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The map label for this gene is pepQ [H]

Identifier: 197105769

GI number: 197105769

Start: 2613057

End: 2614871

Strand: Direct

Name: pepQ [H]

Synonym: PHZ_c2307

Alternate gene names: 197105769

Gene position: 2613057-2614871 (Clockwise)

Preceding gene: 197105767

Following gene: 197105776

Centisome position: 65.39

GC content: 72.67

Gene sequence:

>1815_bases
ATGCGCCAGACCTTCGACGAGACGACCGACCGCAGCTTCGGTCCCAAGCACGTCCCCCTGATCCGCCAGGCCATGGAGGC
CCAGGGGCTCGACGGCTTCCTCGTGCCGCACGAGGATGAGCACCAGAACGAATACCTGCCGGCGGCCAACGACCGCCTGG
CCTGGGCCACCGGCTTCACCGGCTCGGCCGGAGCGGCGGTGATCCTCAAGGACAAGGCCGCGGTGTTCGTGGACGGCCGC
TACACGATCCAGGTCCGCGACCAGGTGGATCCGGCCTTCTTCGAGATCCGCGACCTGGTGGACGGCGGCGTGCCGGCCTA
CCTCGAGCAGGCGGCCGCCAGCGGCCAGAAGATCGGCTACGACCCCCGCCTGCACAGCCCCGACGCCCTGCACCACCTGC
GCGCCGCCGCCGCCAAGGCCGGCGCCGAGCTCCTGCCGGTGGCCGAGAACCCGCTGGACCGAGCCTGGGGCCAGGCGCGC
CCGCCGCAGCCGACCGCCCCCGTCGTTCCCCATCCGCTGGAGTACGCGGGCGAGGATTCGGCCGACAAGCGCGCCCGCGT
GGGCGAGCTGATCGCCAAGAGGGGCGCCGACGCGGCGGTGCTGACCGCCCCCGCCTCGATCGCCTGGCTGTTCAACGTGC
GCGGCGGCGACGTCATCCGCAGCCCCCTGCCCCTCGGCCAGGCCATCCTGAACAAGGACGGCACGGCGCGGCTGTTCCTG
GACCCGCAGAAGGTCACGCCCGAGCTGCCGGCCTGGCTCGGCAACCAGGTGCGCCTGGAGACGCCGGGCGACCTGCCCCA
GGCGCTGGCCGACCTGAAGGGCCTGAAGGTGGCGGTGGATCCCGCGCAGTCCTCGGCCTGGTACTTCGAGGCCCTGCAGA
GCGCCGGCGCCGAGGTGGTCCGCGCCGAGGACCCCTGCGCCATCCCCCGCGCCTGCAAGAACAAGGTTGAGATCGAGGGC
AGCCGCAAGGCGCATGTGCGCGACGGCGCGGCCCTGTCGCGCTTCCTCCACTGGCTGGCCACCGAGGGCCAGGAGAGCCC
GCCCGACGAGATCACCGCGGTCCAGAAGCTGGAGCAGTTCCGCGAGGCCACCGGCGCGCTGAAGGACCTGTCCTTCGACA
CCATCGCCGGCGCGCTCTCCAACGGCGCCATCTGCCACTACCGGCCCACCGCGCGGCTGAACAAGCGGGCGGAGAAGGGC
AGCCTGCTCCTGGTGGACTCCGGCGGCCAGTACCTGGACGGCACCACCGACGTGACCCGCACCGTGGCCATCGGCGAGCC
GACCCGCGAGATGTGCGAGCGCTTCACCCTGGTGCTGAAGGGCCATCTGGCCCTGGCGCGGGTGCGCTTCCCGGCCGGCA
CCACCGGCAGCCAGCTCGACGCGCTGGCCCGCGTGCCGCTGTGGGAGGCGGGCCTCGACTACGACCACGGCACCGGCCAC
GGCGTCGGCAGCTACCTGGGCGTCCACGAGGGTCCGCAGCGGATCTCCAAAGCCCCGAACACCGTCGCCCTGCGGCCGGG
GATGATCGTCTCGAACGAGCCCGGCTACTACAAGGAAGGCGAGTACGGCATCCGCATCGAGAACCTGCAGTTCGTCACCG
AGGCCGAGCCGGTGGCCGGCGGCGAGCGGCCGATGCACGGCTTCGAGGCCCTGACCCTGGCGCCCATCGACCGGCGGCTG
GTGGTCAAAGAGATGCTGACCCCCGAGGAGCTGGCCCAGTTCGACGCCTACCACGCCCGCGTGGCGCGCGAGATCGGCCC
GCTGCTGGACGGCGAGGCCAAGGCCTGGCTCGCCGAGGTCACCGCCCCGCTCTAG

Upstream 100 bases:

>100_bases
GGACATGGGCCAGCGTTAGCCGGCCCCGGCCGCAGCGTCAATTATATCCGGGTAAAATAGAGCCTTTGATCGGCGCGCGG
CGAGGGCCTACATCGAGGTC

Downstream 100 bases:

>100_bases
ACGGCTTCGGCGTCCGCCAGGGCCCGGACCTGGCGGACGTAGGCCTCGGCGTCGAACTTCTTGAAGGTGTTCGGGCCCAT
CGACCTGACCGTGCCGAACA

Product: metallopeptidase M24 family protein

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MRQTFDETTDRSFGPKHVPLIRQAMEAQGLDGFLVPHEDEHQNEYLPAANDRLAWATGFTGSAGAAVILKDKAAVFVDGR
YTIQVRDQVDPAFFEIRDLVDGGVPAYLEQAAASGQKIGYDPRLHSPDALHHLRAAAAKAGAELLPVAENPLDRAWGQAR
PPQPTAPVVPHPLEYAGEDSADKRARVGELIAKRGADAAVLTAPASIAWLFNVRGGDVIRSPLPLGQAILNKDGTARLFL
DPQKVTPELPAWLGNQVRLETPGDLPQALADLKGLKVAVDPAQSSAWYFEALQSAGAEVVRAEDPCAIPRACKNKVEIEG
SRKAHVRDGAALSRFLHWLATEGQESPPDEITAVQKLEQFREATGALKDLSFDTIAGALSNGAICHYRPTARLNKRAEKG
SLLLVDSGGQYLDGTTDVTRTVAIGEPTREMCERFTLVLKGHLALARVRFPAGTTGSQLDALARVPLWEAGLDYDHGTGH
GVGSYLGVHEGPQRISKAPNTVALRPGMIVSNEPGYYKEGEYGIRIENLQFVTEAEPVAGGERPMHGFEALTLAPIDRRL
VVKEMLTPEELAQFDAYHARVAREIGPLLDGEAKAWLAEVTAPL

Sequences:

>Translated_604_residues
MRQTFDETTDRSFGPKHVPLIRQAMEAQGLDGFLVPHEDEHQNEYLPAANDRLAWATGFTGSAGAAVILKDKAAVFVDGR
YTIQVRDQVDPAFFEIRDLVDGGVPAYLEQAAASGQKIGYDPRLHSPDALHHLRAAAAKAGAELLPVAENPLDRAWGQAR
PPQPTAPVVPHPLEYAGEDSADKRARVGELIAKRGADAAVLTAPASIAWLFNVRGGDVIRSPLPLGQAILNKDGTARLFL
DPQKVTPELPAWLGNQVRLETPGDLPQALADLKGLKVAVDPAQSSAWYFEALQSAGAEVVRAEDPCAIPRACKNKVEIEG
SRKAHVRDGAALSRFLHWLATEGQESPPDEITAVQKLEQFREATGALKDLSFDTIAGALSNGAICHYRPTARLNKRAEKG
SLLLVDSGGQYLDGTTDVTRTVAIGEPTREMCERFTLVLKGHLALARVRFPAGTTGSQLDALARVPLWEAGLDYDHGTGH
GVGSYLGVHEGPQRISKAPNTVALRPGMIVSNEPGYYKEGEYGIRIENLQFVTEAEPVAGGERPMHGFEALTLAPIDRRL
VVKEMLTPEELAQFDAYHARVAREIGPLLDGEAKAWLAEVTAPL
>Mature_604_residues
MRQTFDETTDRSFGPKHVPLIRQAMEAQGLDGFLVPHEDEHQNEYLPAANDRLAWATGFTGSAGAAVILKDKAAVFVDGR
YTIQVRDQVDPAFFEIRDLVDGGVPAYLEQAAASGQKIGYDPRLHSPDALHHLRAAAAKAGAELLPVAENPLDRAWGQAR
PPQPTAPVVPHPLEYAGEDSADKRARVGELIAKRGADAAVLTAPASIAWLFNVRGGDVIRSPLPLGQAILNKDGTARLFL
DPQKVTPELPAWLGNQVRLETPGDLPQALADLKGLKVAVDPAQSSAWYFEALQSAGAEVVRAEDPCAIPRACKNKVEIEG
SRKAHVRDGAALSRFLHWLATEGQESPPDEITAVQKLEQFREATGALKDLSFDTIAGALSNGAICHYRPTARLNKRAEKG
SLLLVDSGGQYLDGTTDVTRTVAIGEPTREMCERFTLVLKGHLALARVRFPAGTTGSQLDALARVPLWEAGLDYDHGTGH
GVGSYLGVHEGPQRISKAPNTVALRPGMIVSNEPGYYKEGEYGIRIENLQFVTEAEPVAGGERPMHGFEALTLAPIDRRL
VVKEMLTPEELAQFDAYHARVAREIGPLLDGEAKAWLAEVTAPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=610, Percent_Identity=37.3770491803279, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI93141226, Length=598, Percent_Identity=33.7792642140468, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI264681565, Length=610, Percent_Identity=36.0655737704918, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1788728, Length=185, Percent_Identity=35.1351351351351, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=594, Percent_Identity=33.8383838383838, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI25149105, Length=602, Percent_Identity=27.7408637873754, Blast_Score=224, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6322999, Length=663, Percent_Identity=33.1825037707391, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17137632, Length=599, Percent_Identity=35.0584307178631, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI161078230, Length=588, Percent_Identity=30.1020408163265, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21357287, Length=588, Percent_Identity=30.1020408163265, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65230; Mature: 65230

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTFDETTDRSFGPKHVPLIRQAMEAQGLDGFLVPHEDEHQNEYLPAANDRLAWATGFT
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEEECCC
GSAGAAVILKDKAAVFVDGRYTIQVRDQVDPAFFEIRDLVDGGVPAYLEQAAASGQKIGY
CCCCCEEEEECCEEEEECCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
DPRLHSPDALHHLRAAAAKAGAELLPVAENPLDRAWGQARPPQPTAPVVPHPLEYAGEDS
CCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCHHHCCCCC
ADKRARVGELIAKRGADAAVLTAPASIAWLFNVRGGDVIRSPLPLGQAILNKDGTARLFL
HHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCEECCCCCCCHHHHCCCCCEEEEE
DPQKVTPELPAWLGNQVRLETPGDLPQALADLKGLKVAVDPAQSSAWYFEALQSAGAEVV
CHHHCCCCCHHHCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEE
RAEDPCAIPRACKNKVEIEGSRKAHVRDGAALSRFLHWLATEGQESPPDEITAVQKLEQF
ECCCCCCCCHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
REATGALKDLSFDTIAGALSNGAICHYRPTARLNKRAEKGSLLLVDSGGQYLDGTTDVTR
HHHHHHHHHCCHHHHHHHHCCCCEEEECCCHHHHHHCCCCCEEEEECCCCCCCCCCCCEE
TVAIGEPTREMCERFTLVLKGHLALARVRFPAGTTGSQLDALARVPLWEAGLDYDHGTGH
EEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCHHHCCCCCCCCCCC
GVGSYLGVHEGPQRISKAPNTVALRPGMIVSNEPGYYKEGEYGIRIENLQFVTEAEPVAG
CCHHHCCCCCCHHHHHCCCCEEEECCCEEEECCCCCCCCCCCCEEEECEEEEECCCCCCC
GERPMHGFEALTLAPIDRRLVVKEMLTPEELAQFDAYHARVAREIGPLLDGEAKAWLAEV
CCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TAPL
CCCC
>Mature Secondary Structure
MRQTFDETTDRSFGPKHVPLIRQAMEAQGLDGFLVPHEDEHQNEYLPAANDRLAWATGFT
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEEECCC
GSAGAAVILKDKAAVFVDGRYTIQVRDQVDPAFFEIRDLVDGGVPAYLEQAAASGQKIGY
CCCCCEEEEECCEEEEECCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
DPRLHSPDALHHLRAAAAKAGAELLPVAENPLDRAWGQARPPQPTAPVVPHPLEYAGEDS
CCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCHHHCCCCC
ADKRARVGELIAKRGADAAVLTAPASIAWLFNVRGGDVIRSPLPLGQAILNKDGTARLFL
HHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCEECCCCCCCHHHHCCCCCEEEEE
DPQKVTPELPAWLGNQVRLETPGDLPQALADLKGLKVAVDPAQSSAWYFEALQSAGAEVV
CHHHCCCCCHHHCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEE
RAEDPCAIPRACKNKVEIEGSRKAHVRDGAALSRFLHWLATEGQESPPDEITAVQKLEQF
ECCCCCCCCHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
REATGALKDLSFDTIAGALSNGAICHYRPTARLNKRAEKGSLLLVDSGGQYLDGTTDVTR
HHHHHHHHHCCHHHHHHHHCCCCEEEECCCHHHHHHCCCCCEEEEECCCCCCCCCCCCEE
TVAIGEPTREMCERFTLVLKGHLALARVRFPAGTTGSQLDALARVPLWEAGLDYDHGTGH
EEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCHHHCCCCCCCCCCC
GVGSYLGVHEGPQRISKAPNTVALRPGMIVSNEPGYYKEGEYGIRIENLQFVTEAEPVAG
CCHHHCCCCCCHHHHHCCCCEEEECCCEEEECCCCCCCCCCCCEEEECEEEEECCCCCCC
GERPMHGFEALTLAPIDRRLVVKEMLTPEELAQFDAYHARVAREIGPLLDGEAKAWLAEV
CCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TAPL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]