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The map label for this gene is serS

Identifier: 197105423

GI number: 197105423

Start: 2193934

End: 2195214

Strand: Reverse

Name: serS

Synonym: PHZ_c1960

Alternate gene names: 197105423

Gene position: 2195214-2193934 (Counterclockwise)

Preceding gene: 197105424

Following gene: 197105422

Centisome position: 54.93

GC content: 71.43

Gene sequence:

>1281_bases
ATGCACGACATCCGAGCCATCCGCGAAACCCCCGAGCTTTACGAGAAAGCCTGGGCCGCGAAGGGCTCGCCCGGCAAGGT
CGCCGAGATCCTGAAGCTGGACGAGGCCCTGCGCGCCGCCCAGACCGCCCTGCAGGCGGCCCAGGCCGAGCGCAACGAGG
CCTCCAAGAAGATCGGCCAGGCCAAGGCGCAGAAGGACGAGGCCGAGGCCACGCGGCTGATGGCCCACGTCGAGACCCTG
AAGAAGGCGCTGGAGGAGCAGGGCGAGGTCGAGCGCTCGGCCGGCGAGGCGCTGCGCGCCCTCCTGGCCGGCCTGCCGAA
CATCCCCGCCGCCGAGGTGCCGGACGGCGCCGACGAGCACGACAACGTCGAGGTCCGCCGCTGGGGCGAGCCGCGCGCGA
TCGCCGCGCCCAAGGACCACGCGACCCTCGGCGAGGCGATGGGCCTGATGGACTTCGAGGCCGCGGCCCGCATGAGCGGC
GCCCGCTTCGTGGTGCTGAAGGGCCAGCTCGCCCGTCTGGAGCGCGCGCTCGGCCAGTTCATGCTGGACCTGCAGACCCA
GGAGCACGGCTACACCGAGGTGAACCCGCCGCTGCTGGTCAACGACGCGGCTGCCTACGGCACCGACAAGCTGCCGAAGT
TCGCCGAGGACCTGTTCCAGACGACGGACGGCCGCTGGCTGATCCCCACGGCCGAGGTGCCGCTGACCAGCCTGGTCATG
GGCCAGATCGTCGCCGAGGAGGAGCTGCCGCTCCGCTACACGGCCCTGACGCCGTGCTTCCGCTCCGAGGCCGGGGCCTC
GGGACGCGACACCCGCGGCATGATCCGCCAGCACCAGTTCAACAAGGTCGAGCTCGTCTCCATCACCACGCCCGAGCAGT
CGGCGGACGAGCACGAGCGGATGGTGGGCTGCGCCGAGGCCGTGCTGAAGCGGCTCGAGCTGCCGTTCCGCACCATGCTG
CTGTGCCGCGGCGACATGGGCTTCGGGGCCCGCAAGACCTACGACCTCGAGGTCTGGCTGCCGTCCCAGGAGAAGTACCG
CGAGATCAGCTCCTGCTCGAACACCGGCGACTTCCAGGCCCGCCGCATGGACGCCCGCGCCAAGAAGGCCGGCGAGAAGG
GCACGCGCTACGTCCACACGCTCAACGGCTCGGGCTTGGCCGTCGGCCGCACGCTGGTGGCCGTGCTGGAGAACTACCAG
GACGAGGGCGGCCGGATCGCCATCCCCGAGGCCCTGCGCCCGTACATGCCGGGGATGACCCACATCGGGGGCGCGGCTTG
A

Upstream 100 bases:

>100_bases
AAGGACGTCGTGCCGACCTGACGCGGCTTCTTGGCCGGCCCTTCTTGGCGCCTGTTCCGACGCGCTCTAGAGAGGTCCGC
TCAACCGACAAGCGGGCCCC

Downstream 100 bases:

>100_bases
GGATTCTCATCACCAACGACGACGGGATCAACGCCGACGGCCTCGCGGCGCTGGAGCGCATCGCCGCCCAGCTGTCGGAC
GACGTCTGGGTCTGCGCGCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHDIRAIRETPELYEKAWAAKGSPGKVAEILKLDEALRAAQTALQAAQAERNEASKKIGQAKAQKDEAEATRLMAHVETL
KKALEEQGEVERSAGEALRALLAGLPNIPAAEVPDGADEHDNVEVRRWGEPRAIAAPKDHATLGEAMGLMDFEAAARMSG
ARFVVLKGQLARLERALGQFMLDLQTQEHGYTEVNPPLLVNDAAAYGTDKLPKFAEDLFQTTDGRWLIPTAEVPLTSLVM
GQIVAEEELPLRYTALTPCFRSEAGASGRDTRGMIRQHQFNKVELVSITTPEQSADEHERMVGCAEAVLKRLELPFRTML
LCRGDMGFGARKTYDLEVWLPSQEKYREISSCSNTGDFQARRMDARAKKAGEKGTRYVHTLNGSGLAVGRTLVAVLENYQ
DEGGRIAIPEALRPYMPGMTHIGGAA

Sequences:

>Translated_426_residues
MHDIRAIRETPELYEKAWAAKGSPGKVAEILKLDEALRAAQTALQAAQAERNEASKKIGQAKAQKDEAEATRLMAHVETL
KKALEEQGEVERSAGEALRALLAGLPNIPAAEVPDGADEHDNVEVRRWGEPRAIAAPKDHATLGEAMGLMDFEAAARMSG
ARFVVLKGQLARLERALGQFMLDLQTQEHGYTEVNPPLLVNDAAAYGTDKLPKFAEDLFQTTDGRWLIPTAEVPLTSLVM
GQIVAEEELPLRYTALTPCFRSEAGASGRDTRGMIRQHQFNKVELVSITTPEQSADEHERMVGCAEAVLKRLELPFRTML
LCRGDMGFGARKTYDLEVWLPSQEKYREISSCSNTGDFQARRMDARAKKAGEKGTRYVHTLNGSGLAVGRTLVAVLENYQ
DEGGRIAIPEALRPYMPGMTHIGGAA
>Mature_426_residues
MHDIRAIRETPELYEKAWAAKGSPGKVAEILKLDEALRAAQTALQAAQAERNEASKKIGQAKAQKDEAEATRLMAHVETL
KKALEEQGEVERSAGEALRALLAGLPNIPAAEVPDGADEHDNVEVRRWGEPRAIAAPKDHATLGEAMGLMDFEAAARMSG
ARFVVLKGQLARLERALGQFMLDLQTQEHGYTEVNPPLLVNDAAAYGTDKLPKFAEDLFQTTDGRWLIPTAEVPLTSLVM
GQIVAEEELPLRYTALTPCFRSEAGASGRDTRGMIRQHQFNKVELVSITTPEQSADEHERMVGCAEAVLKRLELPFRTML
LCRGDMGFGARKTYDLEVWLPSQEKYREISSCSNTGDFQARRMDARAKKAGEKGTRYVHTLNGSGLAVGRTLVAVLENYQ
DEGGRIAIPEALRPYMPGMTHIGGAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=453, Percent_Identity=31.1258278145695, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI8923421, Length=401, Percent_Identity=27.930174563591, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI225579074, Length=320, Percent_Identity=30.625, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=54.7344110854504, Blast_Score=453, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17539260, Length=452, Percent_Identity=28.9823008849558, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=31.2302839116719, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=32.4263038548753, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=381, Percent_Identity=29.6587926509186, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24581334, Length=322, Percent_Identity=34.1614906832298, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17737985, Length=361, Percent_Identity=32.1329639889197, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PHEZH (B4RDI1)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130800.1
- GeneID:   6791476
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1960
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46701; Mature: 46701

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRAIRETPELYEKAWAAKGSPGKVAEILKLDEALRAAQTALQAAQAERNEASKKIGQ
CCCHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAQKDEAEATRLMAHVETLKKALEEQGEVERSAGEALRALLAGLPNIPAAEVPDGADEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DNVEVRRWGEPRAIAAPKDHATLGEAMGLMDFEAAARMSGARFVVLKGQLARLERALGQF
CCCEEEECCCCCEECCCCCHHHHHHHHCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
MLDLQTQEHGYTEVNPPLLVNDAAAYGTDKLPKFAEDLFQTTDGRWLIPTAEVPLTSLVM
HHHHHHCCCCCCCCCCCEEEECHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHH
GQIVAEEELPLRYTALTPCFRSEAGASGRDTRGMIRQHQFNKVELVSITTPEQSADEHER
HHHHHHCCCCEEEEHHCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
MVGCAEAVLKRLELPFRTMLLCRGDMGFGARKTYDLEVWLPSQEKYREISSCSNTGDFQA
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCHHH
RRMDARAKKAGEKGTRYVHTLNGSGLAVGRTLVAVLENYQDEGGRIAIPEALRPYMPGMT
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEECHHHHHHHCCCCC
HIGGAA
CCCCCC
>Mature Secondary Structure
MHDIRAIRETPELYEKAWAAKGSPGKVAEILKLDEALRAAQTALQAAQAERNEASKKIGQ
CCCHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAQKDEAEATRLMAHVETLKKALEEQGEVERSAGEALRALLAGLPNIPAAEVPDGADEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DNVEVRRWGEPRAIAAPKDHATLGEAMGLMDFEAAARMSGARFVVLKGQLARLERALGQF
CCCEEEECCCCCEECCCCCHHHHHHHHCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
MLDLQTQEHGYTEVNPPLLVNDAAAYGTDKLPKFAEDLFQTTDGRWLIPTAEVPLTSLVM
HHHHHHCCCCCCCCCCCEEEECHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHH
GQIVAEEELPLRYTALTPCFRSEAGASGRDTRGMIRQHQFNKVELVSITTPEQSADEHER
HHHHHHCCCCEEEEHHCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
MVGCAEAVLKRLELPFRTMLLCRGDMGFGARKTYDLEVWLPSQEKYREISSCSNTGDFQA
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCHHH
RRMDARAKKAGEKGTRYVHTLNGSGLAVGRTLVAVLENYQDEGGRIAIPEALRPYMPGMT
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEECHHHHHHHCCCCC
HIGGAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA