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The map label for this gene is atoC [H]

Identifier: 197118787

GI number: 197118787

Start: 2788044

End: 2789492

Strand: Reverse

Name: atoC [H]

Synonym: Gbem_2408

Alternate gene names: 197118787

Gene position: 2789492-2788044 (Counterclockwise)

Preceding gene: 197118788

Following gene: 197118784

Centisome position: 60.44

GC content: 59.83

Gene sequence:

>1449_bases
ATGACTGCAAAATTGCTCATATTGGATGACGATCACGACATCCTGCTCATGCTGAAGAGCGTCTTCGCGGGCGAAGATTA
CGAGCTGCTGTTGGAAAGCGACAGCGAAGGGGCACTAAAGCGCGTCATCTCGGATCGTCCCAATGTGGCTATCATGGACA
TCAGCCTGCCGCAGAAGTCGGGCATCGAGGTGCTCAAGGAAGCGAAGAAGATCGACCCCGGCCTCGCCGTCATCATGGCC
ACCGGCTACAAGACCACGCAAAACGCCATCGAAGCGATGAAACACGGCGCCTTCGACTACGTCACCAAGCCCTTCGACAT
GACCAAGTTAAAAGGGGCGGTGAAGAAGGCCCTGGAGTGCAACCTTCTGAGCCGCAAGGTCCGTTACACCCGTGAACGCC
CGCAGGTCGAGGAGGATCTCACCGAGGACCTGATGATAGGTTCCTCGCCGGAGATGATCGAGATCTGGAAGATGGTGGGG
ACCGTGGCCGATTCCGACGCGACCGTGCTGATCCAGGGCGAGTCCGGAACCGGGAAGGAACTGCTGGCGCGCGCGGTCTA
CAACAACTCCAAGAGAAAGAACCGCCCCTTCCTGGCGGTAAACTGCGCCGCACTCCCCGAGGCGCTGCTGGAGTCCGAGC
TTTTCGGCCACGAGAAGGGAGCCTTCACCGACGCCCATTCCCGGAGGATCGGGAAGTTCGAGCAGTGCAACGGCGGCACC
ATCTTCCTCGACGAGATAGGCGAGATGAGCCAGGCGAACCAGGGGAAGTTCCTGCGGGTCCTGGAGAACCAGGAGTTCGA
GAGGGTAGGTGGGAACGAGACCATCAAGGTGGACGTCCGTGTGATCGCGGCGACCAACAAGAGCCTCATCACCAACGTCA
AGGAAAAGACCTTCCGGATGGACCTGTACTACCGCCTGCGCGTGGTGAACTTCTTTCTGCCGCCGCTGCGGGACCGTGCC
GAGGACATACCGCTCCTGGTCGAGCTCTTCGTGAAGAAGTTCTCCAAGAAGTACGGCAAGAACATCAAGGCGGTGGCGCC
CGAGACCCTGGCGATGTTGACCTCGCACCCGTGGGAAGGGAACATCAGGGAGCTGAAGAACGTCATCAACTCGGCCACCG
TCTTCTGCCGCGGCGACATCCTGGTTCCCGGAGATTTCGAGTCGTTCCTGACCGCCAAGGCCGGCTTCAAGGAGGTCGAC
CTAGAGGCGGCCGGCGACGACTACTACGAGGTCTTCTGGAGCATGCTGGAACCGGTCTTTGACGGGATCTGCCAGAAGAA
CAAGGGGGCGATCTACGAGAGCGTCAACATGGGGCTGGAGAAGGCCCTGATCCACATGGCCATGGAGAAGAGCAACAACA
ACCAGGTCTTTGCCGCGAAGCTCCTGGGCATCAGCCGCAATACCCTGAGGGACAGGCTGGAGCGCTATCGCATAGGCGCC
GCTGACTAG

Upstream 100 bases:

>100_bases
ATGTAAACAAGAGAACCGCTTACCTCAGGCGGTTCTTTTGGTTACTGCCTGACACTTCCAATCCTAATGCGATCGTATAA
CAGCCCATCGGGGGACGGCC

Downstream 100 bases:

>100_bases
AAGCTGGCCGTAGCACTGCCGCAAGGCGGGTACCTGATAAAGAAAAGCCGGAATGAACCCCACACTGGGTTCGTTCCGGC
TTTTTTCGTACTGCGCTCGG

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTAKLLILDDDHDILLMLKSVFAGEDYELLLESDSEGALKRVISDRPNVAIMDISLPQKSGIEVLKEAKKIDPGLAVIMA
TGYKTTQNAIEAMKHGAFDYVTKPFDMTKLKGAVKKALECNLLSRKVRYTRERPQVEEDLTEDLMIGSSPEMIEIWKMVG
TVADSDATVLIQGESGTGKELLARAVYNNSKRKNRPFLAVNCAALPEALLESELFGHEKGAFTDAHSRRIGKFEQCNGGT
IFLDEIGEMSQANQGKFLRVLENQEFERVGGNETIKVDVRVIAATNKSLITNVKEKTFRMDLYYRLRVVNFFLPPLRDRA
EDIPLLVELFVKKFSKKYGKNIKAVAPETLAMLTSHPWEGNIRELKNVINSATVFCRGDILVPGDFESFLTAKAGFKEVD
LEAAGDDYYEVFWSMLEPVFDGICQKNKGAIYESVNMGLEKALIHMAMEKSNNNQVFAAKLLGISRNTLRDRLERYRIGA
AD

Sequences:

>Translated_482_residues
MTAKLLILDDDHDILLMLKSVFAGEDYELLLESDSEGALKRVISDRPNVAIMDISLPQKSGIEVLKEAKKIDPGLAVIMA
TGYKTTQNAIEAMKHGAFDYVTKPFDMTKLKGAVKKALECNLLSRKVRYTRERPQVEEDLTEDLMIGSSPEMIEIWKMVG
TVADSDATVLIQGESGTGKELLARAVYNNSKRKNRPFLAVNCAALPEALLESELFGHEKGAFTDAHSRRIGKFEQCNGGT
IFLDEIGEMSQANQGKFLRVLENQEFERVGGNETIKVDVRVIAATNKSLITNVKEKTFRMDLYYRLRVVNFFLPPLRDRA
EDIPLLVELFVKKFSKKYGKNIKAVAPETLAMLTSHPWEGNIRELKNVINSATVFCRGDILVPGDFESFLTAKAGFKEVD
LEAAGDDYYEVFWSMLEPVFDGICQKNKGAIYESVNMGLEKALIHMAMEKSNNNQVFAAKLLGISRNTLRDRLERYRIGA
AD
>Mature_481_residues
TAKLLILDDDHDILLMLKSVFAGEDYELLLESDSEGALKRVISDRPNVAIMDISLPQKSGIEVLKEAKKIDPGLAVIMAT
GYKTTQNAIEAMKHGAFDYVTKPFDMTKLKGAVKKALECNLLSRKVRYTRERPQVEEDLTEDLMIGSSPEMIEIWKMVGT
VADSDATVLIQGESGTGKELLARAVYNNSKRKNRPFLAVNCAALPEALLESELFGHEKGAFTDAHSRRIGKFEQCNGGTI
FLDEIGEMSQANQGKFLRVLENQEFERVGGNETIKVDVRVIAATNKSLITNVKEKTFRMDLYYRLRVVNFFLPPLRDRAE
DIPLLVELFVKKFSKKYGKNIKAVAPETLAMLTSHPWEGNIRELKNVINSATVFCRGDILVPGDFESFLTAKAGFKEVDL
EAAGDDYYEVFWSMLEPVFDGICQKNKGAIYESVNMGLEKALIHMAMEKSNNNQVFAAKLLGISRNTLRDRLERYRIGAA
D

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=487, Percent_Identity=42.5051334702259, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790437, Length=471, Percent_Identity=38.6411889596603, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=37.6068376068376, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1788905, Length=401, Percent_Identity=37.9052369077307, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1789087, Length=309, Percent_Identity=45.9546925566343, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082117, Length=255, Percent_Identity=50.5882352941176, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1789233, Length=239, Percent_Identity=43.9330543933054, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI87082152, Length=325, Percent_Identity=39.3846153846154, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1786524, Length=344, Percent_Identity=37.5, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787583, Length=254, Percent_Identity=43.7007874015748, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI87081872, Length=344, Percent_Identity=36.6279069767442, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1789828, Length=258, Percent_Identity=33.7209302325581, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI87081858, Length=233, Percent_Identity=35.1931330472103, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54014; Mature: 53883

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKLLILDDDHDILLMLKSVFAGEDYELLLESDSEGALKRVISDRPNVAIMDISLPQKS
CCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCC
GIEVLKEAKKIDPGLAVIMATGYKTTQNAIEAMKHGAFDYVTKPFDMTKLKGAVKKALEC
CHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
NLLSRKVRYTRERPQVEEDLTEDLMIGSSPEMIEIWKMVGTVADSDATVLIQGESGTGKE
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LLARAVYNNSKRKNRPFLAVNCAALPEALLESELFGHEKGAFTDAHSRRIGKFEQCNGGT
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCE
IFLDEIGEMSQANQGKFLRVLENQEFERVGGNETIKVDVRVIAATNKSLITNVKEKTFRM
EEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHH
DLYYRLRVVNFFLPPLRDRAEDIPLLVELFVKKFSKKYGKNIKAVAPETLAMLTSHPWEG
HHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHCCCCCC
NIRELKNVINSATVFCRGDILVPGDFESFLTAKAGFKEVDLEAAGDDYYEVFWSMLEPVF
CHHHHHHHHCCCEEEEECCEEECCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
DGICQKNKGAIYESVNMGLEKALIHMAMEKSNNNQVFAAKLLGISRNTLRDRLERYRIGA
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCC
AD
CC
>Mature Secondary Structure 
TAKLLILDDDHDILLMLKSVFAGEDYELLLESDSEGALKRVISDRPNVAIMDISLPQKS
CEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCC
GIEVLKEAKKIDPGLAVIMATGYKTTQNAIEAMKHGAFDYVTKPFDMTKLKGAVKKALEC
CHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
NLLSRKVRYTRERPQVEEDLTEDLMIGSSPEMIEIWKMVGTVADSDATVLIQGESGTGKE
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LLARAVYNNSKRKNRPFLAVNCAALPEALLESELFGHEKGAFTDAHSRRIGKFEQCNGGT
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCE
IFLDEIGEMSQANQGKFLRVLENQEFERVGGNETIKVDVRVIAATNKSLITNVKEKTFRM
EEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHH
DLYYRLRVVNFFLPPLRDRAEDIPLLVELFVKKFSKKYGKNIKAVAPETLAMLTSHPWEG
HHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHCCCCCC
NIRELKNVINSATVFCRGDILVPGDFESFLTAKAGFKEVDLEAAGDDYYEVFWSMLEPVF
CHHHHHHHHCCCEEEEECCEEECCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
DGICQKNKGAIYESVNMGLEKALIHMAMEKSNNNQVFAAKLLGISRNTLRDRLERYRIGA
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCC
AD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]