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The map label for this gene is envZ [H]

Identifier: 197105367

GI number: 197105367

Start: 2130666

End: 2132003

Strand: Direct

Name: envZ [H]

Synonym: PHZ_c1904

Alternate gene names: 197105367

Gene position: 2130666-2132003 (Clockwise)

Preceding gene: 197105366

Following gene: 197105368

Centisome position: 53.32

GC content: 73.09

Gene sequence:

>1338_bases
ATGAGTCCGGCGGGCCGGCCGACGGCCTCGTTCTTCGTCCAGCTCCTGACCCTGACCGGCCTGACGCTGGTGGCCGCCTG
GGCGATCAGCATCCTGCTGCTGTTCAGCCTGCCGCCGCCGATCCCGGACTTCTACCGCCTGAGCGAGATCCAGCGGACCT
TCGCGGGCTCTCCGCCGACCTTCACCGAGCGTCGCCCGCTGGTGCTGCGCCAGGCCTCCCGGCCTCCGGGGCCCGAGCTG
GAGGGCCGCACCATGCCGGTCATCCGCGGCAAGCTAGCCGAGGAGCTCGGGGTGGCGCCCGAGGCCATCGTCATCGCCGG
CGAACGGGGCCCCCTCTCCGACCGCCGGATCGGCCGCGTCCTGCGCGACCGCGCCGCGCGCGAGGGCATCCGGGAGGAAC
ACTTCCTGATCGCCCCGTTCCAGGTCGGCGTGCGGCAGGCGGACGGGAGCTGGAAGGTCGTGCAGACCCAGAACCGGCTG
GGCCTGTCGGACTGGCAGCAGCGCCTCGTCCTGTGGTTCGTGCTTTCGGCCCTGGCCATGGCGCCGGTGGCCTGGATCTT
CGCGCGCCGCCTCTCGGCGCCGATCAAGCTGTTCGCCAGCGCCGCCGAGCGGCTCGGCCGGGATCCGAAGGCCGCGCCGC
TGACCCTGAAGGGCCCCACCGAGATCGAGGTGGCCGCCCGCGCCTTCAACGAGATGCAGCAGCGCCTGCGCCGCTACGTC
GAGGATCGCACGGCCATGGTGGCGGCCATCGCCCACGACCTGCGCACGCCCCTCACCCGCCTGCGGTTCCGCATCGAGGC
CCTGCCCGAGGAGCAGCGGGCCAAGTTCTCCTCCGACCTCGACCAGATGGAGGAGATGATCACCGCCACGCTGGCCTTCG
TGCGCGACACCAGCCGCACCGGCGAGCGCACGCCCCTGGAGCTGTCGTCCCTGCTGGAGAGCCTCTGCGACGAGATGGCG
GAAACCGGCGCCCGGACCGAGGCCGAGCGGGGCGAGAAGGTGGTGCTGGAGGGCGATCCCATGGCGCTGCGCCGCCTGTT
CGCCAACCTGCTGGAGAACGCAGTGAAGTTCGGCGGCGGCGCCCGCGCGCGGGTGTTCCGCGAGGAGAGCCATGCGGTCG
TCGAGATCGACGACGAGGGCCCCGGCATCCCGCCGTCTGAGGCCGAGCGGGTGTTCGAGCCCTTCTACCGCCGCGAGCCG
TCCCGTAGCCGCCAGACGGGGGGTATCGGCCTGGGCCTGGCCGTGGTGCGCTCGATCGCCCGCAGCCACGGCGGCGACGT
CACGCTCGCCAACCGCAGCGGGGGCGGCCTGCGGGCCAGGGTGCTGCTGCCGCTCTGA

Upstream 100 bases:

>100_bases
GCCGGCTGCGGCGCAAGCTGGACGACGGCGGCGGGGGCCACGACCTGATCCGCACCATCCGCAACGAAGGCTACATGTTC
ACCGCCAAGGTGAAGCGGAC

Downstream 100 bases:

>100_bases
ACCGCATTTGCGGCGGGCGGATCGGACGGCCGGCCCCGCCCCTGAACGCCATCTGGGCCCTCAGGCGCGATTAAGCGTCG
CACCACGCAACCTCTGCCGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSPAGRPTASFFVQLLTLTGLTLVAAWAISILLLFSLPPPIPDFYRLSEIQRTFAGSPPTFTERRPLVLRQASRPPGPEL
EGRTMPVIRGKLAEELGVAPEAIVIAGERGPLSDRRIGRVLRDRAAREGIREEHFLIAPFQVGVRQADGSWKVVQTQNRL
GLSDWQQRLVLWFVLSALAMAPVAWIFARRLSAPIKLFASAAERLGRDPKAAPLTLKGPTEIEVAARAFNEMQQRLRRYV
EDRTAMVAAIAHDLRTPLTRLRFRIEALPEEQRAKFSSDLDQMEEMITATLAFVRDTSRTGERTPLELSSLLESLCDEMA
ETGARTEAERGEKVVLEGDPMALRRLFANLLENAVKFGGGARARVFREESHAVVEIDDEGPGIPPSEAERVFEPFYRREP
SRSRQTGGIGLGLAVVRSIARSHGGDVTLANRSGGGLRARVLLPL

Sequences:

>Translated_445_residues
MSPAGRPTASFFVQLLTLTGLTLVAAWAISILLLFSLPPPIPDFYRLSEIQRTFAGSPPTFTERRPLVLRQASRPPGPEL
EGRTMPVIRGKLAEELGVAPEAIVIAGERGPLSDRRIGRVLRDRAAREGIREEHFLIAPFQVGVRQADGSWKVVQTQNRL
GLSDWQQRLVLWFVLSALAMAPVAWIFARRLSAPIKLFASAAERLGRDPKAAPLTLKGPTEIEVAARAFNEMQQRLRRYV
EDRTAMVAAIAHDLRTPLTRLRFRIEALPEEQRAKFSSDLDQMEEMITATLAFVRDTSRTGERTPLELSSLLESLCDEMA
ETGARTEAERGEKVVLEGDPMALRRLFANLLENAVKFGGGARARVFREESHAVVEIDDEGPGIPPSEAERVFEPFYRREP
SRSRQTGGIGLGLAVVRSIARSHGGDVTLANRSGGGLRARVLLPL
>Mature_444_residues
SPAGRPTASFFVQLLTLTGLTLVAAWAISILLLFSLPPPIPDFYRLSEIQRTFAGSPPTFTERRPLVLRQASRPPGPELE
GRTMPVIRGKLAEELGVAPEAIVIAGERGPLSDRRIGRVLRDRAAREGIREEHFLIAPFQVGVRQADGSWKVVQTQNRLG
LSDWQQRLVLWFVLSALAMAPVAWIFARRLSAPIKLFASAAERLGRDPKAAPLTLKGPTEIEVAARAFNEMQQRLRRYVE
DRTAMVAAIAHDLRTPLTRLRFRIEALPEEQRAKFSSDLDQMEEMITATLAFVRDTSRTGERTPLELSSLLESLCDEMAE
TGARTEAERGEKVVLEGDPMALRRLFANLLENAVKFGGGARARVFREESHAVVEIDDEGPGIPPSEAERVFEPFYRREPS
RSRQTGGIGLGLAVVRSIARSHGGDVTLANRSGGGLRARVLLPL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=267, Percent_Identity=32.5842696629214, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787894, Length=284, Percent_Identity=31.6901408450704, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790346, Length=287, Percent_Identity=28.2229965156794, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788393, Length=308, Percent_Identity=27.9220779220779, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=27.0627062706271, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=29.0909090909091, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=33.0316742081448, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=281, Percent_Identity=28.8256227758007, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=24.6666666666667, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=26.6393442622951, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=25.5060728744939, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=255, Percent_Identity=28.6274509803922, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=23.7762237762238, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=320, Percent_Identity=27.1875, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788549, Length=217, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=22.0264317180617, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=208, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=25.4295532646048, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=24.4239631336406, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=72, Percent_Identity=43.0555555555556, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49216; Mature: 49085

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAGRPTASFFVQLLTLTGLTLVAAWAISILLLFSLPPPIPDFYRLSEIQRTFAGSPPT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
FTERRPLVLRQASRPPGPELEGRTMPVIRGKLAEELGVAPEAIVIAGERGPLSDRRIGRV
CCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
LRDRAAREGIREEHFLIAPFQVGVRQADGSWKVVQTQNRLGLSDWQQRLVLWFVLSALAM
HHHHHHHCCCCCCCEEEEHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
APVAWIFARRLSAPIKLFASAAERLGRDPKAAPLTLKGPTEIEVAARAFNEMQQRLRRYV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
EDRTAMVAAIAHDLRTPLTRLRFRIEALPEEQRAKFSSDLDQMEEMITATLAFVRDTSRT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GERTPLELSSLLESLCDEMAETGARTEAERGEKVVLEGDPMALRRLFANLLENAVKFGGG
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCC
ARARVFREESHAVVEIDDEGPGIPPSEAERVFEPFYRREPSRSRQTGGIGLGLAVVRSIA
CHHHEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
RSHGGDVTLANRSGGGLRARVLLPL
HHCCCCEEEEECCCCCEEEEEECCC
>Mature Secondary Structure 
SPAGRPTASFFVQLLTLTGLTLVAAWAISILLLFSLPPPIPDFYRLSEIQRTFAGSPPT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
FTERRPLVLRQASRPPGPELEGRTMPVIRGKLAEELGVAPEAIVIAGERGPLSDRRIGRV
CCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
LRDRAAREGIREEHFLIAPFQVGVRQADGSWKVVQTQNRLGLSDWQQRLVLWFVLSALAM
HHHHHHHCCCCCCCEEEEHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
APVAWIFARRLSAPIKLFASAAERLGRDPKAAPLTLKGPTEIEVAARAFNEMQQRLRRYV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
EDRTAMVAAIAHDLRTPLTRLRFRIEALPEEQRAKFSSDLDQMEEMITATLAFVRDTSRT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GERTPLELSSLLESLCDEMAETGARTEAERGEKVVLEGDPMALRRLFANLLENAVKFGGG
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCC
ARARVFREESHAVVEIDDEGPGIPPSEAERVFEPFYRREPSRSRQTGGIGLGLAVVRSIA
CHHHEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
RSHGGDVTLANRSGGGLRARVLLPL
HHCCCCEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]