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The map label for this gene is lktA [H]

Identifier: 197105625

GI number: 197105625

Start: 2433815

End: 2434663

Strand: Reverse

Name: lktA [H]

Synonym: PHZ_c2162

Alternate gene names: 197105625

Gene position: 2434663-2433815 (Counterclockwise)

Preceding gene: 197105627

Following gene: 197105624

Centisome position: 60.92

GC content: 75.62

Gene sequence:

>849_bases
GTGATCGGCGGCGCAGGGTCCCAGAGCGTCTGGGGCGACGGCGCCGACCAGTCCCTCTTCCTCGGCGCGGACGACGATGT
GCTGCACGGCGGCGGCGGCGCCGACACGGTCGCCTCGGCCGGCGGCGACGACCGCCTGTTCGGCGACGACGGCGACGATG
CGGTGTCCGGCGGCGAAGGCGCCGACCAGGTCTGGGGCGGGGCCGGCGAGGACCATGTCCACGGCAACGTCGGCGACGAC
TTCGTCCACGGCGGCGAGGGGCGCGACACCCTGCACGGCGGTCAGGGCCATGACGTGGTCCGGGGCGGCCAGGGCGACGA
CATCGCCCTCGGCGACCTCGGCTACGACACCCTCTTCGGCGACCTCGGCGCGGACGTGCTGCAGGGCGGGGCGGGCGACG
ACGTGGTCTGGGGCGGCGGCGGCTTGGTCCCCGGCGCGGACGCCGGCGACTGGATCGACGGCGGCGAGGGCAGCGACTTC
GTCCACGGCAACCAGGGCGACGACACGGTGCTGGGCGGGCTCGGCGCCGACGTCGTCCACGGCGGCCAGGGCGCCGACCG
GCTGGAGGGCGGGGACGGTGCGGATACGCTGTCCGGCGACCAGGGAGACGACGTCCTGATCGGCGGCGCCGGCGCCGACC
GCTTCCTGGTGTTCGCCGGCGGCGGCGTCGACCGCATCCTGGACTTCGACGTTCAGGAGGGCGACCGCCTGCACCTGGAC
GCCGGTCTCAGCTACACGCTTCGCCAGGACGGCGCCGACACCATCGTCGGCCTCGGCGGCGGCCAGCGCGTCGTGCTTGC
GGACGTGCGCCTGGAGACCCTCGGCGACGGCTGGATCGTCGGCGGCTGA

Upstream 100 bases:

>100_bases
GCCGAACACGGCCCTGGTGATCGACACGCGCAGCCTGCCCTCGGGCGTGACTCTCCAGCTCGACAACGTCGGCTTCGCCG
CGGTGGTCGGGGCGGCCCGG

Downstream 100 bases:

>100_bases
CGAGGGCCGCCGGCCCCCGTCCGCGCAGTTCCGGCGCTGCAGGGACAGCCGGCTCGCCCAAAGGCGCTCGTTCGGCGTTC
TCCCCCGGAGCGGGTCCGCC

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIGGAGSQSVWGDGADQSLFLGADDDVLHGGGGADTVASAGGDDRLFGDDGDDAVSGGEGADQVWGGAGEDHVHGNVGDD
FVHGGEGRDTLHGGQGHDVVRGGQGDDIALGDLGYDTLFGDLGADVLQGGAGDDVVWGGGGLVPGADAGDWIDGGEGSDF
VHGNQGDDTVLGGLGADVVHGGQGADRLEGGDGADTLSGDQGDDVLIGGAGADRFLVFAGGGVDRILDFDVQEGDRLHLD
AGLSYTLRQDGADTIVGLGGGQRVVLADVRLETLGDGWIVGG

Sequences:

>Translated_282_residues
MIGGAGSQSVWGDGADQSLFLGADDDVLHGGGGADTVASAGGDDRLFGDDGDDAVSGGEGADQVWGGAGEDHVHGNVGDD
FVHGGEGRDTLHGGQGHDVVRGGQGDDIALGDLGYDTLFGDLGADVLQGGAGDDVVWGGGGLVPGADAGDWIDGGEGSDF
VHGNQGDDTVLGGLGADVVHGGQGADRLEGGDGADTLSGDQGDDVLIGGAGADRFLVFAGGGVDRILDFDVQEGDRLHLD
AGLSYTLRQDGADTIVGLGGGQRVVLADVRLETLGDGWIVGG
>Mature_282_residues
MIGGAGSQSVWGDGADQSLFLGADDDVLHGGGGADTVASAGGDDRLFGDDGDDAVSGGEGADQVWGGAGEDHVHGNVGDD
FVHGGEGRDTLHGGQGHDVVRGGQGDDIALGDLGYDTLFGDLGADVLQGGAGDDVVWGGGGLVPGADAGDWIDGGEGSDF
VHGNQGDDTVLGGLGADVVHGGQGADRLEGGDGADTLSGDQGDDVLIGGAGADRFLVFAGGGVDRILDFDVQEGDRLHLD
AGLSYTLRQDGADTIVGLGGGQRVVLADVRLETLGDGWIVGG

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 27731; Mature: 27731

Theoretical pI: Translated: 3.65; Mature: 3.65

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGGAGSQSVWGDGADQSLFLGADDDVLHGGGGADTVASAGGDDRLFGDDGDDAVSGGEG
CCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
ADQVWGGAGEDHVHGNVGDDFVHGGEGRDTLHGGQGHDVVRGGQGDDIALGDLGYDTLFG
HHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEECCCCCEEEECCCCHHHHHH
DLGADVLQGGAGDDVVWGGGGLVPGADAGDWIDGGEGSDFVHGNQGDDTVLGGLGADVVH
HHCHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHEEE
GGQGADRLEGGDGADTLSGDQGDDVLIGGAGADRFLVFAGGGVDRILDFDVQEGDRLHLD
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCEEEEE
AGLSYTLRQDGADTIVGLGGGQRVVLADVRLETLGDGWIVGG
CCCEEEEECCCCCEEEECCCCCEEEEEEEEEEECCCEEEECC
>Mature Secondary Structure
MIGGAGSQSVWGDGADQSLFLGADDDVLHGGGGADTVASAGGDDRLFGDDGDDAVSGGEG
CCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
ADQVWGGAGEDHVHGNVGDDFVHGGEGRDTLHGGQGHDVVRGGQGDDIALGDLGYDTLFG
HHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEECCCCCEEEECCCCHHHHHH
DLGADVLQGGAGDDVVWGGGGLVPGADAGDWIDGGEGSDFVHGNQGDDTVLGGLGADVVH
HHCHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHEEE
GGQGADRLEGGDGADTLSGDQGDDVLIGGAGADRFLVFAGGGVDRILDFDVQEGDRLHLD
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCEEEEE
AGLSYTLRQDGADTIVGLGGGQRVVLADVRLETLGDGWIVGG
CCCEEEEECCCCCEEEECCCCCEEEEEEEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]