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The map label for this gene is iolS [H]

Identifier: 197117766

GI number: 197117766

Start: 1592544

End: 1593539

Strand: Direct

Name: iolS [H]

Synonym: Gbem_1378

Alternate gene names: 197117766

Gene position: 1592544-1593539 (Clockwise)

Preceding gene: 197117765

Following gene: 197117767

Centisome position: 34.51

GC content: 66.16

Gene sequence:

>996_bases
ATGCACAAACGGAAACTGGGGCAGCAGGGACTCGAAGTTTCGGCGCTGGGGCTTGGCTGCATGGGGATGTCCTATGTCTA
CGGGCACAGGGACGACGCTGCATCGATCAACGTCCTGCGCCGGGCGGTGGAGCTGGGAATTACCTTCTGGGATACCGCCG
AGGTCTACGGTCCCTTCTGCAACGAGCAGCTTTTGGGGCGCGTGCTGAAGGAGGTGCCGCGCCAGCGGCTGGTTCTGGCC
ACCAAGTTTGCCTGGAGGTTCGGCCCCCACGGCCGGGAGATCGGCCTGGACAGCAGCCCCGCCCAGGTGCGCCGCGCCAT
CGACGGTTCACTCAAGAGGCTCGGTACCGACTACATCGACCTCTACTACCAGCATCGCCTCGACCCCGCCGTCCCGATCG
AGGAGACGGTAGGCGCGCTGGCAGAACTGGTGCAACAGGGAAAGGTCCGCTACATAGGCCTTTCCGAAGTGGGGCCGGGC
ATCGTGCGTCGGGCGCATGCGGTGCATCCGCTGAGCGCGGTACAGTCCGAGTTTTCCCTGTGGGAGCGGGGGGTGGAGGA
CAAGCTTCTGCCGGTGCTGCGGGAGCTGGGGATCGGGTTCGTCGCCTACAGCCCGATGGGGCGCGGGTTCCTGGCGGGCA
AGATCAGGACCCCTGAAGACCTTGAGCCCTGCGACTGGCGCCGCAAGAACCCGCGCTTTCTGGCGGAGAACCTGAGCCAC
AACTTCAGGCTGGTTTCCATGGTGAACGACATCGCCCGCGCCCACGACGCGACCCCGGCCCAGGTGGCGCTTGCCTGGAT
ACTGGGCCGCGGCGGCGACCTGGTCCCCATACCCGGCACCAAGCATCTGCGCTACCTGGAGGAAAACGCCCAGGCGGCGG
GGCTGAAACTCTCCGAGGAGGTCTGGGCCGACCTGGACCGCTCCGTGGCCTGCTTCAAGGTGGCGGGAGAGCGCTACCAG
GAGGAGGCACTGCGCTTCATCGACAGCACCGAGTAG

Upstream 100 bases:

>100_bases
GGCGGCAGGGTGGGGCCTGTTCATGGCGGGAGTCGCCAGCACCATCCCGCTGGTGAGACTGGTATTGGACAAAAGGTGCT
AGTAAGGTCAGGAGGCGGAT

Downstream 100 bases:

>100_bases
CTCAACATGTCTTCATCTTTGCTCCATCACTTGCTATAGTGGCTCGGGGCGGCAGCGCCAGGGAAACACCTTGGCCCCCC
CACAACCCCACAACTTCATG

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MHKRKLGQQGLEVSALGLGCMGMSYVYGHRDDAASINVLRRAVELGITFWDTAEVYGPFCNEQLLGRVLKEVPRQRLVLA
TKFAWRFGPHGREIGLDSSPAQVRRAIDGSLKRLGTDYIDLYYQHRLDPAVPIEETVGALAELVQQGKVRYIGLSEVGPG
IVRRAHAVHPLSAVQSEFSLWERGVEDKLLPVLRELGIGFVAYSPMGRGFLAGKIRTPEDLEPCDWRRKNPRFLAENLSH
NFRLVSMVNDIARAHDATPAQVALAWILGRGGDLVPIPGTKHLRYLEENAQAAGLKLSEEVWADLDRSVACFKVAGERYQ
EEALRFIDSTE

Sequences:

>Translated_331_residues
MHKRKLGQQGLEVSALGLGCMGMSYVYGHRDDAASINVLRRAVELGITFWDTAEVYGPFCNEQLLGRVLKEVPRQRLVLA
TKFAWRFGPHGREIGLDSSPAQVRRAIDGSLKRLGTDYIDLYYQHRLDPAVPIEETVGALAELVQQGKVRYIGLSEVGPG
IVRRAHAVHPLSAVQSEFSLWERGVEDKLLPVLRELGIGFVAYSPMGRGFLAGKIRTPEDLEPCDWRRKNPRFLAENLSH
NFRLVSMVNDIARAHDATPAQVALAWILGRGGDLVPIPGTKHLRYLEENAQAAGLKLSEEVWADLDRSVACFKVAGERYQ
EEALRFIDSTE
>Mature_331_residues
MHKRKLGQQGLEVSALGLGCMGMSYVYGHRDDAASINVLRRAVELGITFWDTAEVYGPFCNEQLLGRVLKEVPRQRLVLA
TKFAWRFGPHGREIGLDSSPAQVRRAIDGSLKRLGTDYIDLYYQHRLDPAVPIEETVGALAELVQQGKVRYIGLSEVGPG
IVRRAHAVHPLSAVQSEFSLWERGVEDKLLPVLRELGIGFVAYSPMGRGFLAGKIRTPEDLEPCDWRRKNPRFLAENLSH
NFRLVSMVNDIARAHDATPAQVALAWILGRGGDLVPIPGTKHLRYLEENAQAAGLKLSEEVWADLDRSVACFKVAGERYQ
EEALRFIDSTE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=325, Percent_Identity=30.1538461538462, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI27436969, Length=325, Percent_Identity=29.8461538461538, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI27436966, Length=325, Percent_Identity=30.1538461538462, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4504825, Length=322, Percent_Identity=29.8136645962733, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI27436962, Length=325, Percent_Identity=30.1538461538462, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI27436971, Length=285, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI223718702, Length=307, Percent_Identity=31.2703583061889, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI41327764, Length=225, Percent_Identity=30.2222222222222, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI41152114, Length=308, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081735, Length=343, Percent_Identity=32.6530612244898, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789375, Length=331, Percent_Identity=32.9305135951662, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788070, Length=313, Percent_Identity=31.629392971246, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787674, Length=304, Percent_Identity=33.2236842105263, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789199, Length=341, Percent_Identity=31.3782991202346, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788081, Length=276, Percent_Identity=28.6231884057971, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994888, Length=288, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=161, Percent_Identity=27.3291925465839, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6325384, Length=333, Percent_Identity=25.8258258258258, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325169, Length=331, Percent_Identity=25.9818731117825, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323998, Length=316, Percent_Identity=26.5822784810127, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=294, Percent_Identity=25.8503401360544, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322615, Length=247, Percent_Identity=26.3157894736842, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319951, Length=315, Percent_Identity=25.3968253968254, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24646159, Length=245, Percent_Identity=29.3877551020408, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646155, Length=159, Percent_Identity=37.7358490566038, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24640980, Length=336, Percent_Identity=24.702380952381, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549126, Length=217, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24657054, Length=326, Percent_Identity=23.0061349693252, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36937; Mature: 36937

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKRKLGQQGLEVSALGLGCMGMSYVYGHRDDAASINVLRRAVELGITFWDTAEVYGPFC
CCCHHHHHCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCHHHHCCCC
NEQLLGRVLKEVPRQRLVLATKFAWRFGPHGREIGLDSSPAQVRRAIDGSLKRLGTDYID
CHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
LYYQHRLDPAVPIEETVGALAELVQQGKVRYIGLSEVGPGIVRRAHAVHPLSAVQSEFSL
HHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHH
WERGVEDKLLPVLRELGIGFVAYSPMGRGFLAGKIRTPEDLEPCDWRRKNPRFLAENLSH
HHCCCHHHHHHHHHHHCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHCCC
NFRLVSMVNDIARAHDATPAQVALAWILGRGGDLVPIPGTKHLRYLEENAQAAGLKLSEE
CEEHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCHHHCCCCCHHH
VWADLDRSVACFKVAGERYQEEALRFIDSTE
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHKRKLGQQGLEVSALGLGCMGMSYVYGHRDDAASINVLRRAVELGITFWDTAEVYGPFC
CCCHHHHHCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCHHHHCCCC
NEQLLGRVLKEVPRQRLVLATKFAWRFGPHGREIGLDSSPAQVRRAIDGSLKRLGTDYID
CHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
LYYQHRLDPAVPIEETVGALAELVQQGKVRYIGLSEVGPGIVRRAHAVHPLSAVQSEFSL
HHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHH
WERGVEDKLLPVLRELGIGFVAYSPMGRGFLAGKIRTPEDLEPCDWRRKNPRFLAENLSH
HHCCCHHHHHHHHHHHCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHCCC
NFRLVSMVNDIARAHDATPAQVALAWILGRGGDLVPIPGTKHLRYLEENAQAAGLKLSEE
CEEHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCHHHCCCCCHHH
VWADLDRSVACFKVAGERYQEEALRFIDSTE
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]