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The map label for this gene is pth

Identifier: 197106325

GI number: 197106325

Start: 3276623

End: 3277252

Strand: Direct

Name: pth

Synonym: PHZ_c2864

Alternate gene names: 197106325

Gene position: 3276623-3277252 (Clockwise)

Preceding gene: 197106324

Following gene: 197106326

Centisome position: 81.99

GC content: 70.48

Gene sequence:

>630_bases
ATGCTGCTCATCGCGGGGCTGGGGAATCCCGGCCCGACCTACGCCAAGAACCGCCACAACATCGGCTTCATGGCCGTGGA
CGAGATCGCGCGCCGCTGGGGCTTCCCCGCGGCGCGTTCGCGTTTCCGCAGCCTCGCCGCAGAGGGCGCGATCGACACGC
CCCAGGGGCCGGTGCGCACCCTGATCCTGAAGCCGCAGACCTACTACAACGAGAGCGGCCGCGCCGTGGGCGAAGCCATG
AAGTTCTTCAAGCTCCAGCCTTCCGACGTGGTGGTCTTCTACGATGAGATCGACCTGGCCCCCGGCCGCTTCCGCATGAA
GACGGGCGGCGGGGCGGCCGGCAACAACGGCATCCGCTCGGTCGCCAGCCAGATCGGCCCCGACTTCCGCCGCGCCCGCC
TGGGCACCGGCCATCCGGGCCAGAAGGAGCTGGTGCACGGCCACGTGCTCTCCGACTTCCACAAGGCCGAGATGAAGTGG
GTCGAGCCGCTCCTCGAAGCCTGCGCCGACGCCGCCCCCCTCCTGGCCCTGGGCGACGACGAGAAGTACCAGGCCGAGGT
CATGCGCCTCGCCCCCGCCGAGAAGGCCGACCCCCGCAAGCTGGCCCAAGGGAAGCCCCGGGGGGAATGA

Upstream 100 bases:

>100_bases
CGCCGGCGCCATGGCCGAGGTCGCTGAAGAGGCCGCCGAAGGCGCCGAGGGCGAAGCCGCCGCCGAGGGCGGCGAGGAGT
AGTCCTCCTCCCGCCGGCCG

Downstream 100 bases:

>100_bases
CGCCTCCGGCGGCCCGTGCTAGGTCCGCCGCCACACTAGGAAACCCGAAAGTCTCATGGCTCTGAAAGTCGCCATCGTCG
GCCTGCCGAACGTCGGCAAG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MLLIAGLGNPGPTYAKNRHNIGFMAVDEIARRWGFPAARSRFRSLAAEGAIDTPQGPVRTLILKPQTYYNESGRAVGEAM
KFFKLQPSDVVVFYDEIDLAPGRFRMKTGGGAAGNNGIRSVASQIGPDFRRARLGTGHPGQKELVHGHVLSDFHKAEMKW
VEPLLEACADAAPLLALGDDEKYQAEVMRLAPAEKADPRKLAQGKPRGE

Sequences:

>Translated_209_residues
MLLIAGLGNPGPTYAKNRHNIGFMAVDEIARRWGFPAARSRFRSLAAEGAIDTPQGPVRTLILKPQTYYNESGRAVGEAM
KFFKLQPSDVVVFYDEIDLAPGRFRMKTGGGAAGNNGIRSVASQIGPDFRRARLGTGHPGQKELVHGHVLSDFHKAEMKW
VEPLLEACADAAPLLALGDDEKYQAEVMRLAPAEKADPRKLAQGKPRGE
>Mature_209_residues
MLLIAGLGNPGPTYAKNRHNIGFMAVDEIARRWGFPAARSRFRSLAAEGAIDTPQGPVRTLILKPQTYYNESGRAVGEAM
KFFKLQPSDVVVFYDEIDLAPGRFRMKTGGGAAGNNGIRSVASQIGPDFRRARLGTGHPGQKELVHGHVLSDFHKAEMKW
VEPLLEACADAAPLLALGDDEKYQAEVMRLAPAEKADPRKLAQGKPRGE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=169, Percent_Identity=36.6863905325444, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1787455, Length=169, Percent_Identity=38.4615384615385, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PHEZH (B4R8Q8)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002131702.1
- GeneID:   6788811
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c2864
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22763; Mature: 22763

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIAGLGNPGPTYAKNRHNIGFMAVDEIARRWGFPAARSRFRSLAAEGAIDTPQGPVRT
CEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEE
LILKPQTYYNESGRAVGEAMKFFKLQPSDVVVFYDEIDLAPGRFRMKTGGGAAGNNGIRS
EEECCHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHH
VASQIGPDFRRARLGTGHPGQKELVHGHVLSDFHKAEMKWVEPLLEACADAAPLLALGDD
HHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
EKYQAEVMRLAPAEKADPRKLAQGKPRGE
HHHHHHHHHHCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MLLIAGLGNPGPTYAKNRHNIGFMAVDEIARRWGFPAARSRFRSLAAEGAIDTPQGPVRT
CEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEE
LILKPQTYYNESGRAVGEAMKFFKLQPSDVVVFYDEIDLAPGRFRMKTGGGAAGNNGIRS
EEECCHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHH
VASQIGPDFRRARLGTGHPGQKELVHGHVLSDFHKAEMKWVEPLLEACADAAPLLALGDD
HHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
EKYQAEVMRLAPAEKADPRKLAQGKPRGE
HHHHHHHHHHCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA