BacMap

Definition	Phenylobacterium zucineum HLK1, complete genome.
Accession	NC_011144
Length	3,996,255

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The map label for this gene is ppi [H]

Identifier: 197104865

GI number: 197104865

Start: 1583463

End: 1583924

Strand: Direct

Name: ppi [H]

Synonym: PHZ_c1399

Alternate gene names: 197104865

Gene position: 1583463-1583924 (Clockwise)

Preceding gene: 197104864

Following gene: 197104866

Centisome position: 39.62

GC content: 68.83

Gene sequence:

>462_bases
ATGGACGCCGAGAACACCCTGATCATGGAGCTGGAGAGCGGTCCGGTGACCATCAAGCTCCGGCCCGACCTGGCGCCCAA
GCACGTGGAGCGCATCAAGGAGCTGGCGCGGGAGGGCTTCTACGACGGCGTGGTCTTCCACCGCGTGATCCCGGGCTTCA
TGGCCCAGGGCGGCGATCCCACCGGCACCGGTTCGGGCGGCTCCAAGAAGCCGAACCTGCCGGCCGAGTTCAGCCGCGAG
CCGCACGTGCGCGGCGTCTGCTCGATGGCGCGCACGCCGAACCCGAACTCGGCCAACAGCCAGTTCTTCATCTGCTTCGA
CGACGCCACCTTCCTCGACGGCCAATACACCGTGTGGGGCGAGGTCACCGAGGGCATGGAGCACGTCGACGCGCTGCCCA
AGGGCGAGCCGCCGCGCGAGCCGGGCAAGATCGTCTCGATGAAGGTCGCCGCGGACGCGTGA

Upstream 100 bases:

>100_bases
ACCCCGCCGGTCCCTGGTTTAAGGCCGAAGTCGCCCGGGTGAAGGCCCAGGGCGGCCTGTTCAAGGCCTGTGACGTGAAC
ATTCCTGCCGAGGTGAAGTG

Downstream 100 bases:

>100_bases
CGCCGGGCCTCGAGGCCGCCTACGCCGAACCGCACCGGCGCTACCACACGCGCCGGCACATCGAGCATTGCCTGGAGATG
CTGGACGCCGTTCCCGACCT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MDAENTLIMELESGPVTIKLRPDLAPKHVERIKELAREGFYDGVVFHRVIPGFMAQGGDPTGTGSGGSKKPNLPAEFSRE
PHVRGVCSMARTPNPNSANSQFFICFDDATFLDGQYTVWGEVTEGMEHVDALPKGEPPREPGKIVSMKVAADA

Sequences:

>Translated_153_residues
MDAENTLIMELESGPVTIKLRPDLAPKHVERIKELAREGFYDGVVFHRVIPGFMAQGGDPTGTGSGGSKKPNLPAEFSRE
PHVRGVCSMARTPNPNSANSQFFICFDDATFLDGQYTVWGEVTEGMEHVDALPKGEPPREPGKIVSMKVAADA
>Mature_153_residues
MDAENTLIMELESGPVTIKLRPDLAPKHVERIKELAREGFYDGVVFHRVIPGFMAQGGDPTGTGSGGSKKPNLPAEFSRE
PHVRGVCSMARTPNPNSANSQFFICFDDATFLDGQYTVWGEVTEGMEHVDALPKGEPPREPGKIVSMKVAADA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=39.8496240601504, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI7706339, Length=129, Percent_Identity=37.2093023255814, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=38.2165605095541, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI64276486, Length=156, Percent_Identity=35.8974358974359, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI310129267, Length=127, Percent_Identity=41.7322834645669, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI310120620, Length=127, Percent_Identity=41.7322834645669, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=41.5384615384615, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=42.8571428571429, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI310110104, Length=127, Percent_Identity=40.9448818897638, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI256017253, Length=129, Percent_Identity=41.0852713178295, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI221139811, Length=129, Percent_Identity=41.0852713178295, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI256017251, Length=129, Percent_Identity=41.0852713178295, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI22547212, Length=154, Percent_Identity=38.3116883116883, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI7657473, Length=154, Percent_Identity=38.3116883116883, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI22547215, Length=154, Percent_Identity=38.3116883116883, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI310127646, Length=128, Percent_Identity=40.625, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310114371, Length=128, Percent_Identity=40.625, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310119221, Length=128, Percent_Identity=40.625, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI178057341, Length=130, Percent_Identity=40, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI45439316, Length=133, Percent_Identity=38.3458646616541, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI209417936, Length=127, Percent_Identity=39.3700787401575, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI30102944, Length=127, Percent_Identity=39.3700787401575, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI219842199, Length=127, Percent_Identity=39.3700787401575, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI5174637, Length=124, Percent_Identity=39.5161290322581, Blast_Score=76, Evalue=9e-15,
Organism=Homo sapiens, GI303305009, Length=124, Percent_Identity=39.5161290322581, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI239751853, Length=127, Percent_Identity=40.1574803149606, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI113428306, Length=127, Percent_Identity=40.1574803149606, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI169214050, Length=127, Percent_Identity=40.1574803149606, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI169164185, Length=128, Percent_Identity=38.28125, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI169163623, Length=128, Percent_Identity=38.28125, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI169163387, Length=128, Percent_Identity=38.28125, Blast_Score=73, Evalue=8e-14,
Organism=Homo sapiens, GI4505991, Length=132, Percent_Identity=39.3939393939394, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI310127745, Length=138, Percent_Identity=37.6811594202899, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310119290, Length=138, Percent_Identity=37.6811594202899, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310114540, Length=138, Percent_Identity=37.6811594202899, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310132444, Length=129, Percent_Identity=37.984496124031, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310113152, Length=129, Percent_Identity=37.984496124031, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5454154, Length=145, Percent_Identity=32.4137931034483, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=160, Percent_Identity=36.875, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1786736, Length=129, Percent_Identity=39.5348837209302, Blast_Score=84, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=152, Percent_Identity=38.1578947368421, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17539496, Length=127, Percent_Identity=38.5826771653543, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17539498, Length=142, Percent_Identity=38.7323943661972, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=148, Percent_Identity=34.4594594594595, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=37.4045801526718, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=129, Percent_Identity=37.984496124031, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559074, Length=134, Percent_Identity=38.0597014925373, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17552782, Length=135, Percent_Identity=37.037037037037, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=134, Percent_Identity=37.3134328358209, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565860, Length=154, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=125, Percent_Identity=36, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=137, Percent_Identity=38.6861313868613, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=118, Percent_Identity=38.135593220339, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=118, Percent_Identity=38.135593220339, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=123, Percent_Identity=43.9024390243902, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323562, Length=127, Percent_Identity=39.3700787401575, Blast_Score=74, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321848, Length=150, Percent_Identity=36, Blast_Score=69, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17986117, Length=154, Percent_Identity=39.6103896103896, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI19922376, Length=127, Percent_Identity=38.5826771653543, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45549139, Length=126, Percent_Identity=40.4761904761905, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664125, Length=126, Percent_Identity=41.2698412698413, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357783, Length=126, Percent_Identity=41.2698412698413, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24652460, Length=157, Percent_Identity=34.3949044585987, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647301, Length=131, Percent_Identity=38.1679389312977, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922912, Length=155, Percent_Identity=33.5483870967742, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20130249, Length=125, Percent_Identity=39.2, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357249, Length=158, Percent_Identity=30.379746835443, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16599; Mature: 16599

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAENTLIMELESGPVTIKLRPDLAPKHVERIKELAREGFYDGVVFHRVIPGFMAQGGDP
CCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
TGTGSGGSKKPNLPAEFSREPHVRGVCSMARTPNPNSANSQFFICFDDATFLDGQYTVWG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCEEEEH
EVTEGMEHVDALPKGEPPREPGKIVSMKVAADA
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MDAENTLIMELESGPVTIKLRPDLAPKHVERIKELAREGFYDGVVFHRVIPGFMAQGGDP
CCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
TGTGSGGSKKPNLPAEFSREPHVRGVCSMARTPNPNSANSQFFICFDDATFLDGQYTVWG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCEEEEH
EVTEGMEHVDALPKGEPPREPGKIVSMKVAADA
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA