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The map label for this gene is rnhA [H]

Identifier: 197118830

GI number: 197118830

Start: 2842626

End: 2843072

Strand: Reverse

Name: rnhA [H]

Synonym: Gbem_2453

Alternate gene names: 197118830

Gene position: 2843072-2842626 (Counterclockwise)

Preceding gene: 197118831

Following gene: 197118829

Centisome position: 61.6

GC content: 67.11

Gene sequence:

>447_bases
ATGCAGGTTGAGATCTTTTGCGACGGGGCCTGCAGCGGCAACCCCGGGGTTGGCGGGTACGGCAGCATTCTGCGCTGCGG
CGAGACGGTGAAGGAGATCTCCGGCGCCGAGGGGGACACCACCAACAACCGGATGGAGATGAGCGCCGCCATCGCCGCGC
TCGACGCGCTGAAGCGCCCCTGCCAGGTGGTGGTGACGACCGATTCCCAGTACCTGGCCAAGGGGATGACCGAATGGCTT
TCCGGCTGGGTCAAGCGTGGGTGGGTGAACTCGAAAAAGGAGCCGGTCCTGAACCGCGACCTCTGGGAGCGGCTCCTGGA
GCTCTCCCGGGTGCACCAGATCCGCTGGGTGTGGGTGCGCGGCCACAACGGCCACGTGGAAAACGAACGCTGCGACGAAC
TGGCGCGCGCCGCCATCGACAGCTACCGCGCAGGCAGCGCCAGGTAG

Upstream 100 bases:

>100_bases
CTCTACCAACTTGAGGACTGCAAGGAGACACACCAGCTGATCGTGGACCGGGTGATGGAGGCGATCGCCACGCTTTTGCG
CCAGGAAGGAGGCAACGTCG

Downstream 100 bases:

>100_bases
CGCGGGAATCACCGAACAAAGGAAGCTGATTGGACTACTTCATCATCGAGGTCTCCGAGGAGGAGATCCGCAGGGAACGT
GAGAAGGCGCGCGAACTGCG

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MQVEIFCDGACSGNPGVGGYGSILRCGETVKEISGAEGDTTNNRMEMSAAIAALDALKRPCQVVVTTDSQYLAKGMTEWL
SGWVKRGWVNSKKEPVLNRDLWERLLELSRVHQIRWVWVRGHNGHVENERCDELARAAIDSYRAGSAR

Sequences:

>Translated_148_residues
MQVEIFCDGACSGNPGVGGYGSILRCGETVKEISGAEGDTTNNRMEMSAAIAALDALKRPCQVVVTTDSQYLAKGMTEWL
SGWVKRGWVNSKKEPVLNRDLWERLLELSRVHQIRWVWVRGHNGHVENERCDELARAAIDSYRAGSAR
>Mature_148_residues
MQVEIFCDGACSGNPGVGGYGSILRCGETVKEISGAEGDTTNNRMEMSAAIAALDALKRPCQVVVTTDSQYLAKGMTEWL
SGWVKRGWVNSKKEPVLNRDLWERLLELSRVHQIRWVWVRGHNGHVENERCDELARAAIDSYRAGSAR

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=145, Percent_Identity=34.4827586206897, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=59.8540145985402, Blast_Score=172, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI115532542, Length=137, Percent_Identity=35.7664233576642, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137476, Length=148, Percent_Identity=35.1351351351351, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45552509, Length=148, Percent_Identity=35.1351351351351, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16451; Mature: 16451

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVEIFCDGACSGNPGVGGYGSILRCGETVKEISGAEGDTTNNRMEMSAAIAALDALKRP
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
CQVVVTTDSQYLAKGMTEWLSGWVKRGWVNSKKEPVLNRDLWERLLELSRVHQIRWVWVR
CEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEE
GHNGHVENERCDELARAAIDSYRAGSAR
CCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQVEIFCDGACSGNPGVGGYGSILRCGETVKEISGAEGDTTNNRMEMSAAIAALDALKRP
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
CQVVVTTDSQYLAKGMTEWLSGWVKRGWVNSKKEPVLNRDLWERLLELSRVHQIRWVWVR
CEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEE
GHNGHVENERCDELARAAIDSYRAGSAR
CCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA