Click here to switch to the map view.

The map label for this gene is maeB-3 [H]

Identifier: 197118271

GI number: 197118271

Start: 2187490

End: 2189739

Strand: Reverse

Name: maeB-3 [H]

Synonym: Gbem_1888

Alternate gene names: 197118271

Gene position: 2189739-2187490 (Counterclockwise)

Preceding gene: 197118272

Following gene: 197118270

Centisome position: 47.45

GC content: 62.76

Gene sequence:

>2250_bases
ATGAGCAAAAAATTGGGTGCCCTTGATTACCACTCAAGCGGCAGAAAAGGTAAGATCGAAGTCATCGCCACCAAGCCGTG
CCAGACCGCAGCCGACCTGTCCCTCGCCTACTCTCCGGGGGTCGCGGAACCCTGCCTGGCCATCCAGGAGAACCCGGACG
ACGCCTACAAGTACACGGCGAAGGGGAACCTCGTGGCGGTCGTATCCAACGGCACCGCGGTCCTGGGCCTTGGGAACCTG
GGCGCCCTCGCCGGCAAGCCGGTCATGGAAGGGAAAGGTGTCCTCTTCAAGCGTTTCGCCGACATCGACGTCTTCGACAT
CGAGCTGAACACCGAGAACCCCGACGAGATCATCAAGGCCTGCCAGCTCCTGGAGCCGACCTTCGGCGGCATCAACCTTG
AGGACATCAAGGCGCCCGAGTGCTTCTATATCGAGGAGCAGCTCAAGAAGACCATGAACATCCCGGTCTTCCACGACGAC
CAGCACGGCACCGCCATCATCTGCTCGGCGGCCCTTCTGAATGCCCTGATGCTGGTGCAAAAGAAGATCGAGGACATAAG
GATCGTCGTCAACGGCGCCGGCGCCTCGGCCAACTCCTGCGCCAAGCTCGCCATCGCGCTCGGTGTGAAACCCAACAACA
TGATCATGTGCGACACCAAGGGGGTCATCTACAAGGGGCGCGTCGAGGGGATGAATCCCTACAAGGAACTCTTCGCAGCC
GAAACCCACTTCCGCACCCTGGAAGAGGCGGCGGTGGGAGCCGACGTCCTTTTCGGCCTCTCGGCCAAGGGGGCCTTCAC
ACCGGAGATGGTCCGCTCCATGGCGCCGAACCCGATCATCTTCGCCATGGCGAACCCCGACCCGGAAATCACCCCGGAAG
AGGCGCACGGGGTGCGCGGCGACGTGATCATCGCGACCGGCAGGAGCGACTACGCGAACCAGGTCAACAACGTCCTCGGC
TTCCCCTTCATCTTCCGCGGCGCGCTCGACGTGCGCGCCACTGCCATCAACGAGGAGATGAAGCTCGCCGCGGTGCACGC
CCTGGCGAAACTTGCCCGCGAGGAGGTGCCCGACTCCGTCAGCAAGGCCTACGGCAACGAGAAGTTCAGCTTCGGCCCGA
CCTACATCATCCCCAAACCCTTCGACCCGCGCGTGCTTTTGCACGTGGCCCCGGCGATCGCCCAGGCCGCCATGGACACG
GGGGTCGCGCGCCTGCCGATCGCCGACATGGGCAAGTACATCGAGCAGCTCGAGTCCTCGCAGGGCAAATCCAAAGAGAT
CATGCGCATGATCATCAACAAGGCGAAGAGCGACCCGAAGAAGGTGGTCTTCTCCGAGGGTGAGGACGACAAGATCCTGC
GCGCGGCCCAGGTGCTGGTCGAGGAGGGGATCGCCAAGCCGATCCTGATCGGAGACCAGAAGAAGATCAAGCAGAAGATG
GACGATCTCAACCTGGACCTCGACGTGCCGATCATGGACCCGTCCGACTCCGAGTTCACCGAGGAGTACGCCGCGGAGCT
CTACCGCTTAAGGCAAAGGAAAGGGCTCACCATTTCCGAGTGCCGCCGCATCATGCGCCGCAAGTCGCGGGCACACTTCG
GCAACATGATGGTGCACATGGGGCACGCCGACGCTCTTCTGGGCGGGATCGACACCCACTACCCGGAAACCATCCGCCCC
GCACTGCAGGTCTTAGGCAAGCAGGGGGGGCTCTCCAGCGTGCACGGCCTCTACATGATGGTGTCCAAACAGAACGTCTA
CTTCCTGGCCGACACCACGGTGACCATCGATCCGACCGCGGAGGAGCTGGCCGAGACGGCCATTCTCGCCGCCGAGATGG
TCACCAAGCTCGACATCGAGCCCCGCGTCGCCATGCTCTCCTTCTCCAACTTCGGCTCGGTGGACCACCCGCAGACGCGC
AAGGTCAAGCGCGCCGTCGAGATCGTCAAGGAGCGCGCCCCCAACCTGATAGTAGAGGGTGAGATGCAGGCCGACACCGC
CGTGGTCCCCGATCTTCTGGACGGCTTCACCTTCTCGAAACTGAAGACCCCGGCCAACATCCTGATCTTCCCCGACCTCA
ACTCCGGGAACATCTGCTACAAGCTCTTGCACCACCTGGGCGGCGCCGAGGCGATAGGCCCGATCCTCATGGGGATGAAC
AAGCCGGTGCACGTACTGCAGCGCGGCGACGACGTCAACGACATCGTCAACATGGCCGCCATCGCCGTGGTGGACGTACA
GAACCTGTAG

Upstream 100 bases:

>100_bases
AGGAGGTCCGGGTGCTGGTAGTCGTGACCAAGTAGTTGCACCGGCAGCAGAGACTTTAATGGCGCATAGCCGCGAATCTG
ATGAGTCAAAGGAGAAATGC

Downstream 100 bases:

>100_bases
ACGGAGCCCCCCTCCCCCGAAAAGGCTCTTCCGAGAGTTGCGGGGATAATAGCCCCCCTCCCTTGACGGGAGGGGGGACC
AAAATCACGTAAACACAAGT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MSKKLGALDYHSSGRKGKIEVIATKPCQTAADLSLAYSPGVAEPCLAIQENPDDAYKYTAKGNLVAVVSNGTAVLGLGNL
GALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEQLKKTMNIPVFHDD
QHGTAIICSAALLNALMLVQKKIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKELFAA
ETHFRTLEEAAVGADVLFGLSAKGAFTPEMVRSMAPNPIIFAMANPDPEITPEEAHGVRGDVIIATGRSDYANQVNNVLG
FPFIFRGALDVRATAINEEMKLAAVHALAKLAREEVPDSVSKAYGNEKFSFGPTYIIPKPFDPRVLLHVAPAIAQAAMDT
GVARLPIADMGKYIEQLESSQGKSKEIMRMIINKAKSDPKKVVFSEGEDDKILRAAQVLVEEGIAKPILIGDQKKIKQKM
DDLNLDLDVPIMDPSDSEFTEEYAAELYRLRQRKGLTISECRRIMRRKSRAHFGNMMVHMGHADALLGGIDTHYPETIRP
ALQVLGKQGGLSSVHGLYMMVSKQNVYFLADTTVTIDPTAEELAETAILAAEMVTKLDIEPRVAMLSFSNFGSVDHPQTR
KVKRAVEIVKERAPNLIVEGEMQADTAVVPDLLDGFTFSKLKTPANILIFPDLNSGNICYKLLHHLGGAEAIGPILMGMN
KPVHVLQRGDDVNDIVNMAAIAVVDVQNL

Sequences:

>Translated_749_residues
MSKKLGALDYHSSGRKGKIEVIATKPCQTAADLSLAYSPGVAEPCLAIQENPDDAYKYTAKGNLVAVVSNGTAVLGLGNL
GALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEQLKKTMNIPVFHDD
QHGTAIICSAALLNALMLVQKKIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKELFAA
ETHFRTLEEAAVGADVLFGLSAKGAFTPEMVRSMAPNPIIFAMANPDPEITPEEAHGVRGDVIIATGRSDYANQVNNVLG
FPFIFRGALDVRATAINEEMKLAAVHALAKLAREEVPDSVSKAYGNEKFSFGPTYIIPKPFDPRVLLHVAPAIAQAAMDT
GVARLPIADMGKYIEQLESSQGKSKEIMRMIINKAKSDPKKVVFSEGEDDKILRAAQVLVEEGIAKPILIGDQKKIKQKM
DDLNLDLDVPIMDPSDSEFTEEYAAELYRLRQRKGLTISECRRIMRRKSRAHFGNMMVHMGHADALLGGIDTHYPETIRP
ALQVLGKQGGLSSVHGLYMMVSKQNVYFLADTTVTIDPTAEELAETAILAAEMVTKLDIEPRVAMLSFSNFGSVDHPQTR
KVKRAVEIVKERAPNLIVEGEMQADTAVVPDLLDGFTFSKLKTPANILIFPDLNSGNICYKLLHHLGGAEAIGPILMGMN
KPVHVLQRGDDVNDIVNMAAIAVVDVQNL
>Mature_748_residues
SKKLGALDYHSSGRKGKIEVIATKPCQTAADLSLAYSPGVAEPCLAIQENPDDAYKYTAKGNLVAVVSNGTAVLGLGNLG
ALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEQLKKTMNIPVFHDDQ
HGTAIICSAALLNALMLVQKKIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKELFAAE
THFRTLEEAAVGADVLFGLSAKGAFTPEMVRSMAPNPIIFAMANPDPEITPEEAHGVRGDVIIATGRSDYANQVNNVLGF
PFIFRGALDVRATAINEEMKLAAVHALAKLAREEVPDSVSKAYGNEKFSFGPTYIIPKPFDPRVLLHVAPAIAQAAMDTG
VARLPIADMGKYIEQLESSQGKSKEIMRMIINKAKSDPKKVVFSEGEDDKILRAAQVLVEEGIAKPILIGDQKKIKQKMD
DLNLDLDVPIMDPSDSEFTEEYAAELYRLRQRKGLTISECRRIMRRKSRAHFGNMMVHMGHADALLGGIDTHYPETIRPA
LQVLGKQGGLSSVHGLYMMVSKQNVYFLADTTVTIDPTAEELAETAILAAEMVTKLDIEPRVAMLSFSNFGSVDHPQTRK
VKRAVEIVKERAPNLIVEGEMQADTAVVPDLLDGFTFSKLKTPANILIFPDLNSGNICYKLLHHLGGAEAIGPILMGMNK
PVHVLQRGDDVNDIVNMAAIAVVDVQNL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=349, Percent_Identity=28.9398280802292, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI62420880, Length=349, Percent_Identity=28.9398280802292, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI239049447, Length=349, Percent_Identity=28.9398280802292, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4505143, Length=348, Percent_Identity=26.7241379310345, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI4505145, Length=353, Percent_Identity=28.0453257790368, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1788806, Length=754, Percent_Identity=52.2546419098143, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=329, Percent_Identity=34.6504559270517, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=32.9479768786127, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17537199, Length=424, Percent_Identity=24.7641509433962, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=267, Percent_Identity=27.3408239700375, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=30.3724928366762, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646386, Length=349, Percent_Identity=30.3724928366762, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281362674, Length=411, Percent_Identity=27.4939172749392, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356279, Length=411, Percent_Identity=27.4939172749392, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281362672, Length=411, Percent_Identity=27.4939172749392, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI78707242, Length=409, Percent_Identity=26.6503667481663, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI78707238, Length=409, Percent_Identity=26.6503667481663, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI78707240, Length=346, Percent_Identity=27.1676300578035, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81402; Mature: 81271

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLGALDYHSSGRKGKIEVIATKPCQTAADLSLAYSPGVAEPCLAIQENPDDAYKYTA
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHCCEEEECCCCCCCCCEEECCCCHHEEEEE
KGNLVAVVSNGTAVLGLGNLGALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEIIKA
CCCEEEEEECCEEEEEECCCCHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEQLKKTMNIPVFHDDQHGTAIICSAALLNALMLVQ
HHHHCCCCCCCCHHHCCCCCEEEHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHH
KKIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKELFAA
HHHCEEEEEEECCCCCCCCHHEEEEEEECCCCCEEEECCCCEEEECCCCCCCHHHHHHHH
ETHFRTLEEAAVGADVLFGLSAKGAFTPEMVRSMAPNPIIFAMANPDPEITPEEAHGVRG
HHHHHHHHHHHCCCHHHEECCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCC
DVIIATGRSDYANQVNNVLGFPFIFRGALDVRATAINEEMKLAAVHALAKLAREEVPDSV
CEEEEECCCHHHHHHHHHCCCHHHHHCCHHHEEEHHCHHHHHHHHHHHHHHHHHHCCHHH
SKAYGNEKFSFGPTYIIPKPFDPRVLLHVAPAIAQAAMDTGVARLPIADMGKYIEQLESS
HHHCCCCCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
QGKSKEIMRMIINKAKSDPKKVVFSEGEDDKILRAAQVLVEEGIAKPILIGDQKKIKQKM
CCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
DDLNLDLDVPIMDPSDSEFTEEYAAELYRLRQRKGLTISECRRIMRRKSRAHFGNMMVHM
HHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEE
GHADALLGGIDTHYPETIRPALQVLGKQGGLSSVHGLYMMVSKQNVYFLADTTVTIDPTA
CCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHCEEEEEEECCCEEEEEECEEEECCCH
EELAETAILAAEMVTKLDIEPRVAMLSFSNFGSVDHPQTRKVKRAVEIVKERAPNLIVEG
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEC
EMQADTAVVPDLLDGFTFSKLKTPANILIFPDLNSGNICYKLLHHLGGAEAIGPILMGMN
CCCCCCHHHHHHHCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCC
KPVHVLQRGDDVNDIVNMAAIAVVDVQNL
CCHHHHHCCCCHHHHHHHHHHEEEEECCC
>Mature Secondary Structure 
SKKLGALDYHSSGRKGKIEVIATKPCQTAADLSLAYSPGVAEPCLAIQENPDDAYKYTA
CCCCCCCCCCCCCCCCEEEEEEECCCCCHHCCEEEECCCCCCCCCEEECCCCHHEEEEE
KGNLVAVVSNGTAVLGLGNLGALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEIIKA
CCCEEEEEECCEEEEEECCCCHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEQLKKTMNIPVFHDDQHGTAIICSAALLNALMLVQ
HHHHCCCCCCCCHHHCCCCCEEEHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHH
KKIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKELFAA
HHHCEEEEEEECCCCCCCCHHEEEEEEECCCCCEEEECCCCEEEECCCCCCCHHHHHHHH
ETHFRTLEEAAVGADVLFGLSAKGAFTPEMVRSMAPNPIIFAMANPDPEITPEEAHGVRG
HHHHHHHHHHHCCCHHHEECCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCC
DVIIATGRSDYANQVNNVLGFPFIFRGALDVRATAINEEMKLAAVHALAKLAREEVPDSV
CEEEEECCCHHHHHHHHHCCCHHHHHCCHHHEEEHHCHHHHHHHHHHHHHHHHHHCCHHH
SKAYGNEKFSFGPTYIIPKPFDPRVLLHVAPAIAQAAMDTGVARLPIADMGKYIEQLESS
HHHCCCCCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
QGKSKEIMRMIINKAKSDPKKVVFSEGEDDKILRAAQVLVEEGIAKPILIGDQKKIKQKM
CCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
DDLNLDLDVPIMDPSDSEFTEEYAAELYRLRQRKGLTISECRRIMRRKSRAHFGNMMVHM
HHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEE
GHADALLGGIDTHYPETIRPALQVLGKQGGLSSVHGLYMMVSKQNVYFLADTTVTIDPTA
CCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHCEEEEEEECCCEEEEEECEEEECCCH
EELAETAILAAEMVTKLDIEPRVAMLSFSNFGSVDHPQTRKVKRAVEIVKERAPNLIVEG
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEC
EMQADTAVVPDLLDGFTFSKLKTPANILIFPDLNSGNICYKLLHHLGGAEAIGPILMGMN
CCCCCCHHHHHHHCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCC
KPVHVLQRGDDVNDIVNMAAIAVVDVQNL
CCHHHHHCCCCHHHHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]