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The map label for this gene is nadC [H]

Identifier: 197118702

GI number: 197118702

Start: 2694482

End: 2695312

Strand: Reverse

Name: nadC [H]

Synonym: Gbem_2321

Alternate gene names: 197118702

Gene position: 2695312-2694482 (Counterclockwise)

Preceding gene: 197118703

Following gene: 197118701

Centisome position: 58.4

GC content: 62.45

Gene sequence:

>831_bases
ATGAACCAAATTGACAAGATAATCGATAACGCCCTCGCCGAAGACATCCACACCGGTGACATAACCACCCTCTCAGTTTT
ACGCAAGCCGCGCCAGATGCGCGCCAGATTGGTCGCCAAGGAACCGATGGTCCTGGCGGGGATCGCCGTGGCCGAGCGCG
TTTTCTCCCGCATCGACGCCAGTGTCAGCTTCAAGGCGGAGTTCTCCGACGGCGATAGCCTCGCCAAGGGGGACGTCATC
GCCCGCATGGAAGGAAACGCCGCCTCGCTTTTGCAGGGGGAGCGGGTCTCTCTGAACCTCTTGCAGCGCATGTGCGGCAT
CGCCACCCAGACCGCAGCCTACGTGAAGGAGCTGGAAGGAACCGGCGCCCGCGTCGTCGACACCAGGAAGACCACCCCGG
GACTGCGCGTGCTTGAGAAATACTCGGTAAGGGTAGGTGGGGGGACCAACCACCGCACCGGGCTCTACGACGGCGTGCTC
ATCAAGGAAAACCACATAGCAGCCGCCGGCGGGATCCTCCAGGCGGTGAGCGCCGCCCGCGCCTACATCGCGCACACCCT
CAAGGTCGAGGTGGAGACCGAGAATCTCGACCAGGTGGCGCAAGCGGTTGAGGCCGGCGCCGACATCATCATGCTCGACA
ACATGGGACTCGAAGAGATGACGAAGGCCGTCCAGATGATCGGCAAAAGGGCGCTGGTCGAGGCCTCGGGCGGGGTGAAT
CTGCAGACCATCAAATCCATCGCCCAGACCGGGGTGGACATCATATCGGTCGGGGCCTTGACCCACTCGGTCAGGGCCAC
CGACATCTCCATGCTGATGGAGGAAGTTTGA

Upstream 100 bases:

>100_bases
GTGGCGACAGTAGCTTTTATAGCGGAAGTATTAGCGGTTGCGGGGCTAGTTAAGCTGTGCTATAAAAAAATGCCGCTTTT
CGAAGGAGATGCCCGATAAC

Downstream 100 bases:

>100_bases
AAGAATCCGGAGTAGACGGGAAAATCCTGGAACTGTTCCGCTCCGGAGACGGTGTGGTATCCGGCGCCGCGCTCAGCAAG
GCGCTGGGGGTTTCGCGAAC

Product: quinolinate phosphoribosyltransferase (decarboxylating)

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNQIDKIIDNALAEDIHTGDITTLSVLRKPRQMRARLVAKEPMVLAGIAVAERVFSRIDASVSFKAEFSDGDSLAKGDVI
ARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEGTGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVL
IKENHIAAAGGILQAVSAARAYIAHTLKVEVETENLDQVAQAVEAGADIIMLDNMGLEEMTKAVQMIGKRALVEASGGVN
LQTIKSIAQTGVDIISVGALTHSVRATDISMLMEEV

Sequences:

>Translated_276_residues
MNQIDKIIDNALAEDIHTGDITTLSVLRKPRQMRARLVAKEPMVLAGIAVAERVFSRIDASVSFKAEFSDGDSLAKGDVI
ARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEGTGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVL
IKENHIAAAGGILQAVSAARAYIAHTLKVEVETENLDQVAQAVEAGADIIMLDNMGLEEMTKAVQMIGKRALVEASGGVN
LQTIKSIAQTGVDIISVGALTHSVRATDISMLMEEV
>Mature_276_residues
MNQIDKIIDNALAEDIHTGDITTLSVLRKPRQMRARLVAKEPMVLAGIAVAERVFSRIDASVSFKAEFSDGDSLAKGDVI
ARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEGTGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVL
IKENHIAAAGGILQAVSAARAYIAHTLKVEVETENLDQVAQAVEAGADIIMLDNMGLEEMTKAVQMIGKRALVEASGGVN
LQTIKSIAQTGVDIISVGALTHSVRATDISMLMEEV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=270, Percent_Identity=40, Blast_Score=168, Evalue=5e-42,
Organism=Escherichia coli, GI1786299, Length=267, Percent_Identity=43.8202247191011, Blast_Score=183, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321162, Length=278, Percent_Identity=35.9712230215827, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29438; Mature: 29438

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQIDKIIDNALAEDIHTGDITTLSVLRKPRQMRARLVAKEPMVLAGIAVAERVFSRIDA
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
SVSFKAEFSDGDSLAKGDVIARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEG
CEEEEEECCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCC
TGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVLIKENHIAAAGGILQAVSAAR
CCCEEEECCCCCCHHHHHHHHEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
AYIAHTLKVEVETENLDQVAQAVEAGADIIMLDNMGLEEMTKAVQMIGKRALVEASGGVN
HHHHHEEEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHEEECCCCCC
LQTIKSIAQTGVDIISVGALTHSVRATDISMLMEEV
HHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNQIDKIIDNALAEDIHTGDITTLSVLRKPRQMRARLVAKEPMVLAGIAVAERVFSRIDA
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
SVSFKAEFSDGDSLAKGDVIARMEGNAASLLQGERVSLNLLQRMCGIATQTAAYVKELEG
CEEEEEECCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCC
TGARVVDTRKTTPGLRVLEKYSVRVGGGTNHRTGLYDGVLIKENHIAAAGGILQAVSAAR
CCCEEEECCCCCCHHHHHHHHEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
AYIAHTLKVEVETENLDQVAQAVEAGADIIMLDNMGLEEMTKAVQMIGKRALVEASGGVN
HHHHHEEEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHEEECCCCCC
LQTIKSIAQTGVDIISVGALTHSVRATDISMLMEEV
HHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]