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The map label for this gene is pdhB-2 [H]

Identifier: 197105589

GI number: 197105589

Start: 2394164

End: 2395135

Strand: Direct

Name: pdhB-2 [H]

Synonym: PHZ_c2126

Alternate gene names: 197105589

Gene position: 2394164-2395135 (Clockwise)

Preceding gene: 197105588

Following gene: 197105590

Centisome position: 59.91

GC content: 68.0

Gene sequence:

>972_bases
GTGCGCAACTCGACCCAGAAGCTCACCTACTTGCAGGCGATCATCGAGGCCCAGCGCGAGGAGATGCGGCGCGACGAGCG
CGTGATCCTCATGGGCGAGGACATCGCCGTCTACGGCGCCCAGACGCTGTTCGACGAGTTCGACGAGAGCCGGCTGCGCA
ACACGCCCATCTCGGAGAACAGCTTCACCGGCGTCGGCGTCGGCGCGGCGCTGACGGGCCTGCGGCCGGTCGTGGACCTG
ACCATCGCCAGCTTCGTCTACCTGGCCTCCGACCAGATCATCAACCAGGCGGCCAAGCTGCGGTTCATGACCGGCGGCCA
GCTGAAGGTGCCGCTCGTGGTGCGGACCAACACCTTCTACAACAACAGCACGGCCGCCCAGCACGCGGACCGCCCCTACC
CCCTGTTCATGAACGTCCCCGGCCTGAAGGTCGTCGCGCCGGCCACGGCCGCCGACGCCAAGGGCCTGCTGAAGTCGGCC
ATCCGCGACGACGACCCGGTGATCGTCTTCGAGGACATGAACCTGTGGGCCAAGAAGGGCGAGGTGCCGGTCGACGACGA
GTTCCTCGTGCCCATCGGCAAGGCCGACATCAAGCGGCCCGGCTCTGACGTGACGATCGTCTCGATCGCCGGCTGCCTGA
TCGCCGCCCTGGCCGCCGCCGAGACGCTGAGCCAGGAGGGGATCGAGGCCGAGGTGATCGACCTGCGGACGATCGCGCCG
ATGGACCGGGAGACCATCCTCGGCTCGGTGGCCCGCACCGGCCGGCTGGTGATCGTGGACAACTCCCACAAGGTGGGCAG
CGTGGCCTCGGAGATCGCGGCTGTCGTCGTCGAGGAGGCCTTCGAGAGCCTGCGCAAGCCAATCCGGCGGGTGGCCACGC
CCTCGGTGCAGATCCCCTACAACCTGAACCTGGAAAAGCAGCTCTATCCGAACAAGGACCGGGTCGCCGAGGCCGTCCGC
AGCCTGCTGTAG

Upstream 100 bases:

>100_bases
TTCGCCAAGGAGAGCCCCGAGCCCGAACTGCAGGACCTGCTGGACTGCATGTACAGCCTTCCCATCCATTTTCCGCCGCG
CGGCGAAGGGGTCTTCTGAC

Downstream 100 bases:

>100_bases
ACCGCGCCTTGAACCGCACGCGCCCAGGTGTCATTATGGCACCCAAGGAGCGCGCCATGGCCTCGTCATTCGCCACCGTG
AAGCTGAACACCCGGCTCGT

Product: pyruvate dehydrogenase E1 component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRNSTQKLTYLQAIIEAQREEMRRDERVILMGEDIAVYGAQTLFDEFDESRLRNTPISENSFTGVGVGAALTGLRPVVDL
TIASFVYLASDQIINQAAKLRFMTGGQLKVPLVVRTNTFYNNSTAAQHADRPYPLFMNVPGLKVVAPATAADAKGLLKSA
IRDDDPVIVFEDMNLWAKKGEVPVDDEFLVPIGKADIKRPGSDVTIVSIAGCLIAALAAAETLSQEGIEAEVIDLRTIAP
MDRETILGSVARTGRLVIVDNSHKVGSVASEIAAVVVEEAFESLRKPIRRVATPSVQIPYNLNLEKQLYPNKDRVAEAVR
SLL

Sequences:

>Translated_323_residues
MRNSTQKLTYLQAIIEAQREEMRRDERVILMGEDIAVYGAQTLFDEFDESRLRNTPISENSFTGVGVGAALTGLRPVVDL
TIASFVYLASDQIINQAAKLRFMTGGQLKVPLVVRTNTFYNNSTAAQHADRPYPLFMNVPGLKVVAPATAADAKGLLKSA
IRDDDPVIVFEDMNLWAKKGEVPVDDEFLVPIGKADIKRPGSDVTIVSIAGCLIAALAAAETLSQEGIEAEVIDLRTIAP
MDRETILGSVARTGRLVIVDNSHKVGSVASEIAAVVVEEAFESLRKPIRRVATPSVQIPYNLNLEKQLYPNKDRVAEAVR
SLL
>Mature_323_residues
MRNSTQKLTYLQAIIEAQREEMRRDERVILMGEDIAVYGAQTLFDEFDESRLRNTPISENSFTGVGVGAALTGLRPVVDL
TIASFVYLASDQIINQAAKLRFMTGGQLKVPLVVRTNTFYNNSTAAQHADRPYPLFMNVPGLKVVAPATAADAKGLLKSA
IRDDDPVIVFEDMNLWAKKGEVPVDDEFLVPIGKADIKRPGSDVTIVSIAGCLIAALAAAETLSQEGIEAEVIDLRTIAP
MDRETILGSVARTGRLVIVDNSHKVGSVASEIAAVVVEEAFESLRKPIRRVATPSVQIPYNLNLEKQLYPNKDRVAEAVR
SLL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=41.4110429447853, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=39.8773006134969, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4557353, Length=329, Percent_Identity=34.6504559270517, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI34101272, Length=329, Percent_Identity=34.6504559270517, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=42.1538461538462, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=35.474006116208, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319698, Length=331, Percent_Identity=39.2749244712991, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI21358145, Length=329, Percent_Identity=40.1215805471125, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24650940, Length=329, Percent_Identity=40.1215805471125, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=32.4159021406728, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=32.4159021406728, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35247; Mature: 35247

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSTQKLTYLQAIIEAQREEMRRDERVILMGEDIAVYGAQTLFDEFDESRLRNTPISEN
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHHHHHCCCCCCCC
SFTGVGVGAALTGLRPVVDLTIASFVYLASDQIINQAAKLRFMTGGQLKVPLVVRTNTFY
CCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEEECCEE
NNSTAAQHADRPYPLFMNVPGLKVVAPATAADAKGLLKSAIRDDDPVIVFEDMNLWAKKG
CCCCHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHCC
EVPVDDEFLVPIGKADIKRPGSDVTIVSIAGCLIAALAAAETLSQEGIEAEVIDLRTIAP
CCCCCCCEEEECCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
MDRETILGSVARTGRLVIVDNSHKVGSVASEIAAVVVEEAFESLRKPIRRVATPSVQIPY
CCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
NLNLEKQLYPNKDRVAEAVRSLL
CCCCHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MRNSTQKLTYLQAIIEAQREEMRRDERVILMGEDIAVYGAQTLFDEFDESRLRNTPISEN
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHHHHHCCCCCCCC
SFTGVGVGAALTGLRPVVDLTIASFVYLASDQIINQAAKLRFMTGGQLKVPLVVRTNTFY
CCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEEECCEE
NNSTAAQHADRPYPLFMNVPGLKVVAPATAADAKGLLKSAIRDDDPVIVFEDMNLWAKKG
CCCCHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHCC
EVPVDDEFLVPIGKADIKRPGSDVTIVSIAGCLIAALAAAETLSQEGIEAEVIDLRTIAP
CCCCCCCEEEECCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
MDRETILGSVARTGRLVIVDNSHKVGSVASEIAAVVVEEAFESLRKPIRRVATPSVQIPY
CCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
NLNLEKQLYPNKDRVAEAVRSLL
CCCCHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]