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The map label for this gene is pepA [H]

Identifier: 197119098

GI number: 197119098

Start: 3152244

End: 3153722

Strand: Direct

Name: pepA [H]

Synonym: Gbem_2725

Alternate gene names: 197119098

Gene position: 3152244-3153722 (Clockwise)

Preceding gene: 197119096

Following gene: 197119100

Centisome position: 68.3

GC content: 64.16

Gene sequence:

>1479_bases
ATGAAGATAGAAACTTCTCGCCTGAACCCAATACAACATGCCACCGCAGCGCTCGTCATCGGCTGTTTCGAAGACGCCAA
AGACGACCTCTTCGCCGCCTGCGACAAAGAGCTCGACGGGTACCTCACCTCCCTTTTCGAAAGCCGCGAGTTTACCGGCA
AGTCCGGCAGCTCCCTTCTATTGCACACCATGGGGAAGCTCCCGGCCCAAAGGCTCCTCCTGGTGGGGCTCGGCAAAAAG
GGAGATGTCAAAGGGGAGCTTTTGCGCCGCGCGGCAGGAACCGCCGTTGGGGCGCTGCAGGGAGTCCGCGTCGCCAGCTT
CAGCAGCGCACTGCACCTTTGCTGTCAATTACCGAAGGCGCTGGAAGCCGTCGTGGCGGGTACCCTTCTGGGGAGCTACA
GGTTCGATCTCTACAAAACCAAGGATAAAGAGGAGCGCTTCCAGTTCGACTCCATGACCCTGCTCCTTGGCGAAGAGAAG
GATACCGGCGACACGCGTCTCAGGATCGAACAGGCGGAGCAGCTCTGCCGCGGGGTCTGCCTCGCGCGCGACCTGGTGTC
GCACCCGGGGAACGTGGTGACACCCGGCTACTTGGCGCAAGAGGCGCAGGAACTCGCGACACGCCACGCACTGGAATGCA
AAGTGTACGAACAGGACGAACTGGAGTCGCTTGGCATGAATGCGCTTTTGGGGGTGGGAAAGGGGGCGGCCGAACCTCCG
CGCCTGATCGTAGTCCGCTACCGGGGCGAAGGGGCCAAGGGGCGCCCGGTGGTGCTGGTCGGCAAGGGAATCACCTTCGA
CTCGGGCGGGATCTCCATCAAGCCGGGACCGGGGATGGAGGAGATGAAGACGGACATGGCGGGAGCCGCGGCAGTACTCG
GGACGCTGGAGGCGGCGGCGCTTTTGCAGCTGCCGGTGGACCTGGTCGGCGTCATTCCCACTGCCGAGAACATGCCCGAC
GGCAAGGCCTTCAAGCCCGGGGACGTGCTGGCCTCGCTCTCCGGGACCACCATCGAGATCACCAACACCGACGCCGAGGG
GCGGCTGATACTCTGCGACGCGCTCCACTTCGCCCAGAAGTTCAAGCCGGCTGCCATGATCGATCTCGCCACCTTGACCG
GCGCCTGCGTGGTCGCCTTGGGGCACGAGGCGAGCGCCGTTCTCGGCAACGACCAGCGCCTGGTGGACGCACTGAAAAAG
AGCGGGGACGAGACCGGGGAACGGCTTTGGCAGCTGCCGCTTTGGGACGAGTACGGCGAGGGGATGAAGAGCGACATCGC
GGATATAAAAAACGCCGGGAGCAGGGACGGCGGAACCATCAAGGCGGCCTGGTTCCTGAAGCAGTTCGTGGGAGAGACTC
GCTGGGCCCACCTGGACATCGCCGGCACCGCCTGGAGCGACAAGGGGCGCCCCTACTCCCCCAAGGGGGCGACCGGGATC
GGGGTACGCCTGCTGATCGAGTACCTGCGGCAGAAGTAG

Upstream 100 bases:

>100_bases
CTTATTTGACTGTACGACAACCTTCACATAGAATCATCCAAGCGTTCGCCGCACTTTTAAGCCAGACTCAGCCACTTCAA
TTCAATCCAAGGGAGCCCCC

Downstream 100 bases:

>100_bases
AGGGTTTAGGGACGGCGGGGCCAGTGGTGCAGGAACACCGGCACCAGGGCAGAGAGGGCCAAAAACCCCATGGCGAGCAT
GGATTTCCCGGACAAGAGAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKIETSRLNPIQHATAALVIGCFEDAKDDLFAACDKELDGYLTSLFESREFTGKSGSSLLLHTMGKLPAQRLLLVGLGKK
GDVKGELLRRAAGTAVGALQGVRVASFSSALHLCCQLPKALEAVVAGTLLGSYRFDLYKTKDKEERFQFDSMTLLLGEEK
DTGDTRLRIEQAEQLCRGVCLARDLVSHPGNVVTPGYLAQEAQELATRHALECKVYEQDELESLGMNALLGVGKGAAEPP
RLIVVRYRGEGAKGRPVVLVGKGITFDSGGISIKPGPGMEEMKTDMAGAAAVLGTLEAAALLQLPVDLVGVIPTAENMPD
GKAFKPGDVLASLSGTTIEITNTDAEGRLILCDALHFAQKFKPAAMIDLATLTGACVVALGHEASAVLGNDQRLVDALKK
SGDETGERLWQLPLWDEYGEGMKSDIADIKNAGSRDGGTIKAAWFLKQFVGETRWAHLDIAGTAWSDKGRPYSPKGATGI
GVRLLIEYLRQK

Sequences:

>Translated_492_residues
MKIETSRLNPIQHATAALVIGCFEDAKDDLFAACDKELDGYLTSLFESREFTGKSGSSLLLHTMGKLPAQRLLLVGLGKK
GDVKGELLRRAAGTAVGALQGVRVASFSSALHLCCQLPKALEAVVAGTLLGSYRFDLYKTKDKEERFQFDSMTLLLGEEK
DTGDTRLRIEQAEQLCRGVCLARDLVSHPGNVVTPGYLAQEAQELATRHALECKVYEQDELESLGMNALLGVGKGAAEPP
RLIVVRYRGEGAKGRPVVLVGKGITFDSGGISIKPGPGMEEMKTDMAGAAAVLGTLEAAALLQLPVDLVGVIPTAENMPD
GKAFKPGDVLASLSGTTIEITNTDAEGRLILCDALHFAQKFKPAAMIDLATLTGACVVALGHEASAVLGNDQRLVDALKK
SGDETGERLWQLPLWDEYGEGMKSDIADIKNAGSRDGGTIKAAWFLKQFVGETRWAHLDIAGTAWSDKGRPYSPKGATGI
GVRLLIEYLRQK
>Mature_492_residues
MKIETSRLNPIQHATAALVIGCFEDAKDDLFAACDKELDGYLTSLFESREFTGKSGSSLLLHTMGKLPAQRLLLVGLGKK
GDVKGELLRRAAGTAVGALQGVRVASFSSALHLCCQLPKALEAVVAGTLLGSYRFDLYKTKDKEERFQFDSMTLLLGEEK
DTGDTRLRIEQAEQLCRGVCLARDLVSHPGNVVTPGYLAQEAQELATRHALECKVYEQDELESLGMNALLGVGKGAAEPP
RLIVVRYRGEGAKGRPVVLVGKGITFDSGGISIKPGPGMEEMKTDMAGAAAVLGTLEAAALLQLPVDLVGVIPTAENMPD
GKAFKPGDVLASLSGTTIEITNTDAEGRLILCDALHFAQKFKPAAMIDLATLTGACVVALGHEASAVLGNDQRLVDALKK
SGDETGERLWQLPLWDEYGEGMKSDIADIKNAGSRDGGTIKAAWFLKQFVGETRWAHLDIAGTAWSDKGRPYSPKGATGI
GVRLLIEYLRQK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=497, Percent_Identity=36.4185110663984, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=36.3924050632911, Blast_Score=149, Evalue=8e-36,
Organism=Escherichia coli, GI1790710, Length=501, Percent_Identity=39.5209580838323, Blast_Score=354, Evalue=6e-99,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=38.2911392405063, Blast_Score=179, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=299, Percent_Identity=35.4515050167224, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=407, Percent_Identity=25.3071253071253, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355725, Length=314, Percent_Identity=37.8980891719745, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161077148, Length=473, Percent_Identity=33.1923890063425, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI20130057, Length=473, Percent_Identity=33.1923890063425, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24661038, Length=375, Percent_Identity=34.4, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI20129969, Length=476, Percent_Identity=30.672268907563, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI21355645, Length=471, Percent_Identity=29.723991507431, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24662223, Length=471, Percent_Identity=29.723991507431, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24662227, Length=501, Percent_Identity=28.9421157684631, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI20129963, Length=432, Percent_Identity=32.4074074074074, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19922386, Length=475, Percent_Identity=30.7368421052632, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=36.6771159874608, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=36.6771159874608, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=36.6771159874608, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24646701, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52622; Mature: 52622

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIETSRLNPIQHATAALVIGCFEDAKDDLFAACDKELDGYLTSLFESREFTGKSGSSLL
CCCCCCCCCHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LHTMGKLPAQRLLLVGLGKKGDVKGELLRRAAGTAVGALQGVRVASFSSALHLCCQLPKA
HHHHHCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LEAVVAGTLLGSYRFDLYKTKDKEERFQFDSMTLLLGEEKDTGDTRLRIEQAEQLCRGVC
HHHHHHHHHHHHHEEEEEECCCHHHHHHHCCEEEEEECCCCCCCCEEEHHHHHHHHHHHH
LARDLVSHPGNVVTPGYLAQEAQELATRHALECKVYEQDELESLGMNALLGVGKGAAEPP
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECHHHHHHCCCHHHHCCCCCCCCCC
RLIVVRYRGEGAKGRPVVLVGKGITFDSGGISIKPGPGMEEMKTDMAGAAAVLGTLEAAA
EEEEEEEECCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
LLQLPVDLVGVIPTAENMPDGKAFKPGDVLASLSGTTIEITNTDAEGRLILCDALHFAQK
HHHCCHHHHEECCCCCCCCCCCCCCCCHHHEECCCCEEEEECCCCCCCEEEEHHHHHHHH
FKPAAMIDLATLTGACVVALGHEASAVLGNDQRLVDALKKSGDETGERLWQLPLWDEYGE
CCCHHHHHHHHHHCEEEEEECCCCHHHCCCCHHHHHHHHHCCCHHHHHEECCCCHHHHCC
GMKSDIADIKNAGSRDGGTIKAAWFLKQFVGETRWAHLDIAGTAWSDKGRPYSPKGATGI
CHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
GVRLLIEYLRQK
HHHHHHHHHHCC
>Mature Secondary Structure
MKIETSRLNPIQHATAALVIGCFEDAKDDLFAACDKELDGYLTSLFESREFTGKSGSSLL
CCCCCCCCCHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LHTMGKLPAQRLLLVGLGKKGDVKGELLRRAAGTAVGALQGVRVASFSSALHLCCQLPKA
HHHHHCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LEAVVAGTLLGSYRFDLYKTKDKEERFQFDSMTLLLGEEKDTGDTRLRIEQAEQLCRGVC
HHHHHHHHHHHHHEEEEEECCCHHHHHHHCCEEEEEECCCCCCCCEEEHHHHHHHHHHHH
LARDLVSHPGNVVTPGYLAQEAQELATRHALECKVYEQDELESLGMNALLGVGKGAAEPP
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECHHHHHHCCCHHHHCCCCCCCCCC
RLIVVRYRGEGAKGRPVVLVGKGITFDSGGISIKPGPGMEEMKTDMAGAAAVLGTLEAAA
EEEEEEEECCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
LLQLPVDLVGVIPTAENMPDGKAFKPGDVLASLSGTTIEITNTDAEGRLILCDALHFAQK
HHHCCHHHHEECCCCCCCCCCCCCCCCHHHEECCCCEEEEECCCCCCCEEEEHHHHHHHH
FKPAAMIDLATLTGACVVALGHEASAVLGNDQRLVDALKKSGDETGERLWQLPLWDEYGE
CCCHHHHHHHHHHCEEEEEECCCCHHHCCCCHHHHHHHHHCCCHHHHHEECCCCHHHHCC
GMKSDIADIKNAGSRDGGTIKAAWFLKQFVGETRWAHLDIAGTAWSDKGRPYSPKGATGI
CHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
GVRLLIEYLRQK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA