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The map label for this gene is lktA [H]

Identifier: 197106217

GI number: 197106217

Start: 3161771

End: 3162742

Strand: Direct

Name: lktA [H]

Synonym: PHZ_c2756

Alternate gene names: 197106217

Gene position: 3161771-3162742 (Clockwise)

Preceding gene: 197106215

Following gene: 197106218

Centisome position: 79.12

GC content: 70.16

Gene sequence:

>972_bases
ATGACCGTCCTCGTCTCCGGTAACACCCCCATCAACGTGAACACGCCCGAGATCGGGGCGCTGGCCTGGGGGGACACGCT
GACCGCCAACTCCAGCTTCATCTCGCTGCGGTTCGAGCAGTGGATCGACGAGTTCACCGGCAGCTTCCAGTACGACGTCT
TCGGCGAGCTGGCGGGCGGCGTGATCACCGGCTGGAAACAGACCTACAATGGCCAGTTGGTCTTCGAGGTGACGGGGGCG
GAAGTCTCGGTCGGCCAATTCCTGATCTGGGTCGCGAACGACGACAACGCGACCGCCGTGCAGACCATCTTCGCCGGCGC
CGACAGCATGACCGGATCGCAGTTCCTGGACATCCTGTCCGGTTACGCCGGAGCGGACTCGCTGTTCGGCATGGGCGGCG
ACGACACGCTGGAGGGCGGCGCGGGCGAGGACTACGTGCGCGGCGGTGACGGGGCGGACAGCCTGGCCGGCGGGGCGGAC
TTCGACGATCTGCACGGCAATCTCGGCAACGACGTCGTGGACGGGGGCCTGGGGACCGACTGGGTGGTCGGCGGCCAGGG
GAACGACCTGCTGCGCGGCGGCGACGATAGCTCCTACGACGTGGTCTACGGCAACCTCGGGAACGACACCTGCTACGGCG
GGGACGGCGGGGACTGGGTGCGCGGCGGCCAGGGCGACGACAGCCTGTCGGCCGGCGGCGGCGCAGACTGGATCTGGGGC
GACCGGGGCAACGACACCATCGAGGGCGGCGCCGGGGCCGACATCTTCTTCGTGTTCGGCGAGGCCGGGACCGACCGGGT
GCTGGACTTCAACGCCGCCGAAGGCGACGTGGTGCGGGTCGAGGCCGGCTACACCTACAGCGCCGCCCAGGTCGGCGCGG
ATGTGGTTGTCAGCGTCGGTGGCGGGGCACAGGTGGTCCTGGCCGGGCGCACCCTGGCGGCGCTCGGCGACGGCTGGCTG
GTCGGCGGCTGA

Upstream 100 bases:

>100_bases
CGAACAAGCTCTGCAATCGTAGGGTGCGGCAAAGACGCGCATGTGGGCGCGTCACAGTCGTCCGCGCTGCGGGCGTCGAG
CAGCAACGGGAGAGCGCAGC

Downstream 100 bases:

>100_bases
GGCGCCGGCGCATTCCCGGCCCGCCTCCCCCAACTGGGGGATGCGGCGGGCCTGCGCCCCCCCGAGGATGACGGCCATCG
TTTGGCTTTAAGTCTCGGGA

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTVLVSGNTPINVNTPEIGALAWGDTLTANSSFISLRFEQWIDEFTGSFQYDVFGELAGGVITGWKQTYNGQLVFEVTGA
EVSVGQFLIWVANDDNATAVQTIFAGADSMTGSQFLDILSGYAGADSLFGMGGDDTLEGGAGEDYVRGGDGADSLAGGAD
FDDLHGNLGNDVVDGGLGTDWVVGGQGNDLLRGGDDSSYDVVYGNLGNDTCYGGDGGDWVRGGQGDDSLSAGGGADWIWG
DRGNDTIEGGAGADIFFVFGEAGTDRVLDFNAAEGDVVRVEAGYTYSAAQVGADVVVSVGGGAQVVLAGRTLAALGDGWL
VGG

Sequences:

>Translated_323_residues
MTVLVSGNTPINVNTPEIGALAWGDTLTANSSFISLRFEQWIDEFTGSFQYDVFGELAGGVITGWKQTYNGQLVFEVTGA
EVSVGQFLIWVANDDNATAVQTIFAGADSMTGSQFLDILSGYAGADSLFGMGGDDTLEGGAGEDYVRGGDGADSLAGGAD
FDDLHGNLGNDVVDGGLGTDWVVGGQGNDLLRGGDDSSYDVVYGNLGNDTCYGGDGGDWVRGGQGDDSLSAGGGADWIWG
DRGNDTIEGGAGADIFFVFGEAGTDRVLDFNAAEGDVVRVEAGYTYSAAQVGADVVVSVGGGAQVVLAGRTLAALGDGWL
VGG
>Mature_322_residues
TVLVSGNTPINVNTPEIGALAWGDTLTANSSFISLRFEQWIDEFTGSFQYDVFGELAGGVITGWKQTYNGQLVFEVTGAE
VSVGQFLIWVANDDNATAVQTIFAGADSMTGSQFLDILSGYAGADSLFGMGGDDTLEGGAGEDYVRGGDGADSLAGGADF
DDLHGNLGNDVVDGGLGTDWVVGGQGNDLLRGGDDSSYDVVYGNLGNDTCYGGDGGDWVRGGQGDDSLSAGGGADWIWGD
RGNDTIEGGAGADIFFVFGEAGTDRVLDFNAAEGDVVRVEAGYTYSAAQVGADVVVSVGGGAQVVLAGRTLAALGDGWLV
GG

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 32894; Mature: 32763

Theoretical pI: Translated: 3.39; Mature: 3.39

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLVSGNTPINVNTPEIGALAWGDTLTANSSFISLRFEQWIDEFTGSFQYDVFGELAGG
CEEEEECCCCEEECCCCCCEEEECCEEECCCCEEEEEHHHHHHHHCCCEEEEEHHHHCCC
VITGWKQTYNGQLVFEVTGAEVSVGQFLIWVANDDNATAVQTIFAGADSMTGSQFLDILS
EEECCEECCCCEEEEEECCCEEEECEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHH
GYAGADSLFGMGGDDTLEGGAGEDYVRGGDGADSLAGGADFDDLHGNLGNDVVDGGLGTD
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEECCCCCCC
WVVGGQGNDLLRGGDDSSYDVVYGNLGNDTCYGGDGGDWVRGGQGDDSLSAGGGADWIWG
EEECCCCCCCEECCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEC
DRGNDTIEGGAGADIFFVFGEAGTDRVLDFNAAEGDVVRVEAGYTYSAAQVGADVVVSVG
CCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCCEECHHHCCCEEEEEEC
GGAQVVLAGRTLAALGDGWLVGG
CCEEEEEECCEEEECCCCEEECC
>Mature Secondary Structure 
TVLVSGNTPINVNTPEIGALAWGDTLTANSSFISLRFEQWIDEFTGSFQYDVFGELAGG
EEEEECCCCEEECCCCCCEEEECCEEECCCCEEEEEHHHHHHHHCCCEEEEEHHHHCCC
VITGWKQTYNGQLVFEVTGAEVSVGQFLIWVANDDNATAVQTIFAGADSMTGSQFLDILS
EEECCEECCCCEEEEEECCCEEEECEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHH
GYAGADSLFGMGGDDTLEGGAGEDYVRGGDGADSLAGGADFDDLHGNLGNDVVDGGLGTD
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEECCCCCCC
WVVGGQGNDLLRGGDDSSYDVVYGNLGNDTCYGGDGGDWVRGGQGDDSLSAGGGADWIWG
EEECCCCCCCEECCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEC
DRGNDTIEGGAGADIFFVFGEAGTDRVLDFNAAEGDVVRVEAGYTYSAAQVGADVVVSVG
CCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCCEECHHHCCCEEEEEEC
GGAQVVLAGRTLAALGDGWLVGG
CCEEEEEECCEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]