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The map label for this gene is hisC [H]

Identifier: 197106212

GI number: 197106212

Start: 3155522

End: 3156586

Strand: Direct

Name: hisC [H]

Synonym: PHZ_c2751

Alternate gene names: 197106212

Gene position: 3155522-3156586 (Clockwise)

Preceding gene: 197106211

Following gene: 197106214

Centisome position: 78.96

GC content: 71.08

Gene sequence:

>1065_bases
ATGGACATCCACGCCTATGTGCCAGGCAAGGCCAAGGCCGAGGGCGTCGCCGACCCCGTCAAGCTGTCGGCCAACGAGAA
CATCCTGGGCTGCAGCGAGCAGGCGCGCGAGGCCTACGCGGGCGCAGCCGGCCAGCTGCACATGTATCCCGACAGCCGCA
CCAGCCTGCTGCGCGCCGCCGTCGCCGAGCGGTTCCGGCTGGAGCCCGAGCGGCTGATCTTCGGCCAGGGCTCGGACGAG
GTGTTCCAGCTGCTGAACCAGGCCTTCCTGGAGCCCGGCGACAACATCGTGCAGGGCGAGTACGGCTTCGCCGCCTACGC
CATCGGCGCCTATGCCTGCCAGGCGCAGGTGCGGCGCGCGAAGGAGCCCAACTACACGATCGACGTGGACGAGATCCTGA
AGTGCGTGGACGAGCGCACGCGGATCGTCTTCATCGCCAATCCCGCCAATCCCACCGGCACCTGGGTCCCGTTCGCCGAG
ATCGAGCGCCTGCATCGGGCCCTGCCGGCCTCGGTCGTGCTGGTGCTGGACGGCGCCTACAGCGAGTTCTGCAACGACCC
GGCGTTCGACGACGGCATGGACCTGGCGCGGACGGCGCAGAACGTCGTCGTCACCCGCACCTTCTCCAAGCTGCACGGCC
TGGCCGCCCTGCGGGTGGGCTGGGGGTATGCGCCGGCCGAGATCGCGGCGGCGGTGGACCGCATCCGCCTGCCGTTCAAC
ATCTCGATCCCCGGCCAGCTCGCCGCCGTCGCCGCCCTGGCGGACGAGGACTTCCAGCGCCGCTCGGTCGAGCACGTGGA
CCGCTGGCGCCCCTGGCTGGCCCAGCAGCTGGGCGGCCTGGGGCTCGAGGTCGTGCTGCCCTCGGCGGCCAACTTCCTGC
TGGTGGGCTTCCCCAAGACCCCGGGCAGGACGGCGGTGGAGGCCGAGGCGTTCCTGGCCGGCAAGGGCCTGCTGGTCCGC
GGCGTCGGCAACTACGGCCTGCCGCACCACGTGCGCATCACCATCGGCCTGGAAGAGCACAACCGCGCCGTCACCGAGGC
GCTGGCCGAGTTCCTGAAGGCCTAG

Upstream 100 bases:

>100_bases
GACGTGTAAAGCGGCCGCCATGGCCGACTCCAACGAACTCCCGACCGCCCCGCAGACCGACCGTTCCCGCGCGACCCGCC
CCCTCCCCAAGCCGGGGATC

Downstream 100 bases:

>100_bases
GCGCCCTCCGCCCGCACCTGCTCCAGGAGGCTCTTGGCCTCGTCGACGAAGGCGGCGACGACCTTGGGGGCGTAGGGGTT
CTGGGTCTGGATGGCCTTGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MDIHAYVPGKAKAEGVADPVKLSANENILGCSEQAREAYAGAAGQLHMYPDSRTSLLRAAVAERFRLEPERLIFGQGSDE
VFQLLNQAFLEPGDNIVQGEYGFAAYAIGAYACQAQVRRAKEPNYTIDVDEILKCVDERTRIVFIANPANPTGTWVPFAE
IERLHRALPASVVLVLDGAYSEFCNDPAFDDGMDLARTAQNVVVTRTFSKLHGLAALRVGWGYAPAEIAAAVDRIRLPFN
ISIPGQLAAVAALADEDFQRRSVEHVDRWRPWLAQQLGGLGLEVVLPSAANFLLVGFPKTPGRTAVEAEAFLAGKGLLVR
GVGNYGLPHHVRITIGLEEHNRAVTEALAEFLKA

Sequences:

>Translated_354_residues
MDIHAYVPGKAKAEGVADPVKLSANENILGCSEQAREAYAGAAGQLHMYPDSRTSLLRAAVAERFRLEPERLIFGQGSDE
VFQLLNQAFLEPGDNIVQGEYGFAAYAIGAYACQAQVRRAKEPNYTIDVDEILKCVDERTRIVFIANPANPTGTWVPFAE
IERLHRALPASVVLVLDGAYSEFCNDPAFDDGMDLARTAQNVVVTRTFSKLHGLAALRVGWGYAPAEIAAAVDRIRLPFN
ISIPGQLAAVAALADEDFQRRSVEHVDRWRPWLAQQLGGLGLEVVLPSAANFLLVGFPKTPGRTAVEAEAFLAGKGLLVR
GVGNYGLPHHVRITIGLEEHNRAVTEALAEFLKA
>Mature_354_residues
MDIHAYVPGKAKAEGVADPVKLSANENILGCSEQAREAYAGAAGQLHMYPDSRTSLLRAAVAERFRLEPERLIFGQGSDE
VFQLLNQAFLEPGDNIVQGEYGFAAYAIGAYACQAQVRRAKEPNYTIDVDEILKCVDERTRIVFIANPANPTGTWVPFAE
IERLHRALPASVVLVLDGAYSEFCNDPAFDDGMDLARTAQNVVVTRTFSKLHGLAALRVGWGYAPAEIAAAVDRIRLPFN
ISIPGQLAAVAALADEDFQRRSVEHVDRWRPWLAQQLGGLGLEVVLPSAANFLLVGFPKTPGRTAVEAEAFLAGKGLLVR
GVGNYGLPHHVRITIGLEEHNRAVTEALAEFLKA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=309, Percent_Identity=25.5663430420712, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786816, Length=285, Percent_Identity=24.5614035087719, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=25.3968253968254, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38470; Mature: 38470

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIHAYVPGKAKAEGVADPVKLSANENILGCSEQAREAYAGAAGQLHMYPDSRTSLLRAA
CCEEEECCCCCCCCCCCCCEEECCCCCEECCCHHHHHHHCCCCCEEEECCCHHHHHHHHH
VAERFRLEPERLIFGQGSDEVFQLLNQAFLEPGDNIVQGEYGFAAYAIGAYACQAQVRRA
HHHHHCCCHHHEEEECCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHC
KEPNYTIDVDEILKCVDERTRIVFIANPANPTGTWVPFAEIERLHRALPASVVLVLDGAY
CCCCCEECHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCH
SEFCNDPAFDDGMDLARTAQNVVVTRTFSKLHGLAALRVGWGYAPAEIAAAVDRIRLPFN
HHHCCCCCCCCCHHHHHHHHHEEEEEEHHHHHCCEEEEECCCCCHHHHHHHHHHEECCEE
ISIPGQLAAVAALADEDFQRRSVEHVDRWRPWLAQQLGGLGLEVVLPSAANFLLVGFPKT
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCC
PGRTAVEAEAFLAGKGLLVRGVGNYGLPHHVRITIGLEEHNRAVTEALAEFLKA
CCCCEEEHHHHEECCCEEEEECCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIHAYVPGKAKAEGVADPVKLSANENILGCSEQAREAYAGAAGQLHMYPDSRTSLLRAA
CCEEEECCCCCCCCCCCCCEEECCCCCEECCCHHHHHHHCCCCCEEEECCCHHHHHHHHH
VAERFRLEPERLIFGQGSDEVFQLLNQAFLEPGDNIVQGEYGFAAYAIGAYACQAQVRRA
HHHHHCCCHHHEEEECCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHC
KEPNYTIDVDEILKCVDERTRIVFIANPANPTGTWVPFAEIERLHRALPASVVLVLDGAY
CCCCCEECHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCH
SEFCNDPAFDDGMDLARTAQNVVVTRTFSKLHGLAALRVGWGYAPAEIAAAVDRIRLPFN
HHHCCCCCCCCCHHHHHHHHHEEEEEEHHHHHCCEEEEECCCCCHHHHHHHHHHEECCEE
ISIPGQLAAVAALADEDFQRRSVEHVDRWRPWLAQQLGGLGLEVVLPSAANFLLVGFPKT
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCC
PGRTAVEAEAFLAGKGLLVRGVGNYGLPHHVRITIGLEEHNRAVTEALAEFLKA
CCCCEEEHHHHEECCCEEEEECCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]