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The map label for this gene is prsA [H]

Identifier: 197116615

GI number: 197116615

Start: 255457

End: 256431

Strand: Direct

Name: prsA [H]

Synonym: Gbem_0215

Alternate gene names: 197116615

Gene position: 255457-256431 (Clockwise)

Preceding gene: 197116614

Following gene: 197116616

Centisome position: 5.54

GC content: 58.97

Gene sequence:

>975_bases
GTGCATTTCACCAAGACCGCCGCAGTGCTGTTACTCGCGCTTTGCGTAGCCGCGACCGGATGCAAGCAAAAGGCAGAGAG
CGAAGCTAAGAAGGGACCGGGTAACGGTATCGTTCTGGCAGAGGTCAACGGCGCGAAGATCACCGATAACGACTTCTACA
AGGAGCAGGCCGCTCTCCCCCCCTACCTCAAGCCGATGACCGAGACCCCGGAAGGGAAAAAGGAGATGCTGGACACCATG
GTGGTGCGCGAGCTGATCCTGCAGCAGTCTAAAAAAGAGGGCATCGACAGCAGCGCTGAAGTGGCGGCGAAGCTCGAAGA
CCTGAAAAAGCGCGTCATCGTCGAAGCTTTCCTCAAGAAGAAGGTCGAAGAGTCCGGCAACATCAGCGACGCCGACATGA
AGGCCTTCTACGAGAAGAACAAGGAAAAGTTCCAAAGCGGCGCACAGATCAGGGCGAGCCATATCCTGGTCAAGAGCGAA
GCCGAGGCTAAAGATATCCAGAACCAGCTGAAAAAGGGCGCAAGCTTCGAGGAGCTGGCCAAGAAACACTCCATAGACGG
CGCAGCGCAAAAAGGTGGGGATCTCGGGTGGTTCAGCAAAGGCTCCATGATTCCCGACTTCGAGAAGGTCGCCTTCGGCC
TGAAGGAGGGGGAGACCTCCGGGATCGTCAAGACCCAGTTCGGCTACCACATCATCAAGAAAACCGGCGACCGCCCCGCA
GGTGCACGCTCCTTCGAGGATGTGAAGGACCAGATCAAGGCGGCCATGGTGCCGGAAAGGCAGCAGGAGACCTTCAAGAA
GCTCAAGGACGAGCTCAAGAAGAACGCCAAGCTTAACATCAAGGAAGATGCCCTGAAGGAGCTGAAAAGCGCGCCGGCAG
AAGGGGGCAAGGGAGCGGGCGCCGCACCCGGGGCAGAGCCCGCGAAACCGGCACAGCAGCCGGCACAGCAGCCGGCACAG
CCCAAGGCGCGCTAG

Upstream 100 bases:

>100_bases
TCCTTTCCGAGGCCAGAAATCTCTTGAAATGCCTAGGCTGATATGCTAGCGTTCGACCGCATTTGAATACACTTACATTT
TTTGGAAAAAGGAGCTAACC

Downstream 100 bases:

>100_bases
CGCCTGCAGGAACCAGGCAGCACCAACGGCGGCCGGGCATGAGCCCGGCCGTTTTTACTAACCGGCAGCAAAAGCAATAG
AGAGAGCATCATGTCCAAGA

Product: peptidylprolyl cis-trans isomerase lipoprotein, PpiC-type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MHFTKTAAVLLLALCVAATGCKQKAESEAKKGPGNGIVLAEVNGAKITDNDFYKEQAALPPYLKPMTETPEGKKEMLDTM
VVRELILQQSKKEGIDSSAEVAAKLEDLKKRVIVEAFLKKKVEESGNISDADMKAFYEKNKEKFQSGAQIRASHILVKSE
AEAKDIQNQLKKGASFEELAKKHSIDGAAQKGGDLGWFSKGSMIPDFEKVAFGLKEGETSGIVKTQFGYHIIKKTGDRPA
GARSFEDVKDQIKAAMVPERQQETFKKLKDELKKNAKLNIKEDALKELKSAPAEGGKGAGAAPGAEPAKPAQQPAQQPAQ
PKAR

Sequences:

>Translated_324_residues
MHFTKTAAVLLLALCVAATGCKQKAESEAKKGPGNGIVLAEVNGAKITDNDFYKEQAALPPYLKPMTETPEGKKEMLDTM
VVRELILQQSKKEGIDSSAEVAAKLEDLKKRVIVEAFLKKKVEESGNISDADMKAFYEKNKEKFQSGAQIRASHILVKSE
AEAKDIQNQLKKGASFEELAKKHSIDGAAQKGGDLGWFSKGSMIPDFEKVAFGLKEGETSGIVKTQFGYHIIKKTGDRPA
GARSFEDVKDQIKAAMVPERQQETFKKLKDELKKNAKLNIKEDALKELKSAPAEGGKGAGAAPGAEPAKPAQQPAQQPAQ
PKAR
>Mature_324_residues
MHFTKTAAVLLLALCVAATGCKQKAESEAKKGPGNGIVLAEVNGAKITDNDFYKEQAALPPYLKPMTETPEGKKEMLDTM
VVRELILQQSKKEGIDSSAEVAAKLEDLKKRVIVEAFLKKKVEESGNISDADMKAFYEKNKEKFQSGAQIRASHILVKSE
AEAKDIQNQLKKGASFEELAKKHSIDGAAQKGGDLGWFSKGSMIPDFEKVAFGLKEGETSGIVKTQFGYHIIKKTGDRPA
GARSFEDVKDQIKAAMVPERQQETFKKLKDELKKNAKLNIKEDALKELKSAPAEGGKGAGAAPGAEPAKPAQQPAQQPAQ
PKAR

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=96, Percent_Identity=40.625, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786645, Length=144, Percent_Identity=36.8055555555556, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790211, Length=82, Percent_Identity=54.8780487804878, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537235, Length=98, Percent_Identity=38.7755102040816, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=113, Percent_Identity=37.1681415929204, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 35136; Mature: 35136

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFTKTAAVLLLALCVAATGCKQKAESEAKKGPGNGIVLAEVNGAKITDNDFYKEQAALP
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEEECCCCEECCCHHHHHHHCCC
PYLKPMTETPEGKKEMLDTMVVRELILQQSKKEGIDSSAEVAAKLEDLKKRVIVEAFLKK
CHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KVEESGNISDADMKAFYEKNKEKFQSGAQIRASHILVKSEAEAKDIQNQLKKGASFEELA
HHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCHHHHHHHHHHHCCCCHHHHH
KKHSIDGAAQKGGDLGWFSKGSMIPDFEKVAFGLKEGETSGIVKTQFGYHIIKKTGDRPA
HHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCC
GARSFEDVKDQIKAAMVPERQQETFKKLKDELKKNAKLNIKEDALKELKSAPAEGGKGAG
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCC
AAPGAEPAKPAQQPAQQPAQPKAR
CCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHFTKTAAVLLLALCVAATGCKQKAESEAKKGPGNGIVLAEVNGAKITDNDFYKEQAALP
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEEECCCCEECCCHHHHHHHCCC
PYLKPMTETPEGKKEMLDTMVVRELILQQSKKEGIDSSAEVAAKLEDLKKRVIVEAFLKK
CHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KVEESGNISDADMKAFYEKNKEKFQSGAQIRASHILVKSEAEAKDIQNQLKKGASFEELA
HHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCHHHHHHHHHHHCCCCHHHHH
KKHSIDGAAQKGGDLGWFSKGSMIPDFEKVAFGLKEGETSGIVKTQFGYHIIKKTGDRPA
HHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCC
GARSFEDVKDQIKAAMVPERQQETFKKLKDELKKNAKLNIKEDALKELKSAPAEGGKGAG
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCC
AAPGAEPAKPAQQPAQQPAQPKAR
CCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]