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The map label for this gene is cyp18 [H]

Identifier: 197117727

GI number: 197117727

Start: 1544610

End: 1545128

Strand: Direct

Name: cyp18 [H]

Synonym: Gbem_1339

Alternate gene names: 197117727

Gene position: 1544610-1545128 (Clockwise)

Preceding gene: 197117725

Following gene: 197117729

Centisome position: 33.47

GC content: 57.03

Gene sequence:

>519_bases
ATGACTGAAGAAAAGAATCCCGTGGTACTCATGGAGACCTCGATGGGCAACGTCAAGATCGAACTCTTCAAGGACAAGGC
CCCGATTTCCGTTCGCAACTTCCTCTCCTATGTCAAGGATGCCTACTACGACGGCACCATCTTCCATCGCGTCATCAAGA
ACTTCATGGTGCAGGGTGGCGGGTTGGACACCGACATGCAGCCCAAGAAGACCAAGTTCGCCATCAAGAACGAGGCCACC
AACGGGCTTAAAAACCTGCGCGGCACCCTGGCCATGGCCAGGACTTCGGTTGTGGACAGCGCGACCTCGCAGTTCTTCAT
CAACGTCGTGGACAACGCCTTCCTCGACCATTCAGGCAAGACCCCGGACCGTTTCGGCTACGCGGTCTTTGCGCAGGTCA
TCGAAGGGATGGACGTGGTCGACGCCATTCGCGAGGTGAAGACCGGCAACAAGGCGGGGCACCAGGATGTTCCTGTCGAG
CCGGTGTTCATCAACTCCATCAGGCTCGTGGAGGAGTAA

Upstream 100 bases:

>100_bases
CAACAATGAGGAAAAAGTTTCCACCGGCCGTGGTTGTATGGTATTGAAGACTGCAACTGCAATGACTGGTGACCATATCA
AATTAAAAGGAGTAATAGCA

Downstream 100 bases:

>100_bases
GCTTCGTCTTATCCTGCAGCAGCGAAAGAAAGATGGGCGGCTGGCGGTTATTCCGTCAGCCGCTCATTGCGTTTTGAGCG
CAAGATGGGGGACTACTCCG

Product: cyclophilin-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MTEEKNPVVLMETSMGNVKIELFKDKAPISVRNFLSYVKDAYYDGTIFHRVIKNFMVQGGGLDTDMQPKKTKFAIKNEAT
NGLKNLRGTLAMARTSVVDSATSQFFINVVDNAFLDHSGKTPDRFGYAVFAQVIEGMDVVDAIREVKTGNKAGHQDVPVE
PVFINSIRLVEE

Sequences:

>Translated_172_residues
MTEEKNPVVLMETSMGNVKIELFKDKAPISVRNFLSYVKDAYYDGTIFHRVIKNFMVQGGGLDTDMQPKKTKFAIKNEAT
NGLKNLRGTLAMARTSVVDSATSQFFINVVDNAFLDHSGKTPDRFGYAVFAQVIEGMDVVDAIREVKTGNKAGHQDVPVE
PVFINSIRLVEE
>Mature_171_residues
TEEKNPVVLMETSMGNVKIELFKDKAPISVRNFLSYVKDAYYDGTIFHRVIKNFMVQGGGLDTDMQPKKTKFAIKNEATN
GLKNLRGTLAMARTSVVDSATSQFFINVVDNAFLDHSGKTPDRFGYAVFAQVIEGMDVVDAIREVKTGNKAGHQDVPVEP
VFINSIRLVEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=34.7826086956522, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547215, Length=161, Percent_Identity=34.1614906832298, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI24308049, Length=161, Percent_Identity=34.1614906832298, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=166, Percent_Identity=33.7349397590361, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7657473, Length=166, Percent_Identity=33.7349397590361, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI19557636, Length=147, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI64276486, Length=107, Percent_Identity=39.2523364485981, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=56.7073170731707, Blast_Score=190, Evalue=4e-50,
Organism=Escherichia coli, GI1789763, Length=170, Percent_Identity=55.2941176470588, Blast_Score=189, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=36.986301369863, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=36.986301369863, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=150, Percent_Identity=34, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=30.4878048780488, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=106, Percent_Identity=37.7358490566038, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=163, Percent_Identity=33.1288343558282, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=156, Percent_Identity=36.5384615384615, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=156, Percent_Identity=32.6923076923077, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17986117, Length=159, Percent_Identity=34.5911949685535, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=35.3658536585366, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=30.7228915662651, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24652460, Length=163, Percent_Identity=31.2883435582822, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19137; Mature: 19006

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEKNPVVLMETSMGNVKIELFKDKAPISVRNFLSYVKDAYYDGTIFHRVIKNFMVQGG
CCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
GLDTDMQPKKTKFAIKNEATNGLKNLRGTLAMARTSVVDSATSQFFINVVDNAFLDHSGK
CCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPDRFGYAVFAQVIEGMDVVDAIREVKTGNKAGHQDVPVEPVFINSIRLVEE
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEECC
>Mature Secondary Structure 
TEEKNPVVLMETSMGNVKIELFKDKAPISVRNFLSYVKDAYYDGTIFHRVIKNFMVQGG
CCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
GLDTDMQPKKTKFAIKNEATNGLKNLRGTLAMARTSVVDSATSQFFINVVDNAFLDHSGK
CCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPDRFGYAVFAQVIEGMDVVDAIREVKTGNKAGHQDVPVEPVFINSIRLVEE
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]