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The map label for this gene is rnd [H]

Identifier: 197105155

GI number: 197105155

Start: 1896963

End: 1898141

Strand: Reverse

Name: rnd [H]

Synonym: PHZ_c1692

Alternate gene names: 197105155

Gene position: 1898141-1896963 (Counterclockwise)

Preceding gene: 197105159

Following gene: 197105149

Centisome position: 47.5

GC content: 70.4

Gene sequence:

>1179_bases
ATGACGCCCATCACAACCACCGCGGAACTTGAAGCGTTCTGCGCCAAGCTCAAGGGTCAGCCTTTCGTCGCCGTGGACAC
CGAGTTCATGCGCGAGACGACCTACTGGCCCAAGCTTTGCCTGATCCAGGCCGCAGCCCCCTCCGCGGAAGCCGTCATCG
ACCCCCTGGCCGACGACATCGACCTCTCGTGCTTCCTCGACATCCTGCGCGACGAGAGCATCCAGAAGGTGTTCCACGCC
GCCCGGCAGGACGTGGAAATCTTCAACAACCTCGGCGCCATGCCGAAGCCGCTGTTCGACACCCAGGTGGCGGGCATGGC
GGCGGGCTTCGGTGAACAGATCGCCTACGACGCCCTCGTGCGGCAGATGCTGAAGATCGAGATCGACAAGTCCAGCCGGT
TCACCGACTGGGCGCGCCGGCCGCTCTCGGACAGCCAGCTGACCTACGCCCTGGCCGACGTGACGCACCTGGCCAAGCTC
TACCCCCTGCTGCGCCAGCGGCTGGAGCGGGAGGGGCGGCTGGCCTGGGTCACCGACGAGATGAACGACCTCACGGACCC
GGCGAACTACGACGTCGAGCCCGAGAACGCCTGGAAGCGGCTGCGCCCGCGCCGGCACACGGCCAAGTACCTGGCGGTCT
ACCGTGCCGTCGCCGCCTGGCGCGAGCGGACCGCCCAGCTGCGCGACCAGCCGCGCGGCCGGATCCTGAAGGACGACGCG
ATCGACGAGATCGCCACGCAGACTCCGACCGACGCCGACGCGCTGGACCGGCTGCGCTCGGTGCCCAAGGGGTTCTCGGG
GTCGCGGTTCGGGCCCGACCTCCTGGCCGCCGTCCGCGAGGCGCTGAAGGACCCGGAAGGCTACGCCCCCGTGATCGAGA
AGACCCGCCAGCCGGCCTCGCCGGCCGCCGGCGCGGTCGTCGAGCTCCTGAAGGTGCTGCTGAAGGCGCGGGCCGAGGAG
GCGGGCGTGGCCTCGAAGCTGATCGCCACCGTCGCCGACCTGGAGCAGATCGCCAACAACGACAACGCCGACACCGCGGC
CCTCAAGGGTTGGCGGCGCGAGGCCTTCGGCGAGGACGCCCTGAAGCTGAAGCGCGGCGAGCTGGCCCTGGTGCTGGACG
GCGCGCGGGTGCGCGTGGTGGAAGTTCGCCGCGCGCCGAAGGCCGCCTCGGCGGGCTGA

Upstream 100 bases:

>100_bases
CCGTTCGGACGCTCGGACATTCAGGAAGCCTATAAAGGAATTGGAGCCGCGTGCATCGCGCACTTGCAGACTCGGTCGCG
CGCGGGGCTATAGCTAATCG

Downstream 100 bases:

>100_bases
CCGCAATCCTGAGGATAACCTCAAGGCTTTGAACGCGCGGGCGGATTCCACCGCCGCGGCGCGTTCTCCACAGCCGTTCC
ACCGGGCGGTCCCAGCGCCA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTPITTTAELEAFCAKLKGQPFVAVDTEFMRETTYWPKLCLIQAAAPSAEAVIDPLADDIDLSCFLDILRDESIQKVFHA
ARQDVEIFNNLGAMPKPLFDTQVAGMAAGFGEQIAYDALVRQMLKIEIDKSSRFTDWARRPLSDSQLTYALADVTHLAKL
YPLLRQRLEREGRLAWVTDEMNDLTDPANYDVEPENAWKRLRPRRHTAKYLAVYRAVAAWRERTAQLRDQPRGRILKDDA
IDEIATQTPTDADALDRLRSVPKGFSGSRFGPDLLAAVREALKDPEGYAPVIEKTRQPASPAAGAVVELLKVLLKARAEE
AGVASKLIATVADLEQIANNDNADTAALKGWRREAFGEDALKLKRGELALVLDGARVRVVEVRRAPKAASAG

Sequences:

>Translated_392_residues
MTPITTTAELEAFCAKLKGQPFVAVDTEFMRETTYWPKLCLIQAAAPSAEAVIDPLADDIDLSCFLDILRDESIQKVFHA
ARQDVEIFNNLGAMPKPLFDTQVAGMAAGFGEQIAYDALVRQMLKIEIDKSSRFTDWARRPLSDSQLTYALADVTHLAKL
YPLLRQRLEREGRLAWVTDEMNDLTDPANYDVEPENAWKRLRPRRHTAKYLAVYRAVAAWRERTAQLRDQPRGRILKDDA
IDEIATQTPTDADALDRLRSVPKGFSGSRFGPDLLAAVREALKDPEGYAPVIEKTRQPASPAAGAVVELLKVLLKARAEE
AGVASKLIATVADLEQIANNDNADTAALKGWRREAFGEDALKLKRGELALVLDGARVRVVEVRRAPKAASAG
>Mature_391_residues
TPITTTAELEAFCAKLKGQPFVAVDTEFMRETTYWPKLCLIQAAAPSAEAVIDPLADDIDLSCFLDILRDESIQKVFHAA
RQDVEIFNNLGAMPKPLFDTQVAGMAAGFGEQIAYDALVRQMLKIEIDKSSRFTDWARRPLSDSQLTYALADVTHLAKLY
PLLRQRLEREGRLAWVTDEMNDLTDPANYDVEPENAWKRLRPRRHTAKYLAVYRAVAAWRERTAQLRDQPRGRILKDDAI
DEIATQTPTDADALDRLRSVPKGFSGSRFGPDLLAAVREALKDPEGYAPVIEKTRQPASPAAGAVVELLKVLLKARAEEA
GVASKLIATVADLEQIANNDNADTAALKGWRREAFGEDALKLKRGELALVLDGARVRVVEVRRAPKAASAG

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=263, Percent_Identity=24.3346007604563, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI50301240, Length=263, Percent_Identity=24.3346007604563, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1788105, Length=376, Percent_Identity=32.7127659574468, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17531757, Length=294, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=333, Percent_Identity=26.1261261261261, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI161078302, Length=264, Percent_Identity=26.5151515151515, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43405; Mature: 43274

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPITTTAELEAFCAKLKGQPFVAVDTEFMRETTYWPKLCLIQAAAPSAEAVIDPLADDI
CCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCHHHHEECCCCCHHHHHHHHHCCC
DLSCFLDILRDESIQKVFHAARQDVEIFNNLGAMPKPLFDTQVAGMAAGFGEQIAYDALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHH
RQMLKIEIDKSSRFTDWARRPLSDSQLTYALADVTHLAKLYPLLRQRLEREGRLAWVTDE
HHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
MNDLTDPANYDVEPENAWKRLRPRRHTAKYLAVYRAVAAWRERTAQLRDQPRGRILKDDA
HHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHH
IDEIATQTPTDADALDRLRSVPKGFSGSRFGPDLLAAVREALKDPEGYAPVIEKTRQPAS
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
PAAGAVVELLKVLLKARAEEAGVASKLIATVADLEQIANNDNADTAALKGWRREAFGEDA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
LKLKRGELALVLDGARVRVVEVRRAPKAASAG
HHHCCCCEEEEECCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TPITTTAELEAFCAKLKGQPFVAVDTEFMRETTYWPKLCLIQAAAPSAEAVIDPLADDI
CCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCHHHHEECCCCCHHHHHHHHHCCC
DLSCFLDILRDESIQKVFHAARQDVEIFNNLGAMPKPLFDTQVAGMAAGFGEQIAYDALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHH
RQMLKIEIDKSSRFTDWARRPLSDSQLTYALADVTHLAKLYPLLRQRLEREGRLAWVTDE
HHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
MNDLTDPANYDVEPENAWKRLRPRRHTAKYLAVYRAVAAWRERTAQLRDQPRGRILKDDA
HHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHH
IDEIATQTPTDADALDRLRSVPKGFSGSRFGPDLLAAVREALKDPEGYAPVIEKTRQPAS
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
PAAGAVVELLKVLLKARAEEAGVASKLIATVADLEQIANNDNADTAALKGWRREAFGEDA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
LKLKRGELALVLDGARVRVVEVRRAPKAASAG
HHHCCCCEEEEECCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]