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The map label for this gene is nodT [H]

Identifier: 197117785

GI number: 197117785

Start: 1610121

End: 1611572

Strand: Direct

Name: nodT [H]

Synonym: Gbem_1397

Alternate gene names: 197117785

Gene position: 1610121-1611572 (Clockwise)

Preceding gene: 197117784

Following gene: 197117786

Centisome position: 34.89

GC content: 66.18

Gene sequence:

>1452_bases
GTGACGGCGCTGCGCGGTCGCATCTTTGCCGCCGCACTCTGCCTCCTCCTTGCGGGGTGCGCGGTTTCGGCCGACTATCG
GCCCCCGAGGCCGGACCTGCCGCCACGCTGGAGCATGGGGGAGGAAGCCGGTGCCCCGCTCGTGACGGCGGAAACCCCCT
GGTGGACCGCATTCGGAGATCCCCTGCTCAACGCTTTGATCGATCGCGCTCTGCGGGCGAACCCGGATGTGAGGCTGGCT
GAAGCACGGGTCCTGGAAGCACGGGCCCGCAGGGGAGCGGCAACGGGTTCCTTGGCCCCCTCGCTTGATGCCAGGGGCTC
CTTTACCAGGGAAAGGGAGAGCAGGAACGCGCCCAACCCCGTGCTGGTGCGACCGGGCGGGGAGGTGGAGCCTCCAGGGA
CGGAGAACCTCTTCCAGGCCGGTTTCGATGCCAGTTGGGAACTCGACCTTTTCGGCGGCAAGCGTCGGGCGGTCGAGGCG
GTGCAGGCCGATCTCGAGTCGGCGCTCTACGAGCGCGGGGGCGTCGTCCTTACTTTAGTCGCGGAGGTGTCGAGAAACTA
CTTCGAATTGCGGGGAATCCAAAGGCAAAGCCGTCTCGCAGCCACGAGCGTCGCCGTCCAGAGGGACAGCCTCGCCTTGC
TTCGCGCGCGATTTGCCGCCGGGATGGCAACCGATCTCGAGGTCGTGCGGGCAGAGGCAGAGGTCGAGCGGAGAGCCTCG
CTGCTACCATCGCTAGACTTTTCCTACCGGAAAGCGCTGCACCGTCTGGGCGTGCTCCTGGGCGAGGCCCCAGGTGCATT
TGCCGGCGAACTGCAACCGGAAAGCATCATCCCCGTCCCCTCTGGCATGCCGCCTGTCGGGGCGCCATCGGATATCCTGC
GCCAGCGGCCCGACTTGCGCAGGGCCGAGAGGCAGCTAGCCGCAGCGTCGGCCAGGGTGGGGGTCGCGAAAGCTGATCTC
TACCCGAGGTTCGTCGTGTCGGGTTCTCTCGCCCTGGCTAGCGAGGAGTTTGGCGATTTCTCCGACCGCGGCAGCGTGTT
GTGGTCGATCGGTCCCTCCATCATCTGGCCGATCTTCCAGCGCGGCAGGATCGTGGCCAGGATCGAGGTGCGCGACGCCC
AAGAGCAGCAGGCATTGATCGCGTACCGGCGGGTGATCCTGGACGCCCTGGAGGATATGGAGAATGCCCTTGCCGGGTAC
CGGGATGAAGCGGACAGGCGCGCAGCTCTGATAAAGGCGGTGGACGCAGATAGGCGTAATGTCGTTTTCGCACGTGGGCG
GTACCAGGGCGGGCTCACGGACTTCCGTGAGGTGCTCGTGGCTGAGAGCAACCTGTTACAGGCGCAAGGCGAGCTGGCTC
AGAGCGAGACCAACCTTTTGCTCGCCCTGGTTGCTTTGTACAAGGCGCTAGGCGGGGGATGGAGCGTTCCAGCCGGGGAG
GGGGGTGAGTGA

Upstream 100 bases:

>100_bases
CAGAGCGGTTGCCGGAAGTCTATATCGGCCAGCAGATGGACGTGTGGATACAGGTTGCGCCGGAAAGTGCAGGAAGTCGG
GCGCCACGGGTCGGGAAGCC

Downstream 100 bases:

>100_bases
AGTGATCTACGTTGCTCTCAAGATGCTCTTCGGCGACCGGGGAAAATTCGCCGGACTCGTCTTCGGTATCGCCTTCACAT
CGTTTCTAGTCACCTTCGCG

Product: RND family efflux pump outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTALRGRIFAAALCLLLAGCAVSADYRPPRPDLPPRWSMGEEAGAPLVTAETPWWTAFGDPLLNALIDRALRANPDVRLA
EARVLEARARRGAATGSLAPSLDARGSFTRERESRNAPNPVLVRPGGEVEPPGTENLFQAGFDASWELDLFGGKRRAVEA
VQADLESALYERGGVVLTLVAEVSRNYFELRGIQRQSRLAATSVAVQRDSLALLRARFAAGMATDLEVVRAEAEVERRAS
LLPSLDFSYRKALHRLGVLLGEAPGAFAGELQPESIIPVPSGMPPVGAPSDILRQRPDLRRAERQLAAASARVGVAKADL
YPRFVVSGSLALASEEFGDFSDRGSVLWSIGPSIIWPIFQRGRIVARIEVRDAQEQQALIAYRRVILDALEDMENALAGY
RDEADRRAALIKAVDADRRNVVFARGRYQGGLTDFREVLVAESNLLQAQGELAQSETNLLLALVALYKALGGGWSVPAGE
GGE

Sequences:

>Translated_483_residues
MTALRGRIFAAALCLLLAGCAVSADYRPPRPDLPPRWSMGEEAGAPLVTAETPWWTAFGDPLLNALIDRALRANPDVRLA
EARVLEARARRGAATGSLAPSLDARGSFTRERESRNAPNPVLVRPGGEVEPPGTENLFQAGFDASWELDLFGGKRRAVEA
VQADLESALYERGGVVLTLVAEVSRNYFELRGIQRQSRLAATSVAVQRDSLALLRARFAAGMATDLEVVRAEAEVERRAS
LLPSLDFSYRKALHRLGVLLGEAPGAFAGELQPESIIPVPSGMPPVGAPSDILRQRPDLRRAERQLAAASARVGVAKADL
YPRFVVSGSLALASEEFGDFSDRGSVLWSIGPSIIWPIFQRGRIVARIEVRDAQEQQALIAYRRVILDALEDMENALAGY
RDEADRRAALIKAVDADRRNVVFARGRYQGGLTDFREVLVAESNLLQAQGELAQSETNLLLALVALYKALGGGWSVPAGE
GGE
>Mature_482_residues
TALRGRIFAAALCLLLAGCAVSADYRPPRPDLPPRWSMGEEAGAPLVTAETPWWTAFGDPLLNALIDRALRANPDVRLAE
ARVLEARARRGAATGSLAPSLDARGSFTRERESRNAPNPVLVRPGGEVEPPGTENLFQAGFDASWELDLFGGKRRAVEAV
QADLESALYERGGVVLTLVAEVSRNYFELRGIQRQSRLAATSVAVQRDSLALLRARFAAGMATDLEVVRAEAEVERRASL
LPSLDFSYRKALHRLGVLLGEAPGAFAGELQPESIIPVPSGMPPVGAPSDILRQRPDLRRAERQLAAASARVGVAKADLY
PRFVVSGSLALASEEFGDFSDRGSVLWSIGPSIIWPIFQRGRIVARIEVRDAQEQQALIAYRRVILDALEDMENALAGYR
DEADRRAALIKAVDADRRNVVFARGRYQGGLTDFREVLVAESNLLQAQGELAQSETNLLLALVALYKALGGGWSVPAGEG
GE

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=475, Percent_Identity=27.1578947368421, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI2367348, Length=472, Percent_Identity=25.8474576271186, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52249; Mature: 52118

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALRGRIFAAALCLLLAGCAVSADYRPPRPDLPPRWSMGEEAGAPLVTAETPWWTAFGD
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCHHHH
PLLNALIDRALRANPDVRLAEARVLEARARRGAATGSLAPSLDARGSFTRERESRNAPNP
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
VLVRPGGEVEPPGTENLFQAGFDASWELDLFGGKRRAVEAVQADLESALYERGGVVLTLV
EEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEH
AEVSRNYFELRGIQRQSRLAATSVAVQRDSLALLRARFAAGMATDLEVVRAEAEVERRAS
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LLPSLDFSYRKALHRLGVLLGEAPGAFAGELQPESIIPVPSGMPPVGAPSDILRQRPDLR
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHH
RAERQLAAASARVGVAKADLYPRFVVSGSLALASEEFGDFSDRGSVLWSIGPSIIWPIFQ
HHHHHHHHHHHHCCCHHHCCCCHHEECCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHH
RGRIVARIEVRDAQEQQALIAYRRVILDALEDMENALAGYRDEADRRAALIKAVDADRRN
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
VVFARGRYQGGLTDFREVLVAESNLLQAQGELAQSETNLLLALVALYKALGGGWSVPAGE
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGE
CCC
>Mature Secondary Structure 
TALRGRIFAAALCLLLAGCAVSADYRPPRPDLPPRWSMGEEAGAPLVTAETPWWTAFGD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCHHHH
PLLNALIDRALRANPDVRLAEARVLEARARRGAATGSLAPSLDARGSFTRERESRNAPNP
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
VLVRPGGEVEPPGTENLFQAGFDASWELDLFGGKRRAVEAVQADLESALYERGGVVLTLV
EEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEH
AEVSRNYFELRGIQRQSRLAATSVAVQRDSLALLRARFAAGMATDLEVVRAEAEVERRAS
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LLPSLDFSYRKALHRLGVLLGEAPGAFAGELQPESIIPVPSGMPPVGAPSDILRQRPDLR
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHH
RAERQLAAASARVGVAKADLYPRFVVSGSLALASEEFGDFSDRGSVLWSIGPSIIWPIFQ
HHHHHHHHHHHHCCCHHHCCCCHHEECCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHH
RGRIVARIEVRDAQEQQALIAYRRVILDALEDMENALAGYRDEADRRAALIKAVDADRRN
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
VVFARGRYQGGLTDFREVLVAESNLLQAQGELAQSETNLLLALVALYKALGGGWSVPAGE
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]