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The map label for this gene is dapA

Identifier: 197105353

GI number: 197105353

Start: 2115940

End: 2116824

Strand: Reverse

Name: dapA

Synonym: PHZ_c1890

Alternate gene names: 197105353

Gene position: 2116824-2115940 (Counterclockwise)

Preceding gene: 197105355

Following gene: 197105352

Centisome position: 52.97

GC content: 71.75

Gene sequence:

>885_bases
ATGATCGATCCCATGTTCCGGGGCGTGCTCCCGGCCCTCGTCACGCCGTACCGTAACGGCCAGGTGGACGAGGACGCCTT
CGTCGCCCTGGTGGAGCGGCAGATCGCGGGCGGCGTCCACGGCCTGGTGCCCGTCGGCACCACCGGCGAGTCCGCCACGC
TGACCCACGAGGAGCACCGCCGGGTCGTCGAGCTGTGCGTGAAGACGGCCCGCGGCCGGGTGCCGGTCGTCGCCGGCGCC
GGCTCCAACTCCACCGCCGAGGCGATCGAGCTGGTGCGCCACGCCAAGACCGTCGGCGCCGACGCGGCCCTGGTGGTCAC
GCCCTACTACAACCGCCCCAGCCAGGAGGGGCTCTACGCCCACTACAGGGCGATCAACGACGCGGTGCAGCTGCCGATCC
TGGTCTACAACGTGCCCACCCGCACCAGCGTGGACATCTCCAACGACGTCCTCGTCCGGCTCTCGAAGCTGCCGAACGTC
GTGGGGATCAAGGACGCCACCTCGGACCTGGTCCGCGCCAGCTTCCAGCGCCTGCACTGCGGCGAGGAGTGGGTGATGCT
GTCGGGCGACGACCCGGTGGCGCTCGGCTACATGGCCCACGGCGGCCACGGCTGCATCTCGGTCACCGCCAACGTCGCCC
CTGAGCAGTGCGCCGACTTCTACAACGCCGCCCTTTCCGGCGACTGGGCGACCGCCCTCCAATGGCAGGACCGCCTGGTG
CGCCTGCACAAGGCGCTGTTCGCCGACGCCTCGCCCGCGCCGACCAAGTTCGCGCTCTCGCATCTGGGCCTGTGCTCGGA
GGAGACCCGCCTGCCGATCACCCCGGCCTCCGAGGCCGCCCGCGCCGAGGTCCTGGCCGCCATGCGGGACGCGGGCCTGA
TCTGA

Upstream 100 bases:

>100_bases
CACGGAATCAACATTGCGGGCTTGGCCCACGCCAACATATTGTCCGCCCAAATCTGAACGTCGCCCCAACAAGCGGCATC
TTCACGGCATTTTGCGCATC

Downstream 100 bases:

>100_bases
GATGGCCGGCAAGACCATCGCCGAGAACCGTCGGGCGCGGTTCGACTACTTCCTCGAGCAGACGTTCGAGGCCGGCATCG
CGCTGACCGGCTCGGAGGTG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MIDPMFRGVLPALVTPYRNGQVDEDAFVALVERQIAGGVHGLVPVGTTGESATLTHEEHRRVVELCVKTARGRVPVVAGA
GSNSTAEAIELVRHAKTVGADAALVVTPYYNRPSQEGLYAHYRAINDAVQLPILVYNVPTRTSVDISNDVLVRLSKLPNV
VGIKDATSDLVRASFQRLHCGEEWVMLSGDDPVALGYMAHGGHGCISVTANVAPEQCADFYNAALSGDWATALQWQDRLV
RLHKALFADASPAPTKFALSHLGLCSEETRLPITPASEAARAEVLAAMRDAGLI

Sequences:

>Translated_294_residues
MIDPMFRGVLPALVTPYRNGQVDEDAFVALVERQIAGGVHGLVPVGTTGESATLTHEEHRRVVELCVKTARGRVPVVAGA
GSNSTAEAIELVRHAKTVGADAALVVTPYYNRPSQEGLYAHYRAINDAVQLPILVYNVPTRTSVDISNDVLVRLSKLPNV
VGIKDATSDLVRASFQRLHCGEEWVMLSGDDPVALGYMAHGGHGCISVTANVAPEQCADFYNAALSGDWATALQWQDRLV
RLHKALFADASPAPTKFALSHLGLCSEETRLPITPASEAARAEVLAAMRDAGLI
>Mature_294_residues
MIDPMFRGVLPALVTPYRNGQVDEDAFVALVERQIAGGVHGLVPVGTTGESATLTHEEHRRVVELCVKTARGRVPVVAGA
GSNSTAEAIELVRHAKTVGADAALVVTPYYNRPSQEGLYAHYRAINDAVQLPILVYNVPTRTSVDISNDVLVRLSKLPNV
VGIKDATSDLVRASFQRLHCGEEWVMLSGDDPVALGYMAHGGHGCISVTANVAPEQCADFYNAALSGDWATALQWQDRLV
RLHKALFADASPAPTKFALSHLGLCSEETRLPITPASEAARAEVLAAMRDAGLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=29.1814946619217, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13540533, Length=248, Percent_Identity=26.2096774193548, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=45.8904109589041, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082415, Length=306, Percent_Identity=33.6601307189542, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786463, Length=244, Percent_Identity=31.5573770491803, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789620, Length=285, Percent_Identity=31.2280701754386, Blast_Score=118, Evalue=5e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PHEZH (B4RCW4)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130730.1
- ProteinModelPortal:   B4RCW4
- GeneID:   6791405
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1890
- HOGENOM:   HBG358848
- OMA:   ELLCYPM
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31453; Mature: 31453

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 164-164 BINDING 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPMFRGVLPALVTPYRNGQVDEDAFVALVERQIAGGVHGLVPVGTTGESATLTHEEHR
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHH
RVVELCVKTARGRVPVVAGAGSNSTAEAIELVRHAKTVGADAALVVTPYYNRPSQEGLYA
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHH
HYRAINDAVQLPILVYNVPTRTSVDISNDVLVRLSKLPNVVGIKDATSDLVRASFQRLHC
HHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCC
GEEWVMLSGDDPVALGYMAHGGHGCISVTANVAPEQCADFYNAALSGDWATALQWQDRLV
CCCEEEEECCCCEEEEEEEECCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLHKALFADASPAPTKFALSHLGLCSEETRLPITPASEAARAEVLAAMRDAGLI
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDPMFRGVLPALVTPYRNGQVDEDAFVALVERQIAGGVHGLVPVGTTGESATLTHEEHR
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHH
RVVELCVKTARGRVPVVAGAGSNSTAEAIELVRHAKTVGADAALVVTPYYNRPSQEGLYA
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHH
HYRAINDAVQLPILVYNVPTRTSVDISNDVLVRLSKLPNVVGIKDATSDLVRASFQRLHC
HHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCC
GEEWVMLSGDDPVALGYMAHGGHGCISVTANVAPEQCADFYNAALSGDWATALQWQDRLV
CCCEEEEECCCCEEEEEEEECCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLHKALFADASPAPTKFALSHLGLCSEETRLPITPASEAARAEVLAAMRDAGLI
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA