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The map label for this gene is phoR-1 [H]

Identifier: 197118247

GI number: 197118247

Start: 2157379

End: 2158761

Strand: Reverse

Name: phoR-1 [H]

Synonym: Gbem_1864

Alternate gene names: 197118247

Gene position: 2158761-2157379 (Counterclockwise)

Preceding gene: 197118248

Following gene: 197118246

Centisome position: 46.78

GC content: 63.77

Gene sequence:

>1383_bases
ATGAGGTTAAAAGTCATCGGCATCCAGTTCGCAGTCGTCATGGCGTTTGCTGCGGTACTTTGCAGCTACGAGCAGCGCCT
GCTCGGAGTTGGCTGGGCTTTGCTCTTGACCGCCACCATCGTCGTCTGCTCCACCTACCTTCTGGCCGATCTCGGCACCA
GGCCGCTTAGGGCCGTTGCCGCCATGGCGTCCAGGATCGGCAAGGGAGAGATCAACACCAAGCTTCCCGCGGTAACCGAC
CCTCAGGTCACCGAGCTTGCCAGGGTGATCAACGAAATGGCGGCAAAGGCCAACGCGCAACTGGACCGCTTGGAGGCGGA
GAAGAATCGGCTGGACGCCATCCTGCGCGGCATGGGCGAAGGAATCATGGTGGCCGACCCTCAGGGATGCATCACGCTGG
TCAACCCCGCCTTCAAGGGACTCTTCGGGCTGCATGACGAGGTGGAAGGACGGCTGCTCATCGACATATCGCGCCATCCC
GCGCTGCACGAGTCGTTCAGGGACATCTTGTCTTCGCGCCAGGAGCGCGTCGAGGAGCTGCAGTTGCACTCCCCTAAAGA
GCGCTCGCTGCTGGTCCACTGGGTGCCGCTCGTGGAGTGCGGGGTGGTGACCGGCGTGGTGGCGGTATTCCACGACATCT
CCGACCTCCGGCAGATGGAGAAGATGCGGCGCGACTTCGTCGCCAACGTCTCCCACGAATTGCGCACTCCCATCACCATC
ATCAAAGGGTACGCAGAAACGCTTCTGGCCGGGGCACTGGAACACCCGACCCAGGCAACGAAGTTCGTCAGCATCGTGCA
CTCGCACGCGGACCGGCTCGCCTCCCTGGTCAGCGACCTGCTCACCCTGTCCCAGCTGGAGTCGGGTGCGGTCCCCCTGG
AGGCCAGGAGCGTGAAGGTGCAGGAGATAGCGGAACGCGTGGTCGTCCTGCTGGAGCGCAAGATCCGGGAGCGCGGCATC
ATAGTCGACCTCGCCGGACTTAAGGATGCTCCCAGCGTGATGGCAGACCCGGGGCGCCTCGAACAGGTGATCGTCAACCT
GCTCGACAACGCGGTGAAATACACCCCCGCCGGGGGCTCGGTGACGCTCAGCGCGGCTGATCGTGAAGAAAGCGTCACCA
TCGCGGTCCAGGATACCGGCATCGGCATCCCCTCCAAGGACCTCTCGCGCATCTTCGAGCGTTTTTACCGGGTCGACTCG
GCGCGCAGCCGCGACGAAGGGGGAACCGGCCTCGGGCTTTCCATCGTGAAACACATAGTCCAGTTGCAGGGTGGAACGGT
GTCGGCGCAAAGCTCCGGACAGGGCTCCACCTTCTTCGTCACCCTCAACCGGGCCGACCCGACTTACGGCTCCGGCATAG
CGCCGGCCGCGGCCCAAGCCTGA

Upstream 100 bases:

>100_bases
GCACCGTCGACACCCACATCACCCGCCTGCGGACCAAGATGGGCAACGCGGGAGATATGATCAAGACGGTGCGCGGCTTC
GGCTACAAATTGGAGGTGCA

Downstream 100 bases:

>100_bases
CCCACACACGAGGTGGCACGATGAACAAGGAACATGTAAGTAGCCAGTTCGACAGCAACTTGGCCTCGATCCGCCTGAAG
CTCCTGGAGATGGGTGGCAA

Product: HAMP/PAS domain-containing phosphate sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MRLKVIGIQFAVVMAFAAVLCSYEQRLLGVGWALLLTATIVVCSTYLLADLGTRPLRAVAAMASRIGKGEINTKLPAVTD
PQVTELARVINEMAAKANAQLDRLEAEKNRLDAILRGMGEGIMVADPQGCITLVNPAFKGLFGLHDEVEGRLLIDISRHP
ALHESFRDILSSRQERVEELQLHSPKERSLLVHWVPLVECGVVTGVVAVFHDISDLRQMEKMRRDFVANVSHELRTPITI
IKGYAETLLAGALEHPTQATKFVSIVHSHADRLASLVSDLLTLSQLESGAVPLEARSVKVQEIAERVVVLLERKIRERGI
IVDLAGLKDAPSVMADPGRLEQVIVNLLDNAVKYTPAGGSVTLSAADREESVTIAVQDTGIGIPSKDLSRIFERFYRVDS
ARSRDEGGTGLGLSIVKHIVQLQGGTVSAQSSGQGSTFFVTLNRADPTYGSGIAPAAAQA

Sequences:

>Translated_460_residues
MRLKVIGIQFAVVMAFAAVLCSYEQRLLGVGWALLLTATIVVCSTYLLADLGTRPLRAVAAMASRIGKGEINTKLPAVTD
PQVTELARVINEMAAKANAQLDRLEAEKNRLDAILRGMGEGIMVADPQGCITLVNPAFKGLFGLHDEVEGRLLIDISRHP
ALHESFRDILSSRQERVEELQLHSPKERSLLVHWVPLVECGVVTGVVAVFHDISDLRQMEKMRRDFVANVSHELRTPITI
IKGYAETLLAGALEHPTQATKFVSIVHSHADRLASLVSDLLTLSQLESGAVPLEARSVKVQEIAERVVVLLERKIRERGI
IVDLAGLKDAPSVMADPGRLEQVIVNLLDNAVKYTPAGGSVTLSAADREESVTIAVQDTGIGIPSKDLSRIFERFYRVDS
ARSRDEGGTGLGLSIVKHIVQLQGGTVSAQSSGQGSTFFVTLNRADPTYGSGIAPAAAQA
>Mature_460_residues
MRLKVIGIQFAVVMAFAAVLCSYEQRLLGVGWALLLTATIVVCSTYLLADLGTRPLRAVAAMASRIGKGEINTKLPAVTD
PQVTELARVINEMAAKANAQLDRLEAEKNRLDAILRGMGEGIMVADPQGCITLVNPAFKGLFGLHDEVEGRLLIDISRHP
ALHESFRDILSSRQERVEELQLHSPKERSLLVHWVPLVECGVVTGVVAVFHDISDLRQMEKMRRDFVANVSHELRTPITI
IKGYAETLLAGALEHPTQATKFVSIVHSHADRLASLVSDLLTLSQLESGAVPLEARSVKVQEIAERVVVLLERKIRERGI
IVDLAGLKDAPSVMADPGRLEQVIVNLLDNAVKYTPAGGSVTLSAADREESVTIAVQDTGIGIPSKDLSRIFERFYRVDS
ARSRDEGGTGLGLSIVKHIVQLQGGTVSAQSSGQGSTFFVTLNRADPTYGSGIAPAAAQA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=36.25, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786600, Length=324, Percent_Identity=32.4074074074074, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788393, Length=222, Percent_Identity=34.2342342342342, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=31.6666666666667, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=34.5833333333333, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=37.037037037037, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=29.6153846153846, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=32.034632034632, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788713, Length=372, Percent_Identity=24.4623655913978, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=221, Percent_Identity=34.841628959276, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=29.646017699115, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=29.5964125560538, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=30.5084745762712, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=247, Percent_Identity=32.3886639676113, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788549, Length=400, Percent_Identity=24, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=31.1688311688312, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=25.6521739130435, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=26.8722466960352, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=240, Percent_Identity=28.75, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790567, Length=352, Percent_Identity=23.5795454545455, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49692; Mature: 49692

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKVIGIQFAVVMAFAAVLCSYEQRLLGVGWALLLTATIVVCSTYLLADLGTRPLRAVA
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AMASRIGKGEINTKLPAVTDPQVTELARVINEMAAKANAQLDRLEAEKNRLDAILRGMGE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GIMVADPQGCITLVNPAFKGLFGLHDEVEGRLLIDISRHPALHESFRDILSSRQERVEEL
CEEEECCCCCEEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
QLHSPKERSLLVHWVPLVECGVVTGVVAVFHDISDLRQMEKMRRDFVANVSHELRTPITI
HCCCCCHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IKGYAETLLAGALEHPTQATKFVSIVHSHADRLASLVSDLLTLSQLESGAVPLEARSVKV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHH
QEIAERVVVLLERKIRERGIIVDLAGLKDAPSVMADPGRLEQVIVNLLDNAVKYTPAGGS
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHEECCCCCC
VTLSAADREESVTIAVQDTGIGIPSKDLSRIFERFYRVDSARSRDEGGTGLGLSIVKHIV
EEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
QLQGGTVSAQSSGQGSTFFVTLNRADPTYGSGIAPAAAQA
HHCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLKVIGIQFAVVMAFAAVLCSYEQRLLGVGWALLLTATIVVCSTYLLADLGTRPLRAVA
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AMASRIGKGEINTKLPAVTDPQVTELARVINEMAAKANAQLDRLEAEKNRLDAILRGMGE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GIMVADPQGCITLVNPAFKGLFGLHDEVEGRLLIDISRHPALHESFRDILSSRQERVEEL
CEEEECCCCCEEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
QLHSPKERSLLVHWVPLVECGVVTGVVAVFHDISDLRQMEKMRRDFVANVSHELRTPITI
HCCCCCHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IKGYAETLLAGALEHPTQATKFVSIVHSHADRLASLVSDLLTLSQLESGAVPLEARSVKV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHH
QEIAERVVVLLERKIRERGIIVDLAGLKDAPSVMADPGRLEQVIVNLLDNAVKYTPAGGS
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHEECCCCCC
VTLSAADREESVTIAVQDTGIGIPSKDLSRIFERFYRVDSARSRDEGGTGLGLSIVKHIV
EEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
QLQGGTVSAQSSGQGSTFFVTLNRADPTYGSGIAPAAAQA
HHCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]