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The map label for this gene is fabG [C]

Identifier: 197105471

GI number: 197105471

Start: 2246045

End: 2246953

Strand: Direct

Name: fabG [C]

Synonym: PHZ_c2008

Alternate gene names: 197105471

Gene position: 2246045-2246953 (Clockwise)

Preceding gene: 197105454

Following gene: 197105479

Centisome position: 56.2

GC content: 70.41

Gene sequence:

>909_bases
GTGGGCGTTCTGAACGGGAAGGTGGTGCTGGTCACGGGCGCCGCGGGCGGCATCGGCAAGGAGTGCGCGCTGCTGGCGGC
CAGGGAAGGCGCCAAGGTGGTGGTGAACGACCTGGGCGGCGGCGTCTCGGGCGGCGACCTGGGCGATGCGGGGCCCGCAG
AGACGACGGCCCAGGAGATCCGCGCCGCCGGCGGCGAGGCGGTCGCCAATTCCGACAGCGTGGCCGACATGGCCGGCGCC
CGGCGCATGTTCGAGCAGGCGATGGATGCATTCGGCGGCCTGCACGCCGTGGTGAACCCCGCCGGCATCCTGCGCGACAA
GATGTTCCACAAGATGGACGAGGCCGACTGGGACGCGGTGATCCAGGTGCACCTGCGCGGCGCCTTCAACGTCACCCGCG
CCACCGTCGAGCACTTCCGCGACCAGCAGGACGGCTCCTACGTCCACTTCACCTCGACCTCGGGCCTGATCGGCAACATC
GGCCAGGCCAACTACGCCGCGGCCAAGCTGGGGGTCATGGGCCTCTCGCGCATCGTGGCCATGGAGGGCGCCGCCAAGAA
CGTCCGTTCCAACATCATCGCGCCCTTCGCCTGGACGCGGATGATCGCCACCATCCCGGTGAAGGACGAGGCCTCGGCCC
AGCGCGTCGAGCGGATGAAGAACTTCATGCGCGCCGACCAGGTGGCCCAGCTCGCGGTCGCCCTCGCCGGGTCCGACGTC
AACGGCCAGATCTTCGCTGCCCGCGGCAACGAGGTCGTGCTGTTCAACCAGCCGCGCCCGGTGAAGTCGGTGACCAGGAT
CGAGGGCTGGACGCCCGAGGCGCTGATCGCCCAGGGCTTCCCGGCCATGTCGGCCAGCTTCACGGACCTCGGCGCCAGCG
CCTCGGTCTTCCCCTACGACCCGGTCTGA

Upstream 100 bases:

>100_bases
GCGGGCGATCCTATTGGGTGGCCGCTGCGTCAACCAACTATAGCTTGGCGATCGATCGGGGCCGCGAGCTGTGGCCGATG
GCAGTAGGGAGAAGACGGAC

Downstream 100 bases:

>100_bases
CCCGGGCGGCTCGGTCCCGGCTGATTCGCCGGGACCGGCCGGAAGTCGAGGTCGTGGAAGTCGTAGCTGAAGTCGGCCAC
CGGCGAGACGGCCTTCATGG

Product: probable short-chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MGVLNGKVVLVTGAAGGIGKECALLAAREGAKVVVNDLGGGVSGGDLGDAGPAETTAQEIRAAGGEAVANSDSVADMAGA
RRMFEQAMDAFGGLHAVVNPAGILRDKMFHKMDEADWDAVIQVHLRGAFNVTRATVEHFRDQQDGSYVHFTSTSGLIGNI
GQANYAAAKLGVMGLSRIVAMEGAAKNVRSNIIAPFAWTRMIATIPVKDEASAQRVERMKNFMRADQVAQLAVALAGSDV
NGQIFAARGNEVVLFNQPRPVKSVTRIEGWTPEALIAQGFPAMSASFTDLGASASVFPYDPV

Sequences:

>Translated_302_residues
MGVLNGKVVLVTGAAGGIGKECALLAAREGAKVVVNDLGGGVSGGDLGDAGPAETTAQEIRAAGGEAVANSDSVADMAGA
RRMFEQAMDAFGGLHAVVNPAGILRDKMFHKMDEADWDAVIQVHLRGAFNVTRATVEHFRDQQDGSYVHFTSTSGLIGNI
GQANYAAAKLGVMGLSRIVAMEGAAKNVRSNIIAPFAWTRMIATIPVKDEASAQRVERMKNFMRADQVAQLAVALAGSDV
NGQIFAARGNEVVLFNQPRPVKSVTRIEGWTPEALIAQGFPAMSASFTDLGASASVFPYDPV
>Mature_301_residues
GVLNGKVVLVTGAAGGIGKECALLAAREGAKVVVNDLGGGVSGGDLGDAGPAETTAQEIRAAGGEAVANSDSVADMAGAR
RMFEQAMDAFGGLHAVVNPAGILRDKMFHKMDEADWDAVIQVHLRGAFNVTRATVEHFRDQQDGSYVHFTSTSGLIGNIG
QANYAAAKLGVMGLSRIVAMEGAAKNVRSNIIAPFAWTRMIATIPVKDEASAQRVERMKNFMRADQVAQLAVALAGSDVN
GQIFAARGNEVVLFNQPRPVKSVTRIEGWTPEALIAQGFPAMSASFTDLGASASVFPYDPV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=281, Percent_Identity=41.6370106761566, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=32.9268292682927, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=31.8548387096774, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI31542939, Length=220, Percent_Identity=30, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI66933014, Length=247, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=30.2904564315353, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=27.6679841897233, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789208, Length=218, Percent_Identity=28.8990825688073, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786812, Length=214, Percent_Identity=31.7757009345794, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790717, Length=208, Percent_Identity=29.8076923076923, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87082160, Length=213, Percent_Identity=24.4131455399061, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788459, Length=237, Percent_Identity=24.8945147679325, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787905, Length=258, Percent_Identity=27.906976744186, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=202, Percent_Identity=47.5247524752475, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25147288, Length=248, Percent_Identity=33.8709677419355, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=208, Percent_Identity=32.6923076923077, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=194, Percent_Identity=26.2886597938144, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=178, Percent_Identity=28.6516853932584, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=199, Percent_Identity=45.7286432160804, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI18859837, Length=201, Percent_Identity=48.7562189054726, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=34.8, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI23397609, Length=238, Percent_Identity=31.0924369747899, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640492, Length=201, Percent_Identity=27.363184079602, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737361, Length=227, Percent_Identity=29.5154185022026, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644339, Length=191, Percent_Identity=29.3193717277487, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357673, Length=139, Percent_Identity=32.3741007194245, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31559; Mature: 31428

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLNGKVVLVTGAAGGIGKECALLAAREGAKVVVNDLGGGVSGGDLGDAGPAETTAQEI
CCCCCCEEEEEEECCCCCCCHHHHEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHH
RAAGGEAVANSDSVADMAGARRMFEQAMDAFGGLHAVVNPAGILRDKMFHKMDEADWDAV
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCEE
IQVHLRGAFNVTRATVEHFRDQQDGSYVHFTSTSGLIGNIGQANYAAAKLGVMGLSRIVA
EEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MEGAAKNVRSNIIAPFAWTRMIATIPVKDEASAQRVERMKNFMRADQVAQLAVALAGSDV
HCCHHHHHHHHCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NGQIFAARGNEVVLFNQPRPVKSVTRIEGWTPEALIAQGFPAMSASFTDLGASASVFPYD
CCEEEEECCCEEEEECCCCCHHHHHHCCCCCCHHHHHCCCCCCCCCHHHCCCCCCCCCCC
PV
CC
>Mature Secondary Structure 
GVLNGKVVLVTGAAGGIGKECALLAAREGAKVVVNDLGGGVSGGDLGDAGPAETTAQEI
CCCCCEEEEEEECCCCCCCHHHHEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHH
RAAGGEAVANSDSVADMAGARRMFEQAMDAFGGLHAVVNPAGILRDKMFHKMDEADWDAV
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCEE
IQVHLRGAFNVTRATVEHFRDQQDGSYVHFTSTSGLIGNIGQANYAAAKLGVMGLSRIVA
EEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MEGAAKNVRSNIIAPFAWTRMIATIPVKDEASAQRVERMKNFMRADQVAQLAVALAGSDV
HCCHHHHHHHHCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NGQIFAARGNEVVLFNQPRPVKSVTRIEGWTPEALIAQGFPAMSASFTDLGASASVFPYD
CCEEEEECCCEEEEECCCCCHHHHHHCCCCCCHHHHHCCCCCCCCCHHHCCCCCCCCCCC
PV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]