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The map label for this gene is ndk

Identifier: 197118041

GI number: 197118041

Start: 1921843

End: 1922256

Strand: Direct

Name: ndk

Synonym: Gbem_1654

Alternate gene names: 197118041

Gene position: 1921843-1922256 (Clockwise)

Preceding gene: 308535256

Following gene: 197118042

Centisome position: 41.64

GC content: 58.45

Gene sequence:

>414_bases
ATGGAAAGAACATTTGCCATCATAAAGCCTGATGCAGTCGAGAGGAACGTCACCGGGAAGGTCCTGGCGATGATAGAAGA
GGGTGGTTTCAAGATCGTCGGCATGAAGAAGATCCGTCTCTCCAAGTGCCAGGCGGAAGGGTTTTACTATGTGCACAAAG
AGCGCCCCTTCTTCGGCGACCTCTGCGCATTCATGTCCCGCGGCCCGGTAATCGCGCTGGTGCTCGAGAAAGAGAACGCC
ATCGCCGACTGGCGCGGCCTGATGGGCGCCACCAACCCGGCTAACGCCGAGGCAGGCACCATCCGCAAGGCTTTGGGCGT
CAGCATCGAGGAGAACACGGTGCACGGCTCCGACTCCCCGGAGTCCGCTTCCTACGAGATTCCTTACTTCTTCAACCAGC
TCGAGCTGGTGTAA

Upstream 100 bases:

>100_bases
GGGCTTTTTTTGTATTTGCTCCCGCCTATTTGCCTTGACAAGCGGCAGGCAGGAATGCTAGTTAAAACGGTCGTCTACTA
CAATGAATCCGGAGGAAGCA

Downstream 100 bases:

>100_bases
TTCGCAACTGGTCTAGGCAGATCGAAAGCCCTTCGCTAGAAGGGCTTTTTTATATCCGAAAAAGGCGATGCAGAAAACAG
ACATAAAGAATTTGACCCTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MERTFAIIKPDAVERNVTGKVLAMIEEGGFKIVGMKKIRLSKCQAEGFYYVHKERPFFGDLCAFMSRGPVIALVLEKENA
IADWRGLMGATNPANAEAGTIRKALGVSIEENTVHGSDSPESASYEIPYFFNQLELV

Sequences:

>Translated_137_residues
MERTFAIIKPDAVERNVTGKVLAMIEEGGFKIVGMKKIRLSKCQAEGFYYVHKERPFFGDLCAFMSRGPVIALVLEKENA
IADWRGLMGATNPANAEAGTIRKALGVSIEENTVHGSDSPESASYEIPYFFNQLELV
>Mature_137_residues
MERTFAIIKPDAVERNVTGKVLAMIEEGGFKIVGMKKIRLSKCQAEGFYYVHKERPFFGDLCAFMSRGPVIALVLEKENA
IADWRGLMGATNPANAEAGTIRKALGVSIEENTVHGSDSPESASYEIPYFFNQLELV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=42.3357664233577, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=42.3357664233577, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=42.3357664233577, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=42.3357664233577, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=42.3357664233577, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=42.6470588235294, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=42.6470588235294, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=41.9117647058824, Blast_Score=116, Evalue=8e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=39.7058823529412, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.8421052631579, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.8421052631579, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=39.2592592592593, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=35.036496350365, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=34.3065693430657, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI30023828, Length=140, Percent_Identity=30.7142857142857, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=54.4117647058823, Blast_Score=149, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=43.3823529411765, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_GEOBB (B5E9D0)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002138468.1
- GeneID:   6781642
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_1654
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15146; Mature: 15146

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFAIIKPDAVERNVTGKVLAMIEEGGFKIVGMKKIRLSKCQAEGFYYVHKERPFFGD
CCCEEEEECCCCCCCCCCCEEEEEEECCCEEEEEEEEEEEEEECCCCEEEEEECCCCHHH
LCAFMSRGPVIALVLEKENAIADWRGLMGATNPANAEAGTIRKALGVSIEENTVHGSDSP
HHHHHCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCEEECCEECCCCCC
ESASYEIPYFFNQLELV
CCCCEECCEEECEEECC
>Mature Secondary Structure
MERTFAIIKPDAVERNVTGKVLAMIEEGGFKIVGMKKIRLSKCQAEGFYYVHKERPFFGD
CCCEEEEECCCCCCCCCCCEEEEEEECCCEEEEEEEEEEEEEECCCCEEEEEECCCCHHH
LCAFMSRGPVIALVLEKENAIADWRGLMGATNPANAEAGTIRKALGVSIEENTVHGSDSP
HHHHHCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCEEECCEECCCCCC
ESASYEIPYFFNQLELV
CCCCEECCEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA