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The map label for this gene is cytR [H]

Identifier: 197105621

GI number: 197105621

Start: 2429534

End: 2430550

Strand: Direct

Name: cytR [H]

Synonym: PHZ_c2158

Alternate gene names: 197105621

Gene position: 2429534-2430550 (Clockwise)

Preceding gene: 197105613

Following gene: 197105626

Centisome position: 60.8

GC content: 73.35

Gene sequence:

>1017_bases
ATGGCCACGATCCAGGATGTCGCCCGCGACGCGGGCGTCTCGACCGCGACCGTATCGCGCGTGCTGAGCGCCCCGGAGCG
CGTGGCCGAGGCGACGCGGGCGCGGGTGCTGGAGTCGGTGGAGCGGCTGGGCTACGCGCCCAACGTGGCGGCCAAGAGCC
TGCGCACGCTGAAGACGGGGAAGATCCTCGTCACGGTCCCGGATATCTCGAACCCGTTCTTCTCGCAGGTGATCCGGGGG
GTCGAGGAAGCCGCGACCGCGGCCGGCTACGCGGTGCTGCTGGGCGACACGCGCCAGGAGGCGGCGCGCGAAGACCAGTA
CGCGCTGCTGCTGCGCCGCAAGGAGGCCGACGGGCTGATCTTCCTCGGCCACCGGCTGCCGCCGGCCCTGGCCGAGCTGG
TGGCCGCGCAGGGCGCGAAGGCCCCCATCGTGAACGGCTGCGAGTTCAGTCCCGAGCTCGGCGTGCCCAGCGCCCATATC
GACAACGCCCGCGCCGCGGCCGAGGCGATGGAGCACCTCTACGGACTGGGCCACCGGCGTGTGGGCGTGATCACCGGTCC
CCTCGCCAGCCCCCTGAGCCGCGATCGCCTGGCCGGCGTGCAGGCCGCCGCCGCGCGCCGGGGGGCCTGGGGCCTGAACA
TCGTCCAGGGCGACTTCTCGATCGAGTCTGGCCTTGCCCAGACGCTGGCGCTGCTCGACGCCGAGCCGCGGCCGACGGCG
ATCTTCTGCTTCAGCGACGAGATGGCCATGGGCGCGCTGACGGCCCTGCGCCGCCGCGGCCTCTCATGCCCGGCGGACGT
CTCGGTCGTGGGCTTCGACGACATCCGCTACGCCCGCCACATGGACCCGCCGCTCACCACCGTCAGCCAGCCGAAGGAGG
CGATCGGCCACGAAGTCGTGCGCCTGCTCCTCGACGTGCTCTCGGGACGGGTGGACACGGTGCGCCACGTCACCCTCGCC
CACCGCCTGGTGATCCGGGCGAGCACCGGGCCAGCCTTCGGGCCTGCGGCGGGCTAA

Upstream 100 bases:

>100_bases
CCTTGACGCCCATGCCTCGCCTCCCCCGGCGGCGAGAACTCTTGTGCGGCCCCGCTCGCGCGATGTAATCGATTACACGT
TCAAGCCGGCGGTGCAAGCT

Downstream 100 bases:

>100_bases
TCCAGCGGCCGGATCTTGATGTTGCGGAAGAAGACCGGGTCGCCGTGGTTCTGGATGGCGATGTGGCCGGACTTCGCGGC
GGCGAACTGCGGCCAGGCCC

Product: transcriptional regulator, LacI family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MATIQDVARDAGVSTATVSRVLSAPERVAEATRARVLESVERLGYAPNVAAKSLRTLKTGKILVTVPDISNPFFSQVIRG
VEEAATAAGYAVLLGDTRQEAAREDQYALLLRRKEADGLIFLGHRLPPALAELVAAQGAKAPIVNGCEFSPELGVPSAHI
DNARAAAEAMEHLYGLGHRRVGVITGPLASPLSRDRLAGVQAAAARRGAWGLNIVQGDFSIESGLAQTLALLDAEPRPTA
IFCFSDEMAMGALTALRRRGLSCPADVSVVGFDDIRYARHMDPPLTTVSQPKEAIGHEVVRLLLDVLSGRVDTVRHVTLA
HRLVIRASTGPAFGPAAG

Sequences:

>Translated_338_residues
MATIQDVARDAGVSTATVSRVLSAPERVAEATRARVLESVERLGYAPNVAAKSLRTLKTGKILVTVPDISNPFFSQVIRG
VEEAATAAGYAVLLGDTRQEAAREDQYALLLRRKEADGLIFLGHRLPPALAELVAAQGAKAPIVNGCEFSPELGVPSAHI
DNARAAAEAMEHLYGLGHRRVGVITGPLASPLSRDRLAGVQAAAARRGAWGLNIVQGDFSIESGLAQTLALLDAEPRPTA
IFCFSDEMAMGALTALRRRGLSCPADVSVVGFDDIRYARHMDPPLTTVSQPKEAIGHEVVRLLLDVLSGRVDTVRHVTLA
HRLVIRASTGPAFGPAAG
>Mature_337_residues
ATIQDVARDAGVSTATVSRVLSAPERVAEATRARVLESVERLGYAPNVAAKSLRTLKTGKILVTVPDISNPFFSQVIRGV
EEAATAAGYAVLLGDTRQEAAREDQYALLLRRKEADGLIFLGHRLPPALAELVAAQGAKAPIVNGCEFSPELGVPSAHID
NARAAAEAMEHLYGLGHRRVGVITGPLASPLSRDRLAGVQAAAARRGAWGLNIVQGDFSIESGLAQTLALLDAEPRPTAI
FCFSDEMAMGALTALRRRGLSCPADVSVVGFDDIRYARHMDPPLTTVSQPKEAIGHEVVRLLLDVLSGRVDTVRHVTLAH
RLVIRASTGPAFGPAAG

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=335, Percent_Identity=43.2835820895522, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=35.8823529411765, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1790194, Length=317, Percent_Identity=37.2239747634069, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1788474, Length=324, Percent_Identity=32.4074074074074, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789202, Length=293, Percent_Identity=33.7883959044369, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789068, Length=318, Percent_Identity=32.0754716981132, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1786540, Length=313, Percent_Identity=32.2683706070287, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787580, Length=337, Percent_Identity=28.486646884273, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI48994940, Length=295, Percent_Identity=28.4745762711864, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=30.9375, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790715, Length=322, Percent_Identity=25.1552795031056, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787906, Length=337, Percent_Identity=29.673590504451, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=22.5396825396825, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35751; Mature: 35620

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIQDVARDAGVSTATVSRVLSAPERVAEATRARVLESVERLGYAPNVAAKSLRTLKTG
CCCHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
KILVTVPDISNPFFSQVIRGVEEAATAAGYAVLLGDTRQEAAREDQYALLLRRKEADGLI
EEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCHHHHHHEEECCCCCEE
FLGHRLPPALAELVAAQGAKAPIVNGCEFSPELGVPSAHIDNARAAAEAMEHLYGLGHRR
EECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
VGVITGPLASPLSRDRLAGVQAAAARRGAWGLNIVQGDFSIESGLAQTLALLDAEPRPTA
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCE
IFCFSDEMAMGALTALRRRGLSCPADVSVVGFDDIRYARHMDPPLTTVSQPKEAIGHEVV
EEEECCHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
RLLLDVLSGRVDTVRHVTLAHRLVIRASTGPAFGPAAG
HHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure 
ATIQDVARDAGVSTATVSRVLSAPERVAEATRARVLESVERLGYAPNVAAKSLRTLKTG
CCHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
KILVTVPDISNPFFSQVIRGVEEAATAAGYAVLLGDTRQEAAREDQYALLLRRKEADGLI
EEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCHHHHHHEEECCCCCEE
FLGHRLPPALAELVAAQGAKAPIVNGCEFSPELGVPSAHIDNARAAAEAMEHLYGLGHRR
EECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
VGVITGPLASPLSRDRLAGVQAAAARRGAWGLNIVQGDFSIESGLAQTLALLDAEPRPTA
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCE
IFCFSDEMAMGALTALRRRGLSCPADVSVVGFDDIRYARHMDPPLTTVSQPKEAIGHEVV
EEEECCHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
RLLLDVLSGRVDTVRHVTLAHRLVIRASTGPAFGPAAG
HHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]