: Reverse

Name: uppS [H]

Synonym: Gbem_2752

Alternate gene names: 197119125

Gene position: 3183050-3182301 (Counterclockwise)

Preceding gene: 197119126

Following gene: 308535318

Centisome position: 68.97

GC content: 62.67

Gene sequence:

>750_bases
ATGGATAGCTTAGATCGGAAGAACCTCCCGGCGCATCTCGCCGTCATCATGGACGGCAACGGCCGCTGGGCCAAGCAGCG
CATGTTACGCAGGATCGTTGGGCACCAAAAAGGAGTTGAGACTGTCCGGGTGATAGTGGAGGAATGCTCGCGTCTGGGCA
TCGGCTATCTTACCCTGTTCGCCTTCTCCGCCGAAAACTGGCTCCGGCCCAAGACCGAGGTCAAGGCACTGATGGCGCTC
CTGAAGCAATACATCCGCGGCGAGACCGCGCGGATGATGCAAAACGACATCCGTTTCAACGTGATAGGAAACCGCTGCGA
CCTCCCCGAGGACGTGAACCGCGAGATCGAAAGCGCCATCCAGAAGACCGCCGGGAACCGCGGCATGCTGCTCACCCTGG
CGCTTTCCTACGGCAGCCGCCAGGAGATCGTAGCGGCGGCCAAAAGGCTCGCCAAGGATGCGGCGGCGGGAAGGCTCGAC
CCCGAGGCGATCGATGAGGCGAGCTTCACCGGCTCGCTCTTCACCGCGGGAATCCCGGACCCGGACCTGCTGATCAGGAC
CAGCGGGGAGATGCGCATCAGCAACTTCCTCCTCTGGCAGTTGGCCTACGCGGAGCTCTACTTCACCGAGGTGAACTGGC
CCGACTTCGACCGCAACGAGTTGGCCCGCGCCTTCCGGGACTTCCAGTCCAGGGAGCGCAGATTCGGCATGACCAGCGAA
CAGCTCTGCCAAGGCGAGCCCGAGGCTTAA

Upstream 100 bases:

>100_bases
TGTGCGGCAGGGGGGAGCACTCCCCCCTGCTGACCGACCGGCCCCTCTCCATTTGCGCAAACCCCCGACCCGCCGGGGAT
TTTTTGTTTTCAGGATGGTC

Downstream 100 bases:

>100_bases
TCTTCCCGGGGGGAAGCCCCATAGGAGTACGCCATCAAACGACTAGCCACCGCAGCGGTGCTGCTGCCGCTTGTGATACT
GTTCATCCTGAAGGCCTCGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MDSLDRKNLPAHLAVIMDGNGRWAKQRMLRRIVGHQKGVETVRVIVEECSRLGIGYLTLFAFSAENWLRPKTEVKALMAL
LKQYIRGETARMMQNDIRFNVIGNRCDLPEDVNREIESAIQKTAGNRGMLLTLALSYGSRQEIVAAAKRLAKDAAAGRLD
PEAIDEASFTGSLFTAGIPDPDLLIRTSGEMRISNFLLWQLAYAELYFTEVNWPDFDRNELARAFRDFQSRERRFGMTSE
QLCQGEPEA

Sequences:

>Translated_249_residues
MDSLDRKNLPAHLAVIMDGNGRWAKQRMLRRIVGHQKGVETVRVIVEECSRLGIGYLTLFAFSAENWLRPKTEVKALMAL
LKQYIRGETARMMQNDIRFNVIGNRCDLPEDVNREIESAIQKTAGNRGMLLTLALSYGSRQEIVAAAKRLAKDAAAGRLD
PEAIDEASFTGSLFTAGIPDPDLLIRTSGEMRISNFLLWQLAYAELYFTEVNWPDFDRNELARAFRDFQSRERRFGMTSE
QLCQGEPEA
>Mature_249_residues
MDSLDRKNLPAHLAVIMDGNGRWAKQRMLRRIVGHQKGVETVRVIVEECSRLGIGYLTLFAFSAENWLRPKTEVKALMAL
LKQYIRGETARMMQNDIRFNVIGNRCDLPEDVNREIESAIQKTAGNRGMLLTLALSYGSRQEIVAAAKRLAKDAAAGRLD
PEAIDEASFTGSLFTAGIPDPDLLIRTSGEMRISNFLLWQLAYAELYFTEVNWPDFDRNELARAFRDFQSRERRFGMTSE
QLCQGEPEA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=37.9464285714286, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=37.9464285714286, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=44.4915254237288, Blast_Score=201, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=34.070796460177, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=34.7417840375587, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=29.7674418604651, Blast_Score=96, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=38.2775119617225, Blast_Score=147, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28233; Mature: 28233

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLDRKNLPAHLAVIMDGNGRWAKQRMLRRIVGHQKGVETVRVIVEECSRLGIGYLTLF
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
AFSAENWLRPKTEVKALMALLKQYIRGETARMMQNDIRFNVIGNRCDLPEDVNREIESAI
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHH
QKTAGNRGMLLTLALSYGSRQEIVAAAKRLAKDAAAGRLDPEAIDEASFTGSLFTAGIPD
HHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEECCCCC
PDLLIRTSGEMRISNFLLWQLAYAELYFTEVNWPDFDRNELARAFRDFQSRERRFGMTSE
CCEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
QLCQGEPEA
HHHCCCCCC
>Mature Secondary Structure
MDSLDRKNLPAHLAVIMDGNGRWAKQRMLRRIVGHQKGVETVRVIVEECSRLGIGYLTLF
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
AFSAENWLRPKTEVKALMALLKQYIRGETARMMQNDIRFNVIGNRCDLPEDVNREIESAI
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHH
QKTAGNRGMLLTLALSYGSRQEIVAAAKRLAKDAAAGRLDPEAIDEASFTGSLFTAGIPD
HHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEECCCCC
PDLLIRTSGEMRISNFLLWQLAYAELYFTEVNWPDFDRNELARAFRDFQSRERRFGMTSE
CCEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
QLCQGEPEA
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA