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The map label for this gene is cheA-8 [H]

Identifier: 197118763

GI number: 197118763

Start: 2761402

End: 2763441

Strand: Direct

Name: cheA-8 [H]

Synonym: Gbem_2382

Alternate gene names: 197118763

Gene position: 2761402-2763441 (Clockwise)

Preceding gene: 197118762

Following gene: 197118764

Centisome position: 59.83

GC content: 65.0

Gene sequence:

>2040_bases
ATGGGAAGCCGCTACCTCGAGATCTTCTGCCGCGAGGCCGAAGAGCATCTTGCCTCGCTGCAAAGCGGGCTCCTGGTCCT
GGAAAGGAACCCGGAGCGGAGCTCGCTTTTGCACGAGCTCTTGAGGAACGCGCACACCCTGAAGGGATCGGCGCGCATGG
TGGGGCTATCCGACATAAGCGCCATCACCCACACCATGGAGGAGCAGCTGAAGGGGATGGAGCGGGGGGAGCGGCAGGTT
GACGCAGACGCCATCGACCTGCTTTTGAAAGGCGCCGATGCCGTGGCGCTGATCACCTCGGCGCTTTTGCGCGGGGAGGT
CCCGGACCTCGACGTGGAGCGCTTCGTGGCCGAGTATGACCGCGGCGAGCTTACCCGCCCGGCGCCCTCCGAAACCCGCG
AGGCCGCGGCCGAACAGCAAAGCGAGACGGTGCGCGCCAACGTCAAGACCCTCGACCACCTGGTGAACCTGATCGGCGAG
ATGATCATCAACAAAAAGCGGCTGGAGGCGAAGCTCTTAACGCTCAAGGAGATCGCCGCCTCGCTTCCCGCCGACCAGGC
TCAGTCCCTCACCCTGTTTCGCCGCGACCTTGAGGAGGACGTCCTCTACCAGGACTACCTGATCCAGGAGCTGCACGAAA
AGGCGATGGCGCTCAGGATGCTCCCCTTGAGAAGCATCTCCGACGGCTTCGAGCGGCTGGTGCGCGATCTGGCCCAGCAG
TTGGGTAAGGAGGTCCGGCTCCAGATCACCGGGCACGGCATCGAGATGGACCGGGTGCTTTTGGAGGGGCTCAAGCCGAT
GCTGATCCACCTCCTTACCAACGCCGTCTGCCATGGCATCGAGTCCCCGCACGAGCGTACCGCGGCCGGCAAGCCGCGCG
AGGGGGTGGTATCGCTTTCGGCGCGCCACGAGGGGCGCTCGGTCATCGTCGAGGTCGCCGACGACGGCAAGGGGATGGAC
CCGGCCAGGATCAAGGCGGCGGCCCTGGCGAAGGGGGTCATCGACCCCCGGGAAGCGGAGGCGATGGGCGACGAGGAGGC
CCTCTACCTCACCTTCTGGCCCGGCTTCTCCACCGCCGAGATCGTCACCGACATCTCGGGGCGCGGCGTCGGCATGGACG
TGGTGAAGCGGAACATCGAACGGGTCAAGGGGAACATCACCCTGACCAGCGAGAAAGGGAGCTTCTCGCGCGTCACCCTG
CAGCTGCCGCTCACCCTCTCGGTGATCGAGGCGCTCCTGATCCAGTGCGGCGGAGAGGACTTCGCGGTTCCCCTCAACTA
CGTACAGGAGATCCTCAAGGTGCGCCCTGAGGAGATCTCGGTGTTGGGAGCGGGCGAGGTGATCAAGGTGCGGGGGGTTA
CCACTCCCCTTTACAGCCTCGCCGCGATGCTGGAATTGCCGCGGCAGACAAAATCCTGCGCGACGCTGGCGGTCATCGTG
CTGAAGCTGGCCGACCAGCGCATGGCCTGCCTCGTGGACGCGCACCTGGGAAGCTCGGAGGTCGTGGTCAAGGGGCTGGG
GAAGCAGTTTCGCAACGTCAGGTTCCTGTTCGGCGCCACCATCATGGGGGACGGCAACCCCGCCCTGATCCTGAACGTCC
CCGACCTCTTCTCGGCAGCGGCAAACGACGGGCGGAGAGCGACCCGCAGCGGCGCGGAACTGGACGAGGAGCGGCGTTTC
AAGGTGCTCGTGGTGGACGACTCCATCACAACCCGGACCATGGAGCAGAGCATCCTCCTCACCCAGGGGTATGACGTGGT
GACGGCCGTCTCCGGTGAGGACGCCTTGCAAAAGTGCGCGGATGAGGATTTCGACCTGATCATCTCCGACGTGGAGATGC
CGGGTATCAACGGCTTCGAGCTGACACGGGCCCTCAGGGAGTCGGAGCGCTACCGGGAGATCCCGATAATCATCGTCTCG
TCGCTGTCGCGCGACGAGGACAAGAGGCAGGCGCTGCAGTCAGGCGCGCAGGCGTACATCGTAAAAGGTGCCTTCGACCA
GGGGATGCTCCTGGAGACGGTGCAGATGCTGATCGGCTGA

Upstream 100 bases:

>100_bases
GCAGCAGGTCGCCATGTCTGCGACAGAAACCGAACGGGCCATCGCCGAAATCCTGGAACTTGCCGAAAGGCTCAAGGAGA
TCACGGAGGAAGAGGCGTAG

Downstream 100 bases:

>100_bases
CGGCAACGATTCGGCGGGGACGGTTTCGATGACCATAAGGATTGTGCTGGCGGACGACTCGGCTTTGGTGCGCCAGATCC
TGAAGGACATACTGCAGGGG

Product: chemotaxis sensor histidine kinase CheA/response receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MGSRYLEIFCREAEEHLASLQSGLLVLERNPERSSLLHELLRNAHTLKGSARMVGLSDISAITHTMEEQLKGMERGERQV
DADAIDLLLKGADAVALITSALLRGEVPDLDVERFVAEYDRGELTRPAPSETREAAAEQQSETVRANVKTLDHLVNLIGE
MIINKKRLEAKLLTLKEIAASLPADQAQSLTLFRRDLEEDVLYQDYLIQELHEKAMALRMLPLRSISDGFERLVRDLAQQ
LGKEVRLQITGHGIEMDRVLLEGLKPMLIHLLTNAVCHGIESPHERTAAGKPREGVVSLSARHEGRSVIVEVADDGKGMD
PARIKAAALAKGVIDPREAEAMGDEEALYLTFWPGFSTAEIVTDISGRGVGMDVVKRNIERVKGNITLTSEKGSFSRVTL
QLPLTLSVIEALLIQCGGEDFAVPLNYVQEILKVRPEEISVLGAGEVIKVRGVTTPLYSLAAMLELPRQTKSCATLAVIV
LKLADQRMACLVDAHLGSSEVVVKGLGKQFRNVRFLFGATIMGDGNPALILNVPDLFSAAANDGRRATRSGAELDEERRF
KVLVVDDSITTRTMEQSILLTQGYDVVTAVSGEDALQKCADEDFDLIISDVEMPGINGFELTRALRESERYREIPIIIVS
SLSRDEDKRQALQSGAQAYIVKGAFDQGMLLETVQMLIG

Sequences:

>Translated_679_residues
MGSRYLEIFCREAEEHLASLQSGLLVLERNPERSSLLHELLRNAHTLKGSARMVGLSDISAITHTMEEQLKGMERGERQV
DADAIDLLLKGADAVALITSALLRGEVPDLDVERFVAEYDRGELTRPAPSETREAAAEQQSETVRANVKTLDHLVNLIGE
MIINKKRLEAKLLTLKEIAASLPADQAQSLTLFRRDLEEDVLYQDYLIQELHEKAMALRMLPLRSISDGFERLVRDLAQQ
LGKEVRLQITGHGIEMDRVLLEGLKPMLIHLLTNAVCHGIESPHERTAAGKPREGVVSLSARHEGRSVIVEVADDGKGMD
PARIKAAALAKGVIDPREAEAMGDEEALYLTFWPGFSTAEIVTDISGRGVGMDVVKRNIERVKGNITLTSEKGSFSRVTL
QLPLTLSVIEALLIQCGGEDFAVPLNYVQEILKVRPEEISVLGAGEVIKVRGVTTPLYSLAAMLELPRQTKSCATLAVIV
LKLADQRMACLVDAHLGSSEVVVKGLGKQFRNVRFLFGATIMGDGNPALILNVPDLFSAAANDGRRATRSGAELDEERRF
KVLVVDDSITTRTMEQSILLTQGYDVVTAVSGEDALQKCADEDFDLIISDVEMPGINGFELTRALRESERYREIPIIIVS
SLSRDEDKRQALQSGAQAYIVKGAFDQGMLLETVQMLIG
>Mature_678_residues
GSRYLEIFCREAEEHLASLQSGLLVLERNPERSSLLHELLRNAHTLKGSARMVGLSDISAITHTMEEQLKGMERGERQVD
ADAIDLLLKGADAVALITSALLRGEVPDLDVERFVAEYDRGELTRPAPSETREAAAEQQSETVRANVKTLDHLVNLIGEM
IINKKRLEAKLLTLKEIAASLPADQAQSLTLFRRDLEEDVLYQDYLIQELHEKAMALRMLPLRSISDGFERLVRDLAQQL
GKEVRLQITGHGIEMDRVLLEGLKPMLIHLLTNAVCHGIESPHERTAAGKPREGVVSLSARHEGRSVIVEVADDGKGMDP
ARIKAAALAKGVIDPREAEAMGDEEALYLTFWPGFSTAEIVTDISGRGVGMDVVKRNIERVKGNITLTSEKGSFSRVTLQ
LPLTLSVIEALLIQCGGEDFAVPLNYVQEILKVRPEEISVLGAGEVIKVRGVTTPLYSLAAMLELPRQTKSCATLAVIVL
KLADQRMACLVDAHLGSSEVVVKGLGKQFRNVRFLFGATIMGDGNPALILNVPDLFSAAANDGRRATRSGAELDEERRFK
VLVVDDSITTRTMEQSILLTQGYDVVTAVSGEDALQKCADEDFDLIISDVEMPGINGFELTRALRESERYREIPIIIVSS
LSRDEDKRQALQSGAQAYIVKGAFDQGMLLETVQMLIG

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=490, Percent_Identity=35.1020408163265, Blast_Score=267, Evalue=2e-72,
Organism=Escherichia coli, GI1788713, Length=104, Percent_Identity=34.6153846153846, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=107, Percent_Identity=33.6448598130841, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=104, Percent_Identity=37.5, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=101, Percent_Identity=34.6534653465347, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74598; Mature: 74467

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSRYLEIFCREAEEHLASLQSGLLVLERNPERSSLLHELLRNAHTLKGSARMVGLSDIS
CCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHH
AITHTMEEQLKGMERGERQVDADAIDLLLKGADAVALITSALLRGEVPDLDVERFVAEYD
HHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHC
RGELTRPAPSETREAAAEQQSETVRANVKTLDHLVNLIGEMIINKKRLEAKLLTLKEIAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
SLPADQAQSLTLFRRDLEEDVLYQDYLIQELHEKAMALRMLPLRSISDGFERLVRDLAQQ
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKEVRLQITGHGIEMDRVLLEGLKPMLIHLLTNAVCHGIESPHERTAAGKPREGVVSLS
CCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEE
ARHEGRSVIVEVADDGKGMDPARIKAAALAKGVIDPREAEAMGDEEALYLTFWPGFSTAE
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEECCCCCHHH
IVTDISGRGVGMDVVKRNIERVKGNITLTSEKGSFSRVTLQLPLTLSVIEALLIQCGGED
HHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECHHHHHHHHHHHHCCCCC
FAVPLNYVQEILKVRPEEISVLGAGEVIKVRGVTTPLYSLAAMLELPRQTKSCATLAVIV
CEECHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LKLADQRMACLVDAHLGSSEVVVKGLGKQFRNVRFLFGATIMGDGNPALILNVPDLFSAA
HHHHCCHHHEEEECCCCCCHHHHHHHHHHHHCEEEEEEEEEEECCCCEEEEECCHHHHHH
ANDGRRATRSGAELDEERRFKVLVVDDSITTRTMEQSILLTQGYDVVTAVSGEDALQKCA
CCCCCHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHEEEECCCCEEEEECCHHHHHHHC
DEDFDLIISDVEMPGINGFELTRALRESERYREIPIIIVSSLSRDEDKRQALQSGAQAYI
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEE
VKGAFDQGMLLETVQMLIG
EECCCCCCHHHHHHHHHHC
>Mature Secondary Structure 
GSRYLEIFCREAEEHLASLQSGLLVLERNPERSSLLHELLRNAHTLKGSARMVGLSDIS
CCHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHH
AITHTMEEQLKGMERGERQVDADAIDLLLKGADAVALITSALLRGEVPDLDVERFVAEYD
HHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHC
RGELTRPAPSETREAAAEQQSETVRANVKTLDHLVNLIGEMIINKKRLEAKLLTLKEIAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
SLPADQAQSLTLFRRDLEEDVLYQDYLIQELHEKAMALRMLPLRSISDGFERLVRDLAQQ
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKEVRLQITGHGIEMDRVLLEGLKPMLIHLLTNAVCHGIESPHERTAAGKPREGVVSLS
CCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEE
ARHEGRSVIVEVADDGKGMDPARIKAAALAKGVIDPREAEAMGDEEALYLTFWPGFSTAE
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEECCCCCHHH
IVTDISGRGVGMDVVKRNIERVKGNITLTSEKGSFSRVTLQLPLTLSVIEALLIQCGGED
HHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECHHHHHHHHHHHHCCCCC
FAVPLNYVQEILKVRPEEISVLGAGEVIKVRGVTTPLYSLAAMLELPRQTKSCATLAVIV
CEECHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LKLADQRMACLVDAHLGSSEVVVKGLGKQFRNVRFLFGATIMGDGNPALILNVPDLFSAA
HHHHCCHHHEEEECCCCCCHHHHHHHHHHHHCEEEEEEEEEEECCCCEEEEECCHHHHHH
ANDGRRATRSGAELDEERRFKVLVVDDSITTRTMEQSILLTQGYDVVTAVSGEDALQKCA
CCCCCHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHEEEECCCCEEEEECCHHHHHHHC
DEDFDLIISDVEMPGINGFELTRALRESERYREIPIIIVSSLSRDEDKRQALQSGAQAYI
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEE
VKGAFDQGMLLETVQMLIG
EECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]