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The map label for this gene is hemH

Identifier: 197116439

GI number: 197116439

Start: 48629

End: 49582

Strand: Reverse

Name: hemH

Synonym: Gbem_0039

Alternate gene names: 197116439

Gene position: 49582-48629 (Counterclockwise)

Preceding gene: 197116440

Following gene: 197116438

Centisome position: 1.07

GC content: 61.22

Gene sequence:

>954_bases
ATGTCATCAAAAACAGCACTCCTTCTGCTCCAGATGGGAGGCCCTGACTCCCTGGACGCCGTGCACCCCTTCCTTATGAA
TCTGTTCACGGACCGGGACATCATCAAAATCGGGCCCGCTTTCCTGCAGCCGTTCATCGCCCGGCGCATCGTCAATAAGC
GCGCGCCCAAGGTGGAGGAGTATTACCGGCAGATCGGCGGCAAGTCCCCGATCCGCGAACTGACCGAGGCACAGGGAGAG
GGGCTGCAGCAGCTATTGGGGGAGGATTTCCGCTCCTTCGTGGCCATGCGCTATTCCCGCCCCTCAACCATCGACGCGCT
GGCGGCGATCAAGCGCGCAGGAATTGAGCGAGTGATCGCGCTGTCGCTCTACCCGCACTACTCTAAGGCGACTACCGGAT
CGAGCCTCAACGAGCTTAAGCGCGTGCTGAAGGAGTCGGGGGCGAAGTTCGAGATCAGCTACATCGACCGCTTCTACAAC
CATCCGCTCTACATCAAGGCCTTGTCGGAGAAGGTGGTGCAGGGGCTGGCCTCGTTCCCCGACCGCAAGGACGTGGAGAT
CGTATTCTCCGCCCACTCGCTCCCCCAGTCCTTCATCGAAGAAGGGGATCCGTACCTGGACCACATCCAGGAGACGGTGC
GCCTGGTCATGGAGCAGGTGGGGGAGGGGAGCCACACCCTCTGCTTCCAGTCCAAGGCGAGCCGGGTCAAGTGGCTGGAG
CCTTCCACCGAGGCGACCATCGAGCAGATGGCCAAGGCCGGGAAAAAGAACCTCCTGATGGTCCCGCTTTCATTTGTTTC
CGACCACATCGAGACCCTGTACGAGATCGACATCCAGTACGGCGAGGAAGCGAAGGCGCTCGGCATCGAGCGTTTCGTGC
GGAGCGAGTCGCTTAACTCCTCGCCGCTCTTCCTGGAGTGCCTGGCGGACCTGGTGAAAACGGCGGCGAAGTGA

Upstream 100 bases:

>100_bases
GAGTTCTCCTAATCGTCTTTTTCTGCTATTAAAAGGGGGACAGGCTACTTTATTTTTTTAAAAAGTAGCCTGTCCCCTTT
TCCCAACTGCCGAGGTCGCT

Downstream 100 bases:

>100_bases
TGAAAACCTGCAGCATCTGCAAGAAAGAGTACGATGAGAACGAGCCAGACACGCTGTACGGCGAAGCGGGGGAATGGCTG
GCGGAAGAGCTTTTTAAGGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSSKTALLLLQMGGPDSLDAVHPFLMNLFTDRDIIKIGPAFLQPFIARRIVNKRAPKVEEYYRQIGGKSPIRELTEAQGE
GLQQLLGEDFRSFVAMRYSRPSTIDALAAIKRAGIERVIALSLYPHYSKATTGSSLNELKRVLKESGAKFEISYIDRFYN
HPLYIKALSEKVVQGLASFPDRKDVEIVFSAHSLPQSFIEEGDPYLDHIQETVRLVMEQVGEGSHTLCFQSKASRVKWLE
PSTEATIEQMAKAGKKNLLMVPLSFVSDHIETLYEIDIQYGEEAKALGIERFVRSESLNSSPLFLECLADLVKTAAK

Sequences:

>Translated_317_residues
MSSKTALLLLQMGGPDSLDAVHPFLMNLFTDRDIIKIGPAFLQPFIARRIVNKRAPKVEEYYRQIGGKSPIRELTEAQGE
GLQQLLGEDFRSFVAMRYSRPSTIDALAAIKRAGIERVIALSLYPHYSKATTGSSLNELKRVLKESGAKFEISYIDRFYN
HPLYIKALSEKVVQGLASFPDRKDVEIVFSAHSLPQSFIEEGDPYLDHIQETVRLVMEQVGEGSHTLCFQSKASRVKWLE
PSTEATIEQMAKAGKKNLLMVPLSFVSDHIETLYEIDIQYGEEAKALGIERFVRSESLNSSPLFLECLADLVKTAAK
>Mature_316_residues
SSKTALLLLQMGGPDSLDAVHPFLMNLFTDRDIIKIGPAFLQPFIARRIVNKRAPKVEEYYRQIGGKSPIRELTEAQGEG
LQQLLGEDFRSFVAMRYSRPSTIDALAAIKRAGIERVIALSLYPHYSKATTGSSLNELKRVLKESGAKFEISYIDRFYNH
PLYIKALSEKVVQGLASFPDRKDVEIVFSAHSLPQSFIEEGDPYLDHIQETVRLVMEQVGEGSHTLCFQSKASRVKWLEP
STEATIEQMAKAGKKNLLMVPLSFVSDHIETLYEIDIQYGEEAKALGIERFVRSESLNSSPLFLECLADLVKTAAK

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=324, Percent_Identity=44.4444444444444, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=44.4444444444444, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=28.7066246056782, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324750, Length=323, Percent_Identity=37.4613003095975, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI17864156, Length=322, Percent_Identity=39.7515527950311, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=38.5214007782101, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI45552018, Length=164, Percent_Identity=41.4634146341463, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_GEOBB (B5EJ44)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002136866.1
- ProteinModelPortal:   B5EJ44
- SMR:   B5EJ44
- GeneID:   6782857
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0039
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   CLSK790160
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35573; Mature: 35442

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKTALLLLQMGGPDSLDAVHPFLMNLFTDRDIIKIGPAFLQPFIARRIVNKRAPKVEE
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHCCCCCHHH
YYRQIGGKSPIRELTEAQGEGLQQLLGEDFRSFVAMRYSRPSTIDALAAIKRAGIERVIA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LSLYPHYSKATTGSSLNELKRVLKESGAKFEISYIDRFYNHPLYIKALSEKVVQGLASFP
HHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
DRKDVEIVFSAHSLPQSFIEEGDPYLDHIQETVRLVMEQVGEGSHTLCFQSKASRVKWLE
CCCCEEEEEECHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCC
PSTEATIEQMAKAGKKNLLMVPLSFVSDHIETLYEIDIQYGEEAKALGIERFVRSESLNS
CCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
SPLFLECLADLVKTAAK
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKTALLLLQMGGPDSLDAVHPFLMNLFTDRDIIKIGPAFLQPFIARRIVNKRAPKVEE
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHCCCCCHHH
YYRQIGGKSPIRELTEAQGEGLQQLLGEDFRSFVAMRYSRPSTIDALAAIKRAGIERVIA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LSLYPHYSKATTGSSLNELKRVLKESGAKFEISYIDRFYNHPLYIKALSEKVVQGLASFP
HHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
DRKDVEIVFSAHSLPQSFIEEGDPYLDHIQETVRLVMEQVGEGSHTLCFQSKASRVKWLE
CCCCEEEEEECHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCC
PSTEATIEQMAKAGKKNLLMVPLSFVSDHIETLYEIDIQYGEEAKALGIERFVRSESLNS
CCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
SPLFLECLADLVKTAAK
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA