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The map label for this gene is ltaE [H]

Identifier: 197118311

GI number: 197118311

Start: 2229204

End: 2230262

Strand: Reverse

Name: ltaE [H]

Synonym: Gbem_1928

Alternate gene names: 197118311

Gene position: 2230262-2229204 (Counterclockwise)

Preceding gene: 308535276

Following gene: 197118310

Centisome position: 48.32

GC content: 60.81

Gene sequence:

>1059_bases
ATGAAGAAAAAGGAAAGCGGACACAGCGAGCTGAAGCACCATTTTGCCAGCGACAACTATGCAGGGATATGCAACGAAGC
CTGGGCGGCGATGGCGGAGGCCAATCGCGGCATGGCCAGCTCCTATGGCGACGATTATTGGACCGCCGAAGCCTGCGAAA
AGATCCGCGAACTGTTCGAGACCGACTGCGAAGTCTTCTTCGTCTTCAACGGCACCGCAGCCAACTCGCTCGCCCTCGCC
TCCTTGTGCCAGTCCTACCACTCCATCGTCTGCCACGAGATGGCGCACATAGAGACCGACGAGTGCGGCGCCTCCGAGTT
CTTCTCCAACGGCACCAAGGTGCTGCTGGTTCCCGGAGAAAACGGCAAGATCGACCTCGATGCGGTGGAGCACACCATCC
ACAAGCGCACCGACATCCACTACCCCAAGCCGAAAGCGCTCAGCATCACCCAGGCCACCGAGCTGGGGACGCTTTACAGC
GTGCAGGAACTGCAGGCGATTGGGGAACTGGCCAAGAAGCACTCGTTGCGGGTGCATATGGACGGCGCACGCTTTGCGAA
CGCAGTAGCGTCTTTGAACGTCGCCCCGAAAGAGATCAGCTGGCAGGCCGGGGTCGACGTCCTCACCTTTGGGGGGACCA
AGAACGGTTTTGCCATAGGCGAGGCGGTAGTCTTCTTCAACAAGGAGCTCGCCTTCGAGTTCGACTACCGCTGCAAGCAG
GCGGGACAGCTCGCCTCCAAGATGCGCTTTCTCACCGCCCCCTGGATCGGCATGCTGGAAAGCGGCGCGTGGCTAAAGAA
CGCGGCGCACGCCAATAACTGCGCGAGGCTCTTGGAAAGCGAGATCAGGAAGATACCGCAAGTGCGGGTCATGTTCCCGA
GCCAGGCGAACTCCGTCTTCCTGGAAATGGCGCCCGAGGCGCTGGAGGCGCTGCGCGGTCGCGGCTGGCACTTCTACACC
TTCATAGGGTCCGGCGGCGCCAGGTTCATGTGCTCCTGGGACACCGATACCGCCGAAGTAGCCAACCTGGTAGCCGACAT
CAAAGCCTCGGTGGCATAA

Upstream 100 bases:

>100_bases
TAGTAAAGTGGCAAAGGTAGCCTGAGTCGAAGCACAAACTGTGATAGGTCCAAGACAAAACAGCACACAAAGAAGTGAAA
GGCGAGGAAGAGAGGAAGAG

Downstream 100 bases:

>100_bases
ATCCAAAGGCACACACCACAGAGGGGCACAGAGGAAAAGCAGAAGCAGGAAAGTCCACACCTTTCCCAGTCGAACCACAG
GTTCATAGCAACACGAAGAA

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKKKESGHSELKHHFASDNYAGICNEAWAAMAEANRGMASSYGDDYWTAEACEKIRELFETDCEVFFVFNGTAANSLALA
SLCQSYHSIVCHEMAHIETDECGASEFFSNGTKVLLVPGENGKIDLDAVEHTIHKRTDIHYPKPKALSITQATELGTLYS
VQELQAIGELAKKHSLRVHMDGARFANAVASLNVAPKEISWQAGVDVLTFGGTKNGFAIGEAVVFFNKELAFEFDYRCKQ
AGQLASKMRFLTAPWIGMLESGAWLKNAAHANNCARLLESEIRKIPQVRVMFPSQANSVFLEMAPEALEALRGRGWHFYT
FIGSGGARFMCSWDTDTAEVANLVADIKASVA

Sequences:

>Translated_352_residues
MKKKESGHSELKHHFASDNYAGICNEAWAAMAEANRGMASSYGDDYWTAEACEKIRELFETDCEVFFVFNGTAANSLALA
SLCQSYHSIVCHEMAHIETDECGASEFFSNGTKVLLVPGENGKIDLDAVEHTIHKRTDIHYPKPKALSITQATELGTLYS
VQELQAIGELAKKHSLRVHMDGARFANAVASLNVAPKEISWQAGVDVLTFGGTKNGFAIGEAVVFFNKELAFEFDYRCKQ
AGQLASKMRFLTAPWIGMLESGAWLKNAAHANNCARLLESEIRKIPQVRVMFPSQANSVFLEMAPEALEALRGRGWHFYT
FIGSGGARFMCSWDTDTAEVANLVADIKASVA
>Mature_352_residues
MKKKESGHSELKHHFASDNYAGICNEAWAAMAEANRGMASSYGDDYWTAEACEKIRELFETDCEVFFVFNGTAANSLALA
SLCQSYHSIVCHEMAHIETDECGASEFFSNGTKVLLVPGENGKIDLDAVEHTIHKRTDIHYPKPKALSITQATELGTLYS
VQELQAIGELAKKHSLRVHMDGARFANAVASLNVAPKEISWQAGVDVLTFGGTKNGFAIGEAVVFFNKELAFEFDYRCKQ
AGQLASKMRFLTAPWIGMLESGAWLKNAAHANNCARLLESEIRKIPQVRVMFPSQANSVFLEMAPEALEALRGRGWHFYT
FIGSGGARFMCSWDTDTAEVANLVADIKASVA

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=258, Percent_Identity=27.5193798449612, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193206520, Length=201, Percent_Identity=29.8507462686567, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193206522, Length=201, Percent_Identity=29.8507462686567, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193206524, Length=201, Percent_Identity=29.8507462686567, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320789, Length=334, Percent_Identity=24.5508982035928, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38693; Mature: 38693

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKESGHSELKHHFASDNYAGICNEAWAAMAEANRGMASSYGDDYWTAEACEKIRELFE
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
TDCEVFFVFNGTAANSLALASLCQSYHSIVCHEMAHIETDECGASEFFSNGTKVLLVPGE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECC
NGKIDLDAVEHTIHKRTDIHYPKPKALSITQATELGTLYSVQELQAIGELAKKHSLRVHM
CCCEEHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DGARFANAVASLNVAPKEISWQAGVDVLTFGGTKNGFAIGEAVVFFNKELAFEFDYRCKQ
CHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCCCCCCHHHEEEEECCCCEEEECHHHHH
AGQLASKMRFLTAPWIGMLESGAWLKNAAHANNCARLLESEIRKIPQVRVMFPSQANSVF
HHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEE
LEMAPEALEALRGRGWHFYTFIGSGGARFMCSWDTDTAEVANLVADIKASVA
EEECHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKKESGHSELKHHFASDNYAGICNEAWAAMAEANRGMASSYGDDYWTAEACEKIRELFE
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
TDCEVFFVFNGTAANSLALASLCQSYHSIVCHEMAHIETDECGASEFFSNGTKVLLVPGE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECC
NGKIDLDAVEHTIHKRTDIHYPKPKALSITQATELGTLYSVQELQAIGELAKKHSLRVHM
CCCEEHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DGARFANAVASLNVAPKEISWQAGVDVLTFGGTKNGFAIGEAVVFFNKELAFEFDYRCKQ
CHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCCCCCCHHHEEEEECCCCEEEECHHHHH
AGQLASKMRFLTAPWIGMLESGAWLKNAAHANNCARLLESEIRKIPQVRVMFPSQANSVF
HHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEE
LEMAPEALEALRGRGWHFYTFIGSGGARFMCSWDTDTAEVANLVADIKASVA
EEECHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]