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The map label for this gene is norM [H]

Identifier: 197105448

GI number: 197105448

Start: 2217121

End: 2218506

Strand: Reverse

Name: norM [H]

Synonym: PHZ_c1985

Alternate gene names: 197105448

Gene position: 2218506-2217121 (Counterclockwise)

Preceding gene: 197105449

Following gene: 197105445

Centisome position: 55.51

GC content: 73.38

Gene sequence:

>1386_bases
TTGCGTGTCATGGACCGCCCGGCGGCCCAGGCGTCCTCGCTGGCCGGGGAACGCTCCAGTCTCGTCCGCGCCGATCTGGC
CCAGCTCCTGAAGCTGTCGGGGCCGGTGGTCCTCGCGCGCCTGGGGATCATGACCATGGGGCTGACGGACGCGGTCGTCG
TCGGCCGCTACTCGGCCCAGCAGCTCGGCTACCACGCCCTGGGCTGGGCCCCCACCAGCGTGATGCTGACGGCGGTCGTG
GGCCTGCTCACCGGCATCCAGGTGATGACCGCCCGGGCGATCGGCGAGGGGCGGCGGCACGAGACCGGCGCGGTGCTGCG
GCGCGGGCTCGTCTACGCGTTCTGGGTCAGCCTCGCCTCCACGGTCCTGCTGGCGCTGGCGGGGCCGCCGTTCCTGCACG
TGATCGGGCTGGAGCCGGACCTGGCCGACGGGGCCACGCGCGCGCTGCTCGTCTTCTCCCTCTCGCTCACCAGCTACGGC
GTCAGCGTCGCCGCCAGCTTCTGGCTCGAAGGGCTGGCCAGGCCGGGCCCGGCGGCCTGGGCCATGTGGGCGGCGAATGT
CGTGAACCTCGGCCTCGTCCTGCTGTTCGTGCCGGGGACCTTCGGCCTGCCCGCCATGGGGGCCGTGGGCGCGGCCTGGG
GCACCTTCGGGGCGCGGACGTTCCTCGCCCTGGCGCTGCTGGCCTACATCGCCCTGATGCCAGAGGCGCGAGCGCTGGGC
GTCTTCCGCAAGCCCGCCCGTGACCGCGCCGCCGAGGCCGAGCAGCGACGGATCGGCTACGGCGCAGGGATTTCCAACTT
CCTGGAGGTCTCGGCCTTCGCCAGCATGAACGTCATCGCCGGCTGGATCGGCGGCCTGGCGGTCGCCGCCTGGGCGATCG
TGCTGAACCTCGCGGCGATCGTCTTCATGGTCCCGCTGGGCCTGGCGACCGGGGCGGCGGTGCTGGTGGGCCGGGCCTAC
GGCGCGCGCGATCCGGCCGGCGTCCATAGGGCCGGGGCGATCTCGTTCGCGGTGACGGCGGTGTTCGGGGTGATCGTCTC
GCTGGCCGTCTGGCCCGCCGCGGGGCTCATCTCGGCCGGCTACACGCGGGATGCGGCGACCATCGCCCTGGCCGCGCCGG
CCCTGGCCCTGTCGTGCCTGTTCTTCCTGCCCGACGCCCTGCAGGTCGTGGCGGCCCAGGCGCTGCGGGCGCGCGGCGAC
GTCTGGCTGCCGACCTACACCCACCTGGCCAGCTACATCGCAGTCATGATGCCGCTCGCCTGGTGGCTGGCGATCCCCAT
GAAGCTCGGCATCGACGGCATCGTCTGGGCCGTGATCGTGGCGAGCCTGGTTTCCTGCGCCCTGCTGCTGGGCCGGTTCT
GGCTGTTGAGCCGCCGGACCCTCTAG

Upstream 100 bases:

>100_bases
GCCGGGCCACTCCGACGTAGGAAGCTCCGGCGGGCGGCGGACCCGGCTTGCGGGCGCGGTCCGGCCGCGCGACTGTCCGC
GGCTTCTTTGACAACCAAGG

Downstream 100 bases:

>100_bases
GCCCCGGCGCCCAGGATCCAGCCTTCCTCGCGCTCGGCGTCCAGCACCACGTCGGCGGCGGCGTCCTTCGGCGGAGCGAA
CAGCGCGCCCAGCTTGCTGG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRVMDRPAAQASSLAGERSSLVRADLAQLLKLSGPVVLARLGIMTMGLTDAVVVGRYSAQQLGYHALGWAPTSVMLTAVV
GLLTGIQVMTARAIGEGRRHETGAVLRRGLVYAFWVSLASTVLLALAGPPFLHVIGLEPDLADGATRALLVFSLSLTSYG
VSVAASFWLEGLARPGPAAWAMWAANVVNLGLVLLFVPGTFGLPAMGAVGAAWGTFGARTFLALALLAYIALMPEARALG
VFRKPARDRAAEAEQRRIGYGAGISNFLEVSAFASMNVIAGWIGGLAVAAWAIVLNLAAIVFMVPLGLATGAAVLVGRAY
GARDPAGVHRAGAISFAVTAVFGVIVSLAVWPAAGLISAGYTRDAATIALAAPALALSCLFFLPDALQVVAAQALRARGD
VWLPTYTHLASYIAVMMPLAWWLAIPMKLGIDGIVWAVIVASLVSCALLLGRFWLLSRRTL

Sequences:

>Translated_461_residues
MRVMDRPAAQASSLAGERSSLVRADLAQLLKLSGPVVLARLGIMTMGLTDAVVVGRYSAQQLGYHALGWAPTSVMLTAVV
GLLTGIQVMTARAIGEGRRHETGAVLRRGLVYAFWVSLASTVLLALAGPPFLHVIGLEPDLADGATRALLVFSLSLTSYG
VSVAASFWLEGLARPGPAAWAMWAANVVNLGLVLLFVPGTFGLPAMGAVGAAWGTFGARTFLALALLAYIALMPEARALG
VFRKPARDRAAEAEQRRIGYGAGISNFLEVSAFASMNVIAGWIGGLAVAAWAIVLNLAAIVFMVPLGLATGAAVLVGRAY
GARDPAGVHRAGAISFAVTAVFGVIVSLAVWPAAGLISAGYTRDAATIALAAPALALSCLFFLPDALQVVAAQALRARGD
VWLPTYTHLASYIAVMMPLAWWLAIPMKLGIDGIVWAVIVASLVSCALLLGRFWLLSRRTL
>Mature_461_residues
MRVMDRPAAQASSLAGERSSLVRADLAQLLKLSGPVVLARLGIMTMGLTDAVVVGRYSAQQLGYHALGWAPTSVMLTAVV
GLLTGIQVMTARAIGEGRRHETGAVLRRGLVYAFWVSLASTVLLALAGPPFLHVIGLEPDLADGATRALLVFSLSLTSYG
VSVAASFWLEGLARPGPAAWAMWAANVVNLGLVLLFVPGTFGLPAMGAVGAAWGTFGARTFLALALLAYIALMPEARALG
VFRKPARDRAAEAEQRRIGYGAGISNFLEVSAFASMNVIAGWIGGLAVAAWAIVLNLAAIVFMVPLGLATGAAVLVGRAY
GARDPAGVHRAGAISFAVTAVFGVIVSLAVWPAAGLISAGYTRDAATIALAAPALALSCLFFLPDALQVVAAQALRARGD
VWLPTYTHLASYIAVMMPLAWWLAIPMKLGIDGIVWAVIVASLVSCALLLGRFWLLSRRTL

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=186, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI48994890, Length=404, Percent_Identity=27.2277227722772, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48064; Mature: 48064

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVMDRPAAQASSLAGERSSLVRADLAQLLKLSGPVVLARLGIMTMGLTDAVVVGRYSAQ
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCHHH
QLGYHALGWAPTSVMLTAVVGLLTGIQVMTARAIGEGRRHETGAVLRRGLVYAFWVSLAS
HCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TVLLALAGPPFLHVIGLEPDLADGATRALLVFSLSLTSYGVSVAASFWLEGLARPGPAAW
HHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AMWAANVVNLGLVLLFVPGTFGLPAMGAVGAAWGTFGARTFLALALLAYIALMPEARALG
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VFRKPARDRAAEAEQRRIGYGAGISNFLEVSAFASMNVIAGWIGGLAVAAWAIVLNLAAI
HHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFMVPLGLATGAAVLVGRAYGARDPAGVHRAGAISFAVTAVFGVIVSLAVWPAAGLISAG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YTRDAATIALAAPALALSCLFFLPDALQVVAAQALRARGDVWLPTYTHLASYIAVMMPLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
WWLAIPMKLGIDGIVWAVIVASLVSCALLLGRFWLLSRRTL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVMDRPAAQASSLAGERSSLVRADLAQLLKLSGPVVLARLGIMTMGLTDAVVVGRYSAQ
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCHHH
QLGYHALGWAPTSVMLTAVVGLLTGIQVMTARAIGEGRRHETGAVLRRGLVYAFWVSLAS
HCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TVLLALAGPPFLHVIGLEPDLADGATRALLVFSLSLTSYGVSVAASFWLEGLARPGPAAW
HHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AMWAANVVNLGLVLLFVPGTFGLPAMGAVGAAWGTFGARTFLALALLAYIALMPEARALG
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VFRKPARDRAAEAEQRRIGYGAGISNFLEVSAFASMNVIAGWIGGLAVAAWAIVLNLAAI
HHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFMVPLGLATGAAVLVGRAYGARDPAGVHRAGAISFAVTAVFGVIVSLAVWPAAGLISAG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YTRDAATIALAAPALALSCLFFLPDALQVVAAQALRARGDVWLPTYTHLASYIAVMMPLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
WWLAIPMKLGIDGIVWAVIVASLVSCALLLGRFWLLSRRTL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]