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The map label for this gene is prx-2 [H]

Identifier: 197116554

GI number: 197116554

Start: 185027

End: 185629

Strand: Direct

Name: prx-2 [H]

Synonym: Gbem_0154

Alternate gene names: 197116554

Gene position: 185027-185629 (Clockwise)

Preceding gene: 197116553

Following gene: 197116555

Centisome position: 4.01

GC content: 58.04

Gene sequence:

>603_bases
ATGAGTCTTACAACCTTGGTTACTAAGGAAGCCCCCGATTTTACAGCGCAGGCTGTGCTGCCTGACAACTCGTTCGCCGA
ACTCACTCTGTCGAAATACCGTGGCAAGTACGTCGTGCTCTTTTTCTACCCGCTCGATTTCACCTTCGTCTGCCCCTCCG
AGATCCTCGCTTTCGACAAGCGGGTGGAGGATTTCAAGGCGAAGAATTGCGAGGTGATCGGCGTATCGGTCGATTCCAGG
TTCACCCACCTCGCTTGGAAGAACACCTCGGTGGAAAACGGCGGCATCGGCAACGTCCAGTATCCGCTGGTCGAGGACCT
GGACAAGTCGATCGCGAGGTCCTACGGGATCCTGCTAAACGAATCGGTCGCCCTGCGCGGGCTGTTCCTGATCGACACCA
AAGGGGTGATCCGCCACTCCGTCATTAACGACCTCCCCTTGGGCAGAAGCGTCGGGGAGGCGCTCAGGATGCTGGATGCG
CTGCAGTTCGTGGAAACCCACGGCGGCGAGGTCTGCCCGGCAAACTGGCAGGAAGGCGAGGAGTCGATGAAGGCTTCCAC
CGAGGGTGTTGCCGAGTATCTCAAGAAGAAGCACGGCAAGTAA

Upstream 100 bases:

>100_bases
AAGATGCTTTTAGTCCTTTTTTGATTGACACCCAATGTGGCTGCTGGTACAGTTGCCCACATTAGATTTCCCAATCAGCA
CTCAAAGGAGAACAGCACTT

Downstream 100 bases:

>100_bases
CAGCCACAAGATGATCGACATGGGAAAGGCGCGGCTCACATGAGAACCGCGCCTTTTCATTTTGTCCTGCTTTCATTGGA
AACCCCTTCTGCGCCTCAGC

Product: peroxiredoxin

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSLTTLVTKEAPDFTAQAVLPDNSFAELTLSKYRGKYVVLFFYPLDFTFVCPSEILAFDKRVEDFKAKNCEVIGVSVDSR
FTHLAWKNTSVENGGIGNVQYPLVEDLDKSIARSYGILLNESVALRGLFLIDTKGVIRHSVINDLPLGRSVGEALRMLDA
LQFVETHGGEVCPANWQEGEESMKASTEGVAEYLKKKHGK

Sequences:

>Translated_200_residues
MSLTTLVTKEAPDFTAQAVLPDNSFAELTLSKYRGKYVVLFFYPLDFTFVCPSEILAFDKRVEDFKAKNCEVIGVSVDSR
FTHLAWKNTSVENGGIGNVQYPLVEDLDKSIARSYGILLNESVALRGLFLIDTKGVIRHSVINDLPLGRSVGEALRMLDA
LQFVETHGGEVCPANWQEGEESMKASTEGVAEYLKKKHGK
>Mature_199_residues
SLTTLVTKEAPDFTAQAVLPDNSFAELTLSKYRGKYVVLFFYPLDFTFVCPSEILAFDKRVEDFKAKNCEVIGVSVDSRF
THLAWKNTSVENGGIGNVQYPLVEDLDKSIARSYGILLNESVALRGLFLIDTKGVIRHSVINDLPLGRSVGEALRMLDAL
QFVETHGGEVCPANWQEGEESMKASTEGVAEYLKKKHGK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=192, Percent_Identity=53.125, Blast_Score=229, Evalue=1e-60,
Organism=Homo sapiens, GI32455266, Length=192, Percent_Identity=53.125, Blast_Score=229, Evalue=1e-60,
Organism=Homo sapiens, GI32455264, Length=192, Percent_Identity=53.125, Blast_Score=229, Evalue=1e-60,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=54.4041450777202, Blast_Score=225, Evalue=2e-59,
Organism=Homo sapiens, GI5802974, Length=191, Percent_Identity=54.9738219895288, Blast_Score=220, Evalue=8e-58,
Organism=Homo sapiens, GI32483377, Length=199, Percent_Identity=53.7688442211055, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=51.3089005235602, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI33188454, Length=80, Percent_Identity=68.75, Blast_Score=120, Evalue=7e-28,
Organism=Escherichia coli, GI1786822, Length=189, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193204376, Length=192, Percent_Identity=52.0833333333333, Blast_Score=209, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI32565831, Length=192, Percent_Identity=52.0833333333333, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17554494, Length=198, Percent_Identity=47.979797979798, Blast_Score=194, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25153706, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=194, Percent_Identity=47.4226804123711, Blast_Score=187, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320661, Length=193, Percent_Identity=45.5958549222798, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319407, Length=185, Percent_Identity=31.3513513513514, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17738015, Length=196, Percent_Identity=54.5918367346939, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=51.5463917525773, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=51.5463917525773, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17157991, Length=190, Percent_Identity=50, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24641739, Length=190, Percent_Identity=50, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=46.3157894736842, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17975518, Length=185, Percent_Identity=29.7297297297297, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24652436, Length=185, Percent_Identity=29.1891891891892, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652434, Length=185, Percent_Identity=29.1891891891892, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581278, Length=179, Percent_Identity=25.6983240223464, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22182; Mature: 22050

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTTLVTKEAPDFTAQAVLPDNSFAELTLSKYRGKYVVLFFYPLDFTFVCPSEILAFDK
CCCEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHH
RVEDFKAKNCEVIGVSVDSRFTHLAWKNTSVENGGIGNVQYPLVEDLDKSIARSYGILLN
HHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHCC
ESVALRGLFLIDTKGVIRHSVINDLPLGRSVGEALRMLDALQFVETHGGEVCPANWQEGE
CCCHHEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ESMKASTEGVAEYLKKKHGK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLTTLVTKEAPDFTAQAVLPDNSFAELTLSKYRGKYVVLFFYPLDFTFVCPSEILAFDK
CCEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHH
RVEDFKAKNCEVIGVSVDSRFTHLAWKNTSVENGGIGNVQYPLVEDLDKSIARSYGILLN
HHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHCC
ESVALRGLFLIDTKGVIRHSVINDLPLGRSVGEALRMLDALQFVETHGGEVCPANWQEGE
CCCHHEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ESMKASTEGVAEYLKKKHGK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]