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The map label for this gene is bhbA [H]

Identifier: 197119066

GI number: 197119066

Start: 3113550

End: 3113954

Strand: Reverse

Name: bhbA [H]

Synonym: Gbem_2691

Alternate gene names: 197119066

Gene position: 3113954-3113550 (Counterclockwise)

Preceding gene: 197119067

Following gene: 197119065

Centisome position: 67.47

GC content: 62.22

Gene sequence:

>405_bases
ATGGCTGAAAGAAGAATACGTGTACTGGTAGGTAAGCCGGGTCTGGACGGCCATGACAGGGGAGCCAAGATCATCGCCCG
CGCTTTACGCGATGCCGGTTTCGAGGTCATCTACACCGGGCTGCACCAGACTCCCGAACAGATAGTTTCCGCCGCTATCC
AGGAAGACGTCGACTGCGTGGCGCTCTCCATCCTCTCCGGCGCCCACAACACGCTGCTGCCGGCGGTCAGGGAGATCATG
AAGGAAAAAGGGGCGAGCGACATCGTGCTCATGGCGGGCGGCGTCATCCCGGAGGACGACATCCCGGGCCTCAAGGCTGC
CGGCATCGCCGAGGTCTTTACCCCGGGTACCTCGACCGAGACCATCGTCGCCTGGATGCGCGACAACGTAACTCCGCACG
CCTAA

Upstream 100 bases:

>100_bases
ACAAGGCCGGAGTGCCGGCGCGGATCGGCATCGAGAAATAGTGACGCTTTAAAAGCTTGGTAGCTTTATATTTCAATACT
GATAAATTCGGAGGTATGCC

Downstream 100 bases:

>100_bases
GACCTGTTCCGCATTTTGTTCTGCGTCACATGCGCCGCATTCTTGCCCACAGGCAGTTCGCGGCGCACCCGCGTAGAAGC
CTGGAGAGACCCTGCGGCAA

Product: methylmalonyl-CoA mutase adenosylcobamide-binding subunit

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 134; Mature: 133

Protein sequence:

>134_residues
MAERRIRVLVGKPGLDGHDRGAKIIARALRDAGFEVIYTGLHQTPEQIVSAAIQEDVDCVALSILSGAHNTLLPAVREIM
KEKGASDIVLMAGGVIPEDDIPGLKAAGIAEVFTPGTSTETIVAWMRDNVTPHA

Sequences:

>Translated_134_residues
MAERRIRVLVGKPGLDGHDRGAKIIARALRDAGFEVIYTGLHQTPEQIVSAAIQEDVDCVALSILSGAHNTLLPAVREIM
KEKGASDIVLMAGGVIPEDDIPGLKAAGIAEVFTPGTSTETIVAWMRDNVTPHA
>Mature_133_residues
AERRIRVLVGKPGLDGHDRGAKIIARALRDAGFEVIYTGLHQTPEQIVSAAIQEDVDCVALSILSGAHNTLLPAVREIMK
EKGASDIVLMAGGVIPEDDIPGLKAAGIAEVFTPGTSTETIVAWMRDNVTPHA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=114, Percent_Identity=45.6140350877193, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1789284, Length=114, Percent_Identity=46.4912280701754, Blast_Score=107, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144500, Length=114, Percent_Identity=45.6140350877193, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 14206; Mature: 14074

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERRIRVLVGKPGLDGHDRGAKIIARALRDAGFEVIYTGLHQTPEQIVSAAIQEDVDCV
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHCHHHH
ALSILSGAHNTLLPAVREIMKEKGASDIVLMAGGVIPEDDIPGLKAAGIAEVFTPGTSTE
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCHH
TIVAWMRDNVTPHA
HHHHHHHCCCCCCC
>Mature Secondary Structure 
AERRIRVLVGKPGLDGHDRGAKIIARALRDAGFEVIYTGLHQTPEQIVSAAIQEDVDCV
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHCHHHH
ALSILSGAHNTLLPAVREIMKEKGASDIVLMAGGVIPEDDIPGLKAAGIAEVFTPGTSTE
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCHH
TIVAWMRDNVTPHA
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2569861; 2569860; 8805541; 9655823 [H]