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The map label for this gene is mexA [H]

Identifier: 197105389

GI number: 197105389

Start: 2156644

End: 2157723

Strand: Direct

Name: mexA [H]

Synonym: PHZ_c1926

Alternate gene names: 197105389

Gene position: 2156644-2157723 (Clockwise)

Preceding gene: 197105387

Following gene: 197105390

Centisome position: 53.97

GC content: 73.7

Gene sequence:

>1080_bases
TTGCGACGTCTCAAGCCGCAGTACGTCTTCATCCTGGTGGTGATCGGGCTGTTCACCCTCTACTTCGTCGCGGGCGCGCT
GTTCCGCGGCGGCGGCGAGGACCGCAACGCCGCCCAGGCCAAGGCCGTGGCCGACGCCGAAGCTCCGCCCAGCGTTCAGG
TGCGCGTGACGCCCGAGACCGTCCGTCAGGTGGACGTGGTCCTGCGCGGCCGGACCGAGGCCGCGCGCGCCGTCGTGGTG
CGGTCCGAGACGGCCGGGGTCGTCGCCGAGACGCCGGCGCGCGAAGGAAGCTTCGTGCGCAAGGGTCAGGTGCTGTGCCG
CCTGGCCGTCGACGCCCGCCAGGCGACGCTGGATCAGGCCAGGGCCAACCTCCGCTCGCGCCAGCTCCAGCTCCAGGCCG
CCCGGCAGCTCGCCGAGAAGGGCTACCGCTCGCAGACCCAGGTGCTGGAGACCCAGGCGGCGCTCGACGCGGCCCAGGCG
CAGGTGCGCCAGACCGAGATCGCGCTGTCGCAGGTGAACATCCGCGCTCCGTTCGCCGGCGTCTTCGACCGCCGCGACGC
CGAGATCGGGACCTACCTCGCTCCCGGCCAGCCGTGCGGGACCATGATCGAACTGAACCCGCTGCTGGTGGTGGGCCACG
TGCCCGAGACGGACGCCACCCGGCTGCGCGTCGGCGCGCCGGCGACCGCCCGGCTGGTGGACGGGCGCGCCCTGAGCGGC
CGGGTGCGCTACGTCGGCCAGGACGCCGATCCCCAGACCCGCACCTACCCGCTGGAAGTCGCCGTGCAGAACCCCGCCAT
GGACGTCCGCTCGGGCCTGTCGGCCGAGCTCCGGATAGGCGCGGGCTCCGGCGCGGCCCACCTCGTGCCCGTCTCGGCCC
TGGTGCTCGACGCCGACGGCCGCCAGGGCGTGCGCTACGTCCTGGCCGACAATCGCGTGGCCTTCGCCCCGGTGCGGGTC
CTCGAGCAGACCGCCGAGGGCATGTGGGTGCAGGGCCTGTCCGGAAACGTCCGGGTGATCACCGTGGGTCAGTCGTTCGT
GGCCGACGGCCAGAAGGTTCGTGTCGCCCAGGCGCGCTAG

Upstream 100 bases:

>100_bases
TCATTTGCCCTCGCATAACGCGGGCATCACAAGCGCAGTTCGGAGGACGTCCGCGAACGAGCATCGGCTCGCGCGGACGA
CGGGGCACGAGGAAACGAAG

Downstream 100 bases:

>100_bases
CGCCCGGTCGGCCCTGGAGAGGCGAGCATGATCGGCCCCCTGATCGACGGAGCCATCAAGCGACGGAAGGTCGTGCTGGG
CGTGACGCTCATCGCGGCGC

Product: efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MRRLKPQYVFILVVIGLFTLYFVAGALFRGGGEDRNAAQAKAVADAEAPPSVQVRVTPETVRQVDVVLRGRTEAARAVVV
RSETAGVVAETPAREGSFVRKGQVLCRLAVDARQATLDQARANLRSRQLQLQAARQLAEKGYRSQTQVLETQAALDAAQA
QVRQTEIALSQVNIRAPFAGVFDRRDAEIGTYLAPGQPCGTMIELNPLLVVGHVPETDATRLRVGAPATARLVDGRALSG
RVRYVGQDADPQTRTYPLEVAVQNPAMDVRSGLSAELRIGAGSGAAHLVPVSALVLDADGRQGVRYVLADNRVAFAPVRV
LEQTAEGMWVQGLSGNVRVITVGQSFVADGQKVRVAQAR

Sequences:

>Translated_359_residues
MRRLKPQYVFILVVIGLFTLYFVAGALFRGGGEDRNAAQAKAVADAEAPPSVQVRVTPETVRQVDVVLRGRTEAARAVVV
RSETAGVVAETPAREGSFVRKGQVLCRLAVDARQATLDQARANLRSRQLQLQAARQLAEKGYRSQTQVLETQAALDAAQA
QVRQTEIALSQVNIRAPFAGVFDRRDAEIGTYLAPGQPCGTMIELNPLLVVGHVPETDATRLRVGAPATARLVDGRALSG
RVRYVGQDADPQTRTYPLEVAVQNPAMDVRSGLSAELRIGAGSGAAHLVPVSALVLDADGRQGVRYVLADNRVAFAPVRV
LEQTAEGMWVQGLSGNVRVITVGQSFVADGQKVRVAQAR
>Mature_359_residues
MRRLKPQYVFILVVIGLFTLYFVAGALFRGGGEDRNAAQAKAVADAEAPPSVQVRVTPETVRQVDVVLRGRTEAARAVVV
RSETAGVVAETPAREGSFVRKGQVLCRLAVDARQATLDQARANLRSRQLQLQAARQLAEKGYRSQTQVLETQAALDAAQA
QVRQTEIALSQVNIRAPFAGVFDRRDAEIGTYLAPGQPCGTMIELNPLLVVGHVPETDATRLRVGAPATARLVDGRALSG
RVRYVGQDADPQTRTYPLEVAVQNPAMDVRSGLSAELRIGAGSGAAHLVPVSALVLDADGRQGVRYVLADNRVAFAPVRV
LEQTAEGMWVQGLSGNVRVITVGQSFVADGQKVRVAQAR

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor. Note=The membrane anchor is not necessary for antibiotic efflux as the protein is functional when targeted to the periplasm by a foreign signal peptide [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081951, Length=188, Percent_Identity=28.7234042553192, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38488; Mature: 38488

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLKPQYVFILVVIGLFTLYFVAGALFRGGGEDRNAAQAKAVADAEAPPSVQVRVTPET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEECHHH
VRQVDVVLRGRTEAARAVVVRSETAGVVAETPAREGSFVRKGQVLCRLAVDARQATLDQA
HHHHHHHCCCCCHHHEEEEEECCCCCEEEECCCCCCCCEECCCEEEEEEHHHHHHHHHHH
RANLRSRQLQLQAARQLAEKGYRSQTQVLETQAALDAAQAQVRQTEIALSQVNIRAPFAG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
VFDRRDAEIGTYLAPGQPCGTMIELNPLLVVGHVPETDATRLRVGAPATARLVDGRALSG
HCCCCCCCCCCEECCCCCCCCEEEECCEEEEECCCCCCCCEEEECCCCCEEEECCCCCCC
RVRYVGQDADPQTRTYPLEVAVQNPAMDVRSGLSAELRIGAGSGAAHLVPVSALVLDADG
EEEEECCCCCCCCCEEEEEEEEECCCHHHHCCCCEEEEEECCCCCEEEEEEEEEEEECCC
RQGVRYVLADNRVAFAPVRVLEQTAEGMWVQGLSGNVRVITVGQSFVADGQKVRVAQAR
CCCEEEEEECCCEEEHHHHHHHHHHCCEEEECCCCCEEEEEECCHHHCCCCEEEEECCC
>Mature Secondary Structure
MRRLKPQYVFILVVIGLFTLYFVAGALFRGGGEDRNAAQAKAVADAEAPPSVQVRVTPET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEECHHH
VRQVDVVLRGRTEAARAVVVRSETAGVVAETPAREGSFVRKGQVLCRLAVDARQATLDQA
HHHHHHHCCCCCHHHEEEEEECCCCCEEEECCCCCCCCEECCCEEEEEEHHHHHHHHHHH
RANLRSRQLQLQAARQLAEKGYRSQTQVLETQAALDAAQAQVRQTEIALSQVNIRAPFAG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
VFDRRDAEIGTYLAPGQPCGTMIELNPLLVVGHVPETDATRLRVGAPATARLVDGRALSG
HCCCCCCCCCCEECCCCCCCCEEEECCEEEEECCCCCCCCEEEECCCCCEEEECCCCCCC
RVRYVGQDADPQTRTYPLEVAVQNPAMDVRSGLSAELRIGAGSGAAHLVPVSALVLDADG
EEEEECCCCCCCCCEEEEEEEEECCCHHHHCCCCEEEEEECCCCCEEEEEEEEEEEECCC
RQGVRYVLADNRVAFAPVRVLEQTAEGMWVQGLSGNVRVITVGQSFVADGQKVRVAQAR
CCCEEEEEECCCEEEHHHHHHHHHHCCEEEECCCCCEEEEEECCHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968531; 10984043; 9989496; 8226684; 8540696; 9603892; 10671490 [H]