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The map label for this gene is kdpD [H]

Identifier: 197117559

GI number: 197117559

Start: 1363019

End: 1364089

Strand: Direct

Name: kdpD [H]

Synonym: Gbem_1171

Alternate gene names: 197117559

Gene position: 1363019-1364089 (Clockwise)

Preceding gene: 308535222

Following gene: 197117560

Centisome position: 29.53

GC content: 65.55

Gene sequence:

>1071_bases
GTGGTCGCGATACGGGGATACCTGATCAGCCTGCTGCTCGTCGCCGGCGCCACGGCCATTTGCGAACTGGTCCGGCCGCA
CCTGATCCCCACCAACATGGTGATGGTGTACCTCTTGGCTGTCGTGGCGGCCGCCGCCAAGCTCGGCCGGCGGCCCGCCA
TAGCGACGGCCTTTTTCAGCGTCCTCGCCTTCGACTTCTTCTTTGTTCCCCCCCGGCTCACCTTCAGCGTCGCGGAGAAG
GAGTACCTGGTCACCTTCCTCGGCTTCTTCGTGGTAGGGGTGATGATAAGCTCGCTGGTCGCGAAGGTCAGGGAGCAGTC
CCTGGAACGCGAGCGGCTCTCGCACGAGGCGGAAAAGGCGAGGATCCTGCAAGCCCGGGAGAACCTGGAACGGGCGCTCT
TGAATTCCATCTCGCACGACCTCAGGACGCCGCTCGTTTCCATCAAGGGGGCGCTCTCGGCCTTGAAGGAACAGGGGGGG
CGCCTCTCCCCTGAGGCGCGCCGGGATCTGCTGGAGACGGCAAACGAAGAGGCGGAGCGGCTGAACCGTTTCGTCGGAAA
CCTCCTCGACCTGAGCCGCCTGGAGGCGGGGGCCCTCCGCCCGAGGATCGAGCCGTGCGACCTGCAGGAACTCATCGGCT
GCGCCATCTCGGCCATGGAGAGCCGGCTTGGGGACCGCAACGTATCGGTGCAGCTGCCGCAGGGGCTCACCCTGGTTCCC
TTGGACCTGGTGCTGATGACCCAGGTACTGGTGAACCTTTTGGACAACGCCAATAAGTACGCCCCCGCGCAAGGGAGCAT
CGAGGTGGAGGCGCGCGTCGCCGGCGCCTGGCTCTCCTTGACCGTCGCCGATCGGGGCCCGGGGGCGCCTGAAGCGGAAC
TCTCCCATATTTTCGACAAATTCCACCGGGTGCAGGTCCCCGAAAAAACCGGTGGAACCGGCCTCGGGCTTTCCATCTGC
AAGGGAATCGTGGAGGCGCACGGGGGAAGGATCGCGGCCAGGAACCGCCCGCAGGGGGGGCTCGCGGTCGAGATCCTTTT
GCCGTTGCAGCAAGGAGCAGAGGAGCCATGA

Upstream 100 bases:

>100_bases
CGCGATTCATTGTCAGCTCCTTTGACTGGAAATCCAGCCGCAAAGCTGATACGCTCTTCAGGATCTTCCAGTATCACTCT
TCAGATGAAAAGGGGAAGTT

Downstream 100 bases:

>100_bases
AAGAGAGCCAAGAGGCGACCGGGCAGCGCATACTCGTCATCGACGACGAGGCGGCCATTCGCCGCTTCCTGCATTCCGCG
CTGTCCTCGGATGAATTCAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MVAIRGYLISLLLVAGATAICELVRPHLIPTNMVMVYLLAVVAAAAKLGRRPAIATAFFSVLAFDFFFVPPRLTFSVAEK
EYLVTFLGFFVVGVMISSLVAKVREQSLERERLSHEAEKARILQARENLERALLNSISHDLRTPLVSIKGALSALKEQGG
RLSPEARRDLLETANEEAERLNRFVGNLLDLSRLEAGALRPRIEPCDLQELIGCAISAMESRLGDRNVSVQLPQGLTLVP
LDLVLMTQVLVNLLDNANKYAPAQGSIEVEARVAGAWLSLTVADRGPGAPEAELSHIFDKFHRVQVPEKTGGTGLGLSIC
KGIVEAHGGRIAARNRPQGGLAVEILLPLQQGAEEP

Sequences:

>Translated_356_residues
MVAIRGYLISLLLVAGATAICELVRPHLIPTNMVMVYLLAVVAAAAKLGRRPAIATAFFSVLAFDFFFVPPRLTFSVAEK
EYLVTFLGFFVVGVMISSLVAKVREQSLERERLSHEAEKARILQARENLERALLNSISHDLRTPLVSIKGALSALKEQGG
RLSPEARRDLLETANEEAERLNRFVGNLLDLSRLEAGALRPRIEPCDLQELIGCAISAMESRLGDRNVSVQLPQGLTLVP
LDLVLMTQVLVNLLDNANKYAPAQGSIEVEARVAGAWLSLTVADRGPGAPEAELSHIFDKFHRVQVPEKTGGTGLGLSIC
KGIVEAHGGRIAARNRPQGGLAVEILLPLQQGAEEP
>Mature_356_residues
MVAIRGYLISLLLVAGATAICELVRPHLIPTNMVMVYLLAVVAAAAKLGRRPAIATAFFSVLAFDFFFVPPRLTFSVAEK
EYLVTFLGFFVVGVMISSLVAKVREQSLERERLSHEAEKARILQARENLERALLNSISHDLRTPLVSIKGALSALKEQGG
RLSPEARRDLLETANEEAERLNRFVGNLLDLSRLEAGALRPRIEPCDLQELIGCAISAMESRLGDRNVSVQLPQGLTLVP
LDLVLMTQVLVNLLDNANKYAPAQGSIEVEARVAGAWLSLTVADRGPGAPEAELSHIFDKFHRVQVPEKTGGTGLGLSIC
KGIVEAHGGRIAARNRPQGGLAVEILLPLQQGAEEP

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=40.4, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=33.8983050847458, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87081816, Length=266, Percent_Identity=31.203007518797, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=25.5144032921811, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=32.4444444444444, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789808, Length=217, Percent_Identity=29.4930875576037, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=30.8880308880309, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=31.1111111111111, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=30.3964757709251, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=235, Percent_Identity=26.8085106382979, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=220, Percent_Identity=30.4545454545455, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=28.735632183908, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=26.2008733624454, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=232, Percent_Identity=28.448275862069, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI48994928, Length=253, Percent_Identity=27.6679841897233, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=26.8722466960352, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=196, Percent_Identity=25, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=226, Percent_Identity=29.646017699115, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790551, Length=213, Percent_Identity=25.8215962441315, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38586; Mature: 38586

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50109 HIS_KIN ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAIRGYLISLLLVAGATAICELVRPHLIPTNMVMVYLLAVVAAAAKLGRRPAIATAFFS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VLAFDFFFVPPRLTFSVAEKEYLVTFLGFFVVGVMISSLVAKVREQSLERERLSHEAEKA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RILQARENLERALLNSISHDLRTPLVSIKGALSALKEQGGRLSPEARRDLLETANEEAER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LNRFVGNLLDLSRLEAGALRPRIEPCDLQELIGCAISAMESRLGDRNVSVQLPQGLTLVP
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEHH
LDLVLMTQVLVNLLDNANKYAPAQGSIEVEARVAGAWLSLTVADRGPGAPEAELSHIFDK
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECEEEEEEEECCCCCCCHHHHHHHHHH
FHRVQVPEKTGGTGLGLSICKGIVEAHGGRIAARNRPQGGLAVEILLPLQQGAEEP
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEHHCCCCCC
>Mature Secondary Structure
MVAIRGYLISLLLVAGATAICELVRPHLIPTNMVMVYLLAVVAAAAKLGRRPAIATAFFS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VLAFDFFFVPPRLTFSVAEKEYLVTFLGFFVVGVMISSLVAKVREQSLERERLSHEAEKA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RILQARENLERALLNSISHDLRTPLVSIKGALSALKEQGGRLSPEARRDLLETANEEAER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LNRFVGNLLDLSRLEAGALRPRIEPCDLQELIGCAISAMESRLGDRNVSVQLPQGLTLVP
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEHH
LDLVLMTQVLVNLLDNANKYAPAQGSIEVEARVAGAWLSLTVADRGPGAPEAELSHIFDK
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECEEEEEEEECCCCCCCHHHHHHHHHH
FHRVQVPEKTGGTGLGLSICKGIVEAHGGRIAARNRPQGGLAVEILLPLQQGAEEP
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]