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The map label for this gene is ndk

Identifier: 197105283

GI number: 197105283

Start: 2037859

End: 2038278

Strand: Reverse

Name: ndk

Synonym: PHZ_c1820

Alternate gene names: 197105283

Gene position: 2038278-2037859 (Counterclockwise)

Preceding gene: 197105286

Following gene: 197105282

Centisome position: 51.0

GC content: 66.19

Gene sequence:

>420_bases
ATGACCGAACGCACCTTCTCGATCATCAAGCCGGACGCCACGCGGCGGAACCTGACCGGCAAGGTCAACGCGGTGATCGA
GGACGCCGGCCTGCGCATCGTCGCCCAGAAACGCATCCGCATGAGCCGCGCCCAGGCCGAGAAGTTCTACGAGGTCCACA
AGGAGCGCCCGTTCTTCGGCGAGCTGGTGGAGTTCATGACCTCGGCCCCCGTCGTGGTGCAGGTGCTGGAGGGCGAGAAC
GCCGTGGCCCGCTACCGCGAAGTCATGGGCGCGACGAACCCGGCCCAGGCCGCCGACGGCACGATCCGCAAGCTGTACGC
CGAGAGCGTCGGCGAGAATTCGGTGCACGGCTCGGACAGCCTGGAGAACGCGAAGATCGAGATCGCGCAGTTCTTCACCG
AGGACGAAATCGTCGGCTGA

Upstream 100 bases:

>100_bases
ATCGCAGCGCCCTTGGCGAGGCGGGGCCTTGCCGCTATAGAGCGCGCCACCTCGCGGGCCGACCGCGATCCCTCCCTGAC
GCACAAGAACAAGAAGACCC

Downstream 100 bases:

>100_bases
GCCGCAACGACTTCGCCGCCGGGGGGTTACCCCCGGCACAGCCCATTCCTAGATTCAAGGTAGCATGAGAGAGTCCAAGC
TTCCGGACTTCTCCGAGCGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MTERTFSIIKPDATRRNLTGKVNAVIEDAGLRIVAQKRIRMSRAQAEKFYEVHKERPFFGELVEFMTSAPVVVQVLEGEN
AVARYREVMGATNPAQAADGTIRKLYAESVGENSVHGSDSLENAKIEIAQFFTEDEIVG

Sequences:

>Translated_139_residues
MTERTFSIIKPDATRRNLTGKVNAVIEDAGLRIVAQKRIRMSRAQAEKFYEVHKERPFFGELVEFMTSAPVVVQVLEGEN
AVARYREVMGATNPAQAADGTIRKLYAESVGENSVHGSDSLENAKIEIAQFFTEDEIVG
>Mature_138_residues
TERTFSIIKPDATRRNLTGKVNAVIEDAGLRIVAQKRIRMSRAQAEKFYEVHKERPFFGELVEFMTSAPVVVQVLEGENA
VARYREVMGATNPAQAADGTIRKLYAESVGENSVHGSDSLENAKIEIAQFFTEDEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.1176470588235, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.8529411764706, Blast_Score=119, Evalue=7e-28,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.8529411764706, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.8529411764706, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.8529411764706, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.8529411764706, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.7956204379562, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.7956204379562, Blast_Score=115, Evalue=8e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=36.7647058823529, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=33.0827067669173, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=33.0827067669173, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=33.5820895522388, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=29.1970802919708, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=55.8823529411765, Blast_Score=156, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=44.8529411764706, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=39.4160583941606, Blast_Score=113, Evalue=8e-27,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=46.3235294117647, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18860097, Length=141, Percent_Identity=31.9148936170213, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PHEZH (B4RCP4)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130660.1
- GeneID:   6791335
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1820
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15462; Mature: 15330

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTFSIIKPDATRRNLTGKVNAVIEDAGLRIVAQKRIRMSRAQAEKFYEVHKERPFFG
CCCCCCEEECCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELVEFMTSAPVVVQVLEGENAVARYREVMGATNPAQAADGTIRKLYAESVGENSVHGSDS
HHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
LENAKIEIAQFFTEDEIVG
CCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TERTFSIIKPDATRRNLTGKVNAVIEDAGLRIVAQKRIRMSRAQAEKFYEVHKERPFFG
CCCCCEEECCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELVEFMTSAPVVVQVLEGENAVARYREVMGATNPAQAADGTIRKLYAESVGENSVHGSDS
HHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
LENAKIEIAQFFTEDEIVG
CCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA