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The map label for this gene is panE-2 [C]

Identifier: 197117810

GI number: 197117810

Start: 1639453

End: 1640421

Strand: Direct

Name: panE-2 [C]

Synonym: Gbem_1422

Alternate gene names: 197117810

Gene position: 1639453-1640421 (Clockwise)

Preceding gene: 197117809

Following gene: 197117811

Centisome position: 35.52

GC content: 63.05

Gene sequence:

>969_bases
ATGAAGGGAAATAGCAGTTATACGCCAAAGAAGTTCGCGGTCATAGGCGCCGGCCCCGTCGGGTGCGTGCTTGCCGCTTT
CCTGACCCGGGGAGGATACGAGGTAACCCTTTGCGACGTCGTCCCCACCCTGCTCGTGCCGGCCCTTGACCCGGGGATCA
TCGTCGAGGGGGCCGACTCGCTCCAGGCGAAGGTCGCCAAGGTGACCACCACCCTCGACGATATCGTAAGCGACCCACCC
GATGTCATCTTCGTCACCGTGAAGGCGACCGCTCTCCCCTTGATAGCCTCGGCGCTGGAGGGGTTCGTCGCCGATGGGCG
CTACGTGGTCAGCTGGCAAAACGGCATAGATACCGAACTGGAACTGGCAAAGCATCTGGGGACCAAGGCCGTGATGCGCG
CGGTGGTCAATTACGGTTGCGTGCCGCTCAGCCCCGCCCACGTGCGGGTCGCCTTCCATCACCGCCCCCATTTCCTCCAG
GAGCTGGACCCTGAGTCCCGCGAAGCGGCCGTCGGCATCTGTGAAGCCTTGAGCGGGACGGGGCTCGAGACCCAGCACAC
CGACCGGATCGTGGACAAGGTGTGGCGCAAGTCCGTGATGAACTCCTGCATGAACGCCATCTGCGCGGTGACCGGCAAGA
CCATGGTGCAGATCATCCTCGACCCCATCCTGTTGAACCTGGTGGATTCGTTGATCAAGGAGGGGGTCGCGGTGGCCAGG
GCGAACGAGTTCACGCTGGGGTCCGACTTCTACCCCTACTGCATCAACTACCTGAAGAACGCTGGGAACCACAAGCCCTC
CATGCTGCAGGACATCGAGGCGGGGCGCAGGACCGAAGTCGACTACATCAACGGCAAGATCGTCGAGTACGGCGCGCAGG
CCGGCATGCCCACCCCGTACAACACCATGATCCACGGCCTGGTCAAGGCGCTGGAGTGCAGGCCGTTCGATGAGGCCAAA
GCTGCGTGA

Upstream 100 bases:

>100_bases
ATTTGTGGGTGTGGCACCCCCCTTTGAGAAGGGGGACTTTCCGCTGAGGCTTAACGAGAGCTTCTCGATCAAGTAAATCT
TTAGAGCAAGGAGAGACGCC

Downstream 100 bases:

>100_bases
GCCCCTCACCCCAACCCTCTCCCAGAGGGAGAGGGGGCATGGACGCAGGCCCTGCGTTCCCAAGGTGGACCTTGGGAACG
AGATTAAATAGGAGAAAGTT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKGNSSYTPKKFAVIGAGPVGCVLAAFLTRGGYEVTLCDVVPTLLVPALDPGIIVEGADSLQAKVAKVTTTLDDIVSDPP
DVIFVTVKATALPLIASALEGFVADGRYVVSWQNGIDTELELAKHLGTKAVMRAVVNYGCVPLSPAHVRVAFHHRPHFLQ
ELDPESREAAVGICEALSGTGLETQHTDRIVDKVWRKSVMNSCMNAICAVTGKTMVQIILDPILLNLVDSLIKEGVAVAR
ANEFTLGSDFYPYCINYLKNAGNHKPSMLQDIEAGRRTEVDYINGKIVEYGAQAGMPTPYNTMIHGLVKALECRPFDEAK
AA

Sequences:

>Translated_322_residues
MKGNSSYTPKKFAVIGAGPVGCVLAAFLTRGGYEVTLCDVVPTLLVPALDPGIIVEGADSLQAKVAKVTTTLDDIVSDPP
DVIFVTVKATALPLIASALEGFVADGRYVVSWQNGIDTELELAKHLGTKAVMRAVVNYGCVPLSPAHVRVAFHHRPHFLQ
ELDPESREAAVGICEALSGTGLETQHTDRIVDKVWRKSVMNSCMNAICAVTGKTMVQIILDPILLNLVDSLIKEGVAVAR
ANEFTLGSDFYPYCINYLKNAGNHKPSMLQDIEAGRRTEVDYINGKIVEYGAQAGMPTPYNTMIHGLVKALECRPFDEAK
AA
>Mature_322_residues
MKGNSSYTPKKFAVIGAGPVGCVLAAFLTRGGYEVTLCDVVPTLLVPALDPGIIVEGADSLQAKVAKVTTTLDDIVSDPP
DVIFVTVKATALPLIASALEGFVADGRYVVSWQNGIDTELELAKHLGTKAVMRAVVNYGCVPLSPAHVRVAFHHRPHFLQ
ELDPESREAAVGICEALSGTGLETQHTDRIVDKVWRKSVMNSCMNAICAVTGKTMVQIILDPILLNLVDSLIKEGVAVAR
ANEFTLGSDFYPYCINYLKNAGNHKPSMLQDIEAGRRTEVDYINGKIVEYGAQAGMPTPYNTMIHGLVKALECRPFDEAK
AA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34638; Mature: 34638

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGNSSYTPKKFAVIGAGPVGCVLAAFLTRGGYEVTLCDVVPTLLVPALDPGIIVEGADS
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEECCHH
LQAKVAKVTTTLDDIVSDPPDVIFVTVKATALPLIASALEGFVADGRYVVSWQNGIDTEL
HHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHH
ELAKHLGTKAVMRAVVNYGCVPLSPAHVRVAFHHRPHFLQELDPESREAAVGICEALSGT
HHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCC
GLETQHTDRIVDKVWRKSVMNSCMNAICAVTGKTMVQIILDPILLNLVDSLIKEGVAVAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
ANEFTLGSDFYPYCINYLKNAGNHKPSMLQDIEAGRRTEVDYINGKIVEYGAQAGMPTPY
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHCCEEEEECCCCCCCCCH
NTMIHGLVKALECRPFDEAKAA
HHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MKGNSSYTPKKFAVIGAGPVGCVLAAFLTRGGYEVTLCDVVPTLLVPALDPGIIVEGADS
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEECCHH
LQAKVAKVTTTLDDIVSDPPDVIFVTVKATALPLIASALEGFVADGRYVVSWQNGIDTEL
HHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHH
ELAKHLGTKAVMRAVVNYGCVPLSPAHVRVAFHHRPHFLQELDPESREAAVGICEALSGT
HHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCC
GLETQHTDRIVDKVWRKSVMNSCMNAICAVTGKTMVQIILDPILLNLVDSLIKEGVAVAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
ANEFTLGSDFYPYCINYLKNAGNHKPSMLQDIEAGRRTEVDYINGKIVEYGAQAGMPTPY
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHCCEEEEECCCCCCCCCH
NTMIHGLVKALECRPFDEAKAA
HHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]