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The map label for this gene is prx-1 [H]

Identifier: 197117726

GI number: 197117726

Start: 1543782

End: 1544414

Strand: Reverse

Name: prx-1 [H]

Synonym: Gbem_1338

Alternate gene names: 197117726

Gene position: 1544414-1543782 (Counterclockwise)

Preceding gene: 197117728

Following gene: 197117724

Centisome position: 33.46

GC content: 60.51

Gene sequence:

>633_bases
ATGAGATTAACCAGTTTCACACTGTTGGCGGCACTAGCTATCTCAATCGCCACGACCCCTTTTCCCTTGGCTGCGGCGGA
ATTGCAGTCGCAACAGGTGGCGAAGGTCGGGGAACCCGCTCCCGATTTCACCCTGGATGCCTGGGTAGGGACCGCCCCCG
GTAAGGAATTCAAGCAGATAAACCTGAAAGAGCTGCGCGGCAAGTGGGTCGTGCTCTTCTTTTATCCCATGGACTTCACC
TTCGTCTGTCCCACCGAGATCAAGGGGTTCAACGACGCACTGGCGCAGTTCGAGAAGCTGGACGCCGTGGTCCTGGGCGC
CTCCACCGACAGCAAGTTCTCGCACCTGGCCTGGGTGAAGCGCGGCGACCTGGGGGCCGTAGGTTATCCGCTCCTTTCGG
ACATCAAGAAGGAGGCCGCGCGGAAGTACGGCTGCCTGGACGAGAAGGACGGCGTTGCGCTGCGTGCGCTTTACATCATC
GACCCGCAGGGAGTGCTGCAGTACCAGGTGGTGCACAACCTCGATGTGGGAAGGAGCGTGGATGAGACGCTGCGCGTGCT
GGAAGCGTTGCAGACCGGCTCGCTCTGCCCGCTCGGCTGGAAACCAGGCCAGAAAACCCTTGGAAAACCTTGA

Upstream 100 bases:

>100_bases
TGTTGACGCGCTGAGGCCTGACGGTAATACTGTAGCGACCGCGAGTGTAACAGACGGTGACGAAACCGCAGCTTTCAGCC
TATACGCACAGGAGAGACAC

Downstream 100 bases:

>100_bases
AACTTTTCAAACCAAAACCCTTGACAAGGAGAACATCTGAGAACTTCTGAGAAACCGAAATCCGAGGAACCCAAACTCAA
GAACAACTGAAATTCTTTTT

Product: peroxiredoxin

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRLTSFTLLAALAISIATTPFPLAAAELQSQQVAKVGEPAPDFTLDAWVGTAPGKEFKQINLKELRGKWVVLFFYPMDFT
FVCPTEIKGFNDALAQFEKLDAVVLGASTDSKFSHLAWVKRGDLGAVGYPLLSDIKKEAARKYGCLDEKDGVALRALYII
DPQGVLQYQVVHNLDVGRSVDETLRVLEALQTGSLCPLGWKPGQKTLGKP

Sequences:

>Translated_210_residues
MRLTSFTLLAALAISIATTPFPLAAAELQSQQVAKVGEPAPDFTLDAWVGTAPGKEFKQINLKELRGKWVVLFFYPMDFT
FVCPTEIKGFNDALAQFEKLDAVVLGASTDSKFSHLAWVKRGDLGAVGYPLLSDIKKEAARKYGCLDEKDGVALRALYII
DPQGVLQYQVVHNLDVGRSVDETLRVLEALQTGSLCPLGWKPGQKTLGKP
>Mature_210_residues
MRLTSFTLLAALAISIATTPFPLAAAELQSQQVAKVGEPAPDFTLDAWVGTAPGKEFKQINLKELRGKWVVLFFYPMDFT
FVCPTEIKGFNDALAQFEKLDAVVLGASTDSKFSHLAWVKRGDLGAVGYPLLSDIKKEAARKYGCLDEKDGVALRALYII
DPQGVLQYQVVHNLDVGRSVDETLRVLEALQTGSLCPLGWKPGQKTLGKP

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=182, Percent_Identity=50.5494505494505, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI32455266, Length=182, Percent_Identity=50.5494505494505, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI32455264, Length=182, Percent_Identity=50.5494505494505, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI32189392, Length=182, Percent_Identity=49.4505494505495, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI5453549, Length=183, Percent_Identity=46.9945355191257, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI5802974, Length=187, Percent_Identity=45.9893048128342, Blast_Score=167, Evalue=6e-42,
Organism=Homo sapiens, GI32483377, Length=160, Percent_Identity=49.375, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI33188454, Length=89, Percent_Identity=53.9325842696629, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI4758638, Length=194, Percent_Identity=30.4123711340206, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786822, Length=159, Percent_Identity=37.1069182389937, Blast_Score=120, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI193204376, Length=182, Percent_Identity=48.9010989010989, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32565831, Length=182, Percent_Identity=48.9010989010989, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=46.3276836158192, Blast_Score=159, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25153706, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323613, Length=183, Percent_Identity=46.448087431694, Blast_Score=158, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=183, Percent_Identity=45.9016393442623, Blast_Score=154, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6319407, Length=213, Percent_Identity=28.6384976525822, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17157991, Length=181, Percent_Identity=48.6187845303867, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24641739, Length=181, Percent_Identity=48.6187845303867, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17738015, Length=192, Percent_Identity=44.2708333333333, Blast_Score=170, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=46.3917525773196, Blast_Score=169, Evalue=9e-43,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=46.3917525773196, Blast_Score=169, Evalue=9e-43,
Organism=Drosophila melanogaster, GI21357347, Length=184, Percent_Identity=43.4782608695652, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17975518, Length=196, Percent_Identity=32.6530612244898, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24652434, Length=196, Percent_Identity=32.6530612244898, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24652436, Length=196, Percent_Identity=32.6530612244898, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581278, Length=196, Percent_Identity=30.1020408163265, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 22941; Mature: 22941

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTSFTLLAALAISIATTPFPLAAAELQSQQVAKVGEPAPDFTLDAWVGTAPGKEFKQI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHC
NLKELRGKWVVLFFYPMDFTFVCPTEIKGFNDALAQFEKLDAVVLGASTDSKFSHLAWVK
CHHHHCCCEEEEEEECCCEEEECCHHCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHEEE
RGDLGAVGYPLLSDIKKEAARKYGCLDEKDGVALRALYIIDPQGVLQYQVVHNLDVGRSV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCEEEHEECCCCCCCCH
DETLRVLEALQTGSLCPLGWKPGQKTLGKP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLTSFTLLAALAISIATTPFPLAAAELQSQQVAKVGEPAPDFTLDAWVGTAPGKEFKQI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHC
NLKELRGKWVVLFFYPMDFTFVCPTEIKGFNDALAQFEKLDAVVLGASTDSKFSHLAWVK
CHHHHCCCEEEEEEECCCEEEECCHHCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHEEE
RGDLGAVGYPLLSDIKKEAARKYGCLDEKDGVALRALYIIDPQGVLQYQVVHNLDVGRSV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCEEEHEECCCCCCCCH
DETLRVLEALQTGSLCPLGWKPGQKTLGKP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]