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The map label for this gene is hapE [H]

Identifier: 197105270

GI number: 197105270

Start: 2020841

End: 2022766

Strand: Reverse

Name: hapE [H]

Synonym: PHZ_c1807

Alternate gene names: 197105270

Gene position: 2022766-2020841 (Counterclockwise)

Preceding gene: 197105271

Following gene: 197105269

Centisome position: 50.62

GC content: 67.96

Gene sequence:

>1926_bases
ATGGCCGAGCAACGGGCCGATCTCGACGAGATCCTGAAGGACGCGCACCTTCCGTCGCTGATGGCGGCGCTGGTCCACAT
GACCGGCGATCCGGGCTTCATCCGACCCGAGTGGGCGCCGACCTACAATCCGATGGAGCGCGAGGACATCGGCCTGTCGT
CCGAGACCCAGGCCGAGATGCGGAGCGAGGCGAAGGCGGCGATCCAGGCGTTCCTCGACGGCCGCCCGCTGCAGCTTCGC
GAGCCCGACGGGGCGACCCTGCGCCGGATGATCGACTTCGTGGCCGGCGCTCCGATCCCCGAAGGCTACGCCGATTTCCT
GACGGACGAGCTGGCCCTGGCCGGCAAGTCCACCAAGGACCCCCAGTTCGAGCAGCCGCGCCTGAAGGAGGCGGCCCGCA
AGCTGAAGGTGCTGGTGATCGGCGCGGGCATGTCGGGGATCCTGACCGGCATCCGGCTGTCGCAGGCCGGGGTGCCCTTC
GAGATCGTCGACAAGAACCCCGACGTGGGGGGGACCTGGTTCGAGAACACCTATCCCGGCTGCCGCGTCGACAACTCGAA
CCACATGTACAGCTACTCGTTCGAGCCGAACCATTTCTGGCCGCAGCACTTCTCGACCCAGCCGGTCCTGCTCAGCTATT
TCCGCGGGATCGCCGAGAAGTACGGCCTGCGCCAGCACATCCGCTTCGAGACGTTCGTCGAGCAACTGACCTGGGACGAG
GCCAAGGCCGTCTGGCGGGTCGAGATGCGCGGCAAGGACGGTCAGCGCGAGGTCGTCGAGGCCAACGCCGTCGTCACCGC
GGTGGGCCAGCTGAACCGGCCGCGGTTCCCCGACATCGAGGGCATGGGCAGCTTCGAGGGGCCGGCCTTCCACTCTGCGG
AGTGGCGGCACGACGTCGATCTGAAGGGCAAACGCGTGGCGGTGATCGGCACCGGCGCCTCGGCCTATCAGTTCGTGCCC
GAGATCGCGCCCGAGGTGGCGAGCCTGAAGGTGTTCCAGCGGACCCCGCCCTGGGGCCTGCCTGCGCCGCACTACCACGA
GAACGTGCCCGAGGGCATGAAGTGGCTGCTGGAGCACGTGCCCTACTACGACAAGTGGTACCGCTTCTGGCTGTTCTGGA
TGGTCACCGACGGCTTCCTGCCGATGGTCAAGGCCGACCCGACCTGGAACGGCGGCCCCGCGGCCGTGGGTCCCGAGAAC
GCCATGCTGCGCGAGATGTGCGTGCAGTCGATCATGGCCCAGGTCGCCGACCGGCCGGACCTGCTGCCCAAGGTGGTCCC
CGACTACCCGATCGGCGGCAAGCGGGCGGTGCTGGACAACGGCGTCTGGCTGGCGGCGCTCAAGCGGCCGAACGTGGACC
TCATCACCGACAGGATCGTGAGGATCACGCCCAAGGGCGTGGTCACCGCCGACGGGGCCGAGCACGAGGTGGACGTCATC
ATCTACGGCACCGGCTTCCAGGCCTCGAACTTCCTGTCGTTCCTGAAGGTGAAGGGCCGGGGCGGGCGCGACCTGCACGA
GAGCTGGGGCGGCGATGCGCGCGCCTACCTGGGGATCACCAACCCGGGCTTCCCGAACCTGTTCATGATCTACGGACCCA
ACACCAACATCGTGGTCAACGGCTCGATCGTGTTCTTCTCGGAGTGCGCCGTCCGCTACATCGTCGGCTGCCTGAAGCTT
CTGGCCGAGACCGGCGCGCGAGCCCTGGAGCCGAAGCGCGAGGTGCACGATGCGTTCAACGCGCGGGTGGACGAGGCGAA
CAAGGGCTGGGCCTGGGGCTCGCCGCACGTGTCGAGCTGGTACAAGAACGCGTTCGGCCGCGTCAGCCAGAACTGGCCGT
TCGGCCTGATCGACTACTGGCGCGCCACGCTGGCGCCGAATCCGGACGACTACGTTCTGGAGAAGGCCCCGGAGGCCGTC
GCCTGA

Upstream 100 bases:

>100_bases
GCCTGACCTGACCTCACGTCCTGACGTGGCGTGAGGCCTTCCGCTCCCGGATCGGGGGAGTCATGCTCGGCTCAAGAACA
ACGATAAGCTGGGTAGGAAC

Downstream 100 bases:

>100_bases
CCTGAACCGAAAGAGAGGCCCGCATGCGCGCAGCCGTCCTGACCCTCGCCCTCGCGCCGTTGCTGATCGGGGCCTGGGGA
TGCCAGCGGACGGACGCGGC

Product: 4-hydroxyacetophenone monooxygenase

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MAEQRADLDEILKDAHLPSLMAALVHMTGDPGFIRPEWAPTYNPMEREDIGLSSETQAEMRSEAKAAIQAFLDGRPLQLR
EPDGATLRRMIDFVAGAPIPEGYADFLTDELALAGKSTKDPQFEQPRLKEAARKLKVLVIGAGMSGILTGIRLSQAGVPF
EIVDKNPDVGGTWFENTYPGCRVDNSNHMYSYSFEPNHFWPQHFSTQPVLLSYFRGIAEKYGLRQHIRFETFVEQLTWDE
AKAVWRVEMRGKDGQREVVEANAVVTAVGQLNRPRFPDIEGMGSFEGPAFHSAEWRHDVDLKGKRVAVIGTGASAYQFVP
EIAPEVASLKVFQRTPPWGLPAPHYHENVPEGMKWLLEHVPYYDKWYRFWLFWMVTDGFLPMVKADPTWNGGPAAVGPEN
AMLREMCVQSIMAQVADRPDLLPKVVPDYPIGGKRAVLDNGVWLAALKRPNVDLITDRIVRITPKGVVTADGAEHEVDVI
IYGTGFQASNFLSFLKVKGRGGRDLHESWGGDARAYLGITNPGFPNLFMIYGPNTNIVVNGSIVFFSECAVRYIVGCLKL
LAETGARALEPKREVHDAFNARVDEANKGWAWGSPHVSSWYKNAFGRVSQNWPFGLIDYWRATLAPNPDDYVLEKAPEAV
A

Sequences:

>Translated_641_residues
MAEQRADLDEILKDAHLPSLMAALVHMTGDPGFIRPEWAPTYNPMEREDIGLSSETQAEMRSEAKAAIQAFLDGRPLQLR
EPDGATLRRMIDFVAGAPIPEGYADFLTDELALAGKSTKDPQFEQPRLKEAARKLKVLVIGAGMSGILTGIRLSQAGVPF
EIVDKNPDVGGTWFENTYPGCRVDNSNHMYSYSFEPNHFWPQHFSTQPVLLSYFRGIAEKYGLRQHIRFETFVEQLTWDE
AKAVWRVEMRGKDGQREVVEANAVVTAVGQLNRPRFPDIEGMGSFEGPAFHSAEWRHDVDLKGKRVAVIGTGASAYQFVP
EIAPEVASLKVFQRTPPWGLPAPHYHENVPEGMKWLLEHVPYYDKWYRFWLFWMVTDGFLPMVKADPTWNGGPAAVGPEN
AMLREMCVQSIMAQVADRPDLLPKVVPDYPIGGKRAVLDNGVWLAALKRPNVDLITDRIVRITPKGVVTADGAEHEVDVI
IYGTGFQASNFLSFLKVKGRGGRDLHESWGGDARAYLGITNPGFPNLFMIYGPNTNIVVNGSIVFFSECAVRYIVGCLKL
LAETGARALEPKREVHDAFNARVDEANKGWAWGSPHVSSWYKNAFGRVSQNWPFGLIDYWRATLAPNPDDYVLEKAPEAV
A
>Mature_640_residues
AEQRADLDEILKDAHLPSLMAALVHMTGDPGFIRPEWAPTYNPMEREDIGLSSETQAEMRSEAKAAIQAFLDGRPLQLRE
PDGATLRRMIDFVAGAPIPEGYADFLTDELALAGKSTKDPQFEQPRLKEAARKLKVLVIGAGMSGILTGIRLSQAGVPFE
IVDKNPDVGGTWFENTYPGCRVDNSNHMYSYSFEPNHFWPQHFSTQPVLLSYFRGIAEKYGLRQHIRFETFVEQLTWDEA
KAVWRVEMRGKDGQREVVEANAVVTAVGQLNRPRFPDIEGMGSFEGPAFHSAEWRHDVDLKGKRVAVIGTGASAYQFVPE
IAPEVASLKVFQRTPPWGLPAPHYHENVPEGMKWLLEHVPYYDKWYRFWLFWMVTDGFLPMVKADPTWNGGPAAVGPENA
MLREMCVQSIMAQVADRPDLLPKVVPDYPIGGKRAVLDNGVWLAALKRPNVDLITDRIVRITPKGVVTADGAEHEVDVII
YGTGFQASNFLSFLKVKGRGGRDLHESWGGDARAYLGITNPGFPNLFMIYGPNTNIVVNGSIVFFSECAVRYIVGCLKLL
AETGARALEPKREVHDAFNARVDEANKGWAWGSPHVSSWYKNAFGRVSQNWPFGLIDYWRATLAPNPDDYVLEKAPEAVA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=217, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI50541965, Length=217, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI50541961, Length=217, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI4503755, Length=219, Percent_Identity=28.310502283105, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI4503759, Length=219, Percent_Identity=26.4840182648402, Blast_Score=70, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25145785, Length=215, Percent_Identity=25.5813953488372, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921694, Length=252, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 71586; Mature: 71455

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQRADLDEILKDAHLPSLMAALVHMTGDPGFIRPEWAPTYNPMEREDIGLSSETQAEM
CCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHCCCCCHHHHHH
RSEAKAAIQAFLDGRPLQLREPDGATLRRMIDFVAGAPIPEGYADFLTDELALAGKSTKD
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
PQFEQPRLKEAARKLKVLVIGAGMSGILTGIRLSQAGVPFEIVDKNPDVGGTWFENTYPG
CCCCCCHHHHHHHHEEEEEEECCHHHHHHHHEECCCCCCEEEECCCCCCCCCCCCCCCCC
CRVDNSNHMYSYSFEPNHFWPQHFSTQPVLLSYFRGIAEKYGLRQHIRFETFVEQLTWDE
CEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AKAVWRVEMRGKDGQREVVEANAVVTAVGQLNRPRFPDIEGMGSFEGPAFHSAEWRHDVD
HCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LKGKRVAVIGTGASAYQFVPEIAPEVASLKVFQRTPPWGLPAPHYHENVPEGMKWLLEHV
CCCCEEEEEECCCHHHHHHHHHHHHHHHEEHEECCCCCCCCCCCCCCCCHHHHHHHHHHC
PYYDKWYRFWLFWMVTDGFLPMVKADPTWNGGPAAVGPENAMLREMCVQSIMAQVADRPD
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
LLPKVVPDYPIGGKRAVLDNGVWLAALKRPNVDLITDRIVRITPKGVVTADGAEHEVDVI
CCHHHCCCCCCCCCEEEEECCEEEEEECCCCCCEECCCEEEECCCCEEEECCCCCEEEEE
IYGTGFQASNFLSFLKVKGRGGRDLHESWGGDARAYLGITNPGFPNLFMIYGPNTNIVVN
EEECCCCHHHHHHHHEECCCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCEEEE
GSIVFFSECAVRYIVGCLKLLAETGARALEPKREVHDAFNARVDEANKGWAWGSPHVSSW
CCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
YKNAFGRVSQNWPFGLIDYWRATLAPNPDDYVLEKAPEAVA
HHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
AEQRADLDEILKDAHLPSLMAALVHMTGDPGFIRPEWAPTYNPMEREDIGLSSETQAEM
CCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHCCCCCHHHHHH
RSEAKAAIQAFLDGRPLQLREPDGATLRRMIDFVAGAPIPEGYADFLTDELALAGKSTKD
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
PQFEQPRLKEAARKLKVLVIGAGMSGILTGIRLSQAGVPFEIVDKNPDVGGTWFENTYPG
CCCCCCHHHHHHHHEEEEEEECCHHHHHHHHEECCCCCCEEEECCCCCCCCCCCCCCCCC
CRVDNSNHMYSYSFEPNHFWPQHFSTQPVLLSYFRGIAEKYGLRQHIRFETFVEQLTWDE
CEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AKAVWRVEMRGKDGQREVVEANAVVTAVGQLNRPRFPDIEGMGSFEGPAFHSAEWRHDVD
HCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LKGKRVAVIGTGASAYQFVPEIAPEVASLKVFQRTPPWGLPAPHYHENVPEGMKWLLEHV
CCCCEEEEEECCCHHHHHHHHHHHHHHHEEHEECCCCCCCCCCCCCCCCHHHHHHHHHHC
PYYDKWYRFWLFWMVTDGFLPMVKADPTWNGGPAAVGPENAMLREMCVQSIMAQVADRPD
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
LLPKVVPDYPIGGKRAVLDNGVWLAALKRPNVDLITDRIVRITPKGVVTADGAEHEVDVI
CCHHHCCCCCCCCCEEEEECCEEEEEECCCCCCEECCCEEEECCCCEEEECCCCCEEEEE
IYGTGFQASNFLSFLKVKGRGGRDLHESWGGDARAYLGITNPGFPNLFMIYGPNTNIVVN
EEECCCCHHHHHHHHEECCCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCEEEE
GSIVFFSECAVRYIVGCLKLLAETGARALEPKREVHDAFNARVDEANKGWAWGSPHVSSW
CCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
YKNAFGRVSQNWPFGLIDYWRATLAPNPDDYVLEKAPEAVA
HHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]