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The map label for this gene is lolC [H]

Identifier: 197105247

GI number: 197105247

Start: 1997949

End: 1999244

Strand: Reverse

Name: lolC [H]

Synonym: PHZ_c1784

Alternate gene names: 197105247

Gene position: 1999244-1997949 (Counterclockwise)

Preceding gene: 197105248

Following gene: 197105246

Centisome position: 50.03

GC content: 69.21

Gene sequence:

>1296_bases
TTGAGCGACGCCGCCGCCGTCATGGGGGCCAGCGCCCCGCCGTTCGGCTACTGGGAGCGGATGCTCGCAGGCCGCTACCT
GCGGGCCAAGCGCAGCCAGGGCGGCGTGGCGCTGATCTCGGTCATCTCGTTCATCGGCATCCTGCTCGCGGTGGCGGTGC
TCATCATCGTGATGAGCGTGATGAACGGCTTCCGGTCCGAGATGCTGACCCGCATCCTGGGCTTCCAGGGCCATCTCTAC
GTCACCGGCGGGGTGCTGGACGGTCCCGACCGCGAGGCGGCGGTGCAGCGGCTAAGGCAGGTCCCCCGCGTCACCCAGGC
CGCGTCCATCGTCGAGGCCCAGGCCATCGCGCTCGGCCCCACCCAGATCACCGGCGCCATCGTGCGCGGGATCAGCCCGG
CCGACCTGAAGGCGACGCGGCTCGTCTCGGCCAACGTCACCCAGGGCTCGCTCGAGGAGTTCGGGGTGGGCGAGTATGGG
GGCGAGACCATCGTCATCGGCGAGCGCCTGGCGCAGTCGCTGGGAGTCGCCCCTGGCGACGTCCTCACTCTGATCTCGCC
CTCCGGCGGGGCCACCGCCTTCGGCGGCACGCCGATGCAGAAGGACTATGTGGTCGGCGCCACCTTCAGCGTGGGGATGA
GCCAGTACGACCAGGCCTATGTCTTCATGCCCTTCGAGCAGGCGCAGCTCTTCTTCGGGCGCGAGGGTACGGCCGACGCC
ATCGAGGTGCGGGTGGACGATCCCGACCAGGCCGCGCGGATGAAGGCGGCGATCGCTCAGGCGGCCGGACCGGCCGCCAT
CGTCACCGACTGGACCCAGCGCGACAGCTCGTTCTGGGGCGCGCTGAAGATCGAGCGCAACGTCATGCGGCTGATCCTGA
TGCTGCTGGTGGCCATCGCCGCCATGAACATCATCTCGGGCCTCGTCATGCTGGTGAAGAACAAGGGCCGCGACATCGCC
ATCCTGCGCACCATGGGGGCCGGGCAGGGCGCGATCATGCGCATCTTCTTCATGTCGGGCGCCGCGGTCGGCGTGCTGGG
CACGGCGGCGGGCCTGCTGCTGGGCGTCCTGTTCTGCATCTACATCGGCCCCATCCAGGGCTTCGTGGAGATGGTCACGG
GCGCGACCGTGTTCTCGTCGGACGTCTATTTCCTCTCCCACATCCCGGCGAAGGTGGACTGGCGCGAGGTGCTGATCATC
ACCGCCTGGGCGCTGGGCATGAGCTTCGTGGCGACCCTCGCGCCGGCCTGGCGAGCCTCGCGGATCGATCCGGTGGAGGC
GCTCCGCTATGAGTGA

Upstream 100 bases:

>100_bases
GCCCCAAGGGCGTCGCCGAGGGCGTGGTCGAGATCAAGCGCCGGGCCACCGGCGAGCGCCAGACCCTGCCGCTGGATGCG
GCCCTGAAGGCGATCACCGC

Downstream 100 bases:

>100_bases
GCCCGTCCTTTCGATACGCGGGCTGGAGCGCACCTACCGCACGGCGGCGGGGCCGCTGACGGTGCTGCGCGGCGTGGACC
TCGACCTGCGGCCCGGCGAG

Product: ABC-type transport system, involved in lipoprotein release, permease component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSDAAAVMGASAPPFGYWERMLAGRYLRAKRSQGGVALISVISFIGILLAVAVLIIVMSVMNGFRSEMLTRILGFQGHLY
VTGGVLDGPDREAAVQRLRQVPRVTQAASIVEAQAIALGPTQITGAIVRGISPADLKATRLVSANVTQGSLEEFGVGEYG
GETIVIGERLAQSLGVAPGDVLTLISPSGGATAFGGTPMQKDYVVGATFSVGMSQYDQAYVFMPFEQAQLFFGREGTADA
IEVRVDDPDQAARMKAAIAQAAGPAAIVTDWTQRDSSFWGALKIERNVMRLILMLLVAIAAMNIISGLVMLVKNKGRDIA
ILRTMGAGQGAIMRIFFMSGAAVGVLGTAAGLLLGVLFCIYIGPIQGFVEMVTGATVFSSDVYFLSHIPAKVDWREVLII
TAWALGMSFVATLAPAWRASRIDPVEALRYE

Sequences:

>Translated_431_residues
MSDAAAVMGASAPPFGYWERMLAGRYLRAKRSQGGVALISVISFIGILLAVAVLIIVMSVMNGFRSEMLTRILGFQGHLY
VTGGVLDGPDREAAVQRLRQVPRVTQAASIVEAQAIALGPTQITGAIVRGISPADLKATRLVSANVTQGSLEEFGVGEYG
GETIVIGERLAQSLGVAPGDVLTLISPSGGATAFGGTPMQKDYVVGATFSVGMSQYDQAYVFMPFEQAQLFFGREGTADA
IEVRVDDPDQAARMKAAIAQAAGPAAIVTDWTQRDSSFWGALKIERNVMRLILMLLVAIAAMNIISGLVMLVKNKGRDIA
ILRTMGAGQGAIMRIFFMSGAAVGVLGTAAGLLLGVLFCIYIGPIQGFVEMVTGATVFSSDVYFLSHIPAKVDWREVLII
TAWALGMSFVATLAPAWRASRIDPVEALRYE
>Mature_430_residues
SDAAAVMGASAPPFGYWERMLAGRYLRAKRSQGGVALISVISFIGILLAVAVLIIVMSVMNGFRSEMLTRILGFQGHLYV
TGGVLDGPDREAAVQRLRQVPRVTQAASIVEAQAIALGPTQITGAIVRGISPADLKATRLVSANVTQGSLEEFGVGEYGG
ETIVIGERLAQSLGVAPGDVLTLISPSGGATAFGGTPMQKDYVVGATFSVGMSQYDQAYVFMPFEQAQLFFGREGTADAI
EVRVDDPDQAARMKAAIAQAAGPAAIVTDWTQRDSSFWGALKIERNVMRLILMLLVAIAAMNIISGLVMLVKNKGRDIAI
LRTMGAGQGAIMRIFFMSGAAVGVLGTAAGLLLGVLFCIYIGPIQGFVEMVTGATVFSSDVYFLSHIPAKVDWREVLIIT
AWALGMSFVATLAPAWRASRIDPVEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=395, Percent_Identity=29.620253164557, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1787360, Length=414, Percent_Identity=30.9178743961353, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45717; Mature: 45586

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAAAVMGASAPPFGYWERMLAGRYLRAKRSQGGVALISVISFIGILLAVAVLIIVMSV
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MNGFRSEMLTRILGFQGHLYVTGGVLDGPDREAAVQRLRQVPRVTQAASIVEAQAIALGP
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHEECCC
TQITGAIVRGISPADLKATRLVSANVTQGSLEEFGVGEYGGETIVIGERLAQSLGVAPGD
HHHHHHHHHCCCCCCCHHEEEEECCCCCCCHHHCCCCCCCCCEEEEHHHHHHHHCCCCCC
VLTLISPSGGATAFGGTPMQKDYVVGATFSVGMSQYDQAYVFMPFEQAQLFFGREGTADA
EEEEECCCCCCCCCCCCCCCCCEEEECCHHHCHHCCCCEEEEEEHHHHHHEECCCCCCCE
IEVRVDDPDQAARMKAAIAQAAGPAAIVTDWTQRDSSFWGALKIERNVMRLILMLLVAIA
EEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
AMNIISGLVMLVKNKGRDIAILRTMGAGQGAIMRIFFMSGAAVGVLGTAAGLLLGVLFCI
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHH
YIGPIQGFVEMVTGATVFSSDVYFLSHIPAKVDWREVLIITAWALGMSFVATLAPAWRAS
HHHHHHHHHHHHHCCHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RIDPVEALRYE
CCCHHHHHCCC
>Mature Secondary Structure 
SDAAAVMGASAPPFGYWERMLAGRYLRAKRSQGGVALISVISFIGILLAVAVLIIVMSV
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MNGFRSEMLTRILGFQGHLYVTGGVLDGPDREAAVQRLRQVPRVTQAASIVEAQAIALGP
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHEECCC
TQITGAIVRGISPADLKATRLVSANVTQGSLEEFGVGEYGGETIVIGERLAQSLGVAPGD
HHHHHHHHHCCCCCCCHHEEEEECCCCCCCHHHCCCCCCCCCEEEEHHHHHHHHCCCCCC
VLTLISPSGGATAFGGTPMQKDYVVGATFSVGMSQYDQAYVFMPFEQAQLFFGREGTADA
EEEEECCCCCCCCCCCCCCCCCEEEECCHHHCHHCCCCEEEEEEHHHHHHEECCCCCCCE
IEVRVDDPDQAARMKAAIAQAAGPAAIVTDWTQRDSSFWGALKIERNVMRLILMLLVAIA
EEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
AMNIISGLVMLVKNKGRDIAILRTMGAGQGAIMRIFFMSGAAVGVLGTAAGLLLGVLFCI
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHH
YIGPIQGFVEMVTGATVFSSDVYFLSHIPAKVDWREVLIITAWALGMSFVATLAPAWRAS
HHHHHHHHHHHHHCCHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RIDPVEALRYE
CCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]