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The map label for this gene is folP [H]

Identifier: 197119015

GI number: 197119015

Start: 3053181

End: 3054017

Strand: Reverse

Name: folP [H]

Synonym: Gbem_2638

Alternate gene names: 197119015

Gene position: 3054017-3053181 (Counterclockwise)

Preceding gene: 197119016

Following gene: 197119014

Centisome position: 66.17

GC content: 66.07

Gene sequence:

>837_bases
ATGGCAGTACCCGAAACGTGGCAGCTTTCCCGCCGCGCCCTTTCGCTTGAGCGCCCGCTGATCATGGGCATATTGAACGT
GACCCCCGATTCCTTTTCGGACGGGGGTCGCTTCTTCTCTCTCGACGCAGCCATAGAGCGCGCGCAGGAGATGGAGCGCG
AGGGAGCCGACATCATCGATATCGGGGGCGAGAGCACCCGCCCCAACGCCCCGGCTGTTGGGGCGGCGCAGGAACTGGAC
CGGGTGGTCCCGGTCATAGAGGCGCTCTCCCACCGCATACAACTCCCCATCTCCATCGACACCTACAAGGCAGAGGTCGC
CCGCGCTGCGTGCGCCGCCGGGGCCGAGATCGTCAACGACGTCACCGGCCTCATGTTCGATCCGGACATGGCACGCGTCA
CCGCCGAGGCCGACGCCGGGGTGGTGGTGATGCATACGCGCGGCATGCCCGATACCATGCAGGCGGAGACCGGCTACGAC
GATCTCATGGCGGAGGTGAAAAGGTACCTGGAGCAGAGCGTGGCCCTCGCGCGGGAGGCAGGCATCGCCGACGGGCGCAT
CGTGGTCGACCCGGGGCTTGGCTTCGGCAAGAGCGTCCAGGGGAACTTGGAGCTGATCAAGAGGCTCGCCGAGTTCCGGG
AACTGGGGTTTCCCATCCTGGTCGGGCCGTCCCGGAAGTCCTTCGTGGGAGCGGTAACCGGCAGGGGAGGGGGAGAGAGA
ATTTTCGGTACTGCTGTCGCGGTGGCTATGTCCGTCGCGCACGGCGCCTCCATCATCAGGGTGCATGACGTGGCTGCCAT
GAAGGACGTCGCCGTCATGGCGCGGGCGCTCATGTAG

Upstream 100 bases:

>100_bases
TCTCTCTGGCGCTCATCGAGCGCGAGAATCTCTCGGGCGAAGAAGTCGACCGCATTATCGCCGGCGAGCAGCTCGCGCCG
GAACCGGCAGCCGCGGAGTG

Downstream 100 bases:

>100_bases
CCCACGGCCCAAACCAGGAAGCCGTTGACGCTTCCCGACTGGTGCGGATGAATCTATTCCTGCAAAACATAGCCGTGCTG
CGGGACCTGCTGGACCTGTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MAVPETWQLSRRALSLERPLIMGILNVTPDSFSDGGRFFSLDAAIERAQEMEREGADIIDIGGESTRPNAPAVGAAQELD
RVVPVIEALSHRIQLPISIDTYKAEVARAACAAGAEIVNDVTGLMFDPDMARVTAEADAGVVVMHTRGMPDTMQAETGYD
DLMAEVKRYLEQSVALAREAGIADGRIVVDPGLGFGKSVQGNLELIKRLAEFRELGFPILVGPSRKSFVGAVTGRGGGER
IFGTAVAVAMSVAHGASIIRVHDVAAMKDVAVMARALM

Sequences:

>Translated_278_residues
MAVPETWQLSRRALSLERPLIMGILNVTPDSFSDGGRFFSLDAAIERAQEMEREGADIIDIGGESTRPNAPAVGAAQELD
RVVPVIEALSHRIQLPISIDTYKAEVARAACAAGAEIVNDVTGLMFDPDMARVTAEADAGVVVMHTRGMPDTMQAETGYD
DLMAEVKRYLEQSVALAREAGIADGRIVVDPGLGFGKSVQGNLELIKRLAEFRELGFPILVGPSRKSFVGAVTGRGGGER
IFGTAVAVAMSVAHGASIIRVHDVAAMKDVAVMARALM
>Mature_277_residues
AVPETWQLSRRALSLERPLIMGILNVTPDSFSDGGRFFSLDAAIERAQEMEREGADIIDIGGESTRPNAPAVGAAQELDR
VVPVIEALSHRIQLPISIDTYKAEVARAACAAGAEIVNDVTGLMFDPDMARVTAEADAGVVVMHTRGMPDTMQAETGYDD
LMAEVKRYLEQSVALAREAGIADGRIVVDPGLGFGKSVQGNLELIKRLAEFRELGFPILVGPSRKSFVGAVTGRGGGERI
FGTAVAVAMSVAHGASIIRVHDVAAMKDVAVMARALM

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=252, Percent_Identity=47.6190476190476, Blast_Score=236, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6324073, Length=301, Percent_Identity=31.8936877076412, Blast_Score=152, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29544; Mature: 29413

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVPETWQLSRRALSLERPLIMGILNVTPDSFSDGGRFFSLDAAIERAQEMEREGADIID
CCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEE
IGGESTRPNAPAVGAAQELDRVVPVIEALSHRIQLPISIDTYKAEVARAACAAGAEIVND
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCEEEHHHHHHHHHHHHHHHHHHHHH
VTGLMFDPDMARVTAEADAGVVVMHTRGMPDTMQAETGYDDLMAEVKRYLEQSVALAREA
HHHCEECCCHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIADGRIVVDPGLGFGKSVQGNLELIKRLAEFRELGFPILVGPSRKSFVGAVTGRGGGER
CCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCCCH
IFGTAVAVAMSVAHGASIIRVHDVAAMKDVAVMARALM
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVPETWQLSRRALSLERPLIMGILNVTPDSFSDGGRFFSLDAAIERAQEMEREGADIID
CCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEE
IGGESTRPNAPAVGAAQELDRVVPVIEALSHRIQLPISIDTYKAEVARAACAAGAEIVND
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCEEEHHHHHHHHHHHHHHHHHHHHH
VTGLMFDPDMARVTAEADAGVVVMHTRGMPDTMQAETGYDDLMAEVKRYLEQSVALAREA
HHHCEECCCHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIADGRIVVDPGLGFGKSVQGNLELIKRLAEFRELGFPILVGPSRKSFVGAVTGRGGGER
CCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCCCH
IFGTAVAVAMSVAHGASIIRVHDVAAMKDVAVMARALM
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]