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The map label for this gene is dspA [H]

Identifier: 197118716

GI number: 197118716

Start: 2709706

End: 2711790

Strand: Reverse

Name: dspA [H]

Synonym: Gbem_2335

Alternate gene names: 197118716

Gene position: 2711790-2709706 (Counterclockwise)

Preceding gene: 197118722

Following gene: 197118715

Centisome position: 58.76

GC content: 57.94

Gene sequence:

>2085_bases
ATGAAAATGACCCTGGAAAAACGCATCTTACTGTTCTCTTTCCTGATCCTGTTCCTAGCGATTTCAATCGGTTCCGGAAT
GGATATCATGGCGCTGCGTCGAGATCACGTCAACGCGCTCAACCTTCGGTCCAAAGGCCTCGCCACCGCACTCAAATCCA
ATATCGAAAAAGTCCTCAACCTGGGTCTGGAACTGAAGGATATGACCGGGGTCTCCGAGAAGTGCCGAGAGATCATCGAG
GGAAACCAGGACATAGCCTACTGTCTGGTTTCCGACCTCTCCGGCAAGGTTCTTTTTGCCAGCGATCCCCGCTTCATGAA
TTTTCCTGCGCGTCTGCTGCAATCCGACCAAAAGAAAGAAGGAGACCGTCCGGAATCCGGAGTCTACAAGAACCGGATTT
CCATGCCGGTCGACGGCGTAGATACCTCCTTTTACGATTCCGCCGTCTCCGTCGTCGGCCCCTACGGCAAACCGATCGCC
ATGGCGCACGTCGGCTTCAGCGAGCAGGTGGTCTCGGACAAGATGAAGGGAATGGTGTTGAAGACCCTATTCCTTTTGGC
CGTCTCGCTCTTCACCTCCTTCTCGCTCATCATGCTCTTCATGAAAAAGTACGTGATGCAGCCCATCTCGATGCTTCTCA
AGGGGGTGAAACAGATCTCCGAAGGGGCTTTCGACACCCACATCGGAGAGGTTGAGGTCTACGAGTTCAACGAGCTTGCC
CGCAACGTCAACATCATGTCCCAGTTTCTCAAGAACAGGGACGCCGAGATCAAAAAGAACTACCAGGACATGGAGCGGAC
CTTCGAAGAGCTCCAGGCGTCCTACCGGAAGCTGGAGCGACTCTCCAACGACCTTGAGCGTTCCGAGGAGCTTTACAAGT
CGCTGATGGAAGACGCAAGCGACGCTATCGTCGTCATCGGCGGCGACGAGTCCGTCCGCATGGTCAACAAGATGGCGGAG
GAGTTCTTCGGCTACGAGGCGAAGGAGCTTTTGGGTCTGCCGCTCACCAAGATGCTGCTCCTTTTGAACATCAGCAACAT
CCCCAAGGTGCACCGGATCTTCCGGGAGGCGGCGCAAGGTGCGCACATAGCTGAGGAGATGCAGCTCTGCAAGAAGCAAG
GCGGCGCCATGGTCGCCATGCTGCACGCCTCCAGCATCAAGAGCGGTTCTGAGAACGTGGTGCAGGCGATCTTCCGCGAC
GTGACCCGCGAGCGCGAGATCATCCTGAACCTGGAGAAGAGTTCCGCCGACCTCGCGCGGCTGAACCGCATGAAGGATTC
CTTCCTGGGCCTTGCCTCCCACGAGCTGAAAACGCCGCTTACCGTCATCATGGGGTACTCCGAGCTGATCACCACCGACC
TTGCCGACCGCATGGACAAGACCGTGCTGGAGATGGTGGTGAACATCGCCAACGCCGCCTCGCGCCTGGACAACATCATC
AAGGACATGGTTGACGTTTCCATGATCGACGAGAAGAGGCTGCAGCTGAAGGTGGAGGACATCCAACTAAACCGGCTCAT
CGAAGCCTCGGTGAACGAGCTCCGCTTCTTCTTCTCGATGAGGAAGCAGGAGGTGGTGGTAAACCTGGACGAGTCGATCC
CCACTATTCGCGGCGACGCGCTGCGCCTCATGCAGCTCCTCTCCAACATCCTCGGCAACGCCATCAAGTTCACCCCCGAC
GGCGGCAAGATCACCGTCAGCACCTCGGCAAAATACCTTTTGCGCGGCAAGGGTGGTGCCGAGGGGGGCGGGGAAGGGCA
CGAGCACCATCTTTTCCTGGAGATCACCGTCACCGACACCGGCATCGGCATAGACCGCGAGGACCAGCTGAGGGTTTTCG
AAAAGTTCTACGAGGTGGGGAACATCCAGGAACATTCCAGCGGCAAAGTCGCCTTCAAGGCGAAGGGGGCGGGCCTCGGC
CTCTCCATCGCCAAGGGAATCGTCGACATGCACGGCGGCGAGATCTGGGTGGAGTCCACCGGGTACAACCCGGAGCGCTT
CCCGGGATCCACCTTCCATATCCTGCTGCCGCTGGCGCCCGGGCTCGGCGAGAACGCGACCGACTACAGCAGACTTCTGC
GTTAA

Upstream 100 bases:

>100_bases
TCCATATAATAATTGACTTTTCCAAAGCGGATAAATTACTCTTGCGTGGACCATGATGCGCACTTCCTTTGCCCACGATA
GATGTCGGATTGACTAATAG

Downstream 100 bases:

>100_bases
TCAAATCTCAGCAACTTCATCTTGAATCTGCCACCCGTTTCCTGTATAAAAATAAGGTTTTTCTGCCGTTCTTGAGCCCC
CGTTTCCGGGCTTGATCTGC

Product: HAMP domain-containing sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MKMTLEKRILLFSFLILFLAISIGSGMDIMALRRDHVNALNLRSKGLATALKSNIEKVLNLGLELKDMTGVSEKCREIIE
GNQDIAYCLVSDLSGKVLFASDPRFMNFPARLLQSDQKKEGDRPESGVYKNRISMPVDGVDTSFYDSAVSVVGPYGKPIA
MAHVGFSEQVVSDKMKGMVLKTLFLLAVSLFTSFSLIMLFMKKYVMQPISMLLKGVKQISEGAFDTHIGEVEVYEFNELA
RNVNIMSQFLKNRDAEIKKNYQDMERTFEELQASYRKLERLSNDLERSEELYKSLMEDASDAIVVIGGDESVRMVNKMAE
EFFGYEAKELLGLPLTKMLLLLNISNIPKVHRIFREAAQGAHIAEEMQLCKKQGGAMVAMLHASSIKSGSENVVQAIFRD
VTREREIILNLEKSSADLARLNRMKDSFLGLASHELKTPLTVIMGYSELITTDLADRMDKTVLEMVVNIANAASRLDNII
KDMVDVSMIDEKRLQLKVEDIQLNRLIEASVNELRFFFSMRKQEVVVNLDESIPTIRGDALRLMQLLSNILGNAIKFTPD
GGKITVSTSAKYLLRGKGGAEGGGEGHEHHLFLEITVTDTGIGIDREDQLRVFEKFYEVGNIQEHSSGKVAFKAKGAGLG
LSIAKGIVDMHGGEIWVESTGYNPERFPGSTFHILLPLAPGLGENATDYSRLLR

Sequences:

>Translated_694_residues
MKMTLEKRILLFSFLILFLAISIGSGMDIMALRRDHVNALNLRSKGLATALKSNIEKVLNLGLELKDMTGVSEKCREIIE
GNQDIAYCLVSDLSGKVLFASDPRFMNFPARLLQSDQKKEGDRPESGVYKNRISMPVDGVDTSFYDSAVSVVGPYGKPIA
MAHVGFSEQVVSDKMKGMVLKTLFLLAVSLFTSFSLIMLFMKKYVMQPISMLLKGVKQISEGAFDTHIGEVEVYEFNELA
RNVNIMSQFLKNRDAEIKKNYQDMERTFEELQASYRKLERLSNDLERSEELYKSLMEDASDAIVVIGGDESVRMVNKMAE
EFFGYEAKELLGLPLTKMLLLLNISNIPKVHRIFREAAQGAHIAEEMQLCKKQGGAMVAMLHASSIKSGSENVVQAIFRD
VTREREIILNLEKSSADLARLNRMKDSFLGLASHELKTPLTVIMGYSELITTDLADRMDKTVLEMVVNIANAASRLDNII
KDMVDVSMIDEKRLQLKVEDIQLNRLIEASVNELRFFFSMRKQEVVVNLDESIPTIRGDALRLMQLLSNILGNAIKFTPD
GGKITVSTSAKYLLRGKGGAEGGGEGHEHHLFLEITVTDTGIGIDREDQLRVFEKFYEVGNIQEHSSGKVAFKAKGAGLG
LSIAKGIVDMHGGEIWVESTGYNPERFPGSTFHILLPLAPGLGENATDYSRLLR
>Mature_694_residues
MKMTLEKRILLFSFLILFLAISIGSGMDIMALRRDHVNALNLRSKGLATALKSNIEKVLNLGLELKDMTGVSEKCREIIE
GNQDIAYCLVSDLSGKVLFASDPRFMNFPARLLQSDQKKEGDRPESGVYKNRISMPVDGVDTSFYDSAVSVVGPYGKPIA
MAHVGFSEQVVSDKMKGMVLKTLFLLAVSLFTSFSLIMLFMKKYVMQPISMLLKGVKQISEGAFDTHIGEVEVYEFNELA
RNVNIMSQFLKNRDAEIKKNYQDMERTFEELQASYRKLERLSNDLERSEELYKSLMEDASDAIVVIGGDESVRMVNKMAE
EFFGYEAKELLGLPLTKMLLLLNISNIPKVHRIFREAAQGAHIAEEMQLCKKQGGAMVAMLHASSIKSGSENVVQAIFRD
VTREREIILNLEKSSADLARLNRMKDSFLGLASHELKTPLTVIMGYSELITTDLADRMDKTVLEMVVNIANAASRLDNII
KDMVDVSMIDEKRLQLKVEDIQLNRLIEASVNELRFFFSMRKQEVVVNLDESIPTIRGDALRLMQLLSNILGNAIKFTPD
GGKITVSTSAKYLLRGKGGAEGGGEGHEHHLFLEITVTDTGIGIDREDQLRVFEKFYEVGNIQEHSSGKVAFKAKGAGLG
LSIAKGIVDMHGGEIWVESTGYNPERFPGSTFHILLPLAPGLGENATDYSRLLR

Specific function: Member Of The Two-Component Regulatory System Uvry/Bara Involved In The Regulation Of Carbon Metabolism Via The Csra/Csrb Regulatory System. Phosphorylates Uvry, Probably Via A Four-Step Phosphorelay. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=317, Percent_Identity=30.2839116719243, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI145693157, Length=292, Percent_Identity=31.1643835616438, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1788549, Length=445, Percent_Identity=24.0449438202247, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI48994928, Length=458, Percent_Identity=24.235807860262, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=28.4090909090909, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=422, Percent_Identity=23.9336492890995, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786600, Length=415, Percent_Identity=23.855421686747, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081816, Length=277, Percent_Identity=27.0758122743682, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=27.6752767527675, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1790436, Length=281, Percent_Identity=25.6227758007117, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790300, Length=383, Percent_Identity=24.5430809399478, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=265, Percent_Identity=26.0377358490566, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=240, Percent_Identity=23.75, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786783, Length=257, Percent_Identity=26.4591439688716, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 77414; Mature: 77414

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMTLEKRILLFSFLILFLAISIGSGMDIMALRRDHVNALNLRSKGLATALKSNIEKVLN
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHH
LGLELKDMTGVSEKCREIIEGNQDIAYCLVSDLSGKVLFASDPRFMNFPARLLQSDQKKE
CCCCCHHHCCHHHHHHHHHCCCCCEEHHEECCCCCCEEEECCCCCCCCHHHHHCCHHHHC
GDRPESGVYKNRISMPVDGVDTSFYDSAVSVVGPYGKPIAMAHVGFSEQVVSDKMKGMVL
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
KTLFLLAVSLFTSFSLIMLFMKKYVMQPISMLLKGVKQISEGAFDTHIGEVEVYEFNELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHH
RNVNIMSQFLKNRDAEIKKNYQDMERTFEELQASYRKLERLSNDLERSEELYKSLMEDAS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAIVVIGGDESVRMVNKMAEEFFGYEAKELLGLPLTKMLLLLNISNIPKVHRIFREAAQG
CEEEEECCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
AHIAEEMQLCKKQGGAMVAMLHASSIKSGSENVVQAIFRDVTREREIILNLEKSSADLAR
CHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
LNRMKDSFLGLASHELKTPLTVIMGYSELITTDLADRMDKTVLEMVVNIANAASRLDNII
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDMVDVSMIDEKRLQLKVEDIQLNRLIEASVNELRFFFSMRKQEVVVNLDESIPTIRGDA
HHHHHHHHHCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHH
LRLMQLLSNILGNAIKFTPDGGKITVSTSAKYLLRGKGGAEGGGEGHEHHLFLEITVTDT
HHHHHHHHHHHCCCEEECCCCCEEEEECCCEEEEECCCCCCCCCCCCCEEEEEEEEEEEC
GIGIDREDQLRVFEKFYEVGNIQEHSSGKVAFKAKGAGLGLSIAKGIVDMHGGEIWVEST
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECC
GYNPERFPGSTFHILLPLAPGLGENATDYSRLLR
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MKMTLEKRILLFSFLILFLAISIGSGMDIMALRRDHVNALNLRSKGLATALKSNIEKVLN
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHH
LGLELKDMTGVSEKCREIIEGNQDIAYCLVSDLSGKVLFASDPRFMNFPARLLQSDQKKE
CCCCCHHHCCHHHHHHHHHCCCCCEEHHEECCCCCCEEEECCCCCCCCHHHHHCCHHHHC
GDRPESGVYKNRISMPVDGVDTSFYDSAVSVVGPYGKPIAMAHVGFSEQVVSDKMKGMVL
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
KTLFLLAVSLFTSFSLIMLFMKKYVMQPISMLLKGVKQISEGAFDTHIGEVEVYEFNELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHH
RNVNIMSQFLKNRDAEIKKNYQDMERTFEELQASYRKLERLSNDLERSEELYKSLMEDAS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAIVVIGGDESVRMVNKMAEEFFGYEAKELLGLPLTKMLLLLNISNIPKVHRIFREAAQG
CEEEEECCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
AHIAEEMQLCKKQGGAMVAMLHASSIKSGSENVVQAIFRDVTREREIILNLEKSSADLAR
CHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
LNRMKDSFLGLASHELKTPLTVIMGYSELITTDLADRMDKTVLEMVVNIANAASRLDNII
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDMVDVSMIDEKRLQLKVEDIQLNRLIEASVNELRFFFSMRKQEVVVNLDESIPTIRGDA
HHHHHHHHHCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHH
LRLMQLLSNILGNAIKFTPDGGKITVSTSAKYLLRGKGGAEGGGEGHEHHLFLEITVTDT
HHHHHHHHHHHCCCEEECCCCCEEEEECCCEEEEECCCCCCCCCCCCCEEEEEEEEEEEC
GIGIDREDQLRVFEKFYEVGNIQEHSSGKVAFKAKGAGLGLSIAKGIVDMHGGEIWVEST
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECC
GYNPERFPGSTFHILLPLAPGLGENATDYSRLLR
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8535519; 8905231; 3141423 [H]