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The map label for this gene is acdA [H]

Identifier: 197105867

GI number: 197105867

Start: 2738946

End: 2740094

Strand: Reverse

Name: acdA [H]

Synonym: PHZ_c2406

Alternate gene names: 197105867

Gene position: 2740094-2738946 (Counterclockwise)

Preceding gene: 197105868

Following gene: 197105866

Centisome position: 68.57

GC content: 67.36

Gene sequence:

>1149_bases
GTGTCGCTTGAGTTTCAGCTGGGCGAGTCCGCGGACATGATCCGCGAGACCACGGCCCGGTTCGCTTCCGACAGGATCGC
GCCACTCGCGGCCGAGATCGACCAGACCAACGAATTCCCGCGCCAGCTCTGGCCCCAGATGGGCGAGCTGGGCCTGCACG
GGATCACCGTCGAGGAGGAGTTCGGTGGCCTGGGCCTCGGCTACCTCGAGCATGTCGTGGCCATGGAGGAGGTGTCCCGC
GCCTCGGCCTCGATCGGCCTGAGCTACGGCGCCCACTCGAACCTCTGCGTGAACCAGCTTCGCCGCTGGGGCTCCGACGA
TCAGAAGCGCCGCTACCTGCCCAAGCTGATCTCGGGCGAGCACGTGGGCTCCCTGGCCATGAGCGAGGCGGGGTCGGGCT
CGGACGTGGTCTCGATGCGGCTGAAGGCCGAGAAGAAGGGCGACCGCTACGTCCTGAACGGCACGAAGTTCTGGATCACC
AACGCGCCGCACGCCGACACCCTGATCGTCTACGCCAAGACCGATCCGGACGCCGCGAGCCGCGGCATCACCGCCTTCAT
CATCGAGAAGGAGTTCAAGGGTTTCCGCGTCTCGCAGAAGCTCGACAAGATGGGCATGCGCGGGTCCGACACCGGCGAGC
TGGTGTTCGAGGACTGCGAGGTGCCGGAAGAGAACGTCATGGGGCCGCTGAACGGCGGCGTCGGCGTGCTGATGAGCGGC
CTCGACTACGAGCGCGCCGTGCTTTCGGCGGGCCCGCTGGGCATCATGCAGGCCTGCATGGACGTGGTCCTGCCCTACGT
CCGCGAGCGCAAGCAGTTCGGCAAGCCCATCGGCTCGTTCCAGCTGATGCAGGGCAAGATCGCCGACATGTACGTCGCCC
TGAACTCGGCCCGGGCCTACGTCTATGCCGTGGCCAAGGCGTGCGACGCCGGCATGACCACGCGCTTCGACGCCGCCGGC
GCCATCCTCATGGCCAGCGAGAACGCCGTGAAGGTGTCGCTGGAGGCCGTCCAGGCCCTGGGCGGCGCGGGCTATACGCG
AGAATATCCGGTCGAGCGATTCCTGCGGGACGCGAAGCTGTACGATATCGGCGCCGGCACCAACGAGATCCGGCGCTTCC
TGATCGGGCGGGAGCTGTTGGGCGGATGA

Upstream 100 bases:

>100_bases
GCCAATTCGCCCGATCGCGGTTTCGACGGGTTGATGGCGCCCTGCAAGGCGACATCCCATCACCGCGCGACGCAACGTCG
TTGCATGGGGGAGGTCGGCC

Downstream 100 bases:

>100_bases
GGCGCGTCCATCAGCCTGTCCGATCCCGACGACGGCCATTCTCCACGTCGCTCGCGAGACGCCCGAGCGTAGCGGGGCGG
CTTCCGCCGCTCCCTGCGGG

Product: isovaleryl CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSLEFQLGESADMIRETTARFASDRIAPLAAEIDQTNEFPRQLWPQMGELGLHGITVEEEFGGLGLGYLEHVVAMEEVSR
ASASIGLSYGAHSNLCVNQLRRWGSDDQKRRYLPKLISGEHVGSLAMSEAGSGSDVVSMRLKAEKKGDRYVLNGTKFWIT
NAPHADTLIVYAKTDPDAASRGITAFIIEKEFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGVGVLMSG
LDYERAVLSAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAYVYAVAKACDAGMTTRFDAAG
AILMASENAVKVSLEAVQALGGAGYTREYPVERFLRDAKLYDIGAGTNEIRRFLIGRELLGG

Sequences:

>Translated_382_residues
MSLEFQLGESADMIRETTARFASDRIAPLAAEIDQTNEFPRQLWPQMGELGLHGITVEEEFGGLGLGYLEHVVAMEEVSR
ASASIGLSYGAHSNLCVNQLRRWGSDDQKRRYLPKLISGEHVGSLAMSEAGSGSDVVSMRLKAEKKGDRYVLNGTKFWIT
NAPHADTLIVYAKTDPDAASRGITAFIIEKEFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGVGVLMSG
LDYERAVLSAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAYVYAVAKACDAGMTTRFDAAG
AILMASENAVKVSLEAVQALGGAGYTREYPVERFLRDAKLYDIGAGTNEIRRFLIGRELLGG
>Mature_381_residues
SLEFQLGESADMIRETTARFASDRIAPLAAEIDQTNEFPRQLWPQMGELGLHGITVEEEFGGLGLGYLEHVVAMEEVSRA
SASIGLSYGAHSNLCVNQLRRWGSDDQKRRYLPKLISGEHVGSLAMSEAGSGSDVVSMRLKAEKKGDRYVLNGTKFWITN
APHADTLIVYAKTDPDAASRGITAFIIEKEFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGVGVLMSGL
DYERAVLSAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAYVYAVAKACDAGMTTRFDAAGA
ILMASENAVKVSLEAVQALGGAGYTREYPVERFLRDAKLYDIGAGTNEIRRFLIGRELLGG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=61.6, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=60.8108108108108, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=39.7333333333333, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=35.9673024523161, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=36.0313315926893, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=36.0313315926893, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=32.620320855615, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI21361497, Length=358, Percent_Identity=37.1508379888268, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI76496475, Length=395, Percent_Identity=33.4177215189873, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI4557235, Length=395, Percent_Identity=33.4177215189873, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=32.010582010582, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4503943, Length=389, Percent_Identity=30.3341902313625, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=30.6406685236769, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI48976061, Length=297, Percent_Identity=27.9461279461279, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI211971008, Length=297, Percent_Identity=27.9461279461279, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI38505218, Length=287, Percent_Identity=22.9965156794425, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=30.3896103896104, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=27.2251308900524, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082384, Length=257, Percent_Identity=24.5136186770428, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87081702, Length=296, Percent_Identity=24.6621621621622, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=58.0901856763926, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=37.434554973822, Blast_Score=257, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=37.007874015748, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=34.8051948051948, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=34.9462365591398, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=33.4231805929919, Blast_Score=243, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17533517, Length=369, Percent_Identity=34.1463414634146, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=37.4149659863946, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=34.0974212034384, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=33.0909090909091, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=28.3464566929134, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=30.9139784946237, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.2452316076294, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=33.4782608695652, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=32.9824561403509, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=29.7071129707113, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=59.3175853018373, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=41.1764705882353, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=36.8983957219251, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=35.0404312668464, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=35.978835978836, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI281363737, Length=364, Percent_Identity=34.6153846153846, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=28.5347043701799, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24652780, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41591; Mature: 41460

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEFQLGESADMIRETTARFASDRIAPLAAEIDQTNEFPRQLWPQMGELGLHGITVEEE
CCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECC
FGGLGLGYLEHVVAMEEVSRASASIGLSYGAHSNLCVNQLRRWGSDDQKRRYLPKLISGE
CCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCC
HVGSLAMSEAGSGSDVVSMRLKAEKKGDRYVLNGTKFWITNAPHADTLIVYAKTDPDAAS
CCCCHHHHCCCCCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCEEEEEEECCCCHHH
RGITAFIIEKEFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGVGVLMSG
CCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHCC
LDYERAVLSAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAY
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHEEEHHCCHHH
VYAVAKACDAGMTTRFDAAGAILMASENAVKVSLEAVQALGGAGYTREYPVERFLRDAKL
HHHHHHHHCCCCCEEECCCCEEEEECCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHCCE
YDIGAGTNEIRRFLIGRELLGG
EECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLEFQLGESADMIRETTARFASDRIAPLAAEIDQTNEFPRQLWPQMGELGLHGITVEEE
CEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECC
FGGLGLGYLEHVVAMEEVSRASASIGLSYGAHSNLCVNQLRRWGSDDQKRRYLPKLISGE
CCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCC
HVGSLAMSEAGSGSDVVSMRLKAEKKGDRYVLNGTKFWITNAPHADTLIVYAKTDPDAAS
CCCCHHHHCCCCCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCEEEEEEECCCCHHH
RGITAFIIEKEFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGVGVLMSG
CCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHCC
LDYERAVLSAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAY
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHEEEHHCCHHH
VYAVAKACDAGMTTRFDAAGAILMASENAVKVSLEAVQALGGAGYTREYPVERFLRDAKL
HHHHHHHHCCCCCEEECCCCEEEEECCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHCCE
YDIGAGTNEIRRFLIGRELLGG
EECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]