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The map label for this gene is hisN [H]

Identifier: 197106409

GI number: 197106409

Start: 3369007

End: 3369834

Strand: Direct

Name: hisN [H]

Synonym: PHZ_c2948

Alternate gene names: 197106409

Gene position: 3369007-3369834 (Clockwise)

Preceding gene: 197106408

Following gene: 197106414

Centisome position: 84.3

GC content: 74.4

Gene sequence:

>828_bases
ATGCCGCTCTCCCCCGCCCGCCTCGCCGAATTCGACGCCTTCCTGCTGGAGCTGAACCGCGCGGCGGGCGAGGCGATCCT
GCCGCTGTTCCGGGCCGACCACGGCCTGCACGACAAGGGGATCGCCGGAGCGCAGGGCTACAAGGCCTTCGATCCCGTCA
CCGAGGCCGACCGCGGCGCCGAGCGGGCGATCCGCGCGCTGATCGCGCAGCGCTACCCCGAGCACGGGATCATCGGCGAG
GAGTACGGCGAGGACCGCCCCGACGCCGAGTTCGTCTGGGTGCTCGACCCGGTGGACGGCACGCGCGCGTTCATTTCGGG
CCTGCCGCTGTGGTGCGTGCTCGTCGGGCTCCGGCACGAGGGCCGGCCGGTGCTGGGCTCGATCGGCCAGCCGTTCCTGG
ACGAGGTCTACATCGGCTCGCAGGCCGGCTCGCGGCTGGTGTCGCGGGGCGCGGAGACGCCGCTGAAGGTCAGGCCCTGC
CCGCGGCTGACCGACGCCGTGATCGCCACGACGGACCCGGAAGGCTGCTTCACCGGCGCCGAACTGGGGGCCTGGACCCA
GGTGCGGGCCGCCGCGCGCCTGGCCCGGCTCGGCTGCGACGCCTACGCCTACGCCATGGTGGCGGCGGGGACGATGGACA
TGGTCATCGAGGCGGGCCTGCAGGCATGGGACATCGACGCCGCCATCCCCCTCATCGAGGGGGCGGGCGGGGTGGTGACC
GACTGGCGCGGGCGGCCGGTGGGCCCGAACGGCGGCCAGATCGCCATCGCCGGCGACCGCGCCTGCCTCGAGGAGGCGCT
GGTCGCCCTGAGACGGTCCGCGAACTGA

Upstream 100 bases:

>100_bases
CTGGACGAGCGCCCGCGCCGGCAGCTGCTGGAGCTGGCCAAGGCGATGAACGGCGACGGCGAGGGTTAAGTCCGGGCGCA
AGGCGCGCTAAAGCGGGCGC

Downstream 100 bases:

>100_bases
AGCGGTCGGCCGACCAGAAACGCCCTCCCCCCGAGGGGGAGGGACGCAGGATCACTTCTTCGCCGGGGCCTTCTTGGCGG
CCGGCTTCTTAGCGGCGGCA

Product: inositol monophosphatase family protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPLSPARLAEFDAFLLELNRAAGEAILPLFRADHGLHDKGIAGAQGYKAFDPVTEADRGAERAIRALIAQRYPEHGIIGE
EYGEDRPDAEFVWVLDPVDGTRAFISGLPLWCVLVGLRHEGRPVLGSIGQPFLDEVYIGSQAGSRLVSRGAETPLKVRPC
PRLTDAVIATTDPEGCFTGAELGAWTQVRAAARLARLGCDAYAYAMVAAGTMDMVIEAGLQAWDIDAAIPLIEGAGGVVT
DWRGRPVGPNGGQIAIAGDRACLEEALVALRRSAN

Sequences:

>Translated_275_residues
MPLSPARLAEFDAFLLELNRAAGEAILPLFRADHGLHDKGIAGAQGYKAFDPVTEADRGAERAIRALIAQRYPEHGIIGE
EYGEDRPDAEFVWVLDPVDGTRAFISGLPLWCVLVGLRHEGRPVLGSIGQPFLDEVYIGSQAGSRLVSRGAETPLKVRPC
PRLTDAVIATTDPEGCFTGAELGAWTQVRAAARLARLGCDAYAYAMVAAGTMDMVIEAGLQAWDIDAAIPLIEGAGGVVT
DWRGRPVGPNGGQIAIAGDRACLEEALVALRRSAN
>Mature_274_residues
PLSPARLAEFDAFLLELNRAAGEAILPLFRADHGLHDKGIAGAQGYKAFDPVTEADRGAERAIRALIAQRYPEHGIIGEE
YGEDRPDAEFVWVLDPVDGTRAFISGLPLWCVLVGLRHEGRPVLGSIGQPFLDEVYIGSQAGSRLVSRGAETPLKVRPCP
RLTDAVIATTDPEGCFTGAELGAWTQVRAAARLARLGCDAYAYAMVAAGTMDMVIEAGLQAWDIDAAIPLIEGAGGVVTD
WRGRPVGPNGGQIAIAGDRACLEEALVALRRSAN

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=232, Percent_Identity=31.8965517241379, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193202570, Length=275, Percent_Identity=27.6363636363636, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320493, Length=287, Percent_Identity=28.9198606271777, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321836, Length=286, Percent_Identity=25.8741258741259, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664918, Length=262, Percent_Identity=30.5343511450382, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357957, Length=284, Percent_Identity=27.8169014084507, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357329, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357303, Length=224, Percent_Identity=26.7857142857143, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664926, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 29240; Mature: 29108

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSPARLAEFDAFLLELNRAAGEAILPLFRADHGLHDKGIAGAQGYKAFDPVTEADRGA
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCH
ERAIRALIAQRYPEHGIIGEEYGEDRPDAEFVWVLDPVDGTRAFISGLPLWCVLVGLRHE
HHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHCCC
GRPVLGSIGQPFLDEVYIGSQAGSRLVSRGAETPLKVRPCPRLTDAVIATTDPEGCFTGA
CCCHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCCCCCC
ELGAWTQVRAAARLARLGCDAYAYAMVAAGTMDMVIEAGLQAWDIDAAIPLIEGAGGVVT
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEECCCHHCHHCCCCCCCEE
DWRGRPVGPNGGQIAIAGDRACLEEALVALRRSAN
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLSPARLAEFDAFLLELNRAAGEAILPLFRADHGLHDKGIAGAQGYKAFDPVTEADRGA
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCH
ERAIRALIAQRYPEHGIIGEEYGEDRPDAEFVWVLDPVDGTRAFISGLPLWCVLVGLRHE
HHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHCCC
GRPVLGSIGQPFLDEVYIGSQAGSRLVSRGAETPLKVRPCPRLTDAVIATTDPEGCFTGA
CCCHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCCCCCC
ELGAWTQVRAAARLARLGCDAYAYAMVAAGTMDMVIEAGLQAWDIDAAIPLIEGAGGVVT
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEECCCHHCHHCCCCCCCEE
DWRGRPVGPNGGQIAIAGDRACLEEALVALRRSAN
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]