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The map label for this gene is dhlA

Identifier: 197105712

GI number: 197105712

Start: 2547398

End: 2548303

Strand: Direct

Name: dhlA

Synonym: PHZ_c2250

Alternate gene names: 197105712

Gene position: 2547398-2548303 (Clockwise)

Preceding gene: 197105700

Following gene: 197105713

Centisome position: 63.74

GC content: 72.3

Gene sequence:

>906_bases
ATGCAGGTGTTGAGGACGCCGGACGAACGGTTCGAGGGGCTGGCCGACTGGCCGTTCGCCCCGAAGTACGTTCAGGTGAA
GGACGCCGACGGCACGCTCCTGCGCATCCACCATGTGGACGAAGGCCCCCGGGACGGCGCCCCCGTGCTGCTGATGCACG
GGGAGCCCTCGTGGGCCTACCTGTACCGCCACATCATCCCGCGCCTGGTCGCCGCCGGCCACCGTGCGATCGCGCCGGAC
CTCGTGGGCTTCGGCCGCTCGGACAAGCCGGCCGACCGGGGCGACTACACCTACGCCCGGCACGTGGCCTGGATGAGCGC
CTGGCTCGAGGCGGTGGACCTTCGGGGCGCCTACCTCTTCTGCCAGGACTGGGGCGGTCTGATCGGCCTGCGCCTGGTGG
CCGCCTATCCCGAGCGGTTCGCCGGCGTCGTCGTCTCGAACACCGGCCTGCCCGTCGGCGGCGGAGCCATGACCGACGGG
TTCAAGGCCTGGCTGCAGTTCAGCCAGACGGTCCCCGAGCTGCCGATCGGCTTCCTGCTGAACGGCGGCTCTGTCCGCGA
GCTGTCGGCGGCCGAGATGGCCGCCTACGACGCCCCCTTCCCGGACGAGAGCTACAAGGAGGGCGCGCGCCAGTTCCCGG
CTCTCGTGCCGGTCACCTCCGAGCACGCCGGCGTGGCCGAGAACCAGGCCGCCTGGAAGGTGCTGGAGGCCTGGGACAAG
CCGCTGGTGACCGCCTTCAGCGACGGCGACCCGATCACCAAGGGCGGCGAGGTCCCGTTCCGCGAGCGCGTGCCGGGCGC
CCGGGGCCAGCCGCACGTCACGCTGCATGGCGGCCACTTCGTGCAGGAGGACAGCCCCGCCGAGATCGCCGGGCTGCTCG
ACGGCCTCATCCGCCGCAGCCGCTGA

Upstream 100 bases:

>100_bases
GCCGTCCTCCCGTCTCCCGGGCGGCTTGACGGCCGCCGCTCATAATGACACGCATAATGTCACTATCTGGATCAAGAGCA
AGATCGGGGAGATGCGGCGC

Downstream 100 bases:

>100_bases
GGGACCTCCCCATGAAGGTCGAGAACGCCGTCCTGCCCGCCCCCGCCCAGATGATGGACTTCTTCGGCGCGCCCGAGGAC
GGCCCCTTCATCATGGTCAA

Product: haloalkane dehalogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MQVLRTPDERFEGLADWPFAPKYVQVKDADGTLLRIHHVDEGPRDGAPVLLMHGEPSWAYLYRHIIPRLVAAGHRAIAPD
LVGFGRSDKPADRGDYTYARHVAWMSAWLEAVDLRGAYLFCQDWGGLIGLRLVAAYPERFAGVVVSNTGLPVGGGAMTDG
FKAWLQFSQTVPELPIGFLLNGGSVRELSAAEMAAYDAPFPDESYKEGARQFPALVPVTSEHAGVAENQAAWKVLEAWDK
PLVTAFSDGDPITKGGEVPFRERVPGARGQPHVTLHGGHFVQEDSPAEIAGLLDGLIRRSR

Sequences:

>Translated_301_residues
MQVLRTPDERFEGLADWPFAPKYVQVKDADGTLLRIHHVDEGPRDGAPVLLMHGEPSWAYLYRHIIPRLVAAGHRAIAPD
LVGFGRSDKPADRGDYTYARHVAWMSAWLEAVDLRGAYLFCQDWGGLIGLRLVAAYPERFAGVVVSNTGLPVGGGAMTDG
FKAWLQFSQTVPELPIGFLLNGGSVRELSAAEMAAYDAPFPDESYKEGARQFPALVPVTSEHAGVAENQAAWKVLEAWDK
PLVTAFSDGDPITKGGEVPFRERVPGARGQPHVTLHGGHFVQEDSPAEIAGLLDGLIRRSR
>Mature_301_residues
MQVLRTPDERFEGLADWPFAPKYVQVKDADGTLLRIHHVDEGPRDGAPVLLMHGEPSWAYLYRHIIPRLVAAGHRAIAPD
LVGFGRSDKPADRGDYTYARHVAWMSAWLEAVDLRGAYLFCQDWGGLIGLRLVAAYPERFAGVVVSNTGLPVGGGAMTDG
FKAWLQFSQTVPELPIGFLLNGGSVRELSAAEMAAYDAPFPDESYKEGARQFPALVPVTSEHAGVAENQAAWKVLEAWDK
PLVTAFSDGDPITKGGEVPFRERVPGARGQPHVTLHGGHFVQEDSPAEIAGLLDGLIRRSR

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI27597073, Length=148, Percent_Identity=32.4324324324324, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI218777837, Length=125, Percent_Identity=32, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562298, Length=173, Percent_Identity=28.3236994219653, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHMA_PHEZH (B4RF90)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002131089.1
- ProteinModelPortal:   B4RF90
- GeneID:   6791771
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c2250
- HOGENOM:   HBG748003
- OMA:   SYARHVE
- ProtClustDB:   PRK00870
- HAMAP:   MF_01230
- InterPro:   IPR000073
- InterPro:   IPR000639
- PRINTS:   PR00111
- PRINTS:   PR00412

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =3.8.1.5

Molecular weight: Translated: 32844; Mature: 32844

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: ACT_SITE 123-123 ACT_SITE 250-250 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLRTPDERFEGLADWPFAPKYVQVKDADGTLLRIHHVDEGPRDGAPVLLMHGEPSWAY
CCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEEECCCCHHH
LYRHIIPRLVAAGHRAIAPDLVGFGRSDKPADRGDYTYARHVAWMSAWLEAVDLRGAYLF
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
CQDWGGLIGLRLVAAYPERFAGVVVSNTGLPVGGGAMTDGFKAWLQFSQTVPELPIGFLL
EECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
NGGSVRELSAAEMAAYDAPFPDESYKEGARQFPALVPVTSEHAGVAENQAAWKVLEAWDK
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCC
PLVTAFSDGDPITKGGEVPFRERVPGARGQPHVTLHGGHFVQEDSPAEIAGLLDGLIRRS
CEEEEECCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure
MQVLRTPDERFEGLADWPFAPKYVQVKDADGTLLRIHHVDEGPRDGAPVLLMHGEPSWAY
CCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEEECCCCHHH
LYRHIIPRLVAAGHRAIAPDLVGFGRSDKPADRGDYTYARHVAWMSAWLEAVDLRGAYLF
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
CQDWGGLIGLRLVAAYPERFAGVVVSNTGLPVGGGAMTDGFKAWLQFSQTVPELPIGFLL
EECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
NGGSVRELSAAEMAAYDAPFPDESYKEGARQFPALVPVTSEHAGVAENQAAWKVLEAWDK
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCC
PLVTAFSDGDPITKGGEVPFRERVPGARGQPHVTLHGGHFVQEDSPAEIAGLLDGLIRRS
CEEEEECCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA