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The map label for this gene is phhA [H]

Identifier: 197104875

GI number: 197104875

Start: 1597705

End: 1598631

Strand: Reverse

Name: phhA [H]

Synonym: PHZ_c1409

Alternate gene names: 197104875

Gene position: 1598631-1597705 (Counterclockwise)

Preceding gene: 197104876

Following gene: 197104872

Centisome position: 40.0

GC content: 69.04

Gene sequence:

>927_bases
TTGCGGGCCCATTCAGAACGGAACTTCCGCGAACACGGGTCCATTCTCCCGAGCATGAGCGGAGACGGCCATTTCGAGGG
CCCGCCCCCCGGCGCGCGGCCCGACTGGACCATTGACCAGAACTGGGACGCCTATTCGCGGGCCGACCACGACGTCTGGA
TCACCCTCTACGAGCGGCAGGCGGCCCTCCTGCCCGGACGCGCAGCCGATCCGTTCCTGAAGGGGCTGGAGGCGCTGGAC
CTGCACCGCGCCGGGATTCCCGACTTCGCCCGCATCAACGAGGAGCTGAGGCGCCTGACCGGCTGGACCGTCGTGGCGGT
GCCGGGTCTGGTGCCGGACGACGTCTTCTTCGACCACCTCGCCAACCGCCGCTTCCCCGCGGGCCAGTTCATCCGCAAGC
CGGAGGAGCTGGACTACCTGCAGGAGCCGGACATCTTCCACGACGTGTTCGGCCATGTGCCGATGCTGACCGATCCGGTC
TTCGCCGACTACATGCAGGCTTACGGCGAGGGCGGACGCCGCGCCCTTGGCCTTGGGCGGCTGCACAACCTGGCCCGCCT
CTACTGGTACACCGTGGAGTTCGGCCTGCTGGAGACGCCGCAGGGCCTGCGGATCTACGGCGCCGGGATCGTGTCCAGCC
GCGCCGAGTCGATCTTCGCCCTGGACGATCCCTCCCCCAACCGGCTGGGCTTCGATCTGGAGCGCGTGATGTGCACGCCC
TACCGGATCGACGACTTCCAGCAGGTCTATTTCGTGATCCCCTCGTTGCAGAGCCTGCTGGACGCCACGCTGCAGGACTT
CGCCCCCATCTATGCGCGCCTGGCCGCGGCCAGCGACGTGCCGATCGAGGCGGTCCTCCCGACGGATCGGGTCTTCACCC
GCGGCACCCAGGCCTACGCCAAGGCCGGCGGGCGCACGGCGGCCTAG

Upstream 100 bases:

>100_bases
GCTGCGCCCGCGGATCAGCCACTAAGCGGCGACGGGCGCCGGAGAAATAACCTCTTCGCAGCGGCGCCGGTCGGGAAAAG
TTTCACCTGCAACTAGCCGA

Downstream 100 bases:

>100_bases
TAGTCCCTGCGCCAGCGGACCGCGAGGCGGTTCTCGCCCAGGCCCGTCACCCGCGAGATGATCGCCAGGTTGCGGCGCAC
CCGCCACTCGACCTGGACCG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRAHSERNFREHGSILPSMSGDGHFEGPPPGARPDWTIDQNWDAYSRADHDVWITLYERQAALLPGRAADPFLKGLEALD
LHRAGIPDFARINEELRRLTGWTVVAVPGLVPDDVFFDHLANRRFPAGQFIRKPEELDYLQEPDIFHDVFGHVPMLTDPV
FADYMQAYGEGGRRALGLGRLHNLARLYWYTVEFGLLETPQGLRIYGAGIVSSRAESIFALDDPSPNRLGFDLERVMCTP
YRIDDFQQVYFVIPSLQSLLDATLQDFAPIYARLAAASDVPIEAVLPTDRVFTRGTQAYAKAGGRTAA

Sequences:

>Translated_308_residues
MRAHSERNFREHGSILPSMSGDGHFEGPPPGARPDWTIDQNWDAYSRADHDVWITLYERQAALLPGRAADPFLKGLEALD
LHRAGIPDFARINEELRRLTGWTVVAVPGLVPDDVFFDHLANRRFPAGQFIRKPEELDYLQEPDIFHDVFGHVPMLTDPV
FADYMQAYGEGGRRALGLGRLHNLARLYWYTVEFGLLETPQGLRIYGAGIVSSRAESIFALDDPSPNRLGFDLERVMCTP
YRIDDFQQVYFVIPSLQSLLDATLQDFAPIYARLAAASDVPIEAVLPTDRVFTRGTQAYAKAGGRTAA
>Mature_308_residues
MRAHSERNFREHGSILPSMSGDGHFEGPPPGARPDWTIDQNWDAYSRADHDVWITLYERQAALLPGRAADPFLKGLEALD
LHRAGIPDFARINEELRRLTGWTVVAVPGLVPDDVFFDHLANRRFPAGQFIRKPEELDYLQEPDIFHDVFGHVPMLTDPV
FADYMQAYGEGGRRALGLGRLHNLARLYWYTVEFGLLETPQGLRIYGAGIVSSRAESIFALDDPSPNRLGFDLERVMCTP
YRIDDFQQVYFVIPSLQSLLDATLQDFAPIYARLAAASDVPIEAVLPTDRVFTRGTQAYAKAGGRTAA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=219, Percent_Identity=31.5068493150685, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI31795563, Length=235, Percent_Identity=31.9148936170213, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI88900505, Length=223, Percent_Identity=31.8385650224215, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI88900501, Length=223, Percent_Identity=31.8385650224215, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI88900503, Length=223, Percent_Identity=31.8385650224215, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4759248, Length=219, Percent_Identity=31.9634703196347, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17531391, Length=221, Percent_Identity=33.0316742081448, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71980736, Length=230, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115532103, Length=232, Percent_Identity=30.1724137931034, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533973, Length=226, Percent_Identity=30.9734513274336, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980731, Length=151, Percent_Identity=27.8145695364238, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI62472054, Length=229, Percent_Identity=31.0043668122271, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24660393, Length=229, Percent_Identity=31.0043668122271, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17136774, Length=223, Percent_Identity=29.1479820627803, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17136776, Length=223, Percent_Identity=29.1479820627803, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654994, Length=177, Percent_Identity=32.7683615819209, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 34559; Mature: 34559

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAHSERNFREHGSILPSMSGDGHFEGPPPGARPDWTIDQNWDAYSRADHDVWITLYERQ
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECC
AALLPGRAADPFLKGLEALDLHRAGIPDFARINEELRRLTGWTVVAVPGLVPDDVFFDHL
HHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
ANRRFPAGQFIRKPEELDYLQEPDIFHDVFGHVPMLTDPVFADYMQAYGEGGRRALGLGR
HCCCCCCHHHHCCCHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEHHHHH
LHNLARLYWYTVEFGLLETPQGLRIYGAGIVSSRAESIFALDDPSPNRLGFDLERVMCTP
HHHHHHHHHHHEEECCEECCCCCEEEECCHHHCCCCEEEEECCCCCCCCCCCHHHHEECC
YRIDDFQQVYFVIPSLQSLLDATLQDFAPIYARLAAASDVPIEAVLPTDRVFTRGTQAYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCHHHHH
KAGGRTAA
HCCCCCCC
>Mature Secondary Structure
MRAHSERNFREHGSILPSMSGDGHFEGPPPGARPDWTIDQNWDAYSRADHDVWITLYERQ
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECC
AALLPGRAADPFLKGLEALDLHRAGIPDFARINEELRRLTGWTVVAVPGLVPDDVFFDHL
HHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
ANRRFPAGQFIRKPEELDYLQEPDIFHDVFGHVPMLTDPVFADYMQAYGEGGRRALGLGR
HCCCCCCHHHHCCCHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEHHHHH
LHNLARLYWYTVEFGLLETPQGLRIYGAGIVSSRAESIFALDDPSPNRLGFDLERVMCTP
HHHHHHHHHHHEEECCEECCCCCEEEECCHHHCCCCEEEEECCCCCCCCCCCHHHHEECC
YRIDDFQQVYFVIPSLQSLLDATLQDFAPIYARLAAASDVPIEAVLPTDRVFTRGTQAYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCHHHHH
KAGGRTAA
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]