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The map label for this gene is merA [H]

Identifier: 197104961

GI number: 197104961

Start: 1704275

End: 1705621

Strand: Direct

Name: merA [H]

Synonym: PHZ_c1498

Alternate gene names: 197104961

Gene position: 1704275-1705621 (Clockwise)

Preceding gene: 197104960

Following gene: 197104962

Centisome position: 42.65

GC content: 73.35

Gene sequence:

>1347_bases
ATGGCCGGCTACGACCTGATCGTCATCGGCAGCGGCACCGCCGCCCAGGTTGCGGTCGGCCGTGTCCGCGCGGCCGGCTG
GTCCGTCGCGGTGATCGACCATCGCCCGTTCGGCGGGACCTGCGCGCTGCGCGGCTGCGATCCGAAGAAGATGCTGGTCA
GCGGCGAGGAGGCCCTCGACGCCGCCGCGCGCATGGCCGGACACGGCGTCGAGGGCGCCCTGGCGATCGACTGGCCGGGC
CTGATGGCGTTCAAGCGGACGTTCACCGATCCGATCCCGGCCAAGCAGGAGGCCCGCTACGCCGCGCTGGGCGTCGACGC
TTTCCATGGGACCGCCCGCTTCGTGGGTCCCGATAGGGTCGCGGTTGACGGCCACACCCTGCAGGCCCGCCACATCCTGA
TCGCCAGCGGCGCGCGCCCGGTCCCGCTCGGCATCCCGGGCGAGGACCTGGTCGTCACGAGCGACGCGTTCATGGAGATC
GAGGCCCTCCCGCGCCGCATCGTGCTGATCGGCGGCGGCTACGTCGCCGCGGAGTTCTCGCACCTGGTCGCGCGCGCCGG
CGCCGAGGTCACCATCCTGCAACGGGCTGCGCGGCTCTTGCCGCACTTCGATCCCGACGCAGTGGGCTGGCTCATGCCGC
GGTTCCGGGAGCTCCGCATCGCCGTCGAGACCGGCGCGACGGTCACCCGCGTCGAGCAGTCGCACGACGGCTTGCGCGTC
CACGCCTCCCGGCGTGACGGGCCGCACCTCAGCGTCGCAGCCGACCTGGTGGTCCACGCGGCTGGGCGCGGTCCCGACCT
CGACGCCCTGGACCTGGCGGCCGGCGACGTCGCCGCGCGGGACGGCCGTCTGCAGCTGAACGACCACCTGCAGAGCGTCT
CCAACCCACGGGTCTATGCCGCCGGCGACGCGGCCGGCGTGGGGCCGCCGCTGACGCCGGTCTCCAGCCACGACGCCAAG
GTGGTCGCCGCCAACCTGCTCGACGGCCCCTCGCACCGGCCCGACTATCGCGGCGTCCCGAGCGTCGCCTTCACCGTGCC
GGCCATCGCCGCCGTCGGGCTGTCGGAGGACGAGGCGCATCGCCAGGGGCTCAGGTTCCGGGTCAACGCCGCTTCCACGC
CGGACTGGTTCACCGCGCGGCGCCTGGCCGAGCGGGTCTACGGCCACAAGGTGCTCATCGAGGAGGCCACCGACCGGATC
CTCGGCGCGCACCTGGTGGGGCCGCACGCCGAGGAGGTGATCAACCTCTTCGGCCTCGCCATCCGCCACGGGCTCACCGC
GGCCGACCTGCGATCCACCATGTTCGCCTATCCGACCGGCGCATCGGACGTGAGCTCCATGCTCTGA

Upstream 100 bases:

>100_bases
ACCTTGGTGCTCGCACTCTCCACGTTCCTGGTCGAGCCGGTCTGGGGCAAGTACCGGTCCCGCTGATCGTTCGTCGGCGT
GACCGTCGCAGGAGGACGCC

Downstream 100 bases:

>100_bases
GACGAAGGTTCGGCGGCAGGCCCGGCAGCGCCGGGCCACCCCGGCGATCGGCGGAGCAGGCGCTGGCCGCGCCCGGCCTG
CAACGGCGCGCTTCCGCGCC

Product: putative regulatory protein

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAGYDLIVIGSGTAAQVAVGRVRAAGWSVAVIDHRPFGGTCALRGCDPKKMLVSGEEALDAAARMAGHGVEGALAIDWPG
LMAFKRTFTDPIPAKQEARYAALGVDAFHGTARFVGPDRVAVDGHTLQARHILIASGARPVPLGIPGEDLVVTSDAFMEI
EALPRRIVLIGGGYVAAEFSHLVARAGAEVTILQRAARLLPHFDPDAVGWLMPRFRELRIAVETGATVTRVEQSHDGLRV
HASRRDGPHLSVAADLVVHAAGRGPDLDALDLAAGDVAARDGRLQLNDHLQSVSNPRVYAAGDAAGVGPPLTPVSSHDAK
VVAANLLDGPSHRPDYRGVPSVAFTVPAIAAVGLSEDEAHRQGLRFRVNAASTPDWFTARRLAERVYGHKVLIEEATDRI
LGAHLVGPHAEEVINLFGLAIRHGLTAADLRSTMFAYPTGASDVSSML

Sequences:

>Translated_448_residues
MAGYDLIVIGSGTAAQVAVGRVRAAGWSVAVIDHRPFGGTCALRGCDPKKMLVSGEEALDAAARMAGHGVEGALAIDWPG
LMAFKRTFTDPIPAKQEARYAALGVDAFHGTARFVGPDRVAVDGHTLQARHILIASGARPVPLGIPGEDLVVTSDAFMEI
EALPRRIVLIGGGYVAAEFSHLVARAGAEVTILQRAARLLPHFDPDAVGWLMPRFRELRIAVETGATVTRVEQSHDGLRV
HASRRDGPHLSVAADLVVHAAGRGPDLDALDLAAGDVAARDGRLQLNDHLQSVSNPRVYAAGDAAGVGPPLTPVSSHDAK
VVAANLLDGPSHRPDYRGVPSVAFTVPAIAAVGLSEDEAHRQGLRFRVNAASTPDWFTARRLAERVYGHKVLIEEATDRI
LGAHLVGPHAEEVINLFGLAIRHGLTAADLRSTMFAYPTGASDVSSML
>Mature_447_residues
AGYDLIVIGSGTAAQVAVGRVRAAGWSVAVIDHRPFGGTCALRGCDPKKMLVSGEEALDAAARMAGHGVEGALAIDWPGL
MAFKRTFTDPIPAKQEARYAALGVDAFHGTARFVGPDRVAVDGHTLQARHILIASGARPVPLGIPGEDLVVTSDAFMEIE
ALPRRIVLIGGGYVAAEFSHLVARAGAEVTILQRAARLLPHFDPDAVGWLMPRFRELRIAVETGATVTRVEQSHDGLRVH
ASRRDGPHLSVAADLVVHAAGRGPDLDALDLAAGDVAARDGRLQLNDHLQSVSNPRVYAAGDAAGVGPPLTPVSSHDAKV
VAANLLDGPSHRPDYRGVPSVAFTVPAIAAVGLSEDEAHRQGLRFRVNAASTPDWFTARRLAERVYGHKVLIEEATDRIL
GAHLVGPHAEEVINLFGLAIRHGLTAADLRSTMFAYPTGASDVSSML

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=26.9230769230769, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=27.1334792122538, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI148277065, Length=432, Percent_Identity=26.6203703703704, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI33519430, Length=432, Percent_Identity=26.6203703703704, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519428, Length=432, Percent_Identity=26.6203703703704, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519426, Length=432, Percent_Identity=26.6203703703704, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI148277071, Length=432, Percent_Identity=26.6203703703704, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI22035672, Length=448, Percent_Identity=29.4642857142857, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=26.2672811059908, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=24.6511627906977, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=29.7777777777778, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=27.7404921700224, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=26.304347826087, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=27.0562770562771, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789065, Length=381, Percent_Identity=25.1968503937008, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=28.8421052631579, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=25.9423503325942, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=25.9423503325942, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=25.0517598343685, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=26.1603375527426, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=25.3796095444685, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=22.8511530398323, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358499, Length=453, Percent_Identity=28.6975717439294, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=27.2921108742004, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=27.2921108742004, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=27.2921108742004, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737741, Length=485, Percent_Identity=27.0103092783505, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 47259; Mature: 47128

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYDLIVIGSGTAAQVAVGRVRAAGWSVAVIDHRPFGGTCALRGCDPKKMLVSGEEALD
CCCCEEEEECCCCHHHHHHHHEEECCEEEEEEECCCCCCEEEECCCCHHHHEECCHHHHH
AAARMAGHGVEGALAIDWPGLMAFKRTFTDPIPAKQEARYAALGVDAFHGTARFVGPDRV
HHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCEEEEEEEHHCCCEEECCCCEE
AVDGHTLQARHILIASGARPVPLGIPGEDLVVTSDAFMEIEALPRRIVLIGGGYVAAEFS
EECCCEEEEEEEEEECCCCCCCCCCCCCCEEEECHHHHHHCCCCCEEEEEECCHHHHHHH
HLVARAGAEVTILQRAARLLPHFDPDAVGWLMPRFRELRIAVETGATVTRVEQSHDGLRV
HHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEEEECCCEEEEECCCCCCEEE
HASRRDGPHLSVAADLVVHAAGRGPDLDALDLAAGDVAARDGRLQLNDHLQSVSNPRVYA
EECCCCCCCEEHEEHHHHEECCCCCCCCHHHHCCCCCCCCCCCEEEHHHHHHCCCCEEEE
AGDAAGVGPPLTPVSSHDAKVVAANLLDGPSHRPDYRGVPSVAFTVPAIAAVGLSEDEAH
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHH
RQGLRFRVNAASTPDWFTARRLAERVYGHKVLIEEATDRILGAHLVGPHAEEVINLFGLA
HCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHH
IRHGLTAADLRSTMFAYPTGASDVSSML
HHHCCCHHHHHHHHEECCCCCHHHHHCC
>Mature Secondary Structure 
AGYDLIVIGSGTAAQVAVGRVRAAGWSVAVIDHRPFGGTCALRGCDPKKMLVSGEEALD
CCCEEEEECCCCHHHHHHHHEEECCEEEEEEECCCCCCEEEECCCCHHHHEECCHHHHH
AAARMAGHGVEGALAIDWPGLMAFKRTFTDPIPAKQEARYAALGVDAFHGTARFVGPDRV
HHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCEEEEEEEHHCCCEEECCCCEE
AVDGHTLQARHILIASGARPVPLGIPGEDLVVTSDAFMEIEALPRRIVLIGGGYVAAEFS
EECCCEEEEEEEEEECCCCCCCCCCCCCCEEEECHHHHHHCCCCCEEEEEECCHHHHHHH
HLVARAGAEVTILQRAARLLPHFDPDAVGWLMPRFRELRIAVETGATVTRVEQSHDGLRV
HHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEEEECCCEEEEECCCCCCEEE
HASRRDGPHLSVAADLVVHAAGRGPDLDALDLAAGDVAARDGRLQLNDHLQSVSNPRVYA
EECCCCCCCEEHEEHHHHEECCCCCCCCHHHHCCCCCCCCCCCEEEHHHHHHCCCCEEEE
AGDAAGVGPPLTPVSSHDAKVVAANLLDGPSHRPDYRGVPSVAFTVPAIAAVGLSEDEAH
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHH
RQGLRFRVNAASTPDWFTARRLAERVYGHKVLIEEATDRILGAHLVGPHAEEVINLFGLA
HCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHH
IRHGLTAADLRSTMFAYPTGASDVSSML
HHHCCCHHHHHHHHEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]