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The map label for this gene is hemE

Identifier: 197116416

GI number: 197116416

Start: 22877

End: 23896

Strand: Direct

Name: hemE

Synonym: Gbem_0016

Alternate gene names: 197116416

Gene position: 22877-23896 (Clockwise)

Preceding gene: 197116415

Following gene: 197116417

Centisome position: 0.5

GC content: 62.75

Gene sequence:

>1020_bases
ATGAATACTCGATTTTTAGACGCATGTTGGGGGAAGCCGGTTGATACGGTGCCGGTCTGGCTTATGCGCCAGGCGGGACG
TTATCTCCCCGATTACATGCGCGTTCGCTCCAAATGCACCTTCCTGGAACTGTGCAAGACCCCGGAACTGGCGACCGAGG
TAACTGTTCAGCCGGTCGACATCCTCGGCGTCGACGCCGCGATCCTCTTCTCCGACATCCTCACCCCGATCGAGCCGATG
GGGATGGAGCTCGACTTCACCCCCGGCCCCGTCTTCGCCAAGCCGATCCGTACCATGGCCGACGTCGAGGCACTCAAGAT
CCCGAAGATGGAGACCGACGTCCCCTACGTGCTGGACGCAGTCAAGCTGCTCCGCAAGGAGCTCGCCACCAAGGTGCCGC
TGATCGGCTTCGGCGGCGCGCCGTTCACCCTGGCCTGCTACATGGTCGAGGGTAAGGGTTCCAAGGACTTCGCCGCCCTC
AAGAAGATGATGTACGCCGACCCCGAAGTGTACGCGGCGCTGATGGATAAGATCACCACCATGGACATGGAGTACCTGAA
CGCGCAGATCAAGGCGGGCGCTCAGGCGATCCAGATCTTCGACACCTGGGGCGGCATGCTCTCCCCGGCCGACTACGAGC
GCTACGTCCTCCCCTACACCCAGCGCCTGATCAACGGCCTCGACCGCACCAACATCCCGGTGATCCACTTCGTCAAGGGC
GCAGGGACCATGCTGGAGATCGTGAAGCAGGCCGGCGGCGACGTCATGGGCCTCGACTGGCACGTGAACCTCGGCAAGGC
CCGCGATATCCTGGGCGACATGGCGGTGCAGGGGAACCTGGACCCGACCGTGCTCTTCGCTCCCAACGAGATCATCGAGC
GCGAGGTGAAGAGGGTGCTGGACGAAAACGCAGGCCGGCCCGGTCTCATCTTCAACCTGGGACACGGCATCCTCCCGACC
GTCCCGCCGGAAAAAGCGATCTTCATGGTCGACTGCGTGCACCGGCTGTCGAGGAAATAG

Upstream 100 bases:

>100_bases
ACCGATAGCCCCCTGCCCTGCAGCGTCCCCTGTCCCTCTGGGAGAGGGACAGGGTGAGGGACGTTTTGCATACAATAAAA
ATTCACCCAGGAGGATTACT

Downstream 100 bases:

>100_bases
AGGCAAACCGGAGGGCGGCCGATGAGGCCGCCCTTTTTCTTGACCAGGCAACAAAGGATCCGGTCGAATTTCGCAGGCCA
CGGCTGCCTGCCGCACCGGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVDILGVDAAILFSDILTPIEPM
GMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDAVKLLRKELATKVPLIGFGGAPFTLACYMVEGKGSKDFAAL
KKMMYADPEVYAALMDKITTMDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKG
AGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVLDENAGRPGLIFNLGHGILPT
VPPEKAIFMVDCVHRLSRK

Sequences:

>Translated_339_residues
MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVDILGVDAAILFSDILTPIEPM
GMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDAVKLLRKELATKVPLIGFGGAPFTLACYMVEGKGSKDFAAL
KKMMYADPEVYAALMDKITTMDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKG
AGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVLDENAGRPGLIFNLGHGILPT
VPPEKAIFMVDCVHRLSRK
>Mature_339_residues
MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVDILGVDAAILFSDILTPIEPM
GMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDAVKLLRKELATKVPLIGFGGAPFTLACYMVEGKGSKDFAAL
KKMMYADPEVYAALMDKITTMDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKG
AGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVLDENAGRPGLIFNLGHGILPT
VPPEKAIFMVDCVHRLSRK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=41.9540229885057, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=50.5780346820809, Blast_Score=336, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=36.1581920903955, Blast_Score=230, Evalue=2e-61,
Organism=Drosophila melanogaster, GI221330099, Length=345, Percent_Identity=39.4202898550725, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19921920, Length=345, Percent_Identity=39.4202898550725, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_GEOBB (B5E7R1)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002136843.1
- ProteinModelPortal:   B5E7R1
- SMR:   B5E7R1
- GeneID:   6782834
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0016
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37608; Mature: 37608

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 72-72 BINDING 147-147 BINDING 202-202 BINDING 315-315

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVD
CCCCEEHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCCHHHEEEECCHH
ILGVDAAILFSDILTPIEPMGMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDA
EECCHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
VKLLRKELATKVPLIGFGGAPFTLACYMVEGKGSKDFAALKKMMYADPEVYAALMDKITT
HHHHHHHHHHCCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
MDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKG
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCCCCCEECHHHHHHHCCCCCCCCCEEEEECC
AGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVL
CCHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHH
DENAGRPGLIFNLGHGILPTVPPEKAIFMVDCVHRLSRK
HHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVD
CCCCEEHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCCHHHEEEECCHH
ILGVDAAILFSDILTPIEPMGMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDA
EECCHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
VKLLRKELATKVPLIGFGGAPFTLACYMVEGKGSKDFAALKKMMYADPEVYAALMDKITT
HHHHHHHHHHCCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
MDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKG
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCCCCCEECHHHHHHHCCCCCCCCCEEEEECC
AGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVL
CCHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHH
DENAGRPGLIFNLGHGILPTVPPEKAIFMVDCVHRLSRK
HHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA