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The map label for this gene is hisD [H]

Identifier: 197105662

GI number: 197105662

Start: 2483788

End: 2485077

Strand: Reverse

Name: hisD [H]

Synonym: PHZ_c2199

Alternate gene names: 197105662

Gene position: 2485077-2483788 (Counterclockwise)

Preceding gene: 197105663

Following gene: 197105661

Centisome position: 62.19

GC content: 73.18

Gene sequence:

>1290_bases
ATGCGCCGTTTCGCCTTCACAGACCCGGGCTTCCAAGAGGCTTTCGCCGCGTTCGTCGCCGAGCGCCGCGATACGCCCGA
GGACGTGGACGCGGTCGTAAGGGACGTGCTGGCGGCCGTGCGGAGCGAGGGGCTGGACGCCCTACTGCGTTTCACGCGCG
ACTTCGACCGCGTCGACGTCACCGAGGAAACCATACGCGTCTCGGCGGCCGAGATCGCCGAAGGCGCGGCGGCATGTCCT
GCGGAGGTTCGCGAGGCGATCGCCTTCGCTGCGGCCCGAATCCGCGCCTATCACGAGCGGCAGCGACCGGCGGACCAGCG
GTTCACCGACGAGGCGGGCGTGGAGCTCGGCTGGCGTTGGACGCCGCTCGACGCCGTAGGGATCTATGTCCCCGGGGGGA
GGGCGGCCTATCCCTCGACCGTGCTGATGAACGCCGTCCCGGCGGCTGCGGCCGGCGTCGGCCGGATCGCCATGGTGACG
CCGCCCGGCCGGCTGCAGCCTGCGGTGCTCGCCGCGGCGCAGGCCGCCGGCGTGACCGAGATCTGGCGGGTGGGCGGCGC
CCAGGCCGTGGCGGCGCTGGCCTATGGCGCGGGCCCCATCCGGCCGGTCGATAAGATCGTCGGGCCCGGCAACGCCTTCG
TGACCGCGGCCAAGCGGCGGGTCTACGGCGTCGTGGGCATCGACGCGCTCGCCGGCCCTTCCGAAATCGTCGTCGTCGCG
GACGGTGCGAACGACCCGGACTGGATCGCAGCCGACCTGCTGTCCCAGGCCGAACACGACCCCGCCGCCCAATCCATCCT
GATCACCGACGACGCCGCCTTCGCCGAGCGGGTGGTCAGGGCGGTCGAGGCGCAACTCGCGACCCTCGCCACCGGCGAGG
ACGCCGCCGCCTCGTGGCGCGATCACGGCGCGATCGTCATGGCGCCGCTGGACGAGGCTCCGGGCCTGGTCGATTTCATC
GCCCCCGAACACGTGGAGTTCGCCGTGGAGGCGCCCGAGCGGCTGGCCGATCGCGTCCGGCACGCCGGGGCGATCTTCCT
CGGCCGGCATGCGCCGGAGGCCGTGGGCGACTATGTCGCCGGATCGAACCACGTCCTGCCGACCAGCCGGGCGGCGCGGT
TTTCCTCTGGCCTTTCCCTCTTCGACTTCCTCAAGCGCACCTCGTTCGTGAAGTGCGACCCCGCGGCCTTCGCCGCCCTC
GCGCCCGCCACCATCGCCCTGGCCGAGGCCGAGGGGCTGCCGGCCCATGCCCGGTCCGCCTCCATCCGCCTGGAGCCGCC
GGGCGGCTGA

Upstream 100 bases:

>100_bases
CTGGCGGACGTCTCGCAGCCCTGGCCCACGCCGCGCACGCCCGCGCACGAATCCTAAGCGGCGTAGCGTTCCGCCGCTCG
CGCCGTTAAAGAGGCGCGCC

Downstream 100 bases:

>100_bases
ACGCCCGTTCGGAAAGCTGAACAATTCCTGTCGAACGGGCTCCGGACCCGTTCAGGCCAAGCTCCCTACCGTCGCGAAAT
CGGATCACGCGAAGGACGGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MRRFAFTDPGFQEAFAAFVAERRDTPEDVDAVVRDVLAAVRSEGLDALLRFTRDFDRVDVTEETIRVSAAEIAEGAAACP
AEVREAIAFAAARIRAYHERQRPADQRFTDEAGVELGWRWTPLDAVGIYVPGGRAAYPSTVLMNAVPAAAAGVGRIAMVT
PPGRLQPAVLAAAQAAGVTEIWRVGGAQAVAALAYGAGPIRPVDKIVGPGNAFVTAAKRRVYGVVGIDALAGPSEIVVVA
DGANDPDWIAADLLSQAEHDPAAQSILITDDAAFAERVVRAVEAQLATLATGEDAAASWRDHGAIVMAPLDEAPGLVDFI
APEHVEFAVEAPERLADRVRHAGAIFLGRHAPEAVGDYVAGSNHVLPTSRAARFSSGLSLFDFLKRTSFVKCDPAAFAAL
APATIALAEAEGLPAHARSASIRLEPPGG

Sequences:

>Translated_429_residues
MRRFAFTDPGFQEAFAAFVAERRDTPEDVDAVVRDVLAAVRSEGLDALLRFTRDFDRVDVTEETIRVSAAEIAEGAAACP
AEVREAIAFAAARIRAYHERQRPADQRFTDEAGVELGWRWTPLDAVGIYVPGGRAAYPSTVLMNAVPAAAAGVGRIAMVT
PPGRLQPAVLAAAQAAGVTEIWRVGGAQAVAALAYGAGPIRPVDKIVGPGNAFVTAAKRRVYGVVGIDALAGPSEIVVVA
DGANDPDWIAADLLSQAEHDPAAQSILITDDAAFAERVVRAVEAQLATLATGEDAAASWRDHGAIVMAPLDEAPGLVDFI
APEHVEFAVEAPERLADRVRHAGAIFLGRHAPEAVGDYVAGSNHVLPTSRAARFSSGLSLFDFLKRTSFVKCDPAAFAAL
APATIALAEAEGLPAHARSASIRLEPPGG
>Mature_429_residues
MRRFAFTDPGFQEAFAAFVAERRDTPEDVDAVVRDVLAAVRSEGLDALLRFTRDFDRVDVTEETIRVSAAEIAEGAAACP
AEVREAIAFAAARIRAYHERQRPADQRFTDEAGVELGWRWTPLDAVGIYVPGGRAAYPSTVLMNAVPAAAAGVGRIAMVT
PPGRLQPAVLAAAQAAGVTEIWRVGGAQAVAALAYGAGPIRPVDKIVGPGNAFVTAAKRRVYGVVGIDALAGPSEIVVVA
DGANDPDWIAADLLSQAEHDPAAQSILITDDAAFAERVVRAVEAQLATLATGEDAAASWRDHGAIVMAPLDEAPGLVDFI
APEHVEFAVEAPERLADRVRHAGAIFLGRHAPEAVGDYVAGSNHVLPTSRAARFSSGLSLFDFLKRTSFVKCDPAAFAAL
APATIALAEAEGLPAHARSASIRLEPPGG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=402, Percent_Identity=40.547263681592, Blast_Score=274, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6319819, Length=410, Percent_Identity=34.8780487804878, Blast_Score=226, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44970; Mature: 44970

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFAFTDPGFQEAFAAFVAERRDTPEDVDAVVRDVLAAVRSEGLDALLRFTRDFDRVDV
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
TEETIRVSAAEIAEGAAACPAEVREAIAFAAARIRAYHERQRPADQRFTDEAGVELGWRW
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEECEEE
TPLDAVGIYVPGGRAAYPSTVLMNAVPAAAAGVGRIAMVTPPGRLQPAVLAAAQAAGVTE
CCCCEEEEEECCCCCCCCHHHHHHCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCHHH
IWRVGGAQAVAALAYGAGPIRPVDKIVGPGNAFVTAAKRRVYGVVGIDALAGPSEIVVVA
HHHCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHEEEEEEECCCCCCCEEEEEE
DGANDPDWIAADLLSQAEHDPAAQSILITDDAAFAERVVRAVEAQLATLATGEDAAASWR
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
DHGAIVMAPLDEAPGLVDFIAPEHVEFAVEAPERLADRVRHAGAIFLGRHAPEAVGDYVA
CCCCEEEEECCCCCCCEECCCCCCCEEECCCHHHHHHHHHHCCEEEEECCCCHHHHHHHC
GSNHVLPTSRAARFSSGLSLFDFLKRTSFVKCDPAAFAALAPATIALAEAEGLPAHARSA
CCCCCCCCHHHHHHHCCCHHHHHHHHCCCEEECHHHHHHHHHHHEEEECCCCCCCCCCCC
SIRLEPPGG
EEEECCCCC
>Mature Secondary Structure
MRRFAFTDPGFQEAFAAFVAERRDTPEDVDAVVRDVLAAVRSEGLDALLRFTRDFDRVDV
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
TEETIRVSAAEIAEGAAACPAEVREAIAFAAARIRAYHERQRPADQRFTDEAGVELGWRW
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEECEEE
TPLDAVGIYVPGGRAAYPSTVLMNAVPAAAAGVGRIAMVTPPGRLQPAVLAAAQAAGVTE
CCCCEEEEEECCCCCCCCHHHHHHCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCHHH
IWRVGGAQAVAALAYGAGPIRPVDKIVGPGNAFVTAAKRRVYGVVGIDALAGPSEIVVVA
HHHCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHEEEEEEECCCCCCCEEEEEE
DGANDPDWIAADLLSQAEHDPAAQSILITDDAAFAERVVRAVEAQLATLATGEDAAASWR
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
DHGAIVMAPLDEAPGLVDFIAPEHVEFAVEAPERLADRVRHAGAIFLGRHAPEAVGDYVA
CCCCEEEEECCCCCCCEECCCCCCCEEECCCHHHHHHHHHHCCEEEEECCCCHHHHHHHC
GSNHVLPTSRAARFSSGLSLFDFLKRTSFVKCDPAAFAALAPATIALAEAEGLPAHARSA
CCCCCCCCHHHHHHHCCCHHHHHHHHCCCEEECHHHHHHHHHHHEEEECCCCCCCCCCCC
SIRLEPPGG
EEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]