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The map label for this gene is mazG [H]

Identifier: 197105059

GI number: 197105059

Start: 1801260

End: 1802072

Strand: Reverse

Name: mazG [H]

Synonym: PHZ_c1596

Alternate gene names: 197105059

Gene position: 1802072-1801260 (Counterclockwise)

Preceding gene: 197105060

Following gene: 197105058

Centisome position: 45.09

GC content: 70.11

Gene sequence:

>813_bases
ATGACCCGACCTGCCCCGCCGGCCGACCTTCGGCCCATCGACCGCCTGCTCGCCATCATGGCCAGGCTGCGCGACCGGGA
GGACGGCTGCCCCTGGGACCAGGAGCAGACCTTCGCCACCATCGCCCCCTACACGGTCGAGGAGGCCTACGAGGTGGCCG
ACGCCATCGAACGCGGCGACCTGGCGGACCTCAAGGAGGAGCTGGGCGACCTGCTGCTGCAGGTGGTCTTCCACGCCCGC
ATGGCCGAGGAGCAGGGCGCCTTCGCCTTCGAGGACGTCGCCCGCGCCATCTCGGAGAAGATGGTCCGCCGCCACCCGCA
CGTCTTCGGCGACGAGAGCTACGGCTCGCTGGCCGAGCAGAAGCAGGGCTGGGAGGCGCTGAAGGCGGCCGAGCGCGAAC
GGAAGGGTCGCCAGGAGAGCCTGCTGGATGACGTGCCCGTGGGTCTGCCCGCCCTAACGCGCGCCGTGAAGCTCTCGAAG
CGCGCCGCGGGCGTCGGCTTCGTCTGGCCGACCGTGCAGGACGTCATGGCCAAGCTGCACGAGGAGGTCGCCGAGCTGGC
GCAGGAGGTCGAGGCCGGCGACCTCGAGAAGGCCCGCCAGGAGATGGGCGACGTGCTGTTCGTCGTCGCCAACCTCGCCC
GCACGCTCGACGTCGATCCCGAGGACGCCCTGCGCTACACCAACGCCAAGTTCACCCGGCGTTTCAGATACATAGAGCAG
CGTCTTGAAGAGCGGGGAAAGACCCCCGACCAGTCCGACCTGGCCGAGATGGACGCCCTCTGGGACGAGGCGAAGGCCGC
CGAGAGGGCCTGA

Upstream 100 bases:

>100_bases
GACGCCCGCCCAGGTCGCCCGCCCGAGCTTGCCTCCGGGGACGGCGCGCGGTCTGATCGCCGCGCGCCGTTCTGCTGTTC
CCGGAAGCCCCACGAGCCCC

Downstream 100 bases:

>100_bases
AGGGCGGCCTGAGCCGGGACGTGAGGCGGGGACCTGAGGCGGCCCCCGCCCCACCTCCGCCTCACCGCGCCCGCCCGTCG
CGCCCGCCGGCGTGCAGCAC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTRPAPPADLRPIDRLLAIMARLRDREDGCPWDQEQTFATIAPYTVEEAYEVADAIERGDLADLKEELGDLLLQVVFHAR
MAEEQGAFAFEDVARAISEKMVRRHPHVFGDESYGSLAEQKQGWEALKAAERERKGRQESLLDDVPVGLPALTRAVKLSK
RAAGVGFVWPTVQDVMAKLHEEVAELAQEVEAGDLEKARQEMGDVLFVVANLARTLDVDPEDALRYTNAKFTRRFRYIEQ
RLEERGKTPDQSDLAEMDALWDEAKAAERA

Sequences:

>Translated_270_residues
MTRPAPPADLRPIDRLLAIMARLRDREDGCPWDQEQTFATIAPYTVEEAYEVADAIERGDLADLKEELGDLLLQVVFHAR
MAEEQGAFAFEDVARAISEKMVRRHPHVFGDESYGSLAEQKQGWEALKAAERERKGRQESLLDDVPVGLPALTRAVKLSK
RAAGVGFVWPTVQDVMAKLHEEVAELAQEVEAGDLEKARQEMGDVLFVVANLARTLDVDPEDALRYTNAKFTRRFRYIEQ
RLEERGKTPDQSDLAEMDALWDEAKAAERA
>Mature_269_residues
TRPAPPADLRPIDRLLAIMARLRDREDGCPWDQEQTFATIAPYTVEEAYEVADAIERGDLADLKEELGDLLLQVVFHARM
AEEQGAFAFEDVARAISEKMVRRHPHVFGDESYGSLAEQKQGWEALKAAERERKGRQESLLDDVPVGLPALTRAVKLSKR
AAGVGFVWPTVQDVMAKLHEEVAELAQEVEAGDLEKARQEMGDVLFVVANLARTLDVDPEDALRYTNAKFTRRFRYIEQR
LEERGKTPDQSDLAEMDALWDEAKAAERA

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=261, Percent_Identity=52.1072796934866, Blast_Score=257, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30448; Mature: 30316

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPAPPADLRPIDRLLAIMARLRDREDGCPWDQEQTFATIAPYTVEEAYEVADAIERGD
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCC
LADLKEELGDLLLQVVFHARMAEEQGAFAFEDVARAISEKMVRRHPHVFGDESYGSLAEQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
KQGWEALKAAERERKGRQESLLDDVPVGLPALTRAVKLSKRAAGVGFVWPTVQDVMAKLH
HHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EEVAELAQEVEAGDLEKARQEMGDVLFVVANLARTLDVDPEDALRYTNAKFTRRFRYIEQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RLEERGKTPDQSDLAEMDALWDEAKAAERA
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRPAPPADLRPIDRLLAIMARLRDREDGCPWDQEQTFATIAPYTVEEAYEVADAIERGD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCC
LADLKEELGDLLLQVVFHARMAEEQGAFAFEDVARAISEKMVRRHPHVFGDESYGSLAEQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
KQGWEALKAAERERKGRQESLLDDVPVGLPALTRAVKLSKRAAGVGFVWPTVQDVMAKLH
HHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EEVAELAQEVEAGDLEKARQEMGDVLFVVANLARTLDVDPEDALRYTNAKFTRRFRYIEQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RLEERGKTPDQSDLAEMDALWDEAKAAERA
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]