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The map label for this gene is lepB [H]

Identifier: 197118265

GI number: 197118265

Start: 2179652

End: 2180329

Strand: Reverse

Name: lepB [H]

Synonym: Gbem_1882

Alternate gene names: 197118265

Gene position: 2180329-2179652 (Counterclockwise)

Preceding gene: 197118266

Following gene: 197118264

Centisome position: 47.24

GC content: 59.14

Gene sequence:

>678_bases
ATGGAAGATTACAAAAACGTCTGCGAAGACAACAAGCCTGCGCAGTCTCCGGTCCAGCCGGACCAGCCGGTCAAGGCGAA
GCATGTGGTTCGCGAATACGCAGAGTCGATCATCATAGCGATCCTTTTGGCGCTCGTGATCCGTACCTTCATAGTGCAGG
CCTTCAAGATCCCGTCCGGGTCCATGGAGGATACGCTTGCCATCGGCGACCACCTGCTGGTCAACAAGTTCATCTATGGC
TCGAAGATCCCCTTCACCGGCAACCGCGTCCTCACCATCAGGGACCCGCGCCAGGGCGACGTGGTCGTCTTCGAGTACCC
GGAAGACCCGTCCAAGGACTTCATCAAGCGCGTGGTAGGCGTCCCCGGCGACGTGGTCGAGGTAAAGAACAAGCGGGTGT
ACGTGAACGGGAAACTCTACGCGAACCCGCACGAGGTGCACAAGGAGTCCGACACCATCCCGAAGGAGATGAACCCCAGG
GACAACAAGGATCCCATCACCGTCCCGGCCAACTCCTACTTCGTCATGGGCGACAACAGGGACCGCTCCTACGACAGCCG
CTTCTGGGGGTTCGTGACCCGCGACAAGCTCAAAGGGCTCGCCTTCATCAAGTACTGGTCCTGGGACAAAGACAAGCTCA
GGGTCCGCTTCGGGAGCATCGGCAAGCTGATCGACTAG

Upstream 100 bases:

>100_bases
GAGCTCCCGCAGGAGGCGTTCCTGGCTATCCTCAAGGTAGAGGGGTAGCCCCAACTCGGACGGCTTACGCCTTTCCATCA
AGACAAGGGGATCAAAGGGA

Downstream 100 bases:

>100_bases
CCCCCTCCCCGTTTTCTGTCATTGTCTTAAAAAAACCCCCTGCACGGCCACGCCGTTCAGGGGGTTTTTTTGTTCAAAGT
TCCCCCTCCCCCGGCGGGAG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MEDYKNVCEDNKPAQSPVQPDQPVKAKHVVREYAESIIIAILLALVIRTFIVQAFKIPSGSMEDTLAIGDHLLVNKFIYG
SKIPFTGNRVLTIRDPRQGDVVVFEYPEDPSKDFIKRVVGVPGDVVEVKNKRVYVNGKLYANPHEVHKESDTIPKEMNPR
DNKDPITVPANSYFVMGDNRDRSYDSRFWGFVTRDKLKGLAFIKYWSWDKDKLRVRFGSIGKLID

Sequences:

>Translated_225_residues
MEDYKNVCEDNKPAQSPVQPDQPVKAKHVVREYAESIIIAILLALVIRTFIVQAFKIPSGSMEDTLAIGDHLLVNKFIYG
SKIPFTGNRVLTIRDPRQGDVVVFEYPEDPSKDFIKRVVGVPGDVVEVKNKRVYVNGKLYANPHEVHKESDTIPKEMNPR
DNKDPITVPANSYFVMGDNRDRSYDSRFWGFVTRDKLKGLAFIKYWSWDKDKLRVRFGSIGKLID
>Mature_225_residues
MEDYKNVCEDNKPAQSPVQPDQPVKAKHVVREYAESIIIAILLALVIRTFIVQAFKIPSGSMEDTLAIGDHLLVNKFIYG
SKIPFTGNRVLTIRDPRQGDVVVFEYPEDPSKDFIKRVVGVPGDVVEVKNKRVYVNGKLYANPHEVHKESDTIPKEMNPR
DNKDPITVPANSYFVMGDNRDRSYDSRFWGFVTRDKLKGLAFIKYWSWDKDKLRVRFGSIGKLID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=95, Percent_Identity=49.4736842105263, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25759; Mature: 25759

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDYKNVCEDNKPAQSPVQPDQPVKAKHVVREYAESIIIAILLALVIRTFIVQAFKIPSG
CCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SMEDTLAIGDHLLVNKFIYGSKIPFTGNRVLTIRDPRQGDVVVFEYPEDPSKDFIKRVVG
CCCCHHHHCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHC
VPGDVVEVKNKRVYVNGKLYANPHEVHKESDTIPKEMNPRDNKDPITVPANSYFVMGDNR
CCCCEEEECCCEEEECCEEECCHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCC
DRSYDSRFWGFVTRDKLKGLAFIKYWSWDKDKLRVRFGSIGKLID
CCCCCCHHHCEEEHHHHCCEEEEEEECCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MEDYKNVCEDNKPAQSPVQPDQPVKAKHVVREYAESIIIAILLALVIRTFIVQAFKIPSG
CCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SMEDTLAIGDHLLVNKFIYGSKIPFTGNRVLTIRDPRQGDVVVFEYPEDPSKDFIKRVVG
CCCCHHHHCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHC
VPGDVVEVKNKRVYVNGKLYANPHEVHKESDTIPKEMNPRDNKDPITVPANSYFVMGDNR
CCCCEEEECCCEEEECCEEECCHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCC
DRSYDSRFWGFVTRDKLKGLAFIKYWSWDKDKLRVRFGSIGKLID
CCCCCCHHHCEEEHHHHCCEEEEEEECCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]